BG50273A3 - Method for the preparation of esters of the 1- benzyl- 3- hydroxymethylinedazol - Google Patents

Method for the preparation of esters of the 1- benzyl- 3- hydroxymethylinedazol

Info

Publication number
BG50273A3
BG50273A3 BG091122A BG9112290A BG50273A3 BG 50273 A3 BG50273 A3 BG 50273A3 BG 091122 A BG091122 A BG 091122A BG 9112290 A BG9112290 A BG 9112290A BG 50273 A3 BG50273 A3 BG 50273A3
Authority
BG
Bulgaria
Prior art keywords
benzyl
esters
hydroxymethylinedazol
preparation
general formula
Prior art date
Application number
BG091122A
Other languages
Bulgarian (bg)
English (en)
Inventor
Bruno Silvestrini
Leandro Baiocchi
Original Assignee
Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A. filed Critical Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.P.A.
Priority to BG093291A priority Critical patent/BG51352A3/bg
Priority to BG093295A priority patent/BG50274A3/xx
Priority to BG093296A priority patent/BG50275A3/xx
Publication of BG50273A3 publication Critical patent/BG50273A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
BG091122A 1989-02-07 1990-02-06 Method for the preparation of esters of the 1- benzyl- 3- hydroxymethylinedazol BG50273A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
BG093291A BG51352A3 (bg) 1989-02-07 1990-02-06 Метод за получаване на етери на 1-бензил-3- хидроксиметил-индазол
BG093295A BG50274A3 (en) 1989-02-07 1990-02-06 Method for the preparation of esters of 1- benzyl- 3- hydroxymethyl- indazol
BG093296A BG50275A3 (en) 1989-02-07 1990-02-06 Method for the preparation of derivatives of 1- benzyl- indazol- 3- il

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8947620A IT1230441B (it) 1989-02-07 1989-02-07 Eteri della serie dell'indazolo

Publications (1)

Publication Number Publication Date
BG50273A3 true BG50273A3 (en) 1992-06-15

Family

ID=11261479

Family Applications (1)

Application Number Title Priority Date Filing Date
BG091122A BG50273A3 (en) 1989-02-07 1990-02-06 Method for the preparation of esters of the 1- benzyl- 3- hydroxymethylinedazol

Country Status (36)

Country Link
US (2) US4999367A (cs)
EP (1) EP0382276B1 (cs)
JP (1) JP2870925B2 (cs)
KR (1) KR0145525B1 (cs)
CN (2) CN1046505C (cs)
AR (1) AR247386A1 (cs)
AT (1) ATE127115T1 (cs)
AU (1) AU624895B2 (cs)
BG (1) BG50273A3 (cs)
CA (1) CA2009503C (cs)
CZ (1) CZ280121B6 (cs)
DD (2) DD291995A5 (cs)
DE (2) DE69021902T2 (cs)
DK (1) DK0382276T3 (cs)
EG (1) EG19170A (cs)
ES (1) ES2020171T3 (cs)
FI (1) FI102678B (cs)
GE (1) GEP19971030B (cs)
GR (2) GR910300073T1 (cs)
HU (1) HU204793B (cs)
IL (1) IL93132A (cs)
IN (1) IN170957B (cs)
IT (1) IT1230441B (cs)
LT (1) LT3604B (cs)
LV (1) LV10612B (cs)
NZ (1) NZ232258A (cs)
PE (1) PE25091A1 (cs)
PH (1) PH26552A (cs)
PL (2) PL163720B1 (cs)
PT (1) PT93067B (cs)
RO (1) RO106252B1 (cs)
RU (3) RU2066318C1 (cs)
SK (1) SK56390A3 (cs)
UA (1) UA26852C2 (cs)
YU (1) YU47943B (cs)
ZA (1) ZA90644B (cs)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1253703B (it) * 1991-04-22 1995-08-23 Angelini Francesco Ist Ricerca Uso di acidi metossi alcanoici dell'indazolo per preparare un farmaco attivo nel trattamento di malattie autoimmunitarie
IT1293795B1 (it) 1997-07-28 1999-03-10 Angelini Ricerche Spa Farmaco attivo nel ridurre la produzione di proteina mcp-1
US5943270A (en) * 1997-11-26 1999-08-24 Intel Corporation Two-transistor DRAM cell for logic process technology
US7514463B2 (en) 2004-08-20 2009-04-07 University Of Kansas Lonidamine analogues and their use in male contraception and cancer treatment
ITMI20062254A1 (it) * 2006-11-24 2008-05-25 Acraf Uso di un acido metossi-alcanoico dell'indazolo per preparare una composizione farmaceutca
PT2262778T (pt) 2008-03-07 2019-11-19 Acraf Derivados de 1-benzil-3-hidroximetilindazolo e utilização dos mesmos no tratamento de doenças baseadas na expressão de mcp-1, cxcr1 e p40
MX2010009626A (es) * 2008-03-07 2010-12-20 Acraf Derivados de 1-bencil-3-hidroximetilindazol y su uso en el tratamiento de enfermedades basadas en la expresion de mcp-1, cx3cr1.
AR070813A1 (es) 2008-03-07 2010-05-05 Acraf Nuevos derivados de 1- bencil -3-hidroximetilindazol y su utilizacion en el tratamiento de enfermedades basadas en la expresion de mcp-1 y cx3cr1
CA2765461C (en) * 2009-08-03 2017-04-11 Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F.S.P.A. Process for the preparation of 1-benzyl-3-hydr0xymethyl-1h-indaz0le and its derivatives and required magnesium intermediates
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
WO2013163758A1 (en) 2012-05-01 2013-11-07 Boyd Shelley Romayne Methods for treating and diagnosing blinding eye diseases
RU2645344C2 (ru) 2012-05-18 2018-02-21 Санофи Производные пиразола и их применение в качестве lpar5 антагонистов
EP2850062B1 (en) 2012-05-18 2017-07-19 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
CN108047136B (zh) * 2017-12-20 2021-07-09 长春普华制药股份有限公司 一种苄达酸的精制方法
CA3144861A1 (en) * 2019-06-25 2020-12-30 Translatum Medicus, Inc. Processes of making 2-((1-benzyl-1h-indazol-3-yl)methoxy)-2-methylpropanoic acid and its derivatives
CN113929627A (zh) * 2021-10-19 2022-01-14 吕梁学院 一种宾达利的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3470298A (en) * 1969-01-29 1969-09-30 Acraf Topical anti-inflammatory composition containing (indazole-3-yl)-oxyalkanoic acids
IT1131779B (it) 1980-07-29 1986-06-25 Acraf Sale dell'acido (1-benzil-1h-indazol-3-il)-ossiacetico con la lisina e procedimento per la sua preparazione
IT1189052B (it) 1981-11-27 1988-01-28 Acraf Trattamento della cataratta
IT1194564B (it) 1983-04-18 1988-09-22 Acraf Impiego del bendazac e dei suoi sali nel trattamento della retinite pigmentosa
IT1197805B (it) 1986-08-01 1988-12-06 Acraf Metodo per il tratamento di lenti a contatto

