BE1002129A3 - Derives de dichloroaniline. - Google Patents

Derives de dichloroaniline. Download PDF

Info

Publication number
BE1002129A3
BE1002129A3 BE8700109A BE8700109A BE1002129A3 BE 1002129 A3 BE1002129 A3 BE 1002129A3 BE 8700109 A BE8700109 A BE 8700109A BE 8700109 A BE8700109 A BE 8700109A BE 1002129 A3 BE1002129 A3 BE 1002129A3
Authority
BE
Belgium
Prior art keywords
alkynylene
alkenylene
bond
compounds
alkylene chain
Prior art date
Application number
BE8700109A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of BE1002129A3 publication Critical patent/BE1002129A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Composés dont la formule générale X représente une liaison ou une chaîne alkylène en C1-6, alcénylène en C2-6 ou alcynylène en C2-6, et Y représente une liaison ou une chaîne alkylène en C1-4, alcénylène en C2-4 ou alcynylène en C2-4, Py représente un groupe pyridyle et R1 et R2 représentent chacun un atome d'hydrogene ou un groupe alkyle en C1-3, à condition que la somme totale des atomes de carbone dans R1 et R2 ne soit pas supérieure à 4; et leurs sels et solvates (par exemple hydrates) physiologiquement acceptables. Les composés peuvent être utilisés dans le traitement de maladies associées à l'obstruction réversible des voies aériennes comme l'asthme et la bronchite chronique.
BE8700109A 1986-02-12 1987-02-11 Derives de dichloroaniline. BE1002129A3 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868603475A GB8603475D0 (en) 1986-02-12 1986-02-12 Chemical compounds

Publications (1)

Publication Number Publication Date
BE1002129A3 true BE1002129A3 (fr) 1990-07-24

Family

ID=10592944

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8700109A BE1002129A3 (fr) 1986-02-12 1987-02-11 Derives de dichloroaniline.

Country Status (37)

Country Link
US (1) US4937251A (fr)
JP (2) JPS62258359A (fr)
KR (1) KR870007886A (fr)
CN (1) CN1020095C (fr)
AT (1) AT394364B (fr)
AU (1) AU596824B2 (fr)
BE (1) BE1002129A3 (fr)
CA (1) CA1301762C (fr)
CH (1) CH670636A5 (fr)
CS (1) CS402991A3 (fr)
CY (1) CY1660A (fr)
DE (1) DE3704223C2 (fr)
DK (1) DK163991C (fr)
ES (1) ES2004676A6 (fr)
FI (1) FI83774C (fr)
FR (1) FR2596049B1 (fr)
GB (2) GB8603475D0 (fr)
GR (1) GR870220B (fr)
HK (1) HK85790A (fr)
HU (1) HU199416B (fr)
IE (1) IE59524B1 (fr)
IL (2) IL81535A (fr)
IS (1) IS1489B (fr)
IT (1) IT1205978B (fr)
LU (1) LU86768A1 (fr)
MX (1) MX5220A (fr)
NL (1) NL188408C (fr)
NO (1) NO170629C (fr)
NZ (1) NZ219241A (fr)
PH (1) PH24067A (fr)
PL (1) PL151050B1 (fr)
PT (1) PT84273B (fr)
SE (1) SE462562B (fr)
SG (1) SG70590G (fr)
SU (1) SU1590042A3 (fr)
ZA (1) ZA87974B (fr)
ZW (1) ZW2887A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8703007D0 (en) * 1987-02-10 1987-03-18 Glaxo Group Ltd Chemical compounds
US5149698A (en) * 1987-08-11 1992-09-22 Glaxo Group Limited Chloroaniline derivatives
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
ES2039646T3 (es) * 1987-11-13 1993-10-01 Glaxo Group Limited Derivados de fenetanolamina.
GR1001309B (el) * 1990-06-05 1993-08-31 Glaxo Group Ltd Μεθοδος παρασκευης παραγωγου ενωσεως της διχλωροανιλινης.
GB9104650D0 (en) * 1991-03-05 1991-04-17 Glaxo Group Ltd Medicaments
US6419873B1 (en) 1999-03-19 2002-07-16 Q2100, Inc. Plastic lens systems, compositions, and methods
US6436972B1 (en) 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
US7106046B2 (en) * 2002-06-18 2006-09-12 Asahi Kasei Emd Corporation Current measuring method and current measuring device
WO2007103970A2 (fr) * 2006-03-07 2007-09-13 Endacea, Inc. Compositions et procédés de traitement de troubles respiratoires
JP5626621B2 (ja) 2010-03-19 2014-11-19 株式会社 日立産業制御ソリューションズ フェイズドアレイ合成開口ソナーシステム
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
PT3738434T (pt) 2011-12-28 2023-11-13 Global Blood Therapeutics Inc Intermediários para obter compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN111454200A (zh) 2013-03-15 2020-07-28 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CA2902711C (fr) 2013-03-15 2021-07-06 Global Blood Therapeutics, Inc. Derives de pyridinyl-6-methoxy-2-hydroxybenzaldehyde substitues et compositions pharmaceutiques de ceux-ci pour utilisation dans la modulation de l'hemoglobine
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
SG10201802911RA (en) 2013-03-15 2018-05-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
SI3102208T1 (sl) 2014-02-07 2021-07-30 Global Blood Therapeutics, Inc. Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
TWI752307B (zh) 2016-05-12 2022-01-11 美商全球血液治療公司 新穎化合物及製造化合物之方法
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US11014884B2 (en) 2018-10-01 2021-05-25 Global Blood Therapeutics, Inc. Modulators of hemoglobin

