BG96651A - Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за провеждане на метода - Google Patents
Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за провеждане на методаInfo
- Publication number
- BG96651A BG96651A BG096651A BG9665192A BG96651A BG 96651 A BG96651 A BG 96651A BG 096651 A BG096651 A BG 096651A BG 9665192 A BG9665192 A BG 9665192A BG 96651 A BG96651 A BG 96651A
- Authority
- BG
- Bulgaria
- Prior art keywords
- medium
- culture
- cell
- concentration
- cell mass
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000000855 fermentation Methods 0.000 title abstract 2
- 230000004151 fermentation Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 239000002609 medium Substances 0.000 abstract 4
- 239000001963 growth medium Substances 0.000 abstract 2
- 238000004113 cell culture Methods 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 238000011218 seed culture Methods 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/10—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by centrifugation ; Cyclones
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Методът е приложим в биотехнологиите. По него ферментационната смес се вкарва от време на време в циркулация и се отделят продуктите на обмяната на култивираните клетки и в даден случай клетъчна маса. По метода ферменторът се зарежда с достатъчно количество хранителна среда за стартиране на желаната култура, стерилизира се и желаната концентрация на хранителната среда се регулира. Посевната култура се поставя в хранителната среда и се оставя да расте спокойно за определено време, след което се повишава концентрацията на средата до специфичната за клетъчната култура концентрация, като едновременно се увеличава и обемът на хранителната среда до работния обем на ферментора и до клетъчната концентрация. Следват преход към непрекъснат режим на работа при смяна на хранителната среда и отделяне на продуктите на обмяната на веществата, и пълно или частично връщане на клетки. Непрекъснатият режим на работа се прекъсва в желан момент и клетъчната маса се събира при стерилни условия. В даден случай се повтарят част или всички операции в посочената последователност. Изобретението се отнася и до устройство за осъществяване на метода. 21 претенции, 10 фигури
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4037325A DE4037325A1 (de) | 1990-11-23 | 1990-11-23 | Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchfuehrung des verfahrens |
PCT/EP1991/002189 WO1992009683A1 (de) | 1990-11-23 | 1991-11-21 | Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchführung des verfahrens |
Publications (2)
Publication Number | Publication Date |
---|---|
BG96651A true BG96651A (bg) | 1993-12-24 |
BG61039B1 BG61039B1 (bg) | 1996-09-30 |
Family
ID=6418808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG96651A BG61039B1 (bg) | 1990-11-23 | 1992-07-20 | Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му |
Country Status (17)
Country | Link |
---|---|
US (1) | US5981260A (bg) |
EP (1) | EP0487867B1 (bg) |
JP (1) | JPH05503635A (bg) |
KR (1) | KR920703786A (bg) |
AT (1) | ATE138684T1 (bg) |
AU (1) | AU672745B2 (bg) |
BG (1) | BG61039B1 (bg) |
BR (1) | BR9106024A (bg) |
CA (1) | CA2074466C (bg) |
CZ (1) | CZ283799B6 (bg) |
DE (2) | DE4037325A1 (bg) |
DK (1) | DK0487867T3 (bg) |
ES (1) | ES2090199T3 (bg) |
FI (1) | FI101083B (bg) |
HU (1) | HUT65380A (bg) |
NO (1) | NO303230B1 (bg) |
WO (1) | WO1992009683A1 (bg) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1080761C (zh) * | 1993-12-24 | 2002-03-13 | Basf公司 | 2-酮基-l-古洛糖酸的改良性生产方法 |
DE9419230U1 (de) * | 1994-12-02 | 1995-03-09 | Forschungszentrum Jülich GmbH, 52428 Jülich | Anordnung für fed-batch-Prozeßuntersuchungen in einer Schüttelkolbenserie |
FI100338B (fi) * | 1995-07-18 | 1997-11-14 | Danisco Sugar Finland Oy | Menetelmä puhtaan maitohapon valmistamiseksi |
DE19718608A1 (de) * | 1997-05-02 | 1998-11-05 | Ireks Gmbh | Verfahren zur Herstellung von Milchsäure |
US7879593B2 (en) * | 1999-12-16 | 2011-02-01 | Whiteman G Robert | Fermentation systems, methods and apparatus |
US9969633B2 (en) * | 1999-12-16 | 2018-05-15 | Robert Whiteman | Systems and methods for treating oil, fat and grease in collection systems |