Also Published As

Publication number Publication date
JP2870925B2 (ja) 1999-03-17
KR0145525B1 (ko) 1998-08-17
ES2020171T3 (es) 1995-12-01
SK278441B6 (en) 1997-05-07
CZ280121B6 (cs) 1995-11-15
LV10612A (lv) 1995-04-20
NZ232258A (en) 1991-06-25
IT8947620A0 (it) 1989-02-07
CN1088201A (zh) 1994-06-22
GR3018165T3 (en) 1996-02-29
US5112986A (en) 1992-05-12
PE25091A1 (es) 1991-08-17
FI900577A0 (fi) 1990-02-06
EP0382276B1 (en) 1995-08-30
HU900689D0 (en) 1990-04-28
GEP19971030B (en) 1997-06-13
DD291995A5 (de) 1991-07-18
EG19170A (en) 1994-11-30
LT3604B (en) 1995-12-27
EP0382276A2 (en) 1990-08-16
CN1046505C (zh) 1999-11-17
CN1034016C (zh) 1997-02-12
CZ56390A3 (en) 1995-06-14
PT93067A (pt) 1990-08-31
IN170957B (cs) 1992-06-20
AR247386A1 (es) 1994-12-29
PL163720B1 (pl) 1994-04-29
ZA90644B (en) 1991-01-30
AU624895B2 (en) 1992-06-25
CA2009503A1 (en) 1990-08-07
RU2055071C1 (ru) 1996-02-27
LV10612B (en) 1995-08-20
YU20690A (sh) 1992-07-20
SK56390A3 (en) 1997-05-07
IL93132A0 (en) 1990-11-05
YU47943B (sh) 1996-07-24
DK0382276T3 (da) 1996-01-15
HU204793B (en) 1992-02-28
IT1230441B (it) 1991-10-23
ES2020171A4 (es) 1991-08-01
DE69021902D1 (de) 1995-10-05
ATE127115T1 (de) 1995-09-15
AU4906690A (en) 1990-08-16
IL93132A (en) 1994-05-30
JPH02240065A (ja) 1990-09-25
LTIP872A (en) 1995-03-27
HUT53088A (en) 1990-09-28
UA26852C2 (uk) 1999-12-29
RO106252B1 (ro) 1993-03-31
PH26552A (en) 1992-08-19
DE382276T1 (de) 1991-11-28
DE69021902T2 (de) 1996-05-23
RU2066318C1 (ru) 1996-09-10
FI102678B1 (fi) 1999-01-29
PL163730B1 (pl) 1994-04-29
EP0382276A3 (en) 1990-12-12
US4999367A (en) 1991-03-12
KR900012913A (ko) 1990-09-03
GR910300073T1 (en) 1991-11-15
PT93067B (pt) 1995-12-29
CA2009503C (en) 2000-04-11
CN1044810A (zh) 1990-08-22
DD295363A5 (de) 1991-10-31
FI102678B (fi) 1999-01-29
RU2044729C1 (ru) 1995-09-27

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