BG51041A3 - Process for the preparation of (s)- alpha- ethyl- 2- oxo- 1- pyrrolidineacetamide - Google Patents
Process for the preparation of (s)- alpha- ethyl- 2- oxo- 1- pyrrolidineacetamide Download PDFInfo
- Publication number
- BG51041A3 BG51041A3 BG090398A BG9039889A BG51041A3 BG 51041 A3 BG51041 A3 BG 51041A3 BG 090398 A BG090398 A BG 090398A BG 9039889 A BG9039889 A BG 9039889A BG 51041 A3 BG51041 A3 BG 51041A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- pyrrolidineacetamide
- oxo
- ethyl
- alpha
- preparation
- Prior art date
Links
- HPHUVLMMVZITSG-LURJTMIESA-N levetiracetam Chemical compound CC[C@@H](C(N)=O)N1CCCC1=O HPHUVLMMVZITSG-LURJTMIESA-N 0.000 title 1
- -1 (s)-(2-(methylthio)ethyl)-2-oxo-1-pyrrolidineacetamide Chemical compound 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003009 desulfurizing effect Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB888827389A GB8827389D0 (en) | 1988-11-23 | 1988-11-23 | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG51041A3 true BG51041A3 (en) | 1993-01-15 |
Family
ID=10647345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG090398A BG51041A3 (en) | 1988-11-23 | 1989-11-20 | Process for the preparation of (s)- alpha- ethyl- 2- oxo- 1- pyrrolidineacetamide |
Country Status (17)
| Country | Link |
|---|---|
| KR (1) | KR0157610B1 (es) |
| CN (1) | CN1020604C (es) |
| AT (1) | AT392781B (es) |
| BG (1) | BG51041A3 (es) |
| CY (1) | CY1672A (es) |
| ES (1) | ES2023532A6 (es) |
| FI (1) | FI91961C (es) |
| GB (2) | GB8827389D0 (es) |
| GR (1) | GR1000719B (es) |
| HK (1) | HK102492A (es) |
| HU (1) | HU204508B (es) |
| NO (1) | NO173823C (es) |
| PH (1) | PH26332A (es) |
| PL (1) | PL161781B1 (es) |
| PT (1) | PT92365B (es) |
| RU (1) | RU1797607C (es) |
| SG (1) | SG89392G (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9319732D0 (en) | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
| US6107492A (en) * | 1998-05-08 | 2000-08-22 | Ucb, S.A. | Process for the preparation of levetiracetam |
| ES2287039T3 (es) | 1999-12-01 | 2007-12-16 | Ucb, S.A. | Un derivado de pirrolidinacetamida para el tratamiento de dolor cronico o neuropatico. |
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US7132552B2 (en) * | 2003-02-03 | 2006-11-07 | Teva Pharmaceutical Industries, Ltd. | Process for producing levetiracetam |
| ES2214147B1 (es) * | 2003-02-28 | 2005-10-01 | Farma-Lepori S.A. | Procedimiento de obtencion de un agente antiepileptico. |
| PL1667967T3 (pl) | 2003-09-24 | 2012-11-30 | Ucb Pharma Sa | Sposób wytwarzania pochodnych 2-okso-1-pirolidyny |
| CA2488325C (en) | 2004-11-22 | 2010-08-24 | Apotex Pharmachem Inc. | Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| AU2006254336B9 (en) | 2005-06-01 | 2013-02-28 | Ucb Pharma, S.A. | 2 -oxo-I -pyrrolidine derivatives/ processes for preparing them and their therapeutic use on the central nervous system |
| US8338621B2 (en) | 2005-12-21 | 2012-12-25 | Ucb S.A. | Process for the preparation of 2-oxo-1-pyrrolidine derivatives |
