DK0644878T3 - 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister - Google Patents

2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister

Info

Publication number
DK0644878T3
DK0644878T3 DK93913323T DK93913323T DK0644878T3 DK 0644878 T3 DK0644878 T3 DK 0644878T3 DK 93913323 T DK93913323 T DK 93913323T DK 93913323 T DK93913323 T DK 93913323T DK 0644878 T3 DK0644878 T3 DK 0644878T3
Authority
DK
Denmark
Prior art keywords
benz
azepines
dioxo
dihydro
receptor antagonists
Prior art date
Application number
DK93913323T
Other languages
English (en)
Inventor
Gregory David Harris
Marc Jerome Chapdelaine
Paul Francis Jackson
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK0644878T3 publication Critical patent/DK0644878T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK93913323T 1992-06-10 1993-06-09 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister DK0644878T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929212308A GB9212308D0 (en) 1992-06-10 1992-06-10 Therapeutic compositions
PCT/GB1993/001218 WO1993025534A1 (en) 1992-06-10 1993-06-09 2,5-DIOXO-2,5-DIHYDRO-1H-BENZ[b]AZEPINES AS NMDA RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
DK0644878T3 true DK0644878T3 (da) 2002-03-18

Family

ID=10716859

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93913323T DK0644878T3 (da) 1992-06-10 1993-06-09 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister

Country Status (18)

Country Link
US (3) US5492905A (da)
EP (1) EP0644878B1 (da)
JP (1) JPH09502157A (da)
KR (1) KR100298377B1 (da)
AT (1) ATE205480T1 (da)
AU (1) AU672799B2 (da)
CA (1) CA2137834A1 (da)
DE (1) DE69330754T2 (da)
DK (1) DK0644878T3 (da)
ES (1) ES2161718T3 (da)
FI (2) FI106714B (da)
GB (1) GB9212308D0 (da)
HU (1) HUT71404A (da)
NO (1) NO305168B1 (da)
NZ (1) NZ253252A (da)
PT (1) PT644878E (da)
RU (1) RU94046322A (da)
WO (1) WO1993025534A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles
US5476933A (en) * 1994-11-16 1995-12-19 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Azepine synthesis via a diels-alder reaction
AR040126A1 (es) 2002-05-29 2005-03-16 Glaxo Group Ltd Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
LT3372605T (lt) 2008-10-22 2022-02-10 Array Biopharma, Inc. Pakeistieji pirazolo[1,5-a]pirimidino junginiai, kaip trk kinazės inhibitoriai
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
JPWO2016199789A1 (ja) * 2015-06-08 2018-03-29 国立大学法人名古屋大学 トリフルオロメチル置換セミスクアレートの製造方法、トリフルオロメチル置換セミスクアレートを起点とするトリフルオロメチル化合物の製造方法及びトリフルオロメチル基含有化合物
HRP20230704T1 (hr) * 2016-05-18 2023-10-27 Loxo Oncology, Inc. Priprava (s)-n-(5-((r)-2-(2,5-difluorfenil)pirolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroksipirolidin-1-karboksamida
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB130538A (en) * 1918-12-13 1919-08-07 John Algernon Launder Improvements in or relating to Means for Supporting Garments and Garment Hangers.
GB1340334A (en) * 1970-07-06 1973-12-12 Rees A H Synthesis of benzazetropolones and hence of kynurenic acids
JPS5129522B2 (da) * 1972-07-13 1976-08-26
JPS5520970B2 (da) * 1972-07-15 1980-06-06
DE3269625D1 (en) * 1981-08-11 1986-04-10 Ciba Geigy Ag Benzazepin-2-ones, process for their preparation, pharmaceutical preparations containing these compounds and the compounds for therapeutical use
US4410520A (en) * 1981-11-09 1983-10-18 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
US4575503A (en) * 1983-02-10 1986-03-11 Ciba-Geigy Corporation 3-Amino-[1]-benzazepin-2-one-1-alkanoic acids
DE3323568A1 (de) * 1983-06-30 1985-01-10 Bayerische Motoren Werke AG, 8000 München Heiz- und/oder klimaanlage fuer kraftfahrzeuge
US4477446A (en) * 1983-07-01 1984-10-16 Usv Pharmaceutical Corporation 1-Benzazepines and their pharmaceutical uses
DE3416695A1 (de) * 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
ES2089033T3 (es) * 1989-10-20 1996-10-01 Otsuka Pharma Co Ltd Compuestos benzoheterociclicos.
GB9100028D0 (en) * 1991-01-02 1991-02-20 Ici Plc Compounds
JPH05105292A (ja) * 1991-10-15 1993-04-27 Nec Corp ロール紙のカール解消装置
GB9212308D0 (en) * 1992-06-10 1992-07-22 Ici Plc Therapeutic compositions
JP3301024B2 (ja) * 1992-06-22 2002-07-15 ザ・リージェンツ・オブ・ザ・ユニバーシテイ・オブ・カリフォルニア グリシンレセプター拮抗物質及びその用途
GB9311948D0 (en) * 1993-06-10 1993-07-28 Zeneca Ltd Substituted nitrogen heterocycles

