BG105137A - Antiparasitic artemisinin derivatives (endoperoxides) - Google Patents

Antiparasitic artemisinin derivatives (endoperoxides)

Info

Publication number
BG105137A
BG105137A BG105137A BG10513701A BG105137A BG 105137 A BG105137 A BG 105137A BG 105137 A BG105137 A BG 105137A BG 10513701 A BG10513701 A BG 10513701A BG 105137 A BG105137 A BG 105137A
Authority
BG
Bulgaria
Prior art keywords
endoperoxides
substituted derivatives
artemisinin derivatives
artemisinin
antiparasitic
Prior art date
Application number
BG105137A
Other languages
Bulgarian (bg)
English (en)
Inventor
Richard Haynes
Ho-Wai Chan
Wai-Lun Lam
Hing-Wo Tsang
Man-Ki Cheung
Arnd Voerste
Gabriele Schmuck
Gisela Greif
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of BG105137A publication Critical patent/BG105137A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
BG105137A 1998-07-14 2001-01-10 Antiparasitic artemisinin derivatives (endoperoxides) BG105137A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98305596 1998-07-14
PCT/GB1999/002267 WO2000004024A1 (en) 1998-07-14 1999-07-14 Antiparasitic artemisinin derivatives (endoperoxides)

Publications (1)

Publication Number Publication Date
BG105137A true BG105137A (en) 2001-08-31

Family

ID=8234942

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105137A BG105137A (en) 1998-07-14 2001-01-10 Antiparasitic artemisinin derivatives (endoperoxides)

Country Status (27)

Country Link
US (4) US6984640B1 (de)
EP (2) EP1655302A3 (de)
JP (1) JP2002520416A (de)
KR (1) KR100640113B1 (de)
CN (1) CN1122035C (de)
AT (1) ATE314373T1 (de)
AU (1) AU765860B2 (de)
BG (1) BG105137A (de)
BR (1) BR9912810A (de)
CA (1) CA2337119A1 (de)
DE (1) DE69929203T2 (de)
DK (1) DK1095042T5 (de)
ES (1) ES2257062T4 (de)
HK (1) HK1040709B (de)
HU (1) HUP0102851A3 (de)
IL (1) IL140402A0 (de)
NO (1) NO20010223L (de)
NZ (1) NZ509324A (de)
PL (1) PL345503A1 (de)
PT (1) PT1095042E (de)
RU (1) RU2236413C2 (de)
SI (1) SI1095042T1 (de)
SK (1) SK542001A3 (de)
TR (1) TR200100073T2 (de)
UA (1) UA75325C2 (de)
WO (1) WO2000004024A1 (de)
YU (1) YU2101A (de)

