BE888895A - Nouveaux derives d'imidazo-rifamycine a activite antibacterienne - Google Patents

Nouveaux derives d'imidazo-rifamycine a activite antibacterienne

Info

Publication number
BE888895A
BE888895A BE2/59169A BE2059169A BE888895A BE 888895 A BE888895 A BE 888895A BE 2/59169 A BE2/59169 A BE 2/59169A BE 2059169 A BE2059169 A BE 2059169A BE 888895 A BE888895 A BE 888895A
Authority
BE
Belgium
Prior art keywords
antibacterial activity
rifamycin derivatives
novel imidazo
imidazo
novel
Prior art date
Application number
BE2/59169A
Other languages
English (en)
French (fr)
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of BE888895A publication Critical patent/BE888895A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BE2/59169A 1980-05-22 1981-05-21 Nouveaux derives d'imidazo-rifamycine a activite antibacterienne BE888895A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (1)

Publication Number Publication Date
BE888895A true BE888895A (fr) 1981-09-16

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2/59169A BE888895A (fr) 1980-05-22 1981-05-21 Nouveaux derives d'imidazo-rifamycine a activite antibacterienne

Country Status (25)

Country Link
US (1) US4341785A (OSRAM)
JP (1) JPS5711987A (OSRAM)
AR (1) AR226212A1 (OSRAM)
AT (1) AT373599B (OSRAM)
AU (1) AU537093B2 (OSRAM)
BE (1) BE888895A (OSRAM)
CA (1) CA1142518A (OSRAM)
CH (1) CH648037A5 (OSRAM)
DE (1) DE3120460A1 (OSRAM)
DK (1) DK157876C (OSRAM)
EG (1) EG14891A (OSRAM)
ES (1) ES8203388A1 (OSRAM)
FI (1) FI69467C (OSRAM)
FR (1) FR2482967A1 (OSRAM)
GB (1) GB2079270B (OSRAM)
GR (1) GR75640B (OSRAM)
IE (1) IE51204B1 (OSRAM)
IT (1) IT1154655B (OSRAM)
LU (1) LU83376A1 (OSRAM)
NL (1) NL187022C (OSRAM)
NO (1) NO155622C (OSRAM)
PH (2) PH17207A (OSRAM)
PT (1) PT73064B (OSRAM)
SE (1) SE453089B (OSRAM)
ZA (1) ZA813430B (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008155728A1 (en) * 2007-06-20 2008-12-24 Solmag S.P.A. Process for preparing amorphous rifaximin and the amorphous rifaximin thus obtained

