BG106924A - Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие - Google Patents

Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие Download PDF

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Publication number
BG106924A
BG106924A BG106924A BG10692402A BG106924A BG 106924 A BG106924 A BG 106924A BG 106924 A BG106924 A BG 106924A BG 10692402 A BG10692402 A BG 10692402A BG 106924 A BG106924 A BG 106924A
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BG
Bulgaria
Prior art keywords
group
cooh
acid
residue
amino
Prior art date
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BG106924A
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Bulgarian (bg)
English (en)
Inventor
Eckhard Gunther
Peter Emig
Dietmar Reichert
Baut Guillaume Le
Bernd Nickel
Gerald Bacher
Original Assignee
Zentaris Gmbh
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Filing date
Publication date
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of BG106924A publication Critical patent/BG106924A/bg

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
BG106924A 1999-12-23 2002-07-16 Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие BG106924A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19962300A DE19962300A1 (de) 1999-12-23 1999-12-23 Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
PCT/EP2000/012947 WO2001047913A2 (de) 1999-12-23 2000-12-19 Substituierte n-benzyl-indol-3-yl- glyoxylsäure-derivate antitumorwirkung

Publications (1)

Publication Number Publication Date
BG106924A true BG106924A (bg) 2003-04-30

Family

ID=7934006

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106924A BG106924A (bg) 1999-12-23 2002-07-16 Заместени производни на n-бензил-индол-3-ил-глиоксиловаta киселина с противотуморно действие

Country Status (31)

Country Link
US (1) US6432987B2 (zh)
EP (1) EP1240157B1 (zh)
JP (1) JP2003519137A (zh)
KR (1) KR100747425B1 (zh)
CN (1) CN1283637C (zh)
AR (1) AR027098A1 (zh)
AT (1) ATE259364T1 (zh)
AU (1) AU772745B2 (zh)
BG (1) BG106924A (zh)
BR (1) BR0016712A (zh)
CA (1) CA2395259A1 (zh)
CO (1) CO5251472A1 (zh)
CZ (1) CZ20022094A3 (zh)
DE (2) DE19962300A1 (zh)
DK (1) DK1240157T3 (zh)
ES (1) ES2215768T3 (zh)
HK (1) HK1054038B (zh)
HU (1) HUP0203716A3 (zh)
IL (1) IL150235A0 (zh)
MX (1) MXPA02006229A (zh)
NO (1) NO324750B1 (zh)
NZ (2) NZ519977A (zh)
PL (1) PL195014B1 (zh)
PT (1) PT1240157E (zh)
RU (1) RU2266280C2 (zh)
SK (1) SK8752002A3 (zh)
TR (1) TR200400601T4 (zh)
TW (1) TWI284128B (zh)
UA (1) UA75060C2 (zh)
WO (1) WO2001047913A2 (zh)
ZA (1) ZA200204896B (zh)

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DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DE19946301A1 (de) * 1998-04-02 2001-04-19 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit therapeutisch wertvollen Eigenschaften
DE10037310A1 (de) * 2000-07-28 2002-02-07 Asta Medica Ag Neue Indolderivate und deren Verwendung als Arzneimittel
DE10318611A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
DE10318609A1 (de) * 2003-04-24 2004-11-11 Elbion Ag 5-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika
CA2526663C (en) * 2003-06-05 2011-07-19 Zentaris Gmbh Indole derivatives with apoptosis-inducing effect
US7211588B2 (en) * 2003-07-25 2007-05-01 Zentaris Gmbh N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation
CN102060806A (zh) 2003-09-11 2011-05-18 iTherX药品公司 细胞因子抑制剂
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
DE102004031538A1 (de) * 2004-06-29 2006-02-09 Baxter International Inc., Deerfield Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit
ES2644450T3 (es) 2004-12-31 2017-11-29 Dr. Reddy's Laboratories Ltd. Nuevos derivados de bencilamina como inhibidores de CETP
US8604055B2 (en) 2004-12-31 2013-12-10 Dr. Reddy's Laboratories Ltd. Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors
WO2006099256A2 (en) * 2005-03-11 2006-09-21 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
EP2049520A4 (en) 2006-08-07 2011-01-05 Ironwood Pharmaceuticals Inc indole compounds
WO2008066807A1 (en) * 2006-11-28 2008-06-05 Ziopharm Oncology, Inc. Use of indolyl-3-glyoxylic acid derivatives including indibulin, alone or in combination with further agents for treating cancer
EP3791880A1 (en) 2009-04-29 2021-03-17 Amarin Pharmaceuticals Ireland Limited Pharmaceutical compositions comprising epa
AR084433A1 (es) 2010-12-22 2013-05-15 Ironwood Pharmaceuticals Inc Inhibidores de la faah y composiciones farmaceuticas que los contienen
CA2845284C (en) 2011-08-18 2018-03-06 Dr. Reddy's Laboratories Ltd. Substituted heterocyclic amine compounds as cholesteryl ester-transfer protein (cetp) inhibitors
JP6140168B2 (ja) 2011-09-27 2017-05-31 ドクター レディズ ラボラトリーズ リミテッド アテローム性動脈硬化症の処置のために有用なコレステリルエステル転送タンパク質（ｃｅｔｐ）インヒビターとしての５−ベンジルアミノメチル−６−アミノピラゾロ［３，４−ｂ］ピリジン誘導体

