AU725516B2 - Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids - Google Patents

Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids Download PDF

Info

Publication number
AU725516B2
AU725516B2 AU94968/98A AU9496898A AU725516B2 AU 725516 B2 AU725516 B2 AU 725516B2 AU 94968/98 A AU94968/98 A AU 94968/98A AU 9496898 A AU9496898 A AU 9496898A AU 725516 B2 AU725516 B2 AU 725516B2
Authority
AU
Australia
Prior art keywords
host
coli
coa transferase
coa
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU94968/98A
Other languages
English (en)
Other versions
AU9496898A (en
Inventor
Gjalt W. Huisman
David P. Martin
Oliver P. Peoples
Frank A. Skraly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yield10 Bioscience Inc
Original Assignee
Metabolix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolix Inc filed Critical Metabolix Inc
Publication of AU9496898A publication Critical patent/AU9496898A/en
Application granted granted Critical
Publication of AU725516B2 publication Critical patent/AU725516B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1096Transferases (2.) transferring nitrogenous groups (2.6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters
    • C12P7/625Polyesters of hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Enzymes And Modification Thereof (AREA)
AU94968/98A 1997-09-19 1998-09-18 Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids Ceased AU725516B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5937397P 1997-09-19 1997-09-19
US60/059373 1997-09-19
PCT/US1998/019659 WO1999014313A2 (en) 1997-09-19 1998-09-18 Biological systems for manufacture of polyhydroxylalkanoate polymers containing 4-hydroxyacids

Publications (2)

Publication Number Publication Date
AU9496898A AU9496898A (en) 1999-04-05
AU725516B2 true AU725516B2 (en) 2000-10-12

Family

ID=22022544

Family Applications (1)

Application Number Title Priority Date Filing Date
AU94968/98A Ceased AU725516B2 (en) 1997-09-19 1998-09-18 Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids

Country Status (8)