Also Published As

Publication number Publication date
FI945807A0 (fi) 1994-12-09
WO1993025534A1 (en) 1993-12-23
US5492905A (en) 1996-02-20
JPH09502157A (ja) 1997-03-04
AU672799B2 (en) 1996-10-17
NO944781D0 (no) 1994-12-09
US5654295A (en) 1997-08-05
HUT71404A (en) 1995-11-28
FI20002725A (fi) 2000-12-12
RU94046322A (ru) 1996-11-10
US5712272A (en) 1998-01-27
FI106714B (fi) 2001-03-30
EP0644878B1 (en) 2001-09-12
ATE205480T1 (de) 2001-09-15
EP0644878A1 (en) 1995-03-29
FI945807A (fi) 1994-12-09
AU4343693A (en) 1994-01-04
ES2161718T3 (es) 2001-12-16
DE69330754T2 (de) 2002-07-04
PT644878E (pt) 2002-02-28
NO944781L (no) 1995-01-30
DE69330754D1 (de) 2001-10-18
GB9212308D0 (en) 1992-07-22
KR100298377B1 (ko) 2001-12-01
NO305168B1 (no) 1999-04-12
NZ253252A (en) 1996-11-26
CA2137834A1 (en) 1993-12-23

Similar Documents

Publication Publication Date Title
DK0644878T3 (da) 2,5-Dioxo-2,5-dihydro-1H-benz[b[azepiner som NDMA-receptor-antagonister
AR002705A1 (es) Un nuevo compuesto de indolina, un proceso para su preparacion y composiciones farmaceuticas que lo contienen.
MY121047A (en) Bicyclo [2.2.1] heptanes and related compounds
NZ223772A (en) Substituted benzodiazepine derivatives and pharmaceutical compositions
BG101715A (en) Tetracyclic spiro compounds, process for their preparation and their use as 5ht 1 d receptor antagonists
AU6877694A (en) Tricyclic benzazepine vasopressin antagonists
MX9605023A (es) Compuestos substituidos de imidazolidin-2,4-diona como substancias farmaceuticamente activas.
IL146871A0 (en) Metabotropic glutamate receptor antagonists and their use for treating central nervous system diseases
UA29416C2 (uk) Похідні 1,5 - бензодіазепіну, що є антагоністами гастрину та холецистокініну, спосіб їх одержання, фармацевтична композиція
BR0113980A (pt) Compostos de succinimida heterocìclicos fundidos e seus análogos, moduladores de função de receptor de hormÈnio nuclear
IL117824A (en) Pharmaceutical compositions containing 2-aryl-imidazol¬1,2-a¾pyridine-3-acetamide derivatives for treatment of neuropsychiatric syndromes associated with dysfunction of the neural circuits of the basal ganglia
IL104853A0 (en) Benzodiazepine derivatives,their preparation and pharmaceutical compositions containing them
BR9803385A (pt) AtropisÈmeros de 2,3-dissubstituìdo-(5,6)-heteroaril condensado-pirimidin-4-onas.
IL113365A (en) 5-Heterocyclo-1,5-benzodiazepine derivatives their preparation and pharmaceutical compositions containing them
GR3034354T3 (en) IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL109076A0 (en) Imidazolo-quinoxalinones, their preparation and pharmaceutical compositions containing them
ITTO930661A1 (it) Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.
IL102880A0 (en) Hexahydrobenzo(f)quinolinones
HUP0004362A2 (hu) Karbamazepint vagy származékait tartalmazó parenterális készítmények
BR9714184A (pt) Utilização de bonzoillquil-1,2,3,6-tetraidropiridinas
MX9804631A (es) Antagonistas quinazolin-4-ona del ampa.
IL111246A0 (en) Tricyclic compounds and pharmaceutical compositions containing them
UA27715C2 (uk) Похідні лактаму та фармацевтична композиція, яка є антагоністом 5-окситриптоміну /5-нт/ на 5-нт рецепторах