BG60249B2 - Thiazole compound for treatment of ulcers - Google Patents
Thiazole compound for treatment of ulcersInfo
- Publication number
- BG60249B2 BG60249B2 BG53730A BG5373081A BG60249B2 BG 60249 B2 BG60249 B2 BG 60249B2 BG 53730 A BG53730 A BG 53730A BG 5373081 A BG5373081 A BG 5373081A BG 60249 B2 BG60249 B2 BG 60249B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- ulcers
- treatment
- thiazole compound
- compound
- thiazole
- Prior art date
Links
- 208000025865 Ulcer Diseases 0.000 title abstract 2
- 231100000397 ulcer Toxicity 0.000 title abstract 2
- -1 Thiazole compound Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/193,192 US4375547A (en) | 1980-10-02 | 1980-10-02 | N-Methyl-N'-2-([(2-dimethylaminomethyl)-4-thiazolyl]methylthio)ethyl 2-nitro-1,1-ethenediamine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG60249B1 BG60249B1 (bg) | 1994-03-24 |
| BG60249B2 true BG60249B2 (en) | 1994-03-24 |
Family
ID=22712591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG53730A BG60249B2 (en) | 1980-10-02 | 1981-10-02 | Thiazole compound for treatment of ulcers |
Country Status (36)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4904792A (en) * | 1980-10-02 | 1990-02-27 | Eli Lilly And Company | N-thiazolymethylthioalkyl-N'-alkylamidines and related compounds |
| CA1206151A (en) * | 1981-12-28 | 1986-06-17 | Richard P. Pioch | Pyrimidone anti-ulcer agents |
| US4474794A (en) * | 1982-03-19 | 1984-10-02 | Eli Lilly And Company | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds |
| FR2531703A1 (fr) * | 1982-08-13 | 1984-02-17 | Sanofi Sa | 2-aza-5-thiahexan-1-ones 1,6-disubstituees, leurs sels, procede pour leur preparation et compositions pharmaceutiques les renfermant |
| US4587344A (en) * | 1983-02-07 | 1986-05-06 | Eli Lilly And Company | Isothiourea synthesis process |
| PT78063A (en) * | 1983-02-07 | 1984-03-01 | Lilly Co Eli | Improvements in or relating to the process of synthesis of nizatidine |
| US4468517A (en) * | 1983-05-12 | 1984-08-28 | Eli Lilly And Company | Synthesis of thiazoles |
| DE3417127A1 (de) * | 1984-05-09 | 1985-11-14 | Papst-Motoren GmbH & Co KG, 7742 St Georgen | Kleinstventilator |
| DE3531504A1 (de) * | 1985-09-04 | 1987-03-12 | Basf Ag | 3-aminomethylpyrrol-1-yl-alkylamine und diese verbindungen enthaltende therapeutische mittel |
| US4777260A (en) * | 1985-12-18 | 1988-10-11 | Eli Lilly And Company | Synthesis of nizatidine intermediate |
| IL80961A0 (en) * | 1985-12-18 | 1987-03-31 | Lilly Co Eli | Synthesis of nizatidine |
| ATE86619T1 (de) * | 1987-04-06 | 1993-03-15 | Heumann Pharma Gmbh & Co | Verfahren zur herstellung von nitroethenderivaten. |
| ES2007959A6 (es) * | 1988-07-11 | 1989-07-01 | Vinas Lab | Procedimiento para la obtencion de derivados tiazolicos. |
| DK0515121T3 (da) * | 1991-05-21 | 2000-11-27 | Lilly Co Eli | Fremgangsmåde til fremstilling af mellemprodukter for nizatidin og beslægtede forbindelser |
| ES2038922B1 (es) * | 1991-12-30 | 1994-04-16 | Fermentaciones Y Sintesis Espa | Procedimiento para la obtencion de nizatidina. |
| US5294433A (en) * | 1992-04-15 | 1994-03-15 | The Procter & Gamble Company | Use of H-2 antagonists for treatment of gingivitis |
| AU662454B2 (en) * | 1992-05-12 | 1995-08-31 | Zeria Pharmaceutical Co., Ltd. | Novel quaternary ammonium salts and use thereof as medicine |