GB2378709B (en) * | 1999-12-16 | 2004-11-03 | Robert G Whiteman | Fermentation system methods and apparatus |
CA2431230C (en) * | 2000-12-20 | 2011-02-22 | Bayer Pharmaceuticals Corporation | A device and method for seed-train expansion of mammalian cells |
JP3958089B2 (ja) * | 2002-03-26 | 2007-08-15 | 有限会社新世紀発酵研究所 | 嫌気性菌の連続培養法 |
US7081361B2 (en) * | 2003-08-07 | 2006-07-25 | Nch Corporation | Biomass generator |
US7635586B2 (en) * | 2003-11-26 | 2009-12-22 | Broadley-James Corporation | Integrated bio-reactor monitor and control system |
US7435581B2 (en) * | 2003-11-26 | 2008-10-14 | Broadley-James Corporation | Integrated bio-reactor monitor and control system |
US20080305213A1 (en) * | 2007-06-11 | 2008-12-11 | Kerry Group Services International, Ltd. | Method and composition for preparing cured meat products |
US20120028345A1 (en) * | 2009-02-18 | 2012-02-02 | Darah Ibrahim | solid state fermentation (ssf) system |
US8961893B2 (en) | 2009-07-07 | 2015-02-24 | Nch Corporation | Automated chemical diluter system having disposable components |
US8551762B2 (en) | 2009-07-07 | 2013-10-08 | Nch Corporation | System and apparatus for feeding, solubilizing, growing and discharging a biological material |
JP5711751B2 (ja) | 2009-10-26 | 2015-05-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | グリコシル化された免疫グロブリンの調製方法 |
US8889400B2 (en) | 2010-05-20 | 2014-11-18 | Pond Biofuels Inc. | Diluting exhaust gas being supplied to bioreactor |
US20120156669A1 (en) | 2010-05-20 | 2012-06-21 | Pond Biofuels Inc. | Biomass Production |
US11512278B2 (en) | 2010-05-20 | 2022-11-29 | Pond Technologies Inc. | Biomass production |
US8969067B2 (en) | 2010-05-20 | 2015-03-03 | Pond Biofuels Inc. | Process for growing biomass by modulating supply of gas to reaction zone |
US8940520B2 (en) | 2010-05-20 | 2015-01-27 | Pond Biofuels Inc. | Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply |
US20120276633A1 (en) | 2011-04-27 | 2012-11-01 | Pond Biofuels Inc. | Supplying treated exhaust gases for effecting growth of phototrophic biomass |
US9534261B2 (en) | 2012-10-24 | 2017-01-03 | Pond Biofuels Inc. | Recovering off-gas from photobioreactor |
DE102018120885B4 (de) * | 2018-08-27 | 2020-06-18 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur kontrollierten Zuführung von Substrat |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591455A (en) * | 1968-02-14 | 1971-07-06 | Nalco Chemical Co | Continuous microbial process |
DE1953430A1 (de) * | 1968-10-25 | 1970-04-30 | Tanabe Seiyaku Co | Verfahren zur kontinuierlichen Fermentation mit Hilfe von aeroben Mikroorganismen |
GB1290444A (bg) * | 1970-02-02 | 1972-09-27 | ||
US3857757A (en) * | 1972-11-30 | 1974-12-31 | Gen Electric | Means for the oxygen/temperature control of aerobic fermentations |
US4105804A (en) * | 1973-01-31 | 1978-08-08 | Gyozo Terui | Method for separation of bacteria cells from culture broth |
US3956482A (en) * | 1973-06-25 | 1976-05-11 | W. R. Grace & Co. | Milk production |
FR2259903A1 (en) * | 1974-02-05 | 1975-08-29 | Univ Moskovsk | Continuous propagation of micro-organisms in a closed circuit - with accurately controlled process parameters and uniformity in operation |
GB1545766A (en) * | 1975-07-22 | 1979-05-16 | Novo Industri As | Process for the production of a glucose isomerase product by fermentation |
GB1514425A (en) * | 1976-02-20 | 1978-06-14 | Gist Brocades Nv | Vinegar production and other fermentation processes |
CH621363A5 (bg) * | 1976-05-18 | 1981-01-30 | Mueller Hans Dr Ing Fa | |
US4167450A (en) * | 1977-07-13 | 1979-09-11 | University Of New Hampshire | Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms |
US4357424A (en) * | 1979-12-13 | 1982-11-02 | Sim-Chem Limited | Process for the continuous production of fermentation alcohol |
DE3171017D1 (en) * | 1980-08-19 | 1985-07-25 | Ici Plc | Fermentation process |
US4342835A (en) * | 1980-10-03 | 1982-08-03 | Provesta Corporation | Fermentation process and apparatus |
DE3049381A1 (de) * | 1980-12-29 | 1982-07-29 | Rudolf 8034 Germering Schanze | Verfahren zur herstellung von ammoniumlactat enthaltenden mischungen, waessriges ammoniumlactat und vorrichtung zur durchfuehrung des verfahrens |
