BG102229A - Endothelium receptor antagonists - Google Patents

Endothelium receptor antagonists

Info

Publication number
BG102229A
BG102229A BG102229A BG10222998A BG102229A BG 102229 A BG102229 A BG 102229A BG 102229 A BG102229 A BG 102229A BG 10222998 A BG10222998 A BG 10222998A BG 102229 A BG102229 A BG 102229A
Authority
BG
Bulgaria
Prior art keywords
receptor antagonists
endothelium receptor
endothelium
antagonistsand
andtriazoles
Prior art date
Application number
BG102229A
Other languages
Bulgarian (bg)
English (en)
Inventor
Juan Luengo
John Elliott
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG102229A publication Critical patent/BG102229A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
BG102229A 1995-08-02 1998-02-02 Endothelium receptor antagonists BG102229A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US179295P 1995-08-02 1995-08-02
US1098296P 1996-02-01 1996-02-01
PCT/US1996/012581 WO1997004772A1 (en) 1995-08-02 1996-08-02 Endothelin receptor antagonists

Publications (1)

Publication Number Publication Date
BG102229A true BG102229A (en) 1998-09-30

Family

ID=26669471

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102229A BG102229A (en) 1995-08-02 1998-02-02 Endothelium receptor antagonists

Country Status (25)

Country Link
US (5) US5969151A (cs)
EP (2) EP0841925B1 (cs)
JP (2) JPH11511133A (cs)
KR (1) KR19990036032A (cs)
CN (1) CN1196680A (cs)
AP (1) AP9801182A0 (cs)
AT (1) ATE341324T1 (cs)
AU (2) AU6646396A (cs)
BG (1) BG102229A (cs)
BR (1) BR9609914A (cs)
CA (2) CA2228296A1 (cs)
CZ (1) CZ30498A3 (cs)
DE (2) DE69619116T2 (cs)
EA (1) EA000952B1 (cs)
ES (2) ES2171697T3 (cs)
HU (1) HU220776B1 (cs)
MX (1) MX9800975A (cs)
NO (1) NO980422L (cs)
NZ (1) NZ315846A (cs)
OA (1) OA10755A (cs)
PL (1) PL184272B1 (cs)
RO (1) RO115802B1 (cs)
SK (1) SK282584B6 (cs)
TR (1) TR199800152T1 (cs)
WO (2) WO1997004772A1 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017426A1 (es) 1997-12-08 2001-09-05 Smithkline Beecham Corp Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion
DE10155076A1 (de) * 2001-11-09 2003-05-22 Merck Patent Gmbh Verwendung von Endothelin-Rezeptor-Antagonisten zur Behandlung von Tumorerkrankungen
JP2006501179A (ja) * 2002-06-27 2006-01-12 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
WO2006075955A1 (en) * 2005-01-13 2006-07-20 Astrazeneca Ab Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease
US7521435B2 (en) * 2005-02-18 2009-04-21 Pharma Diagnostics, N.V. Silicon containing compounds having selective COX-2 inhibitory activity and methods of making and using the same
US8012038B1 (en) 2008-12-11 2011-09-06 Taylor Made Golf Company, Inc. Golf club head
US10086240B1 (en) 2015-08-14 2018-10-02 Taylor Made Golf Company, Inc. Golf club head
US10626096B2 (en) 2015-11-24 2020-04-21 Sanford Burnham Prebys Medical Discovery Institute Azole derivatives as apelin receptor agonist
US10773135B1 (en) 2019-08-28 2020-09-15 Taylor Made Golf Company, Inc. Golf club head

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1937241A1 (de) * 1968-08-02 1970-02-19 Sumitomo Chemical Co 3,5-Dioxopyrazolidinderivate und Verfahren zu ihrer Herstellung
JPH01211582A (ja) * 1988-02-16 1989-08-24 Tanabe Seiyaku Co Ltd ベンゾジオキソール誘導体
EP0403158A3 (en) * 1989-06-14 1991-12-18 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
AU9137791A (en) * 1990-12-14 1992-07-08 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
FR2682379B1 (fr) * 1991-10-09 1994-02-11 Rhone Poulenc Agrochimie Nouveaux phenylpyrazoles fongicides.
WO1994022830A1 (en) * 1993-03-31 1994-10-13 Smithkline Beecham Corporation Chemical compounds
DE69426698T2 (de) * 1993-08-18 2001-08-16 Banyu Pharmaceutical Co., Ltd. Kondensierte heteroaromatische cyclopentenderivate mit endothelin-antagonistischer aktivität
IL111613A0 (en) * 1993-11-12 1995-01-24 Rhone Poulenc Rorer Ltd Substituted phenyl compounds, their preparation and pharmaceutical compositions containing them
WO1996007653A1 (en) * 1994-09-02 1996-03-14 Smithkline Beecham Corporation Endothelin receptor antagonists

Also Published As

Publication number Publication date
ATE341324T1 (de) 2006-10-15
ES2273350T3 (es) 2007-05-01
JP2001517195A (ja) 2001-10-02
TR199800152T1 (xx) 1998-05-21
MX9800975A (es) 1998-04-30
NO980422D0 (no) 1998-01-30
EP0843551B1 (en) 2002-02-06
HU220776B1 (hu) 2002-05-28
CN1196680A (zh) 1998-10-21
EP0843551A4 (en) 1998-08-12
EP0841925A4 (en) 2001-10-17
CZ30498A3 (cs) 1998-07-15
OA10755A (en) 2002-12-13
BR9609914A (pt) 1999-07-06
AP9801182A0 (en) 1998-01-31
US5958968A (en) 1999-09-28
EA199800185A1 (ru) 1998-10-29
WO1997004772A1 (en) 1997-02-13
US6482956B2 (en) 2002-11-19
DE69619116T2 (de) 2002-09-19
NZ315846A (en) 1999-01-28
US5969151A (en) 1999-10-19
JPH11511133A (ja) 1999-09-28
EA000952B1 (ru) 2000-08-28
HUP9902817A2 (hu) 1999-12-28
SK11398A3 (en) 1998-07-08
EP0841925B1 (en) 2006-10-04
DE69619116D1 (de) 2002-03-21
HUP9902817A3 (en) 2001-03-28
SK282584B6 (sk) 2002-10-08
KR19990036032A (ko) 1999-05-25
PL184272B1 (pl) 2002-09-30
DE69636597T2 (de) 2007-08-16
AU717172B2 (en) 2000-03-16
NO980422L (no) 1998-03-24
EP0843551A1 (en) 1998-05-27
AU6764596A (en) 1997-02-26
US6353116B1 (en) 2002-03-05
CA2228296A1 (en) 1997-02-13
WO1997004773A1 (en) 1997-02-13
ES2171697T3 (es) 2002-09-16
PL324745A1 (en) 1998-06-08
CA2228293A1 (en) 1997-02-13
RO115802B1 (ro) 2000-06-30
US20020072614A1 (en) 2002-06-13
AU6646396A (en) 1997-02-26
EP0841925A1 (en) 1998-05-20
DE69636597D1 (de) 2006-11-16
US6096897A (en) 2000-08-01

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