BG105064A - Пептидни антиангиогенни лекарствени средства - Google Patents

Пептидни антиангиогенни лекарствени средства

Info

Publication number
BG105064A
BG105064A BG105064A BG10506400A BG105064A BG 105064 A BG105064 A BG 105064A BG 105064 A BG105064 A BG 105064A BG 10506400 A BG10506400 A BG 10506400A BG 105064 A BG105064 A BG 105064A
Authority
BG
Bulgaria
Prior art keywords
peptide
antiangiogenic drugs
peptide antiangiogenic
drugs
acyl
Prior art date
Application number
BG105064A
Other languages
English (en)
Other versions
BG65065B1 (bg
Inventor
Jack Henkin
Fortuna Haviv
Michael Bradley
Douglas Kalvin
Andrew Schneider
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of BG105064A publication Critical patent/BG105064A/bg
Publication of BG65065B1 publication Critical patent/BG65065B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Изобретението се отнася до пептиди с формула А0-А1-А2-А3-А4-А5-А6-А7-А8-А9-А10,в която А0 е избран от водород или ацилова група, А10 е хидроксилна група или аминокиселинен амид, и А0, А1, А2, А3, А4,А5, А6, А7, А8 и А9 са аминоацилови остатъци, посочени в описанието.
BG105064A 1998-05-22 2000-12-18 Пептидни антиангиогенни лекарствени средства BG65065B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8374598A 1998-05-22 1998-05-22
US25057499A 1999-02-16 1999-02-16
US27746699A 1999-03-26 1999-03-26

Publications (2)

Publication Number Publication Date
BG105064A true BG105064A (bg) 2001-08-31
BG65065B1 BG65065B1 (bg) 2007-01-31

Family

ID=27374598

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105064A BG65065B1 (bg) 1998-05-22 2000-12-18 Пептидни антиангиогенни лекарствени средства

Country Status (26)

Country Link
EP (1) EP1078002B1 (bg)
JP (3) JP3753612B2 (bg)
KR (1) KR100447696B1 (bg)
CN (1) CN1311796A (bg)
AR (1) AR018371A1 (bg)
AT (1) ATE396204T1 (bg)
AU (1) AU764277B2 (bg)
BG (1) BG65065B1 (bg)
BR (1) BR9910639A (bg)
CA (1) CA2329250C (bg)
CO (1) CO5080726A1 (bg)
CY (1) CY1109118T1 (bg)
CZ (1) CZ299639B6 (bg)
DE (1) DE69938782D1 (bg)
ES (1) ES2307337T3 (bg)
HK (1) HK1037376A1 (bg)
HU (1) HUP0102579A3 (bg)
NO (1) NO326871B1 (bg)
NZ (1) NZ507912A (bg)
PL (1) PL200471B1 (bg)
PT (1) PT1078002E (bg)
SI (1) SI1078002T1 (bg)
SK (1) SK286554B6 (bg)
TR (1) TR200003442T2 (bg)
TW (1) TWI247748B (bg)
WO (1) WO1999061476A1 (bg)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774211B1 (en) 1998-05-22 2004-08-10 Abbott Laboratories Peptide antiangiogenic drugs
US6753310B1 (en) 1998-10-16 2004-06-22 Otsuka Pharmaceutical Co., Ltd. Neovascular-specific peptides
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
CN1810832B (zh) 1998-10-23 2012-12-12 麒麟-安姆根有限公司 与MPl受体结合并具有血小板生成活性的模拟二聚体血小板生成素肽
US20020183242A1 (en) * 2001-04-11 2002-12-05 Jack Henkin Peptide antiangiogenic drugs
US20030050246A1 (en) * 2001-07-26 2003-03-13 Fortuna Haviv Peptides having antiangiogenic activity
US7169888B2 (en) 2001-10-31 2007-01-30 Abbott Laboratories Tetra-, penta-, hexa- and heptapeptides having antiangiogenic activity
US20030105025A1 (en) * 2001-10-31 2003-06-05 Fortuna Haviv Tri-and tetrapeptides having antiangiogenic activity
US7001984B2 (en) 2001-10-31 2006-02-21 Abbott Laboratories Di-, tri-, and tetra-peptides having antiangiogenic activity
US7037897B2 (en) 2001-10-31 2006-05-02 Abbott Laboratories TRI-, TETRA-, and penta-peptides having antiangiogenic activity
US20030125260A1 (en) * 2001-10-31 2003-07-03 Fortuna Haviv Tetra-and pentapeptides having antiangiogenic activity
US7067490B2 (en) 2001-10-31 2006-06-27 Abbott Laboratories Hepta-, Octa-and nonapeptides having antiangiogenic activity
US20030125259A1 (en) 2001-10-31 2003-07-03 Fortuna Haviv Octa- and nonapeptides having antiangiogenic activity
MXPA04004135A (es) * 2001-10-31 2004-07-08 Abbott Lab Tetra-, penta-, hexa y heptapeptidos con actividad antiangiogenica.
PL374238A1 (en) * 2001-10-31 2005-10-03 Abbott Laboratories Hepta-, octa- and nonapeptides having antiangiogenic activity
US20030119746A1 (en) * 2001-10-31 2003-06-26 Fortuna Haviv Hepta-and octapeptides having antiangiogenic activity
US7122625B2 (en) 2001-10-31 2006-10-17 Abbott Laboratories Hexa-, hepta-, and octapeptides having antiangiogenic activity
BR0308654A (pt) 2002-03-22 2005-02-22 Gpc Biotech Ag Compostos imunossupressores, métodos e usos relacionados a eles
US7432245B2 (en) 2002-06-07 2008-10-07 Abbott Laboratories Inc. Pharmaceutical formulation comprising a peptide angiogenesis inhibitor
US20030228365A1 (en) * 2002-06-07 2003-12-11 Fortuna Haviv Pharmaceutical formulation
WO2006094269A2 (en) 2005-03-03 2006-09-08 Covx Technologies Ireland Limited Anti-angiogenic compounds
US8008453B2 (en) 2005-08-12 2011-08-30 Amgen Inc. Modified Fc molecules
JP2007255910A (ja) * 2006-03-20 2007-10-04 Hokkaido Univ Ｎｍｒシグナルの帰属方法
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
WO2008003013A2 (en) * 2006-06-29 2008-01-03 Abbott Laboratories Antitumorigenic drug combination comprising an hdac inhibitor and a tsp-1 peptidomimetic
CN104004057B (zh) * 2013-02-25 2016-08-24 上海市第一人民医院 一类抑制新生血管的小肽及其应用
CN107778355B (zh) * 2016-08-25 2021-04-20 成都圣诺生物制药有限公司 一种合成西曲瑞克的方法
WO2023033016A1 (ja) * 2021-09-01 2023-03-09 積水メディカル株式会社 アルギニン誘導体

