BG60591B1 - Антипикорнавирусни пиридазинамини - Google Patents

Антипикорнавирусни пиридазинамини Download PDF

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Publication number
BG60591B1
BG60591B1 BG93513A BG9351390A BG60591B1 BG 60591 B1 BG60591 B1 BG 60591B1 BG 93513 A BG93513 A BG 93513A BG 9351390 A BG9351390 A BG 9351390A BG 60591 B1 BG60591 B1 BG 60591B1
Authority
BG
Bulgaria
Prior art keywords
formula
alkyl
hydrogen
ethyl
compound
Prior art date
Application number
BG93513A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG93513A (bg
Inventor
Raymond Stokbroekx
Marcel Luyckx
Gilbert Grauwels
Der Eycken Cyriel Van
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG93513A publication Critical patent/BG93513A/bg
Publication of BG60591B1 publication Critical patent/BG60591B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
BG93513A 1989-12-26 1990-12-21 Антипикорнавирусни пиридазинамини BG60591B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45639589A 1989-12-26 1989-12-26
US51063590A 1990-04-18 1990-04-18

Publications (2)

Publication Number Publication Date
BG93513A BG93513A (bg) 1993-12-24
BG60591B1 true BG60591B1 (bg) 1995-09-29

Family

ID=27038209

Family Applications (1)

Application Number Title Priority Date Filing Date
BG93513A BG60591B1 (bg) 1989-12-26 1990-12-21 Антипикорнавирусни пиридазинамини

Country Status (30)

Country Link
EP (1) EP0435381B1 (sv)
JP (1) JP3157174B2 (sv)
KR (1) KR0183968B1 (sv)
CN (1) CN1037268C (sv)
AT (1) ATE129711T1 (sv)
AU (2) AU635100B2 (sv)
BG (1) BG60591B1 (sv)
CA (1) CA2031889A1 (sv)
CZ (1) CZ281251B6 (sv)
DE (1) DE69023321T2 (sv)
DK (1) DK0435381T3 (sv)
ES (1) ES2078297T3 (sv)
FI (1) FI96949C (sv)
GR (1) GR3018430T3 (sv)
HR (1) HRP930482A2 (sv)
HU (1) HUT59398A (sv)
IE (1) IE69845B1 (sv)
IL (1) IL96770A (sv)
JO (1) JO1645B1 (sv)
MY (1) MY106065A (sv)
NO (1) NO179707C (sv)
NZ (1) NZ236446A (sv)
PH (1) PH27523A (sv)
PL (1) PL165497B1 (sv)
PT (1) PT96361B (sv)
RO (1) RO108867B1 (sv)
RU (1) RU2051149C1 (sv)
TN (1) TNSN90159A1 (sv)
YU (1) YU48137B (sv)
ZW (1) ZW20190A1 (sv)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5242924A (en) * 1992-07-02 1993-09-07 Sterling Winthrop Inc. Tetrazolyl-(phenoxy and phenoxyalkyl)-piperidinylpyridazines as antiviral agents
CA2099630A1 (en) * 1992-07-02 1994-01-03 Guy Dominic Diana Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents
US5364865A (en) * 1992-12-30 1994-11-15 Sterling Winthrop Inc. Phenoxy- and phenoxyalkyl-piperidines as antiviral agents
US5514679A (en) * 1994-05-13 1996-05-07 Sterling Winthrop Inc. Therapeutic phenoxyalklpyridazines and intermediates therefor
EP0876366B1 (en) * 1996-01-15 2001-07-25 Janssen Pharmaceutica N.V. Angiogenesis inhibiting pyridazinamines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6262098B1 (en) 1998-08-07 2001-07-17 Chiron Corporation Estrogen receptor modulators
AUPR213700A0 (en) 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
CA2602336A1 (en) * 2005-03-31 2006-10-05 Ucb Pharma S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
WO2007046867A2 (en) * 2005-05-19 2007-04-26 Xenon Pharmaceuticals Inc. Piperidine derivatives and their uses as therapeutic agents
CA2613235A1 (en) * 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
CN1887875B (zh) * 2005-06-30 2011-04-06 深圳市东阳光实业发展有限公司 哒嗪胺衍生物及其用于制备小rna病毒抑制剂的用途
GB0713602D0 (en) 2007-07-12 2007-08-22 Syngenta Participations Ag Chemical compounds
CN101450049A (zh) 2007-12-07 2009-06-10 辉凌国际制药（瑞士）有限公司 药物组合物
CN102344416B (zh) * 2010-08-02 2015-09-16 中国人民解放军军事医学科学院毒物药物研究所 哒嗪衍生物及其作为抗小rna病毒感染药物的用途
WO2016068453A1 (en) * 2014-10-27 2016-05-06 Dong-A St Co., Ltd. Compound having gpr119 agonistic activity, method for preparing the same, and pharmaceutical composition including the same as effective component
KR101726819B1 (ko) * 2014-10-27 2017-04-13 동아에스티 주식회사 Gpr119 작용 활성을 갖는 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293565A (en) * 1969-05-03 1972-10-18 Aspro Nicholas Ltd Aminophthalazines and pharmaceutical compositions thereof
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
US5001125A (en) * 1984-03-26 1991-03-19 Janssen Pharmaceutica N.V. Anti-virally active pyridazinamines
NZ225045A (en) * 1987-07-01 1990-06-26 Janssen Pharmaceutica Nv Antiviral pharmaceutical compositions containing cyclodextrin and an antiviral agent
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
GB8807275D0 (en) * 1988-03-26 1988-04-27 Synphar Lab Inc Chemical compounds
NZ233526A (en) * 1989-05-15 1991-09-25 Janssen Pharmaceutica Nv Pyridazine derivatives and their pharmaceutical compositions
NZ233503A (en) * 1989-05-15 1991-06-25 Janssen Pharmaceutica Nv Substituted (thio)morpholinyl and piperazinyl alkylphenol ethers

