NO944781D0 - 2,5-diokso-2,5-dihydro-1H-benz(b)azepiner som NMDA-reseptor-antagonister - Google Patents
2,5-diokso-2,5-dihydro-1H-benz(b)azepiner som NMDA-reseptor-antagonisterInfo
- Publication number
- NO944781D0 NO944781D0 NO944781A NO944781A NO944781D0 NO 944781 D0 NO944781 D0 NO 944781D0 NO 944781 A NO944781 A NO 944781A NO 944781 A NO944781 A NO 944781A NO 944781 D0 NO944781 D0 NO 944781D0
- Authority
- NO
- Norway
- Prior art keywords
- benz
- azepines
- dioxo
- dihydro
- receptor antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929212308A GB9212308D0 (en) | 1992-06-10 | 1992-06-10 | Therapeutic compositions |
| PCT/GB1993/001218 WO1993025534A1 (en) | 1992-06-10 | 1993-06-09 | 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO944781D0 true NO944781D0 (no) | 1994-12-09 |
| NO944781L NO944781L (no) | 1995-01-30 |
| NO305168B1 NO305168B1 (no) | 1999-04-12 |
Family
ID=10716859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO944781A NO305168B1 (no) | 1992-06-10 | 1994-12-09 | 2,5-diokso-2,5-dihydro-1H-benz(b)azepiner og farmas°ytiske blandinger inneholdende dem |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5492905A (no) |
| EP (1) | EP0644878B1 (no) |
| JP (1) | JPH09502157A (no) |
| KR (1) | KR100298377B1 (no) |
| AT (1) | ATE205480T1 (no) |
| AU (1) | AU672799B2 (no) |
| CA (1) | CA2137834A1 (no) |
| DE (1) | DE69330754T2 (no) |
| DK (1) | DK0644878T3 (no) |
| ES (1) | ES2161718T3 (no) |
| FI (2) | FI106714B (no) |
| GB (1) | GB9212308D0 (no) |
| HU (1) | HUT71404A (no) |
| NO (1) | NO305168B1 (no) |
| NZ (1) | NZ253252A (no) |
| PT (1) | PT644878E (no) |
| RU (1) | RU94046322A (no) |
| WO (1) | WO1993025534A1 (no) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
| US5476933A (en) * | 1994-11-16 | 1995-12-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Azepine synthesis via a diels-alder reaction |
| AR040126A1 (es) | 2002-05-29 | 2005-03-16 | Glaxo Group Ltd | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento |
| US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| JP5379692B2 (ja) | 2006-11-09 | 2013-12-25 | プロビオドルグ エージー | 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体 |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| NZ579310A (en) | 2007-03-01 | 2012-03-30 | Probiodrug Ag | Use of glutaminyl cyclase inhibitors for the treatment of mild cognitive impairment and diagnostic purposes thereof |
| DK2142514T3 (da) | 2007-04-18 | 2015-03-23 | Probiodrug Ag | Thioureaderivater som glutaminylcyclase-inhibitorer |
| JP5600111B2 (ja) | 2008-10-22 | 2014-10-01 | アレイ バイオファーマ、インコーポレイテッド | ＴＲＫキナーゼ阻害剤としての置換ピラゾロ［１，５−ａ］ピリミジン化合物 |
| US8486940B2 (en) | 2009-09-11 | 2013-07-16 | Probiodrug Ag | Inhibitors |
| EP2542549B1 (en) | 2010-03-03 | 2016-05-11 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| BR112012022478B1 (pt) | 2010-03-10 | 2021-09-21 | Probiodrug Ag | Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica |
| US8541596B2 (en) | 2010-04-21 | 2013-09-24 | Probiodrug Ag | Inhibitors |
| US8530670B2 (en) | 2011-03-16 | 2013-09-10 | Probiodrug Ag | Inhibitors |
| WO2016199789A1 (ja) * | 2015-06-08 | 2016-12-15 | 国立大学法人名古屋大学 | トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物 |
| PL3800189T3 (pl) * | 2016-05-18 | 2023-10-23 | Loxo Oncology, Inc. | Wytwarzanie (s)-n-(5-((r)-2-(2,5-difluorofenylo)pirolidyn-1-ylo)pirazolo[1,5-a]pirymidyn-3-ylo)-3-hydroksypirolidyno-1-karboksyamidu |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB130538A (en) * | 1918-12-13 | 1919-08-07 | John Algernon Launder | Improvements in or relating to Means for Supporting Garments and Garment Hangers. |
| GB1340334A (en) * | 1970-07-06 | 1973-12-12 | Rees A H | Synthesis of benzazetropolones and hence of kynurenic acids |
| JPS5129522B2 (no) * | 1972-07-13 | 1976-08-26 | ||
| JPS5520970B2 (no) * | 1972-07-15 | 1980-06-06 | ||
| CY1403A (en) * | 1981-08-11 | 1987-12-18 | Ciba Geigy Ag | Benzazepin-2-ones |