Country Link
US (6) US6316262B1 (https=)
EP (1) EP1015565B1 (https=)
JP (4) JP2001516574A (https=)
AT (1) ATE323152T1 (https=)
AU (1) AU725516B2 (https=)
CA (1) CA2303070C (https=)
DE (2) DE69834199T2 (https=)
WO (1) WO1999014313A2 (https=)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7455999B2 (en) * 1998-01-22 2008-11-25 Metabolix, Inc. Transgenic systems for the manufacture of poly (3-hydroxy-butyrate-co-3-hydroxyhexanoate)
US6323010B1 (en) 1998-05-22 2001-11-27 Metabolix, Inc. Polyhydroxyalkanoate biopolymer compositions
EP1975236B1 (en) 1998-08-04 2015-05-06 Metabolix, Inc. Polyhydroxyalkanoate production from polyols
EP1700909B1 (en) * 1998-08-18 2015-08-12 Metabolix, Inc. Transgenic microbial polyhydroxyalkanoate producers
DE69930276T2 (de) * 1998-08-18 2006-10-05 Metabolix, Inc., Cambridge Transgene polyhydroxyalkanoat produzierende mikroben
ES2525553T3 (es) 1999-03-25 2014-12-26 Metabolix, Inc. Dispositivos y aplicaciones médicas de polímeros polihidroxialcanoato
US6623730B1 (en) 1999-09-14 2003-09-23 Tepha, Inc. Therapeutic uses of polymers and oligomers comprising gamma-hydroxybutyrate
ES2336641T3 (es) 2000-02-11 2010-04-15 Metabolix, Inc. Constructos de expresion multigenicos que contienen inteinas modificadas.
KR20040014389A (ko) 2000-07-21 2004-02-14 메타볼릭스 인코포레이티드 폴리올로부터 폴리하이드록시알칸노에이트를 제조하는 방법
WO2003051813A1 (en) 2001-12-18 2003-06-26 Metabolix, Inc. Methods of making intermediates from polyhydroxyalkanoates
US7318833B2 (en) 2001-12-19 2008-01-15 Nmt Medical, Inc. PFO closure device with flexible thrombogenic joint and improved dislodgement resistance
WO2003053493A2 (en) 2001-12-19 2003-07-03 Nmt Medical, Inc. Septal occluder and associated methods
WO2003059152A2 (en) * 2002-01-14 2003-07-24 Nmt Medical, Inc. Patent foramen ovale (pfo) closure method and device
EP1487353A4 (en) 2002-03-25 2008-04-16 Nmt Medical Inc FORAMEN OVAL PERSISTENT CLOSURE CLAMPS (PFO)
WO2003103476A2 (en) 2002-06-05 2003-12-18 Nmt Medical, Inc. Patent foramen ovale (pfo) closure device with radial and circumferential support
AUPS318202A0 (en) * 2002-06-26 2002-07-18 Cochlear Limited Parametric fitting of a cochlear implant
WO2004024876A2 (en) 2002-09-12 2004-03-25 Metabolix, Inc. Polyhydroxyalkanoate production by coenzyme a-dependent aldehyde dehydrogenase pathways
AU2003284976A1 (en) 2002-10-25 2004-05-13 Nmt Medical, Inc. Expandable sheath tubing
EP1562653A1 (en) * 2002-11-06 2005-08-17 NMT Medical, Inc. Medical devices utilizing modified shape memory alloy
WO2004052213A1 (en) 2002-12-09 2004-06-24 Nmt Medical, Inc. Septal closure devices
WO2004065609A1 (ja) 2003-01-22 2004-08-05 Showa Denko K.K. アシルコエンザイムaを用いるアシル基転移酵素反応方法
EP2860292B1 (en) 2003-05-08 2020-07-22 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US8480706B2 (en) 2003-07-14 2013-07-09 W.L. Gore & Associates, Inc. Tubular patent foramen ovale (PFO) closure device with catch system
WO2005006990A2 (en) 2003-07-14 2005-01-27 Nmt Medical, Inc. Tubular patent foramen ovale (pfo) closure device with catch system
US9861346B2 (en) 2003-07-14 2018-01-09 W. L. Gore & Associates, Inc. Patent foramen ovale (PFO) closure device with linearly elongating petals
WO2005018728A2 (en) 2003-08-19 2005-03-03 Nmt Medical, Inc. Expandable sheath tubing
US7579176B2 (en) 2003-10-15 2009-08-25 Newlight Technologies, Llc Method for the production of polyhydroxyalkanoic acid
WO2007024255A1 (en) * 2005-08-22 2007-03-01 Herrema-Kimmel, Llc., Process for the treatment of methane emissions
US7745197B1 (en) 2003-10-15 2010-06-29 Newlight Technologies, Llc Process for the utilization of ruminant animal methane emissions
US8735113B2 (en) 2003-10-15 2014-05-27 Newlight Technologies, Llc Methods and systems for production of polyhydroxyalkanoate
US20050273119A1 (en) * 2003-12-09 2005-12-08 Nmt Medical, Inc. Double spiral patent foramen ovale closure clamp
EP1737349A1 (en) 2004-03-03 2007-01-03 NMT Medical, Inc. Delivery/recovery system for septal occluder
US20050267524A1 (en) * 2004-04-09 2005-12-01 Nmt Medical, Inc. Split ends closure device
US8361110B2 (en) 2004-04-26 2013-01-29 W.L. Gore & Associates, Inc. Heart-shaped PFO closure device
US8308760B2 (en) 2004-05-06 2012-11-13 W.L. Gore & Associates, Inc. Delivery systems and methods for PFO closure device with two anchors
US7842053B2 (en) 2004-05-06 2010-11-30 Nmt Medical, Inc. Double coil occluder
