BG50275A3 - Method for the preparation of derivatives of 1- benzyl- indazol- 3- il - Google Patents
Method for the preparation of derivatives of 1- benzyl- indazol- 3- ilInfo
- Publication number
- BG50275A3 BG50275A3 BG093296A BG9329690A BG50275A3 BG 50275 A3 BG50275 A3 BG 50275A3 BG 093296 A BG093296 A BG 093296A BG 9329690 A BG9329690 A BG 9329690A BG 50275 A3 BG50275 A3 BG 50275A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- indazol
- benzyl
- derivatives
- preparation
- general formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 1-benzyl-indazol-3-yl Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Методът намира приложение в медицината за получаване на междинни съединения за производство на аналгетични средства. Производните на 1-бензил-индазол-3-ил са с обща формулаа-сн2-vv i в която а означава 1-бензил-индазол-3-ил, а vv хидроксилна група. По метода алифатен естер на киселина с обща формулаа-соон iii в която а има посоченото значение, се редуцира с литиево-алуминиев хидрид в присъствие на разтворител и при температура от 00с до температурата на кипене на реакционната смес за време от 30 мин до 12 ч.2 претенцииThe method is used in medicine to obtain intermediate compounds for the production of analgesics. Derivatives of 1-benzyl-indazol-3-yl have the general formula aa-cn2-vv i in which a is 1-benzyl-indazol-3-yl and vv is a hydroxyl group. According to the method, an aliphatic ester of an acid with the general formula aa-soon iii in which a has the indicated meaning, is reduced with lithium aluminum hydride in the presence of a solvent and at a temperature from 00C to the boiling temperature of the reaction mixture for a time of 30 min to 12 h .2 claims
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8947620A IT1230441B (en) | 1989-02-07 | 1989-02-07 | ETHERS OF THE INDAZOLE SERIES |
| BG091122A BG50273A3 (en) | 1989-02-07 | 1990-02-06 | Method for the preparation of esters of the 1- benzyl- 3- hydroxymethylinedazol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG50275A3 true BG50275A3 (en) | 1992-06-15 |
Family
ID=25663357
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG093295A BG50274A3 (en) | 1989-02-07 | 1990-02-06 | Method for the preparation of esters of 1- benzyl- 3- hydroxymethyl- indazol |
| BG093296A BG50275A3 (en) | 1989-02-07 | 1990-02-06 | Method for the preparation of derivatives of 1- benzyl- indazol- 3- il |
| BG093291A Active BG51352A3 (en) | 1989-02-07 | 1990-02-06 | Process for preparation of ethers of 1-benzil-3hydroxymethyl-indasol |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG093295A BG50274A3 (en) | 1989-02-07 | 1990-02-06 | Method for the preparation of esters of 1- benzyl- 3- hydroxymethyl- indazol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG093291A Active BG51352A3 (en) | 1989-02-07 | 1990-02-06 | Process for preparation of ethers of 1-benzil-3hydroxymethyl-indasol |
Country Status (1)
| Country | Link |
|---|---|
| BG (3) | BG50274A3 (en) |
-
1990
- 1990-02-06 BG BG093295A patent/BG50274A3/en unknown
- 1990-02-06 BG BG093296A patent/BG50275A3/en unknown
- 1990-02-06 BG BG093291A patent/BG51352A3/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BG51352A3 (en) | 1993-04-15 |
| BG50274A3 (en) | 1992-06-15 |
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