FI870554A0 - Dikloranilinderivat. - Google Patents

Dikloranilinderivat.

Info

Publication number
FI870554A0
FI870554A0 FI870554A FI870554A FI870554A0 FI 870554 A0 FI870554 A0 FI 870554A0 FI 870554 A FI870554 A FI 870554A FI 870554 A FI870554 A FI 870554A FI 870554 A0 FI870554 A0 FI 870554A0
Authority
FI
Finland
Prior art keywords
dikloranilinderivat
Prior art date
Application number
FI870554A
Other languages
English (en)
Other versions
FI870554A (fi
FI83774C (fi
FI83774B (fi
Inventor
Lawrence Henry Charles Lunts
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FI870554A0 publication Critical patent/FI870554A0/fi
Publication of FI870554A publication Critical patent/FI870554A/fi
Application granted granted Critical
Publication of FI83774B publication Critical patent/FI83774B/fi
Publication of FI83774C publication Critical patent/FI83774C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61Halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/65One oxygen atom attached in position 3 or 5
FI870554A 1986-02-12 1987-02-11 Foerfarande foer framstaellning av farmakologiskt vaerdefulla dikloranilinderivat. FI83774C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868603475A GB8603475D0 (en) 1986-02-12 1986-02-12 Chemical compounds
GB8603475 1986-02-12

Publications (4)

Publication Number Publication Date
FI870554A0 true FI870554A0 (fi) 1987-02-11
FI870554A FI870554A (fi) 1987-08-13
FI83774B FI83774B (fi) 1991-05-15
FI83774C FI83774C (fi) 1991-08-26

Family

ID=10592944

Family Applications (1)

Application Number Title Priority Date Filing Date
FI870554A FI83774C (fi) 1986-02-12 1987-02-11 Foerfarande foer framstaellning av farmakologiskt vaerdefulla dikloranilinderivat.

Country Status (37)

Country Link
US (1) US4937251A (fi)
JP (2) JPS62258359A (fi)
KR (1) KR870007886A (fi)
CN (1) CN1020095C (fi)
AT (1) AT394364B (fi)
AU (1) AU596824B2 (fi)
BE (1) BE1002129A3 (fi)
CA (1) CA1301762C (fi)
CH (1) CH670636A5 (fi)
CS (1) CS402991A3 (fi)
CY (1) CY1660A (fi)
DE (1) DE3704223C2 (fi)
DK (1) DK163991C (fi)
ES (1) ES2004676A6 (fi)
FI (1) FI83774C (fi)
FR (1) FR2596049B1 (fi)
GB (2) GB8603475D0 (fi)
GR (1) GR870220B (fi)
HK (1) HK85790A (fi)
HU (1) HU199416B (fi)
IE (1) IE59524B1 (fi)
IL (2) IL81535A (fi)
IS (1) IS1489B (fi)
IT (1) IT1205978B (fi)
LU (1) LU86768A1 (fi)
MX (1) MX5220A (fi)
NL (1) NL188408C (fi)
NO (1) NO170629C (fi)
NZ (1) NZ219241A (fi)
PH (1) PH24067A (fi)
PL (1) PL151050B1 (fi)
PT (1) PT84273B (fi)
SE (1) SE462562B (fi)
SG (1) SG70590G (fi)
SU (1) SU1590042A3 (fi)
ZA (1) ZA87974B (fi)
ZW (1) ZW2887A1 (fi)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
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GB8703007D0 (en) * 1987-02-10 1987-03-18 Glaxo Group Ltd Chemical compounds
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds
US5149698A (en) * 1987-08-11 1992-09-22 Glaxo Group Limited Chloroaniline derivatives
AU609209B2 (en) * 1987-11-13 1991-04-26 Glaxo Group Limited Phenethanolamine derivatives
ES2036920B1 (es) * 1990-06-05 1994-02-16 Glaxo Group Ltd Un metodo para la preparacion de un compuesto de dicloroanilina.
GB9104650D0 (en) * 1991-03-05 1991-04-17 Glaxo Group Ltd Medicaments
US6419873B1 (en) 1999-03-19 2002-07-16 Q2100, Inc. Plastic lens systems, compositions, and methods
US6436972B1 (en) 2000-04-10 2002-08-20 Dalhousie University Pyridones and their use as modulators of serine hydrolase enzymes
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
WO2003107018A1 (ja) * 2002-06-18 2003-12-24 旭化成株式会社 電流測定方法および電流測定装置
JP2009529539A (ja) * 2006-03-07 2009-08-20 エンダセア, インコーポレイテッド 呼吸器障害を治療するための方法および組成物
JP5626621B2 (ja) 2010-03-19 2014-11-19 株式会社 日立産業制御ソリューションズ フェイズドアレイ合成開口ソナーシステム
PT3738434T (pt) 2011-12-28 2023-11-13 Global Blood Therapeutics Inc Intermediários para obter compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US20140274961A1 (en) 2013-03-15 2014-09-18 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
PE20160078A1 (es) 2013-03-15 2016-03-02 Global Blood Therapeutics Inc Compuestos y sus usos para modular la hemoglobina
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA033555B1 (ru) 2013-03-15 2019-10-31 Global Blood Therapeutics Inc Фармацевтические композиции для лечения серповидно-клеточного нарушения
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
MY189995A (en) 2014-02-07 2022-03-22 Global Blood Therapeutics Inc Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
MA41841A (fr) 2015-03-30 2018-02-06 Global Blood Therapeutics Inc Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
US11020382B2 (en) 2015-12-04 2021-06-01 Global Blood Therapeutics, Inc. Dosing regimens for 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
ES2966707T3 (es) 2018-10-01 2024-04-23 Global Blood Therapeutics Inc Moduladores de la hemoglobina para el tratamiento de la drepanocitosis