FR2505359B1 (fr) * | 1981-05-08 | 1985-07-05 | Air Liquide | Procede et installation de fabrication de microorganismes |
US4399223A (en) * | 1981-07-07 | 1983-08-16 | Phillips Petroleum Company | Cellular product separation |
SU1024514A1 (ru) * | 1981-07-28 | 1983-06-23 | Всесоюзный Научно-Исследовательский Биотехнический Институт | Способ культивировани водородных бактерий |
DE3323205A1 (de) * | 1983-06-28 | 1985-01-17 | Carl Schleicher & Schuell Gmbh & Co Kg, 3352 Einbeck | Einrichtung u. kontinuierliches verfahren zur filtration, sterilisation von fermentationsloesungen, kultur von mikroorganismen sowie fuer die fraktinierung von komponenten unterschiedlicher molekulargewichte auf membranen |
CA1232050A (en) * | 1984-02-28 | 1988-01-26 | James A. Zeitlin | Fermentation control system |
US4680267A (en) * | 1985-03-01 | 1987-07-14 | New Brunswick Scientific Company, Inc. | Fermentor control system |
FR2611742B1 (fr) * | 1987-03-02 | 1990-01-05 | Lyonnaise Eaux | Procede de production de cultures enrichies en microorganismes et/ou en metabolites resultant de ces cultures, appareillage pour la mise en oeuvre de ce procede et application de ce dernier, notamment a l'ensemencement et au reensemencement des nitrificateurs et bassins de traitement des eaux |
DE3733748A1 (de) * | 1987-10-06 | 1989-04-20 | Westphal Kg Georg | Verfahren zur gewinnung von ethanol und biomasse aus vergorener maische |
CA1293217C (en) * | 1987-11-09 | 1991-12-17 | Sooyoung Stanford Lee | Controlled growth rate fermentation |
US4885241A (en) * | 1988-10-13 | 1989-12-05 | University Of Queensland | Ethanol production by zymomonas cultured in yeast-conditioned media |
US4985355A (en) * | 1988-10-13 | 1991-01-15 | University Of Queensland | Ethanol production by zymomonas cultured in yeast-conditioned media |
-
1990
- 1990-11-23 DE DE4037325A patent/DE4037325A1/de active Granted
-
1991
- 1991-10-07 AT AT91117048T patent/ATE138684T1/de not_active IP Right Cessation
- 1991-10-07 DE DE59107860T patent/DE59107860D1/de not_active Expired - Lifetime
- 1991-10-07 ES ES91117048T patent/ES2090199T3/es not_active Expired - Lifetime
- 1991-10-07 DK DK91117048.8T patent/DK0487867T3/da active
- 1991-10-07 EP EP91117048A patent/EP0487867B1/de not_active Expired - Lifetime
- 1991-11-21 US US07/795,899 patent/US5981260A/en not_active Expired - Lifetime
- 1991-11-21 WO PCT/EP1991/002189 patent/WO1992009683A1/de active IP Right Grant
- 1991-11-21 CZ CS921883A patent/CZ283799B6/cs unknown
- 1991-11-21 BR BR919106024A patent/BR9106024A/pt not_active Application Discontinuation
- 1991-11-21 AU AU89466/91A patent/AU672745B2/en not_active Ceased
- 1991-11-21 JP JP3518666A patent/JPH05503635A/ja active Pending
- 1991-11-21 HU HU9202189A patent/HUT65380A/hu unknown
- 1991-11-21 KR KR1019920701770A patent/KR920703786A/ko not_active Application Discontinuation
- 1991-11-21 CA CA002074466A patent/CA2074466C/en not_active Expired - Lifetime
-
1992
- 1992-05-13 FI FI922172A patent/FI101083B/fi active
- 1992-07-20 BG BG96651A patent/BG61039B1/bg unknown
- 1992-07-21 NO NO922887A patent/NO303230B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE138684T1 (de) | 1996-06-15 |
JPH05503635A (ja) | 1993-06-17 |
AU672745B2 (en) | 1996-10-17 |
NO922887D0 (no) | 1992-07-21 |
FI922172A (fi) | 1992-05-24 |
US5981260A (en) | 1999-11-09 |
CZ283799B6 (cs) | 1998-06-17 |
DE4037325A1 (de) | 1992-05-27 |
NO303230B1 (no) | 1998-06-15 |
HUT65380A (en) | 1994-05-02 |
DK0487867T3 (da) | 1996-10-07 |
CA2074466A1 (en) | 1992-05-24 |
NO922887L (no) | 1992-09-11 |
FI101083B (fi) | 1998-04-15 |
ES2090199T3 (es) | 1996-10-16 |
DE4037325C2 (bg) | 1993-08-19 |
CS188392A3 (en) | 1992-12-16 |
CA2074466C (en) | 2007-07-03 |
AU8946691A (en) | 1992-06-25 |
HU9202189D0 (en) | 1992-12-28 |
DE59107860D1 (de) | 1996-07-04 |
FI922172A0 (fi) | 1992-05-13 |
KR920703786A (ko) | 1992-12-18 |
EP0487867A1 (de) | 1992-06-03 |
EP0487867B1 (de) | 1996-05-29 |
BR9106024A (pt) | 1993-03-02 |
WO1992009683A1 (de) | 1992-06-11 |
BG61039B1 (bg) | 1996-09-30 |
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