ES2023532A6 - Procedimiento de preparacion de (s)-*-etil-2-oxo-1-pirrolidinoacetamida> - Google Patents

Procedimiento de preparacion de (s)-*-etil-2-oxo-1-pirrolidinoacetamida>

Info

Publication number
ES2023532A6
ES2023532A6 ES8903978A ES8903978A ES2023532A6 ES 2023532 A6 ES2023532 A6 ES 2023532A6 ES 8903978 A ES8903978 A ES 8903978A ES 8903978 A ES8903978 A ES 8903978A ES 2023532 A6 ES2023532 A6 ES 2023532A6
Authority
ES
Spain
Prior art keywords
pyrrolidineacetamide
oxo
alpha
ethyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8903978A
Other languages
English (en)
Inventor
Eric Cossement
Gnevieve Motte
Jean Pierre Geerts
Jean Gobert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Publication of ES2023532A6 publication Critical patent/ES2023532A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE (S) -A-ETIL-2-OXO-1-PIRROLIDINOACETAMIDA, POR HIDROGENOLISIS DE (S) -[2-(METILTIO) ETIL]-2-OXO-1-PIRROLIDINOACETAMIDA EN PRESENCIA DE UN REACTIVO DE DESULFURACION TAL COMO NABH4/NICL2.6H2O, NIQUEL RANEY W-2 O PREFERIBLEMENTE NIQUEL RANEY T-1. LA (S) -A-ETIL-2-OXO-1-PIRROLIDINOACETAMIDA ES UTIL PARA EL TRATAMIENTO Y LA PREVENCIION DE AGRESIONES DE TIPO HIPOXICO E ISQUEMICO DEL SISTEMA NERVIOSO CENTRAL.
ES8903978A 1988-11-23 1989-11-22 Procedimiento de preparacion de (s)-*-etil-2-oxo-1-pirrolidinoacetamida> Expired - Lifetime ES2023532A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888827389A GB8827389D0 (en) 1988-11-23 1988-11-23 Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide

Publications (1)

Publication Number Publication Date
ES2023532A6 true ES2023532A6 (es) 1992-01-16

Family

ID=10647345

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8903978A Expired - Lifetime ES2023532A6 (es) 1988-11-23 1989-11-22 Procedimiento de preparacion de (s)-*-etil-2-oxo-1-pirrolidinoacetamida>

Country Status (17)

Country Link
KR (1) KR0157610B1 (es)
CN (1) CN1020604C (es)
AT (1) AT392781B (es)
BG (1) BG51041A3 (es)
CY (1) CY1672A (es)
ES (1) ES2023532A6 (es)
FI (1) FI91961C (es)
GB (2) GB8827389D0 (es)
GR (1) GR1000719B (es)
HK (1) HK102492A (es)
HU (1) HU204508B (es)
NO (1) NO173823C (es)
PH (1) PH26332A (es)
PL (1) PL161781B1 (es)
PT (1) PT92365B (es)
RU (1) RU1797607C (es)
SG (1) SG89392G (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214147A1 (es) * 2003-02-28 2004-09-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9319732D0 (en) 1993-09-24 1993-11-10 Ucb Sa Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
HUP0204023A3 (en) 1999-12-01 2005-03-29 Ucb Sa A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders and pharmaceutical compositions containing them
GB0004297D0 (en) 2000-02-23 2000-04-12 Ucb Sa 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses
CN1802352A (zh) * 2003-02-03 2006-07-12 特瓦制药工业有限公司 制备左乙拉西坦的方法
ES2390455T3 (es) * 2003-09-24 2012-11-13 Ucb Pharma, S.A. Procedimiento para la preparación de derivados de 2-oxo-1-pirrolidina
CA2488325C (en) 2004-11-22 2010-08-24 Apotex Pharmachem Inc. Improved process for the preparation of (s)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide and (r)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
EP1912966A2 (en) 2005-06-01 2008-04-23 Ucb, S.A. 2-oxo-1-pyrrolidine derivatives and their therapeutic use on the central nervous system
US8338621B2 (en) 2005-12-21 2012-12-25 Ucb S.A. Process for the preparation of 2-oxo-1-pyrrolidine derivatives
WO2009050735A1 (en) * 2007-10-15 2009-04-23 Lupin Limited A novel polymorph of levetiracetam and a process for its preparation
EP2147911A1 (en) 2008-07-24 2010-01-27 ZaCh System S.p.A. Process for the preparation of levetiracetam
US7939676B2 (en) 2009-09-17 2011-05-10 Zach System S.P.A. Process for the preparation of levetiracetam
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
MX2016009471A (es) 2014-01-21 2016-10-13 Janssen Pharmaceutica Nv Combinaciones que comprenden agonistas ortostericos o moduladores alostericos positivos del receptor glutamatergico metabotropico de subtipo 2 y su uso.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309692A (en) * 1970-02-13 1973-03-14 Ucb Sa N-substituted lactams
GB8412357D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition
GB8412358D0 (en) * 1984-05-15 1984-06-20 Ucb Sa Pharmaceutical composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2214147A1 (es) * 2003-02-28 2004-09-01 Farma-Lepori S.A. Procedimiento de obtencion de un agente antiepileptico.
WO2004076416A1 (es) * 2003-02-28 2004-09-10 Farma-Lepori S.A. Procedimiento de obtención de un agente antiepiléptico

Also Published As

Publication number Publication date
CY1672A (en) 1993-05-14
HK102492A (en) 1992-12-24
NO894649L (no) 1990-05-25
SG89392G (en) 1992-12-04
PL161781B1 (en) 1993-07-30
HUT53072A (en) 1990-09-28
GR1000719B (el) 1992-11-23
AT392781B (de) 1991-06-10
PH26332A (en) 1992-04-29
GB8926244D0 (en) 1990-01-10
BG51041A3 (en) 1993-01-15
GB8827389D0 (en) 1988-12-29
PT92365A (pt) 1990-05-31
GB2225322B (en) 1992-03-25
NO173823B (no) 1993-11-01
CN1042904A (zh) 1990-06-13
KR0157610B1 (ko) 1998-11-16
CN1020604C (zh) 1993-05-12
GR890100769A (en) 1990-12-31
KR900007797A (ko) 1990-06-02
HU896132D0 (en) 1990-02-28
FI91961C (fi) 1994-09-12
FI895562A0 (fi) 1989-11-22
PT92365B (pt) 1995-07-18
GB2225322A (en) 1990-05-30
HU204508B (en) 1992-01-28
NO173823C (no) 1994-02-09
NO894649D0 (no) 1989-11-22
ATA266689A (de) 1990-11-15
FI91961B (fi) 1994-05-31
RU1797607C (ru) 1993-02-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20071123