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IT1199374B (it) * 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
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US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
CA2230649C (en) * 1997-02-28 2007-11-06 Kaneka Corporation Medicine for a disease caused by infection of helicobacter
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AU2002364162A1 (en) * 2001-12-13 2003-06-30 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
US8758804B2 (en) * 2002-11-05 2014-06-24 Fadim S.R.L. Controlled and continued delivery of rifaximin and/or other substances
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
PL1698630T3 (pl) * 2005-03-03 2014-12-31 Alfasigma Spa Nowe postacie polimorficzne rifaksyminy,sposoby ich wytwarzania i ich zastosowanie w preparatach leczniczych
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
JP5368092B2 (ja) 2005-08-11 2013-12-18 ターガンタ セラピュティクス，インコーポレイティド ホスホン化リファマイシン類および骨と関節感染の予防と治療のためのその投与法
BRPI0708561A2 (pt) 2006-03-09 2011-06-07 Salix Pharmaceuticals Inc preparação farmacêutica, e métodos de tratamento de um indivìduo que sofre de um distúrbio anal, e de avaliação da eficácia de um tratamento de distúrbio anal em um indivìduo, monitoramento do progresso de um indivìduo sendo tratado para um distúrbio anal, ou um método de seleção de um indivìduo para o tratamento de distúrbio anal
EP2054066B1 (en) 2006-08-02 2015-04-15 Salix Pharmaceuticals, Inc. Methods for treatment of radiation enteritis
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
NZ575550A (en) * 2006-09-22 2011-12-22 Cipla Ltd Rifaximin
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
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US8486956B2 (en) * 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
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CN101959412A (zh) 2008-02-26 2011-01-26 萨利克斯药品有限公司 治疗肠病的方法
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US8524691B2 (en) 2008-08-13 2013-09-03 The Medicines Company Phosphonated rifamycins and uses thereof for the prevention and treatment of bone and joint infections
JP5567484B2 (ja) 2008-09-26 2014-08-06 あすか製薬株式会社 機能性消化管障害の予防及び／又は治療剤
LT2350096T (lt) 2008-10-02 2020-03-10 Salix Pharmaceuticals, Ltd. Hepatinės encefalopatijos gydymo būdai
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
CA2745980C (en) 2008-12-10 2017-10-31 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
KR20120025578A (ko) 2009-06-02 2012-03-15 샐릭스 파마슈티컬스 리미티드 간성 뇌병증의 치료방법
BR112012005627A2 (pt) 2009-09-13 2017-02-21 Salix Pharmaceuticals Ltd "uso de rifaximina para preparação de um medicamento para tratar síndrome do intestino irritável (ibs)"
CN102665693A (zh) 2009-10-27 2012-09-12 鲁平有限公司 利福昔明固体分散体
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US8952159B2 (en) 2009-12-28 2015-02-10 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
CA2789929C (en) 2010-02-18 2019-11-26 Salix Pharmaceuticals, Ltd. Methods for treating infection
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
WO2011110930A2 (en) 2010-03-10 2011-09-15 Lupin Limited Rifaximin ready-to-use suspension
DK2593463T3 (da) 2010-07-12 2020-08-10 Salix Pharmaceuticals Inc Formuleringer af rifaximin og anvendelser deraf
US8759513B2 (en) 2010-09-13 2014-06-24 Sequent Scientific Limited Polymorphic form of rifaximin and process for its preparation
CN103827122B (zh) 2011-02-11 2016-08-31 萨利克斯药品有限公司 利福昔明的形式及其用途
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ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
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EP2807148A4 (en) * 2012-01-25 2015-04-08 Salix Pharmaceuticals Ltd RIFAXIMIN DERIVATIVE AND USES THEREOF
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US9849090B2 (en) 2012-12-12 2017-12-26 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of rifaximin
US20160038468A1 (en) 2013-03-15 2016-02-11 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections
US20160047819A1 (en) 2013-03-15 2016-02-18 Alfa Wassermann S.P.A. Method for diagnosing vaginal infections
PL2983647T3 (pl) 2013-04-12 2021-01-25 Alfasigma S.P.A. Podawanie nlpz oraz związane z tym składniki, sposoby i układy
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
EP3134415A4 (en) * 2014-04-19 2017-10-25 Granules India Limited An improved process for the preparation of rifamycin derivatives
JP6693946B2 (ja) 2014-05-04 2020-05-13 サリックス ファーマスーティカルズ，インコーポレーテッド Ｉｂｓ微生物叢及びその使用
RS60576B1 (sr) * 2014-05-12 2020-08-31 Alfasigma Spa Priprema i upotreba tau kristalnog oblika rifaksimina solvatisanog sa degme
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US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
KR102494049B1 (ko) 2016-09-30 2023-01-31 샐릭스 파마슈티컬스 인코포레이티드 리팍시민의 고체 분산물 형태
IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine
DK3645539T3 (da) * 2017-06-26 2021-05-10 Biofer Spa Pyrido-imidazo-rifamycin-derivater som antibakterielt middel

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (OSRAM) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT344898B (de) * 1975-06-13 1978-08-10 Archifar Ind Chim Trentino Verfahren zur herstellung neuer rifamycin-verbindungen
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008155728A1 (en) * 2007-06-20 2008-12-24 Solmag S.P.A. Process for preparing amorphous rifaximin and the amorphous rifaximin thus obtained

Also Published As

Publication number Publication date
PH17207A (en) 1984-06-19
SE453089B (sv) 1988-01-11
LU83376A1 (fr) 1981-09-11
IE51204B1 (en) 1986-10-29
US4341785A (en) 1982-07-27
GB2079270A (en) 1982-01-20
ES502906A0 (es) 1982-04-01
AR226212A1 (es) 1982-06-15
EG14891A (en) 1985-12-31
FR2482967B1 (OSRAM) 1985-03-29
NO811731L (no) 1981-11-23
SE8103216L (sv) 1981-11-23
DE3120460C2 (OSRAM) 1990-12-13
ES8203388A1 (es) 1982-04-01
IT1154655B (it) 1987-01-21
GR75640B (OSRAM) 1984-08-02
CH648037A5 (de) 1985-02-28
AU537093B2 (en) 1984-06-07
DK157876C (da) 1990-07-30
FI811565L (fi) 1981-11-23
DK157876B (da) 1990-02-26
FR2482967A1 (fr) 1981-11-27
NO155622B (no) 1987-01-19
CA1142518A (en) 1983-03-08
GB2079270B (en) 1984-01-18
ATA222781A (de) 1983-06-15
FI69467B (fi) 1985-10-31
DE3120460A1 (de) 1982-03-11
NL187022C (nl) 1991-05-01
PT73064B (en) 1982-07-05
IT8003429A0 (it) 1980-05-22
DK224781A (da) 1981-11-23
JPS6123192B2 (OSRAM) 1986-06-04
ZA813430B (en) 1982-06-30
PT73064A (en) 1981-06-01
JPS5711987A (en) 1982-01-21
PH18704A (en) 1985-09-05
NL8102290A (nl) 1981-12-16
NO155622C (no) 1987-04-29
IE811139L (en) 1981-11-22
AT373599B (de) 1984-02-10
AU7065581A (en) 1981-11-26
FI69467C (fi) 1986-02-10
NL187022B (nl) 1990-12-03

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: ALFA FARMACEUTICI S.P.A.

Effective date: 20010521