| WO2009050735A1 (en) * | 2007-10-15 | 2009-04-23 | Lupin Limited | A novel polymorph of levetiracetam and a process for its preparation |
| EP2147911A1 (en) | 2008-07-24 | 2010-01-27 | ZaCh System S.p.A. | Process for the preparation of levetiracetam |
| US7939676B2 (en) | 2009-09-17 | 2011-05-10 | Zach System S.P.A. | Process for the preparation of levetiracetam |
| KR102461134B1 (ko) | 2014-01-21 | 2022-10-28 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| UA121965C2 (uk) | 2014-01-21 | 2020-08-25 | Янссен Фармацевтика Нв | Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1309692A (en) * | 1970-02-13 | 1973-03-14 | Ucb Sa | N-substituted lactams |
| GB8412358D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8412357D0 (en) * | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
-
1988
- 1988-11-23 GB GB888827389A patent/GB8827389D0/en active Pending
-
1989
- 1989-11-20 BG BG090398A patent/BG51041A3/xx unknown
- 1989-11-20 GR GR890100769A patent/GR1000719B/el not_active IP Right Cessation
- 1989-11-21 PT PT92365A patent/PT92365B/pt not_active IP Right Cessation
- 1989-11-21 GB GB8926244A patent/GB2225322B/en not_active Expired - Lifetime
- 1989-11-22 CN CN89108764A patent/CN1020604C/zh not_active Expired - Fee Related
- 1989-11-22 AT AT2666/89A patent/AT392781B/de not_active IP Right Cessation
- 1989-11-22 RU SU4742434A patent/RU1797607C/ru active
- 1989-11-22 NO NO894649A patent/NO173823C/no unknown
- 1989-11-22 HU HU896132A patent/HU204508B/hu not_active IP Right Cessation
- 1989-11-22 ES ES8903978A patent/ES2023532A6/es not_active Expired - Lifetime
- 1989-11-22 FI FI895562A patent/FI91961C/fi active IP Right Grant
- 1989-11-22 PL PL89282413A patent/PL161781B1/pl unknown
- 1989-11-23 PH PH39568A patent/PH26332A/en unknown
- 1989-11-23 KR KR1019890017038A patent/KR0157610B1/ko not_active IP Right Cessation
-
1992
- 1992-09-05 SG SG893/92A patent/SG89392G/en unknown
- 1992-12-17 HK HK1024/92A patent/HK102492A/xx not_active IP Right Cessation
-
1993
- 1993-05-14 CY CY1672A patent/CY1672A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO894649L (no) | 1990-05-25 |
| GR1000719B (el) | 1992-11-23 |
| GB8926244D0 (en) | 1990-01-10 |
| PH26332A (en) | 1992-04-29 |
| PT92365B (pt) | 1995-07-18 |
| GB8827389D0 (en) | 1988-12-29 |
| RU1797607C (ru) | 1993-02-23 |
| NO173823B (no) | 1993-11-01 |
| KR900007797A (ko) | 1990-06-02 |
| HK102492A (en) | 1992-12-24 |
| NO173823C (no) | 1994-02-09 |
| AT392781B (de) | 1991-06-10 |
| ATA266689A (de) | 1990-11-15 |
| NO894649D0 (no) | 1989-11-22 |
| GR890100769A (en) | 1990-12-31 |
| CN1042904A (zh) | 1990-06-13 |
| HU204508B (en) | 1992-01-28 |
| ES2023532A6 (es) | 1992-01-16 |
| FI91961C (fi) | 1994-09-12 |
| PL161781B1 (en) | 1993-07-30 |
| GB2225322A (en) | 1990-05-30 |
| CY1672A (en) | 1993-05-14 |
| GB2225322B (en) | 1992-03-25 |
| FI91961B (fi) | 1994-05-31 |
| SG89392G (en) | 1992-12-04 |
| PT92365A (pt) | 1990-05-31 |
| KR0157610B1 (ko) | 1998-11-16 |
| HU896132D0 (en) | 1990-02-28 |
| HUT53072A (en) | 1990-09-28 |
| CN1020604C (zh) | 1993-05-12 |
| FI895562A0 (fi) | 1989-11-22 |
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