| US5541335A (en) * | 1994-07-11 | 1996-07-30 | Torcan Chemical Ltd. | Process for preparing nizatidine |
| US5470865A (en) * | 1994-08-30 | 1995-11-28 | Eli Lilly And Company | Pharmaceutical composition |
| JP2001500499A (ja) * | 1996-09-11 | 2001-01-16 | クノル アクチエンゲゼルシャフト | ニザチジンの製造方法 |
| IT1299198B1 (it) | 1998-03-05 | 2000-02-29 | Nicox Sa | Sali nitrati di farmaci antiulcera |
| JP2002529503A (ja) | 1998-11-17 | 2002-09-10 | ニトロメッド，インク． | ニトロソ化及びニトロシル化ｈ２リセプターアンタゴニスト化合物及び組成物並びにその利用方法 |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| EP1750674A4 (en) * | 2004-05-27 | 2012-05-23 | Advanced Bionutrition Corp | MICROPARTICLES FOR THE ORAL LEVY |
| US20080045575A1 (en) * | 2004-12-29 | 2008-02-21 | Van Dyke Thomas E | Delivery of H2 Antagonists |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| US20090275622A1 (en) * | 2008-04-30 | 2009-11-05 | Prasoona Linga | Nizatidine formulations |
| WO2013135852A1 (en) | 2012-03-15 | 2013-09-19 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| HUE054186T2 (hu) | 2013-07-19 | 2021-08-30 | Boehringer Ingelheim Vetmedica Gmbh | Éterezett ciklodextrin-származékokat tartalmazó, tartósított, folyékony, vizes gyógyászati készítmény |
| WO2015082389A1 (en) | 2013-12-04 | 2015-06-11 | Boehringer Ingelheim Vetmedica Gmbh | Improved pharmaceutical compositions of pimobendan |
| EP2929884A1 (en) | 2014-04-11 | 2015-10-14 | Sanovel Ilac Sanayi ve Ticaret A.S. | Pharmaceutical combinations of dabigatran and h2-receptor antagonists |
| WO2015169957A1 (en) | 2014-05-09 | 2015-11-12 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| EP4196793A1 (en) | 2020-08-11 | 2023-06-21 | Université de Strasbourg | H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1338169A (en) * | 1971-03-09 | 1973-11-21 | Smith Kline French Lab | Ureas thioureas and guanidines |
| US3917593A (en) * | 1972-05-22 | 1975-11-04 | Smithkline Corp | N-alkenyl and N-alkynyl (2-quinolyl)thio-acetamides |
| US3853865A (en) * | 1972-06-26 | 1974-12-10 | Smithkline Corp | N-aminomethyl-2-amino(and 2-amino-methyl)-2-heterocyclic-thioacetamides |
| GB1421792A (en) * | 1973-05-17 | 1976-01-21 | Smith Kline French Lab | Heterocyclic substituted-1, 1-diamino-ethylene derivatives methods for their preparation and compositions containing them |
| US4191769A (en) * | 1974-03-12 | 1980-03-04 | Smith Kline & French Laboratories Limited | Isothiourea compounds and pharmacological use |
| US4061637A (en) * | 1974-05-14 | 1977-12-06 | Istituto Luso Farmaco D'italia S.R.L. | Certain 4-aryl-5-(4-phenylpiperazino)alkyl-4-thiazolin-2-ones |
| US4173644A (en) * | 1975-02-03 | 1979-11-06 | Smith Kline & French Laboratories Limited | Thiourea compounds, compositions and methods and use |
| US4166856A (en) * | 1975-05-21 | 1979-09-04 | Smith Kline & French Laboratories Limited | Thiazole and isothiazole derivative as blockers of histamine H2 -receptors |
| GB1574214A (en) * | 1976-03-11 | 1980-09-03 | Smith Kline French Lab | Amidines |
| GB1602458A (en) * | 1977-05-05 | 1981-11-11 | Smith Kline French Lab | Bisamidines as histamine h2-antagonists |
| DE2835695A1 (de) * | 1977-08-29 | 1979-03-15 | Yamanouchi Pharma Co Ltd | Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten |