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2165542A (en) * 1984-10-17 1986-04-16 Glaxo Group Ltd Dichloroaniline derivatives

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618005A1 (de) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen
NL176168C (nl) * 1972-12-18 1985-03-01 Thomae Gmbh Dr K Werkwijze ter bereiding respectievelijk vervaardiging van een farmaceutisch preparaat en werkwijze ter bereiding van daarbij bruikbare nieuwe gesubstitueerde 1-(4-aminofenyl)-2-amino-ethanol-derivaten die, behalve een analgetische, uterusspasmolytische en anti-spastische werking op de dwarsgestreepte spieren, in het bijzonder een betaŸ2-mimetische en/of betaŸ1-blokkerende werking bezitten.
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
CH635320A5 (en) * 1978-01-01 1983-03-31 Ciba Geigy Ag 1-(Azacyclic aralkoxyphenyl)-2- or -3-(bis-arylalkylamino)alkanes
DE3061205D1 (en) * 1979-06-16 1983-01-05 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.
US4379166A (en) * 1981-08-03 1983-04-05 Schering Corporation Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
HU186654B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8525484D0 (en) * 1985-10-16 1985-11-20 Glaxo Group Ltd Chemical compounds
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2165542A (en) * 1984-10-17 1986-04-16 Glaxo Group Ltd Dichloroaniline derivatives

