BG96651A - Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за провеждане на метода - Google Patents

Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за провеждане на метода

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Publication number
BG96651A
BG96651A BG096651A BG9665192A BG96651A BG 96651 A BG96651 A BG 96651A BG 096651 A BG096651 A BG 096651A BG 9665192 A BG9665192 A BG 9665192A BG 96651 A BG96651 A BG 96651A
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BG
Bulgaria
Prior art keywords
medium
culture
cell
concentration
cell mass
Prior art date
Application number
BG096651A
Other languages
English (en)
Other versions
BG61039B1 (bg
Inventor
Michael Metz
Original Assignee
Karl Mueller & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Mueller & Co.Kg filed Critical Karl Mueller & Co.Kg
Publication of BG96651A publication Critical patent/BG96651A/bg
Publication of BG61039B1 publication Critical patent/BG61039B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/10—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by centrifugation ; Cyclones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Методът е приложим в биотехнологиите. По него ферментационната смес се вкарва от време на време в циркулация и се отделят продуктите на обмяната на култивираните клетки и в даден случай клетъчна маса. По метода ферменторът се зарежда с достатъчно количество хранителна среда за стартиране на желаната култура, стерилизира се и желаната концентрация на хранителната среда се регулира. Посевната култура се поставя в хранителната среда и се оставя да расте спокойно за определено време, след което се повишава концентрацията на средата до специфичната за клетъчната култура концентрация, като едновременно се увеличава и обемът на хранителната среда до работния обем на ферментора и до клетъчната концентрация. Следват преход към непрекъснат режим на работа при смяна на хранителната среда и отделяне на продуктите на обмяната на веществата, и пълно или частично връщане на клетки. Непрекъснатият режим на работа се прекъсва в желан момент и клетъчната маса се събира при стерилни условия. В даден случай се повтарят част или всички операции в посочената последователност. Изобретението се отнася и до устройство за осъществяване на метода. 21 претенции, 10 фигури
BG96651A 1990-11-23 1992-07-20 Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му BG61039B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4037325A DE4037325A1 (de) 1990-11-23 1990-11-23 Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchfuehrung des verfahrens
PCT/EP1991/002189 WO1992009683A1 (de) 1990-11-23 1991-11-21 Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchführung des verfahrens

Publications (2)

Publication Number Publication Date
BG96651A true BG96651A (bg) 1993-12-24
BG61039B1 BG61039B1 (bg) 1996-09-30

Family

ID=6418808

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96651A BG61039B1 (bg) 1990-11-23 1992-07-20 Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му

Country Status (17)

Country Link
US (1) US5981260A (bg)
EP (1) EP0487867B1 (bg)
JP (1) JPH05503635A (bg)
KR (1) KR920703786A (bg)
AT (1) ATE138684T1 (bg)
AU (1) AU672745B2 (bg)
BG (1) BG61039B1 (bg)
BR (1) BR9106024A (bg)
CA (1) CA2074466C (bg)
CZ (1) CZ283799B6 (bg)
DE (2) DE4037325A1 (bg)
DK (1) DK0487867T3 (bg)
ES (1) ES2090199T3 (bg)
FI (1) FI101083B (bg)
HU (1) HUT65380A (bg)
NO (1) NO303230B1 (bg)
WO (1) WO1992009683A1 (bg)

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US7879593B2 (en) * 1999-12-16 2011-02-01 Whiteman G Robert Fermentation systems, methods and apparatus
US9969633B2 (en) * 1999-12-16 2018-05-15 Robert Whiteman Systems and methods for treating oil, fat and grease in collection systems
GB2378709B (en) * 1999-12-16 2004-11-03 Robert G Whiteman Fermentation system methods and apparatus
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US7081361B2 (en) * 2003-08-07 2006-07-25 Nch Corporation Biomass generator
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US8551762B2 (en) 2009-07-07 2013-10-08 Nch Corporation System and apparatus for feeding, solubilizing, growing and discharging a biological material
JP5711751B2 (ja) 2009-10-26 2015-05-07 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ グリコシル化された免疫グロブリンの調製方法
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Also Published As

Publication number Publication date
ATE138684T1 (de) 1996-06-15
JPH05503635A (ja) 1993-06-17
AU672745B2 (en) 1996-10-17
NO922887D0 (no) 1992-07-21
FI922172A (fi) 1992-05-24
US5981260A (en) 1999-11-09
CZ283799B6 (cs) 1998-06-17
DE4037325A1 (de) 1992-05-27
NO303230B1 (no) 1998-06-15
HUT65380A (en) 1994-05-02
DK0487867T3 (da) 1996-10-07
CA2074466A1 (en) 1992-05-24
NO922887L (no) 1992-09-11
FI101083B (fi) 1998-04-15
ES2090199T3 (es) 1996-10-16
DE4037325C2 (bg) 1993-08-19
CS188392A3 (en) 1992-12-16
CA2074466C (en) 2007-07-03
AU8946691A (en) 1992-06-25
HU9202189D0 (en) 1992-12-28
DE59107860D1 (de) 1996-07-04
FI922172A0 (fi) 1992-05-13
KR920703786A (ko) 1992-12-18
EP0487867A1 (de) 1992-06-03
EP0487867B1 (de) 1996-05-29
BR9106024A (pt) 1993-03-02
WO1992009683A1 (de) 1992-06-11
BG61039B1 (bg) 1996-09-30

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