| JPS5444660A (en) * | 1977-08-29 | 1979-04-09 | Yamanouchi Pharmaceut Co Ltd | Heterocyclic compound and its preparation |
| US4210658A (en) * | 1977-09-08 | 1980-07-01 | Smith Kline & French Laboratories Limited | Amidinosulphonic acid derivatives |
| DE2905134A1 (de) * | 1978-02-17 | 1979-08-23 | Degussa | Neue acylierte aminoalkyl-cyanoguanidine mit einem heterocyclischen rest |
| ATE1353T1 (de) * | 1978-05-24 | 1982-08-15 | Imperial Chemical Industries Plc | Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
| US4200578A (en) * | 1978-12-18 | 1980-04-29 | Bristol-Myers Company | Thiazole derivatives |
-
1980
- 1980-10-02 US US06/193,192 patent/US4375547A/en not_active Expired - Lifetime
-
1981
- 1981-10-01 FI FI810358A patent/FI813058L/fi not_active Application Discontinuation
- 1981-10-01 YU YU2364/81A patent/YU42728B/xx unknown
- 1981-10-01 HU HU812844A patent/HU188697B/hu unknown
- 1981-10-01 ES ES505950A patent/ES8301950A1/es not_active Expired
- 1981-10-01 PH PH26296A patent/PH18135A/en unknown
- 1981-10-01 CS CS817182A patent/CS227015B2/cs unknown
- 1981-10-01 PT PT73757A patent/PT73757B/pt unknown
- 1981-10-01 DK DK435181A patent/DK164056C/da not_active IP Right Cessation
- 1981-10-01 UA UA3344304A patent/UA6081A1/uk unknown
- 1981-10-01 IE IE2285/81A patent/IE51603B1/en not_active IP Right Cessation
- 1981-10-01 ZA ZA816817A patent/ZA816817B/xx unknown
- 1981-10-01 RO RO110860A patent/RO85815B/ro unknown
- 1981-10-01 NO NO813334A patent/NO155885C/no not_active IP Right Cessation
- 1981-10-01 SU SU813344304A patent/SU1184443A3/ru active
- 1981-10-01 RO RO81105440A patent/RO82215A/ro unknown
- 1981-10-01 CA CA000387139A patent/CA1166248A/en not_active Expired
- 1981-10-01 NZ NZ198523A patent/NZ198523A/en unknown
- 1981-10-01 IL IL63980A patent/IL63980A/xx not_active IP Right Cessation
- 1981-10-01 FI FI813058A patent/FI76570C/fi not_active IP Right Cessation
- 1981-10-01 AU AU75945/81A patent/AU542553B2/en not_active Expired
- 1981-10-02 CY CY135181A patent/CY1351A/xx unknown
- 1981-10-02 EP EP81304572A patent/EP0049618B1/en not_active Expired
- 1981-10-02 BG BG53730A patent/BG60249B2/xx unknown
- 1981-10-02 GB GB8129855A patent/GB2084581B/en not_active Expired
- 1981-10-02 DE DE8181304572T patent/DE3171819D1/de not_active Expired
- 1981-10-02 GR GR66193A patent/GR75023B/el unknown
- 1981-10-02 KR KR1019810003721A patent/KR850001795B1/ko not_active Expired
- 1981-10-02 JP JP56158594A patent/JPS5791980A/ja active Granted
- 1981-10-02 PL PL1981238035A patent/PL130626B1/pl unknown
- 1981-10-02 PL PL1981233295A patent/PL130526B1/pl unknown
- 1981-10-02 DD DD81233851A patent/DD200371A5/de unknown
- 1981-10-03 EG EG566/81A patent/EG15678A/xx active
-
1982
- 1982-08-09 ES ES514868A patent/ES514868A0/es active Granted
- 1982-11-09 AR AR82291229A patent/AR241439A1/es active
-
1986
- 1986-11-25 MX MX572386A patent/MX5723A/es unknown
-
1987
- 1987-02-19 HK HK159/87A patent/HK15987A/en not_active IP Right Cessation
- 1987-12-30 MY MY247/87A patent/MY8700247A/xx unknown
-
1991
- 1991-01-24 DK DK012391A patent/DK167759B1/da not_active IP Right Cessation
-
1993
- 1993-06-09 LU LU88293C patent/LU88293I2/fr unknown
- 1993-06-29 NL NL930107C patent/NL930107I2/nl unknown
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