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AU665690B2 (en) * 1992-05-08 1996-01-11 Otsuka Pharmaceutical Factory, Inc. Indole derivative
IL109311A0 (en) * 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
KR100362864B1 (ko) * 1994-02-22 2003-04-16 메렐 파마슈티칼스 인크. 에스트로겐관련신생물및질환의치료에유용한신규인돌유도체
DK1950200T3 (da) * 1994-04-01 2012-04-10 Lilly Co Eli [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-(PHENYLMETHYL)-11H-INDOL-4-YL]OXY]EDDIKESYREMETHYLESTER SOM sPLA2-INHIBITOR
DE19636150A1 (de) * 1996-09-06 1998-03-12 Asta Medica Ag N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung
EP0987250A4 (en) * 1997-02-20 2000-12-06 Shionogi & Co INDOLDICARBONIC ACID DERIVATIVES
US5972988A (en) * 1997-03-26 1999-10-26 Eli Lilly And Company Method for treatment of chronic bronchitis using indole compounds
WO1998047507A1 (en) * 1997-04-24 1998-10-29 Shionogi & Co., Ltd. Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds
TW455581B (en) * 1997-06-26 2001-09-21 Lilly Co Eli Process for preparing 4-substituted-1H-indole-3-glyoxamides
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JP2001517707A (ja) * 1997-09-26 2001-10-09 イーライ・リリー・アンド・カンパニー 嚢胞性繊維症の処置方法
AU1200899A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company Morpholino-n-ethyl ester prodrugs of indole spla2 inhibitors
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AU1279899A (en) * 1997-10-27 1999-05-17 Eli Lilly And Company N,n-diethylglycolamido ester prodrugs of indole spla2 inhibitors
WO1999024033A1 (en) * 1997-11-12 1999-05-20 Shionogi & Co., Ltd. Method for the treatment of disorders associated with apoptosis using n-heterocyclic glyoxylamide compounds
AU1405899A (en) * 1997-11-14 1999-06-07 Eli Lilly And Company Treatment for alzheimer's disease
ID26250A (id) * 1998-02-25 2000-12-07 Genetics Inst Inhibitor-inhibitor dari enzim-enzim fosfolipase
DE19814838C2 (de) * 1998-04-02 2001-01-18 Asta Medica Ag Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung
DZ2770A1 (fr) * 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
TR200003130T2 (tr) * 1998-04-28 2001-01-22 Arzneimittelwerk Dresden Gmbh Yeni hidroksiindoller, bunların fosfodiesteraz 4 inhibitörleri olarak kullanımları ve hazırlanmaları için işlemler
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AU4834200A (en) * 1999-05-10 2000-11-21 Protarga, Inc. Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
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Also Published As

Publication number Publication date
EP1240157A2 (de) 2002-09-18
TWI284128B (en) 2007-07-21
CA2395259A1 (en) 2001-07-05
KR20020063245A (ko) 2002-08-01
RU2266280C2 (ru) 2005-12-20
HUP0203716A2 (hu) 2003-03-28
CO5251472A1 (es) 2003-02-28
ATE259364T1 (de) 2004-02-15
EP1240157B1 (de) 2004-02-11
AR027098A1 (es) 2003-03-12
PL355684A1 (en) 2004-05-17
CN1283637C (zh) 2006-11-08
HK1054038A1 (en) 2003-11-14
US20010014690A1 (en) 2001-08-16
US6432987B2 (en) 2002-08-13
NZ533731A (en) 2005-03-24
DE19962300A1 (de) 2001-06-28
AU772745B2 (en) 2004-05-06
WO2001047913A3 (de) 2002-04-25
BR0016712A (pt) 2002-09-03
CN1420880A (zh) 2003-05-28
PT1240157E (pt) 2004-06-30
IL150235A0 (en) 2002-12-01
NO324750B1 (no) 2007-12-03
NZ519977A (en) 2004-08-27
RU2002120462A (ru) 2004-01-10
ZA200204896B (en) 2002-12-20
AU2011901A (en) 2001-07-09
HK1054038B (zh) 2007-04-13
TR200400601T4 (tr) 2004-04-21
ES2215768T3 (es) 2004-10-16
NO20023039L (no) 2002-08-09
PL195014B1 (pl) 2007-07-31
KR100747425B1 (ko) 2007-08-09
MXPA02006229A (es) 2003-01-28
SK8752002A3 (en) 2003-01-09
DK1240157T3 (da) 2004-06-14
UA75060C2 (en) 2006-03-15
HUP0203716A3 (en) 2004-05-28
WO2001047913A2 (de) 2001-07-05
CZ20022094A3 (cs) 2002-10-16
NO20023039D0 (no) 2002-06-21
JP2003519137A (ja) 2003-06-17
DE50005284D1 (de) 2004-03-18

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