BG60427B2 - 1,2,4-триазинови производни, метод за получаването им и фармацевтични състави съдържащи ги - Google Patents

1,2,4-триазинови производни, метод за получаването им и фармацевтични състави съдържащи ги Download PDF

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Publication number
BG60427B2
BG60427B2 BG097992A BG9799293A BG60427B2 BG 60427 B2 BG60427 B2 BG 60427B2 BG 097992 A BG097992 A BG 097992A BG 9799293 A BG9799293 A BG 9799293A BG 60427 B2 BG60427 B2 BG 60427B2
Authority
BG
Bulgaria
Prior art keywords
hydrogen
formula
compound
iii
triazine
Prior art date
Application number
BG097992A
Other languages
Bulgarian (bg)
English (en)
Inventor
Martin Baxter
Albert Elphick
Alistair Miller
David Sawyer
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10505597&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG60427(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of BG60427B2 publication Critical patent/BG60427B2/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/15—Preparation of carboxylic acids or their salts, halides or anhydrides by reaction of organic compounds with carbon dioxide, e.g. Kolbe-Schmitt synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG097992A 1979-06-01 1993-07-29 1,2,4-триазинови производни, метод за получаването им и фармацевтични състави съдържащи ги BG60427B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7919257 1979-06-01

Publications (1)

Publication Number Publication Date
BG60427B2 true BG60427B2 (bg) 1995-03-31

Family

ID=10505597

Family Applications (1)

Application Number Title Priority Date Filing Date
BG097992A BG60427B2 (bg) 1979-06-01 1993-07-29 1,2,4-триазинови производни, метод за получаването им и фармацевтични състави съдържащи ги

Country Status (30)

Country Link
US (2) US4486354A (th)
EP (2) EP0021121B1 (th)
JP (2) JPS5625169A (th)
AR (1) AR227521A1 (th)
AT (1) AT370097B (th)
AU (2) AU530999B2 (th)
BG (1) BG60427B2 (th)
CA (1) CA1112643A (th)
CS (1) CS234018B2 (th)
CZ (1) CZ384891A3 (th)
DD (1) DD151309A5 (th)
DK (1) DK153787C (th)
ES (1) ES8104993A1 (th)
FI (1) FI67844C (th)
GE (1) GEP19960470B (th)
GR (1) GR68380B (th)
HU (1) HU182086B (th)
IE (1) IE49823B1 (th)
IL (1) IL60201A (th)
IT (1) IT1147087B (th)
MX (1) MX9202962A (th)
MY (1) MY8500062A (th)
NL (1) NL950007I2 (th)
NZ (1) NZ193890A (th)
PL (1) PL124029B1 (th)
SU (1) SU1055331A3 (th)
UA (1) UA5576A1 (th)
YU (1) YU145680A (th)
ZA (1) ZA803250B (th)
ZW (1) ZW12980A1 (th)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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GB8328757D0 (en) * 1983-10-27 1983-11-30 Wellcome Found Chemical compounds
DE3600891A1 (de) * 1986-01-15 1987-07-16 Bayer Ag 1,8-verbrueckte 4-chinolon-3-carbonsaeuren und diese enthaltende arzneimittel
GB8613183D0 (en) * 1986-05-30 1986-07-02 Wellcome Found Triazine salt
US4972496A (en) * 1986-07-25 1990-11-20 Grid Systems Corporation Handwritten keyboardless entry computer system
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
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GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
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US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB9124807D0 (en) * 1991-11-22 1992-01-15 Wellcome Found Pharmaceutical formulations
GB9203483D0 (en) * 1992-02-19 1992-04-08 Wellcome Found Anti-inflammatory compounds
CA2137782A1 (en) * 1992-06-12 1993-12-23 Meire Nakamura-Craig Therapeutic triazine compounds and use
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
FR2699077B1 (fr) * 1992-12-16 1995-01-13 Rhone Poulenc Rorer Sa Application d'anticonvulsivants dans le traitement de lésions neurologiques liées à des traumatismes.
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GB9305693D0 (en) * 1993-03-19 1993-05-05 Wellcome Found Therapeutic triazine compounds and use
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US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9317146D0 (en) * 1993-08-18 1993-10-06 Wellcome Found Therapeutic combinations
GB9424766D0 (en) * 1994-12-07 1995-02-08 Wellcome Found Pharmaceutical composition
GB9426448D0 (en) * 1994-12-30 1995-03-01 Wellcome Found Process
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GB9512854D0 (en) * 1995-06-23 1995-08-23 Wellcome Found Novel formulation
GB9518027D0 (en) * 1995-09-05 1995-11-08 Wellcome Found Pharmacologically active compound
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WO2004103340A1 (en) * 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Water dispersible tablets of lamotrigine
GB2395483A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Crystalline lamotrigine and its monohydrate
PL1691811T3 (pl) 2003-12-11 2014-12-31 Sunovion Pharmaceuticals Inc Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji
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EP1737473A4 (en) * 2004-04-19 2009-08-26 Noven Therapeutics Llc COMBINATIONS OF LITHIUM AND USES THEREOF
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BRPI0616402A2 (pt) * 2005-09-23 2011-06-21 Janssen Pharmaceutica Nv moduladores de canabinóide de hexaidro-cicloeptapirazol
KR20080050511A (ko) 2005-09-23 2008-06-05 얀센 파마슈티카 엔.브이. 테트라하이드로-사이클로펜틸 피라졸 카나비노이드모듈레이터
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US8378096B2 (en) * 2005-09-23 2013-02-19 Janssen Pharmaceutica N.V. Hexahydro-cycloheptapyrazole cannabinoid modulators
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US20070254911A1 (en) * 2006-03-27 2007-11-01 Mingde Xia Tetrahydro-Pyrazolo[3,4-c]Pyridine Cannabinoid Modulators
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Family Cites Families (8)