Also Published As

Publication number Publication date
FI96949C (sv) 1996-09-25
PT96361A (pt) 1991-09-30
YU244790A (sh) 1993-05-28
NZ236446A (en) 1992-04-28
TNSN90159A1 (fr) 1991-03-05
BG93513A (bg) 1993-12-24
YU48137B (sh) 1997-05-28
DE69023321D1 (de) 1995-12-07
RO108867B1 (ro) 1994-09-30
MY106065A (en) 1995-03-31
DK0435381T3 (da) 1996-02-19
PL165497B1 (pl) 1994-12-30
GR3018430T3 (en) 1996-03-31
PH27523A (en) 1993-08-18
FI906312A0 (sv) 1990-12-20
AU3113793A (en) 1993-03-11
ES2078297T3 (es) 1995-12-16
NO179707C (no) 1996-12-04
CN1037268C (zh) 1998-02-04
IL96770A (en) 1995-01-24
FI906312A (sv) 1991-06-27
IE69845B1 (en) 1996-10-02
DE69023321T2 (de) 1996-03-28
NO179707B (no) 1996-08-26
JO1645B1 (en) 1991-11-27
HUT59398A (en) 1992-05-28
HRP930482A2 (en) 1997-04-30
AU6841890A (en) 1991-07-04
IL96770A0 (en) 1991-09-16
ATE129711T1 (de) 1995-11-15
AU639865B2 (en) 1993-08-05
IE904688A1 (en) 1991-07-17
CZ640190A3 (en) 1996-04-17
EP0435381A1 (en) 1991-07-03
NO905541D0 (no) 1990-12-21
CZ281251B6 (cs) 1996-07-17
CN1052857A (zh) 1991-07-10
PL288406A1 (en) 1992-06-01
NO905541L (no) 1991-06-27
CA2031889A1 (en) 1991-06-27
RU2051149C1 (ru) 1995-12-27
PT96361B (pt) 1998-06-30
KR910011849A (ko) 1991-08-07
JP3157174B2 (ja) 2001-04-16
AU635100B2 (en) 1993-03-11
KR0183968B1 (ko) 1999-05-01
EP0435381B1 (en) 1995-11-02
ZW20190A1 (en) 1992-07-08
FI96949B (sv) 1996-06-14
JPH04128283A (ja) 1992-04-28
HU908413D0 (en) 1991-07-29

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