BG105859A - Тетрахидропиранови производни и тяхното използване като терапевтични вещества - Google Patents

Тетрахидропиранови производни и тяхното използване като терапевтични вещества Download PDF

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Publication number
BG105859A
BG105859A BG105859A BG10585901A BG105859A BG 105859 A BG105859 A BG 105859A BG 105859 A BG105859 A BG 105859A BG 10585901 A BG10585901 A BG 10585901A BG 105859 A BG105859 A BG 105859A
Authority
BG
Bulgaria
Prior art keywords
alkyl
alkoxy
formula
phenyl
hydrogen
Prior art date
Application number
BG105859A
Other languages
Bulgarian (bg)
English (en)
Inventor
Simon OWEN
Eileen SEWARD
Christopher Swain
Brian WILLLIAMS
Original Assignee
Merck Sharp & Dohme Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9906480.0A external-priority patent/GB9906480D0/en
Priority claimed from GBGB9924616.7A external-priority patent/GB9924616D0/en
Application filed by Merck Sharp & Dohme Limited filed Critical Merck Sharp & Dohme Limited
Publication of BG105859A publication Critical patent/BG105859A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
BG105859A 1999-03-19 2001-08-30 Тетрахидропиранови производни и тяхното използване като терапевтични вещества BG105859A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9906480.0A GB9906480D0 (en) 1999-03-19 1999-03-19 Therapeutic agents
GBGB9924616.7A GB9924616D0 (en) 1999-10-18 1999-10-18 Therapeutic agents
PCT/GB2000/000977 WO2000056728A1 (en) 1999-03-19 2000-03-16 Tetrahydropyran derivatives and their use as therapeutic agents

Publications (1)

Publication Number Publication Date
BG105859A true BG105859A (bg) 2002-04-30

Family

ID=26315315

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105859A BG105859A (bg) 1999-03-19 2001-08-30 Тетрахидропиранови производни и тяхното използване като терапевтични вещества

Country Status (23)