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GB759014A (en) * 1952-02-26 1956-10-10 Wellcome Found Improvements in triazines and their manufacture
AT190941B (de) * 1954-09-22 1957-07-25 Chemie Linz Ag Verfahren zur Herstellung neuer Guanylhydrazone
US2952677A (en) * 1956-10-01 1960-09-13 Ici Ltd Aminoguanadine compounds
BE663481A (th) * 1964-05-05
DE1802364C3 (de) * 1967-10-12 1975-03-20 Shell Internationale Research Maatschappij B.V., Den Haag (Niederlande) Arzneimittel mit thymeretischer Wirkung
GB1223492A (en) * 1967-10-13 1971-02-24 American Home Prod Guanidines
US3637688A (en) * 1970-01-09 1972-01-25 American Home Prod 6-(fluoro and trifluoromethyl phenyl)-3 5-diamino - 1 2 4 - triazines and substituted - 6 - phenylalkyl-3,5-diamino-1 2 4-triazines
IT1145308B (it) * 1979-08-16 1986-11-05 Wellcome Found Composti aromatici sostituiti

Also Published As

Publication number Publication date
JPS5625169A (en) 1981-03-10
US4486354A (en) 1984-12-04
NZ193890A (en) 1984-07-06
ES491998A0 (es) 1981-05-16
CA1112643A (en) 1981-11-17
EP0021121B1 (en) 1983-05-11
IL60201A (en) 1984-05-31
DK153787B (da) 1988-09-05
AR227521A1 (es) 1982-11-15
US4602017A (en) 1986-07-22
AU566870B2 (en) 1987-11-05
IE49823B1 (en) 1985-12-25
ZW12980A1 (en) 1982-01-06
FI67844B (fi) 1985-02-28
ZA803250B (en) 1982-01-27
IT8048848A0 (it) 1980-05-30
CS234018B2 (en) 1985-03-14
AU5890680A (en) 1980-12-04
FI801758A7 (fi) 1980-12-02
PL224633A1 (th) 1981-02-13
HU182086B (en) 1983-12-28
IL60201A0 (en) 1980-07-31
EP0059987A1 (en) 1982-09-15
IT1147087B (it) 1986-11-19
DK153787C (da) 1989-01-16
DK233880A (da) 1980-12-02
IE801126L (en) 1980-12-01
YU145680A (en) 1983-02-28
GR68380B (th) 1981-12-28
NL950007I2 (nl) 1997-02-03
JPH0144179B2 (th) 1989-09-26
FI67844C (fi) 1985-06-10
CZ384891A3 (en) 1993-10-13
ATA289680A (de) 1982-07-15
GEP19960470B (en) 1996-08-29
AT370097B (de) 1983-02-25
PL124029B1 (en) 1982-12-31
MY8500062A (en) 1985-12-31
JPH0144706B2 (th) 1989-09-29
SU1055331A3 (ru) 1983-11-15
MX9202962A (es) 1992-07-01
AU530999B2 (en) 1983-08-04
EP0021121A1 (en) 1981-01-07
UA5576A1 (uk) 1994-12-28
EP0059987B1 (en) 1985-08-14
DD151309A5 (de) 1981-10-14
JPS6133163A (ja) 1986-02-17
ES8104993A1 (es) 1981-05-16
NL950007I1 (nl) 1995-06-16

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