| US4410520A (en) * | 1981-11-09 | 1983-10-18 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| US4473575A (en) * | 1982-07-19 | 1984-09-25 | Ciba-Geigy Corporation | 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids |
| US4575503A (en) * | 1983-02-10 | 1986-03-11 | Ciba-Geigy Corporation | 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids |
| DE3323568C2 (de) * | 1983-06-30 | 1987-01-29 | Bayerische Motoren Werke AG, 8000 München | Heiz- und/oder Klimaanlage für Kraftfahrzeuge |
| US4477446A (en) * | 1983-07-01 | 1984-10-16 | Usv Pharmaceutical Corporation | 1-Benzazepines and their pharmaceutical uses |
| DE3416695A1 (de) * | 1984-05-05 | 1985-11-07 | Bayer Ag, 5090 Leverkusen | Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| EP0450097B1 (en) * | 1989-10-20 | 1996-04-24 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
| GB9100028D0 (en) * | 1991-01-02 | 1991-02-20 | Ici Plc | Compounds |
| JPH05105292A (ja) * | 1991-10-15 | 1993-04-27 | Nec Corp | ロール紙のカール解消装置 |
| GB9212308D0 (en) * | 1992-06-10 | 1992-07-22 | Ici Plc | Therapeutic compositions |
| EP0647137B1 (en) * | 1992-06-22 | 2008-08-13 | The Regents Of The University Of California | Glycine receptor antagonists and the use thereof |
| GB9311948D0 (en) * | 1993-06-10 | 1993-07-28 | Zeneca Ltd | Substituted nitrogen heterocycles |
-
1992
- 1992-06-10 GB GB929212308A patent/GB9212308D0/en active Pending
-
1993
- 1993-06-09 CA CA002137834A patent/CA2137834A1/en not_active Abandoned
- 1993-06-09 WO PCT/GB1993/001218 patent/WO1993025534A1/en active IP Right Grant
- 1993-06-09 HU HU9403498A patent/HUT71404A/hu unknown
- 1993-06-09 ES ES93913323T patent/ES2161718T3/es not_active Expired - Lifetime
- 1993-06-09 AU AU43436/93A patent/AU672799B2/en not_active Ceased
- 1993-06-09 RU RU94046322/14A patent/RU94046322A/ru unknown
- 1993-06-09 NZ NZ253252A patent/NZ253252A/en unknown
- 1993-06-09 AT AT93913323T patent/ATE205480T1/de not_active IP Right Cessation
- 1993-06-09 DE DE69330754T patent/DE69330754T2/de not_active Expired - Fee Related
- 1993-06-09 DK DK93913323T patent/DK0644878T3/da active
- 1993-06-09 PT PT93913323T patent/PT644878E/pt unknown
- 1993-06-09 EP EP93913323A patent/EP0644878B1/en not_active Expired - Lifetime
- 1993-06-09 KR KR1019940704503A patent/KR100298377B1/ko not_active IP Right Cessation
- 1993-06-09 JP JP6501262A patent/JPH09502157A/ja not_active Ceased
- 1993-06-10 US US08/074,907 patent/US5492905A/en not_active Expired - Fee Related
-
1994
- 1994-12-09 FI FI945807A patent/FI106714B/fi not_active IP Right Cessation
- 1994-12-09 NO NO944781A patent/NO305168B1/no unknown
-
1995
- 1995-09-07 US US08/524,557 patent/US5654295A/en not_active Expired - Fee Related
-
1997
- 1997-01-13 US US08/782,279 patent/US5712272A/en not_active Expired - Fee Related
-
2000
- 2000-12-12 FI FI20002725A patent/FI20002725A/fi unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR100298377B1 (ko) | 2001-12-01 |
| RU94046322A (ru) | 1996-11-10 |
| US5492905A (en) | 1996-02-20 |
| AU4343693A (en) | 1994-01-04 |
| NO944781L (no) | 1995-01-30 |
| NO305168B1 (no) | 1999-04-12 |
| WO1993025534A1 (en) | 1993-12-23 |
| FI106714B (fi) | 2001-03-30 |
| FI945807A (fi) | 1994-12-09 |
| DK0644878T3 (da) | 2002-03-18 |
| CA2137834A1 (en) | 1993-12-23 |
| HUT71404A (en) | 1995-11-28 |
| US5654295A (en) | 1997-08-05 |
| NZ253252A (en) | 1996-11-26 |
| JPH09502157A (ja) | 1997-03-04 |
| FI20002725A (fi) | 2000-12-12 |
| GB9212308D0 (en) | 1992-07-22 |
| ES2161718T3 (es) | 2001-12-16 |
| DE69330754D1 (de) | 2001-10-18 |
| EP0644878A1 (en) | 1995-03-29 |
| EP0644878B1 (en) | 2001-09-12 |
| PT644878E (pt) | 2002-02-28 |
| DE69330754T2 (de) | 2002-07-04 |
| FI945807A0 (fi) | 1994-12-09 |
| US5712272A (en) | 1998-01-27 |
| AU672799B2 (en) | 1996-10-17 |
| ATE205480T1 (de) | 2001-09-15 |
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