BG102911A - Метод за пречистване на циклоспорин - Google Patents

Метод за пречистване на циклоспорин

Info

Publication number
BG102911A
BG102911A BG102911A BG10291198A BG102911A BG 102911 A BG102911 A BG 102911A BG 102911 A BG102911 A BG 102911A BG 10291198 A BG10291198 A BG 10291198A BG 102911 A BG102911 A BG 102911A
Authority
BG
Bulgaria
Prior art keywords
cyclosporin
purification
silicagel
column filled
withnormal
Prior art date
Application number
BG102911A
Other languages
English (en)
Other versions
BG64215B1 (bg
Inventor
Vilmos Keri
Arvai NAGYNE
Lajos Deak
Gyoergyne Mako
Istvanne Miskolczy
Original Assignee
Teva Gyogyszergyar Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Reszvenytarsasag filed Critical Teva Gyogyszergyar Reszvenytarsasag
Publication of BG102911A publication Critical patent/BG102911A/bg
Publication of BG64215B1 publication Critical patent/BG64215B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Silicon Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Изобретението се отнася до метод за хроматографско пречистване на циклоспорин А от суров продукт, съдържащ циклоспоринов комплекс. Използва се колона, напълнена със силикагел, и се прилага многостепенна хроматография с колона, напълнена с нормална фаза силикагел и смес от разтворители, съдържаща толуол като основен компонент.
BG102911A 1997-03-25 1998-11-10 Метод за пречистване на циклоспорин BG64215B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9700645A HU223054B1 (hu) 1997-03-25 1997-03-25 Tisztítási eljárás nagytisztaságú ciklosporin A előállítására
PCT/HU1998/000029 WO1998042734A1 (en) 1997-03-25 1998-03-23 Process of purification of cyclosporin

Publications (2)

Publication Number Publication Date
BG102911A true BG102911A (bg) 1999-09-30
BG64215B1 BG64215B1 (bg) 2004-05-31

Family

ID=89994909

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102911A BG64215B1 (bg) 1997-03-25 1998-11-10 Метод за пречистване на циклоспорин

Country Status (22)

Country Link
EP (1) EP0920447B1 (bg)
JP (1) JP2000511939A (bg)
AT (1) ATE223434T1 (bg)
AU (1) AU737260B2 (bg)
BG (1) BG64215B1 (bg)
CA (1) CA2255062C (bg)
CZ (1) CZ293687B6 (bg)
DE (1) DE69807635T2 (bg)
DK (1) DK0920447T3 (bg)
ES (1) ES2180159T3 (bg)
HK (1) HK1020740A1 (bg)
HU (1) HU223054B1 (bg)
IL (1) IL126871A0 (bg)
NO (1) NO322211B1 (bg)
NZ (1) NZ332718A (bg)
PL (1) PL194252B1 (bg)
PT (1) PT920447E (bg)
RU (1) RU2182577C2 (bg)
SK (1) SK283672B6 (bg)
UA (1) UA58511C2 (bg)
WO (1) WO1998042734A1 (bg)
YU (1) YU49468B (bg)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151450A1 (de) * 2008-07-29 2010-02-10 Sandoz AG Verfahren zur Aufarbeitung von mikrobiologisch hergestellten zyklischen Oligopeptiden
DE102009037551A1 (de) 2009-08-17 2011-02-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cyclosporinderivate
HUP1500502A2 (en) 2015-10-26 2017-04-28 Rotachrom Tech Kft Process for the purification of cyclosporin-a
CN114653350A (zh) * 2022-02-25 2022-06-24 江苏九阳生物制药有限公司 一种环孢素a层析硅胶的再生方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213553B (en) * 1992-05-25 1997-07-28 Biogal Gyogyszergyar Process for isolating of cyclosporin-a
FI92334C (fi) * 1992-12-30 1994-10-25 Leiras Oy Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta
KR100304324B1 (ko) * 1994-10-13 2001-11-22 김용규 사이클로스포린a의제조방법

Also Published As

Publication number Publication date
SK283672B6 (sk) 2003-11-04
RU2182577C2 (ru) 2002-05-20
NZ332718A (en) 2000-04-28
HU223054B1 (hu) 2004-03-01
ES2180159T3 (es) 2003-02-01
AU737260B2 (en) 2001-08-16
AU6848298A (en) 1998-10-20
DE69807635D1 (de) 2002-10-10
BG64215B1 (bg) 2004-05-31
WO1998042734A1 (en) 1998-10-01
HUP9700645A3 (en) 2001-11-28
PT920447E (pt) 2002-11-29
JP2000511939A (ja) 2000-09-12
NO985483D0 (no) 1998-11-24
IL126871A0 (en) 1999-09-22
DE69807635T2 (de) 2003-08-07
CA2255062C (en) 2008-06-17
DK0920447T3 (da) 2002-12-16
CZ381498A3 (cs) 1999-02-17
PL330142A1 (en) 1999-04-26
SK161898A3 (en) 1999-05-07
YU53598A (en) 1999-11-22
CA2255062A1 (en) 1998-10-01
EP0920447A1 (en) 1999-06-09
HU9700645D0 (en) 1997-05-28
YU49468B (sh) 2006-05-25
CZ293687B6 (cs) 2004-07-14
ATE223434T1 (de) 2002-09-15
EP0920447B1 (en) 2002-09-04
HUP9700645A2 (hu) 1999-06-28
NO322211B1 (no) 2006-08-28
PL194252B1 (pl) 2007-05-31
UA58511C2 (uk) 2003-08-15
NO985483L (no) 1998-11-24
HK1020740A1 (en) 2000-05-19

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