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Publication number Priority date Publication date Assignee Title
DE1618005A1 (de) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen
NL176168C (nl) * 1972-12-18 1985-03-01 Thomae Gmbh Dr K Werkwijze ter bereiding respectievelijk vervaardiging van een farmaceutisch preparaat en werkwijze ter bereiding van daarbij bruikbare nieuwe gesubstitueerde 1-(4-aminofenyl)-2-amino-ethanol-derivaten die, behalve een analgetische, uterusspasmolytische en anti-spastische werking op de dwarsgestreepte spieren, in het bijzonder een betaŸ2-mimetische en/of betaŸ1-blokkerende werking bezitten.
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
CH635320A5 (en) * 1978-01-01 1983-03-31 Ciba Geigy Ag 1-(Azacyclic aralkoxyphenyl)-2- or -3-(bis-arylalkylamino)alkanes
DE3061205D1 (en) * 1979-06-16 1983-01-05 Beecham Group Plc Secondary amines, their preparation and use in pharmaceutical compositions
NL8105170A (nl) * 1980-12-10 1982-07-01 Thomae Gmbh Dr K Nieuwe fenylalkylaminen, werkwijze ter bereiding daarvan en de toepassing daarvan als geneesmiddelen.
US4379166A (en) * 1981-08-03 1983-04-05 Schering Corporation Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
HU186654B (en) * 1982-12-28 1985-09-30 Richter Gedeon Vegyeszet Process for producing new pyridine derivatives, acid additional salts and quaternary salts and pharmaceutical compositions containing them
DE3434271A1 (de) * 1984-09-19 1986-03-20 Beiersdorf Ag, 2000 Hamburg Substituierte 3,4-dihydro-chinolin-2(1h)-one verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
GB8426191D0 (en) * 1984-10-17 1984-11-21 Glaxo Holdings Ltd Chemical compounds
GB8525484D0 (en) * 1985-10-16 1985-11-20 Glaxo Group Ltd Chemical compounds
GB8718939D0 (en) * 1987-08-11 1987-09-16 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
CN87101830A (zh) 1987-09-09
IT1205978B (it) 1989-04-05
AU596824B2 (en) 1990-05-17
US4937251A (en) 1990-06-26
CH670636A5 (fi) 1989-06-30
BE1002129A3 (fr) 1990-07-24
FI870554A (fi) 1987-08-13
SE462562B (sv) 1990-07-16
FI83774C (fi) 1991-08-26
NO170629B (no) 1992-08-03
SG70590G (en) 1990-10-26
KR870007886A (ko) 1987-09-22
IL89205A (en) 1993-04-04
IS3193A7 (is) 1987-08-13
SU1590042A3 (ru) 1990-08-30
GB8603475D0 (en) 1986-03-19
NZ219241A (en) 1990-01-29
ATA28687A (de) 1991-09-15
AU6869587A (en) 1987-08-13
NL188408C (nl) 1992-06-16
NL188408B (nl) 1992-01-16
DK163991C (da) 1992-09-21
IL81535A0 (en) 1987-09-16
JPS62258359A (ja) 1987-11-10
NO870526D0 (no) 1987-02-11
DE3704223A1 (de) 1987-08-20
DE3704223C2 (de) 1995-05-24
PT84273A (en) 1987-03-01
IE59524B1 (en) 1994-03-09
ES2004676A6 (es) 1989-02-01
FR2596049B1 (fr) 1991-02-08
DK163991B (da) 1992-04-27
FI83774B (fi) 1991-05-15
LU86768A1 (fr) 1988-03-02
PL151050B1 (en) 1990-07-31
IS1489B (is) 1992-06-30
CN1020095C (zh) 1993-03-17
CA1301762C (en) 1992-05-26
AT394364B (de) 1992-03-25
CS402991A3 (en) 1992-09-16
PT84273B (pt) 1989-09-14
HK85790A (en) 1990-10-25
GR870220B (en) 1987-05-28
SE8700535L (sv) 1987-08-13
HU199416B (en) 1990-02-28
CY1660A (en) 1993-05-14
NO870526L (no) 1987-08-13
PH24067A (en) 1990-03-05
HUT43566A (en) 1987-11-30
SE8700535D0 (sv) 1987-02-11
DK69887D0 (da) 1987-02-11
IE870350L (en) 1987-08-12
NL8700326A (nl) 1987-09-01
PL264054A1 (en) 1988-10-13
DK69887A (da) 1987-08-13
ZW2887A1 (en) 1987-09-23
GB2187734B (en) 1990-05-30
JPH0462311B2 (fi) 1992-10-05
IL81535A (en) 1990-11-05
IT8747630A0 (it) 1987-02-11
GB2187734A (en) 1987-09-16
GB8703059D0 (en) 1987-03-18
ZA87974B (en) 1987-12-30
FR2596049A1 (fr) 1987-09-25
MX5220A (es) 1993-11-01
JPH0314565A (ja) 1991-01-23
NO170629C (no) 1992-11-11

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Owner name: GLAXO GROUP LIMITED