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IL163870A0 (en) * 2002-03-08 2005-12-18 Bayer Business Services Gmbh Antiparasitic artemisinin derivatives (endoperoxides)
DE102004027871B3 (de) * 2004-06-08 2006-03-16 Lanxess Deutschland Gmbh Verfahren zur Herstellung von 10α-[4'-(S,S-Dioxothiomorpholin-1'-yl)]-10-desoxo-10-dihydroartemisinin
EP1714967A1 (de) * 2005-04-22 2006-10-25 Bayer HealthCare AG Antiparasitär wirkende Artemisinin Derivate
US8431611B2 (en) 2006-10-20 2013-04-30 Johns Hopkins University Artemisinin derivatives
US8193376B2 (en) 2007-01-01 2012-06-05 Bioderm Research Artemisinin derivatives with natural amino acids, peptides, and amino sugars for the treatment of infection and topical condition in mammals
GB0720967D0 (en) * 2007-10-25 2007-12-05 Protophama Ltd Anti-material pharmaceutical composition
PT2285808E (pt) * 2008-04-29 2014-02-24 Novartis Ag Derivados de espiro-indole para o tratamento de doenças parasitárias
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US9675582B2 (en) 2011-10-25 2017-06-13 U.S. Phytotherapy, Inc. Alternative ACT with natural botanical active GRAS ingredients for treatment and prevention of the Zika virus
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US9663532B2 (en) 2012-10-29 2017-05-30 University Of Rochester Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
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USD729631S1 (en) 2013-10-03 2015-05-19 Gk Packaging, Inc. Bottle
USD726544S1 (en) 2013-11-04 2015-04-14 Gk Packaging, Inc. Bottle
USD726543S1 (en) 2013-11-04 2015-04-14 Gk Packaging, Inc. Bottle
USD727160S1 (en) 2013-11-04 2015-04-21 Gk Packaging, Inc. Bottle
USD726545S1 (en) 2013-11-04 2015-04-14 Gk Packaging, Inc. Bottle
CN103664982A (zh) * 2013-12-06 2014-03-26 湖南科源生物制品有限公司 青蒿素类似物及其制备方法
CN103896960A (zh) * 2014-01-14 2014-07-02 李学强 一种高效、绿色的青蒿砜制备方法
USD740125S1 (en) 2014-03-26 2015-10-06 Gk Packaging, Inc. Bottle
USD740677S1 (en) 2014-03-26 2015-10-13 Gk Packaging, Inc. Bottle
USD742748S1 (en) 2014-06-13 2015-11-10 Gk Packaging, Inc. Bottle
USD753502S1 (en) 2014-09-25 2016-04-12 Gk Packaging, Inc. Bottle
USD753503S1 (en) 2014-09-25 2016-04-12 Gk Packaging, Inc. Bottle
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USD784820S1 (en) 2015-02-05 2017-04-25 Gk Packaging, Inc. Bottle
CN105198898A (zh) * 2015-09-23 2015-12-30 山东大学（威海） 一种用于预防和/或治疗癌症的化合物
USD784821S1 (en) 2015-10-13 2017-04-25 Gk Packaging, Inc. Bottle
USD774914S1 (en) 2015-10-13 2016-12-27 Gk Packaging, Inc. Bottle
USD807190S1 (en) 2015-10-13 2018-01-09 Gk Packaging, Inc. Bottle
USD806555S1 (en) 2017-03-15 2018-01-02 Gk Packaging, Inc. Bottle
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USD825342S1 (en) 2017-06-02 2018-08-14 Gk Packaging, Inc. Bottle
EP3768273A4 (de) * 2018-03-22 2022-02-16 Hadasit Medical Research Services and Development Ltd. Verfahren und synergische zusammensetzungen zur behandlung von virusinfektionen
USD908011S1 (en) 2019-04-30 2021-01-19 Gk Packaging, Inc. Bottle
CN110448552B (zh) * 2019-08-23 2023-05-12 西南大学 二氢青蒿素衍生物在制备抗疟药物中的应用
CN110483547B (zh) * 2019-08-28 2022-08-16 西南大学 二氢青蒿素的简单酚类偶联物、合成方法及应用
CN110642869B (zh) * 2019-09-26 2022-03-15 西南大学 二氢青蒿素的硫醚、亚砜与砜衍生物及其应用
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EP1095043A1 (de) 1998-07-14 2001-05-02 The Hong Kong University of Science & Technology Trioxanderivate

Also Published As

Publication number Publication date
KR20010071899A (ko) 2001-07-31
DK1095042T3 (da) 2006-04-18
CN1317006A (zh) 2001-10-10
NO20010223D0 (no) 2001-01-12
DE69929203T2 (de) 2006-08-31
ES2257062T4 (es) 2007-03-16
CN1122035C (zh) 2003-09-24
HK1040709A1 (en) 2002-06-21
PT1095042E (pt) 2006-05-31
US7452915B2 (en) 2008-11-18
RU2236413C2 (ru) 2004-09-20
PL345503A1 (en) 2001-12-17
BR9912810A (pt) 2001-05-02
SI1095042T1 (sl) 2006-04-30
EP1655302A3 (de) 2006-08-23
US20070021409A1 (en) 2007-01-25
US20070191354A1 (en) 2007-08-16
EP1095042B1 (de) 2005-12-28
EP1655302A2 (de) 2006-05-10
JP2002520416A (ja) 2002-07-09
EP1095042B9 (de) 2006-07-05
HUP0102851A3 (en) 2003-03-28
US7439238B2 (en) 2008-10-21
DK1095042T5 (da) 2006-11-06
YU2101A (sh) 2005-06-10
AU765860B2 (en) 2003-10-02
WO2000004024A1 (en) 2000-01-27
DE69929203D1 (de) 2006-02-02
ES2257062T3 (es) 2006-07-16
EP1095042A1 (de) 2001-05-02
TR200100073T2 (tr) 2001-05-21
NO20010223L (no) 2001-03-12
US20060287305A1 (en) 2006-12-21
NZ509324A (en) 2003-07-25
UA75325C2 (en) 2006-04-17
ATE314373T1 (de) 2006-01-15
HK1040709B (zh) 2004-06-25
US6984640B1 (en) 2006-01-10
IL140402A0 (en) 2002-02-10
SK542001A3 (en) 2001-08-06
CA2337119A1 (en) 2000-01-27
AU4921899A (en) 2000-02-07
HUP0102851A2 (hu) 2001-11-28
KR100640113B1 (ko) 2006-10-31

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