Country Link
US (1) US6458830B1 (de)
EP (1) EP1165540B1 (de)
JP (1) JP2002540107A (de)
KR (1) KR20010113773A (de)
CN (1) CN1344264A (de)
AT (1) ATE247096T1 (de)
AU (2) AU3304400A (de)
BG (1) BG105859A (de)
BR (1) BR0009127A (de)
CA (1) CA2367985A1 (de)
CO (1) CO5150225A1 (de)
CZ (1) CZ20013377A3 (de)
DE (1) DE60004504T2 (de)
EA (1) EA200100902A1 (de)
EE (1) EE200100491A (de)
ES (1) ES2203434T3 (de)
HU (1) HUP0200441A3 (de)
IL (1) IL144236A0 (de)
NO (1) NO20014529L (de)
PE (1) PE20001556A1 (de)
PL (1) PL350123A1 (de)
SK (1) SK13322001A3 (de)
WO (2) WO2000056728A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10001785A1 (de) * 2000-01-18 2001-07-19 Boehringer Ingelheim Pharma NK¶1¶-Rezeptor-Antagonisten zur Behandlung des Restless Legs Syndroms
GB0017256D0 (en) 2000-07-13 2000-08-30 Merck Sharp & Dohme Therapeutic agents
GB0020721D0 (en) 2000-08-22 2000-10-11 Merck Sharp & Dohme Therapeutic agents
PE20020444A1 (es) 2000-09-22 2002-06-14 Merck & Co Inc Antagonistas de receptores de taquiquinina zwitterionica
CA2433835A1 (en) 2001-01-17 2002-07-25 Merck Sharp & Dohme Limited Tetrahydropyran derivatives as neurokinin receptor antagonists
GB0121874D0 (en) * 2001-09-10 2001-10-31 Merck Sharp & Dohme Therapeutic agents
GB0217068D0 (en) * 2002-07-23 2002-08-28 Merck Sharp & Dohme Therapeutic agents
EP1562975A2 (de) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroide welche gruppen zur nachahmung von superoxidase dismutase sowie stickoxid donorgruppen beinhalten und ihre verwendung in der darstellung von medikamenten
US20060166894A1 (en) * 2002-11-29 2006-07-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ace-inhibitors having antioxidant and no-donor activity
AU2004218228A1 (en) * 2003-03-07 2004-09-16 Merck Sharp & Dohme Limited Tetrahydropyran compounds as tachykinin antagonists
WO2006027345A2 (en) * 2004-09-08 2006-03-16 Altana Pharma Ag Novel 3-thia-10-aza-phenanthrene derivatives
EP1819661B1 (de) * 2004-11-30 2009-04-22 Mallinckrodt, Inc. Verfahren zur kristallisierung von benzphetamin
CN101203512A (zh) * 2005-04-22 2008-06-18 第一三共株式会社 杂环化合物
CN100395242C (zh) * 2006-06-08 2008-06-18 华东理工大学 烷氧基萘和萘醌类吡喃碳糖苷化合物及其制备方法
DE102007010077B4 (de) * 2007-02-28 2010-04-08 RUHR-UNIVERSITäT BOCHUM [1,3]-Dioxane zur Modulation von GABAa-Rezeptoren
ES2672099T3 (es) 2011-07-04 2018-06-12 Irbm - Science Park S.P.A. Antagonistas del receptor NK-1 para el tratamiento de la neovascularización corneal
WO2014039504A1 (en) * 2012-09-04 2014-03-13 Lauren Sciences Llc Bolaamphiphilic compounds, compositions and uses thereof
CA2951259A1 (en) 2014-06-06 2015-12-10 Flexus Biosciences, Inc. Immunoregulatory agents
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
MX2017005462A (es) * 2014-11-05 2017-07-28 Flexus Biosciences Inc Agentes inmunorreguladores.
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
HU231150B1 (hu) 2017-03-13 2021-03-29 Richter Gedeon Nyrt Eljárás racém 3-alkilpiperidin-3-karbonsav-etil-észterek optikai izomerjeinek elválasztására
WO2019156074A1 (ja) * 2018-02-06 2019-08-15 第一三共株式会社 アミノアルキル化合物
US20210015834A1 (en) 2018-02-26 2021-01-21 Ospedale San Raffaele S.R.L. Nk-1 antagonists for use in the treatment of ocular pain
US20230134843A1 (en) 2020-03-11 2023-05-04 Ospedale San Raffaele S.R.L. Treatment of stem cell deficiency

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9301920D0 (en) 1993-02-01 1993-03-17 Foundation For Ethnobiology Th Polycetylenes

Also Published As

Publication number Publication date
EE200100491A (et) 2002-12-16
WO2000056727A1 (en) 2000-09-28
ATE247096T1 (de) 2003-08-15
AU3304200A (en) 2000-10-09
CO5150225A1 (es) 2002-04-29
ES2203434T3 (es) 2004-04-16
AU746251B2 (en) 2002-04-18
DE60004504D1 (de) 2003-09-18
IL144236A0 (en) 2002-05-23
NO20014529L (no) 2001-11-13
HUP0200441A3 (en) 2002-09-30
CN1344264A (zh) 2002-04-10
CZ20013377A3 (cs) 2002-02-13
SK13322001A3 (sk) 2002-02-05
KR20010113773A (ko) 2001-12-28
US6458830B1 (en) 2002-10-01
CA2367985A1 (en) 2000-09-28
PE20001556A1 (es) 2001-01-13
HUP0200441A2 (hu) 2002-07-29
JP2002540107A (ja) 2002-11-26
AU3304400A (en) 2000-10-09
DE60004504T2 (de) 2004-06-24
WO2000056728A1 (en) 2000-09-28
PL350123A1 (en) 2002-11-04
EA200100902A1 (ru) 2002-02-28
EP1165540A1 (de) 2002-01-02
NO20014529D0 (no) 2001-09-18
EP1165540B1 (de) 2003-08-13
BR0009127A (pt) 2001-12-26

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