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200397A (en) * 1990-02-22 1993-04-06 W. R. Grace & Co.-Conn. Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity
WO1993016716A1 (en) * 1992-02-24 1993-09-02 Northwestern University Method and composition for inhibiting angiogenesis
JP4426650B2 (ja) * 1996-05-03 2010-03-03 アボット・ラボラトリーズ 新規な抗血管形成ペプチド、それをコードするポリヌクレオチド、および血管形成を阻害する方法
ATE280781T1 (de) * 1997-03-17 2004-11-15 Abbott Lab Antiangiogene substanz zur behandlung von krebs, arthritis und netzhauterkrankungen

Also Published As

Publication number Publication date
CZ299639B6 (cs) 2008-10-01
SK286554B6 (sk) 2008-12-05
BR9910639A (pt) 2002-01-15
JP3753612B2 (ja) 2006-03-08
CO5080726A1 (es) 2001-09-25
NO326871B1 (no) 2009-03-09
NZ507912A (en) 2002-10-25
HUP0102579A3 (en) 2002-02-28
PT1078002E (pt) 2008-09-02
SI1078002T1 (sl) 2008-10-31
TWI247748B (en) 2006-01-21
JP2006232840A (ja) 2006-09-07
NO20005890D0 (no) 2000-11-21
HUP0102579A2 (hu) 2002-01-28
PL200471B1 (pl) 2009-01-30
DE69938782D1 (de) 2008-07-03
ES2307337T3 (es) 2008-11-16
NO20005890L (no) 2001-01-12
TR200003442T2 (tr) 2001-03-21
WO1999061476A1 (en) 1999-12-02
JP2002516342A (ja) 2002-06-04
HK1037376A1 (en) 2002-02-08
JP3795906B2 (ja) 2006-07-12
EP1078002B1 (en) 2008-05-21
SK17632000A3 (sk) 2001-07-10
CN1311796A (zh) 2001-09-05
PL344415A1 (en) 2001-11-05
CY1109118T1 (el) 2014-07-02
AR018371A1 (es) 2001-11-14
EP1078002A1 (en) 2001-02-28
KR20010025093A (ko) 2001-03-26
BG65065B1 (bg) 2007-01-31
CA2329250C (en) 2012-03-27
CZ20004327A3 (cs) 2001-08-15
ATE396204T1 (de) 2008-06-15
AU764277B2 (en) 2003-08-14
CA2329250A1 (en) 1999-12-02
KR100447696B1 (ko) 2004-09-08
JP2006001923A (ja) 2006-01-05
AU4407599A (en) 1999-12-13

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