Also Published As

Publication number Publication date
GB2187734B (en) 1990-05-30
FI83774B (fi) 1991-05-15
PL264054A1 (en) 1988-10-13
JPH0314565A (ja) 1991-01-23
AT394364B (de) 1992-03-25
GB8703059D0 (en) 1987-03-18
PL151050B1 (en) 1990-07-31
MX5220A (es) 1993-11-01
IT1205978B (it) 1989-04-05
CN1020095C (zh) 1993-03-17
NO870526D0 (no) 1987-02-11
PH24067A (en) 1990-03-05
IS3193A7 (is) 1987-08-13
DE3704223A1 (de) 1987-08-20
US4937251A (en) 1990-06-26
FI83774C (fi) 1991-08-26
IL81535A (en) 1990-11-05
NL8700326A (nl) 1987-09-01
SE462562B (sv) 1990-07-16
GR870220B (en) 1987-05-28
LU86768A1 (fr) 1988-03-02
CH670636A5 (fr) 1989-06-30
NO870526L (no) 1987-08-13
NZ219241A (en) 1990-01-29
FI870554A0 (fi) 1987-02-11
PT84273A (en) 1987-03-01
IL89205A (en) 1993-04-04
DK69887D0 (da) 1987-02-11
DK69887A (da) 1987-08-13
HK85790A (en) 1990-10-25
NL188408C (nl) 1992-06-16
AU596824B2 (en) 1990-05-17
SU1590042A3 (ru) 1990-08-30
DK163991C (da) 1992-09-21
CY1660A (en) 1993-05-14
PT84273B (pt) 1989-09-14
FI870554A (fi) 1987-08-13
GB2187734A (en) 1987-09-16
NL188408B (nl) 1992-01-16
HU199416B (en) 1990-02-28
NO170629C (no) 1992-11-11
IL81535A0 (en) 1987-09-16
JPH0462311B2 (fr) 1992-10-05
ES2004676A6 (es) 1989-02-01
GB8603475D0 (en) 1986-03-19
ZA87974B (en) 1987-12-30
KR870007886A (ko) 1987-09-22
AU6869587A (en) 1987-08-13
FR2596049B1 (fr) 1991-02-08
IT8747630A0 (it) 1987-02-11
CN87101830A (zh) 1987-09-09
IE870350L (en) 1987-08-12
FR2596049A1 (fr) 1987-09-25
CS402991A3 (en) 1992-09-16
IS1489B (is) 1992-06-30
HUT43566A (en) 1987-11-30
DE3704223C2 (de) 1995-05-24
SE8700535L (sv) 1987-08-13
SE8700535D0 (sv) 1987-02-11
NO170629B (no) 1992-08-03
JPS62258359A (ja) 1987-11-10
ATA28687A (de) 1991-09-15
SG70590G (en) 1990-10-26
DK163991B (da) 1992-04-27
IE59524B1 (en) 1994-03-09
ZW2887A1 (en) 1987-09-23
CA1301762C (fr) 1992-05-26

Similar Documents

Publication Publication Date Title
BE1002129A3 (fr) Derives de dichloroaniline.
MY106250A (en) Azolylmethylcyclopentane benzylidene fungicide.
BE1002211A4 (fr) (pentamethyl-1,2,2,6,6 piperidyl-4-amino)-triazines, leur application comme stabilisants de matieres organiques, et compositions qui en contiennent.
ATE115952T1 (de) Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel.
ATE17249T1 (de) 9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one.
BE900842A (fr) Nouveaux complexes de platine et leur application en therapeutique.
BE902876A (fr) Derives d'aminophenol
CO4700298A1 (es) Derivados de 3-fenilisoquinoleina-1 (2h)-ona, su preparacion y su aplicacion en la terapeutica
MX9606665A (es) Derivados de acido 3-amino-2-mercaptobenzoico y procesos para su preparacion.
ES2151110T3 (es) Derivados de piridazinona y procedimiento de preparacion.
MD382C2 (ro) Procedeu de obţinere a piperazinilalchil-3(2H)-piridazinonelor sau a sărurilor lor farmaceutice admisibile
FR2436779A1 (fr) Derives de pyrrolidine-2 methanol utilisables comme medicaments
HUP0102025A2 (hu) Diaril-1,3,4-oxadiazolon-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
FR2623808B1 (fr) Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
NZ230128A (en) Dibenzooxepine-pyridinium and -pyrrolo derivatives and pharmaceutical compositions
ATE71092T1 (de) Hydroxybutenolid-derivate, ihre herstellung und ihre verwendung.
FI895012A0 (fi) Laekemedel innehaollande nitroxialkylaminer med amidfunktion samt foerfarande foer framstaellning av naemnda foereningar.
FR2618436B1 (fr) Derives de piperidine, leur preparation et leur application en therapeutique
ES523775A0 (es) Procedimiento de preparacion de dederivados de amino-2--tetrahidro-1 2 3 4-naftaleno
ATE104939T1 (de) Dicyclohexylethylenderivate.
HUT74742A (en) Pyridazinone derivatives and pharmaceutical compositions containing them
MA20369A1 (fr) Compositions a base de derives de la piperidine ,nouveaux derives de la piperidine et leurs procedes de preparation
ATE54307T1 (de) Pantothenolderivate.
FR2450835A2 (fr) Derives de la tetrahydroalstonine et leur application en therapeutique
ATE9892T1 (de) Dibenzocycloheptenylidene und ihre verwendung in pharmazeutischen zusammensetzungen.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: GLAXO GROUP LTD

Effective date: 20010228