WO2005110240A1 (en) 2004-05-07 2005-11-24 Nmt Medical, Inc. Catching mechanisms for tubular septal occluder
JP4720114B2 (ja) * 2004-05-20 2011-07-13 三菱化学株式会社 オキザロ酢酸またはオキザロ酢酸誘導体の製造方法
ES2362217T3 (es) 2004-08-03 2011-06-29 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas.
EP1827247B8 (en) 2004-09-24 2020-05-06 W.L. Gore & Associates, Inc. Occluder device double securement system for delivery/recovery of such occluder device
CA2600882C (en) 2005-03-16 2013-02-26 Metabolix, Inc. Chemically inducible expression of biosynthetic pathways
WO2006102213A1 (en) 2005-03-18 2006-09-28 Nmt Medical, Inc. Catch member for pfo occluder
KR100979694B1 (ko) 2005-05-24 2010-09-02 한국과학기술원 폴리락테이트 또는 그 공중합체 생성능을 가지는 세포 또는식물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
EP1948037A2 (en) * 2005-10-24 2008-07-30 NMT Medical, Inc. Radiopaque bioabsorbable occluder
WO2007073566A1 (en) 2005-12-22 2007-06-28 Nmt Medical, Inc. Catch members for occluder devices
US8979921B2 (en) * 2006-02-07 2015-03-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US7618448B2 (en) * 2006-02-07 2009-11-17 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
US9592325B2 (en) * 2006-02-07 2017-03-14 Tepha, Inc. Polymeric, degradable drug-eluting stents and coatings
ES2624589T3 (es) * 2006-02-07 2017-07-17 Tepha, Inc. Métodos y dispositivos para la reparación del manguito de los rotadores
US8870913B2 (en) 2006-03-31 2014-10-28 W.L. Gore & Associates, Inc. Catch system with locking cap for patent foramen ovale (PFO) occluder
CA2647505C (en) 2006-03-31 2014-07-29 Nmt Medical, Inc. Deformable flap catch mechanism for occluder device
US8551135B2 (en) 2006-03-31 2013-10-08 W.L. Gore & Associates, Inc. Screw catch mechanism for PFO occluder and method of use
US9089627B2 (en) 2006-07-11 2015-07-28 Abbott Cardiovascular Systems Inc. Stent fabricated from polymer composite toughened by a dispersed phase
JP5468779B2 (ja) * 2006-07-21 2014-04-09 株式会社カネカ 遺伝子置換微生物およびそれを用いたポリエステルの製造方法
US20080082083A1 (en) * 2006-09-28 2008-04-03 Forde Sean T Perforated expandable implant recovery sheath
JP5565938B2 (ja) * 2006-11-21 2014-08-06 エルジー・ケム・リミテッド 4−ヒドロキシブチレート単位とラクテート単位を含有する共重合体及びその製造方法
US7943683B2 (en) 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US20080188936A1 (en) * 2007-02-02 2008-08-07 Tornier, Inc. System and method for repairing tendons and ligaments
LT2821494T (lt) 2007-03-16 2017-04-25 Genomatica, Inc. 1,4-butandiolio ir jo pirmtakų biosintezės būdai ir kompozicijos
WO2008124603A1 (en) 2007-04-05 2008-10-16 Nmt Medical, Inc. Septal closure device with centering mechanism
US9138562B2 (en) 2007-04-18 2015-09-22 W.L. Gore & Associates, Inc. Flexible catheter system
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
BRPI0816083A2 (pt) * 2007-08-30 2017-05-16 Plant Sensory System Llc métodos alternativos para a biossíntese de gaba
US8581041B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
US8581040B2 (en) 2007-08-30 2013-11-12 Plant Sensory Systems, Llc Methods of producing GABA
TWI356705B (en) * 2007-10-25 2012-01-21 Internat Chlorella Co Ltd Extracts from chlorella sorokiniana
US20110229942A1 (en) * 2007-12-13 2011-09-22 Glycos Biotechnologies, Incorporated Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals
EP2231913B1 (en) * 2007-12-19 2013-01-23 Tepha, Inc. Medical devices containing melt-blown non-wovens of poly-r-hydroxybutyrate and copolymers
KR20090078925A (ko) * 2008-01-16 2009-07-21 주식회사 엘지화학 폴리락테이트 또는 그 공중합체 생성능을 가지는 재조합미생물 및 이를 이용한 폴리락테이트 또는 그 공중합체의제조방법
US20130165967A1 (en) 2008-03-07 2013-06-27 W.L. Gore & Associates, Inc. Heart occlusion devices
US20090253154A1 (en) * 2008-04-02 2009-10-08 Immunosciences Lab., Inc. Blood and saliva test for detection of delayed food allergy and intolerance against modified foods
US8487159B2 (en) * 2008-04-28 2013-07-16 Metabolix, Inc. Production of polyhydroxybutyrate in switchgrass
BRPI0915749A2 (pt) * 2008-07-08 2018-07-10 Opx Biotechnologies Inc métodos, composições e sistemas para produção biossintética de 1,4-butanodiol
US7858350B2 (en) 2008-09-10 2010-12-28 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CN103396978A (zh) 2008-12-12 2013-11-20 麦特波力克斯公司 用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物
JP5698001B2 (ja) * 2009-02-10 2015-04-08 協和発酵バイオ株式会社 アミノ酸の製造法
AU2010221135A1 (en) 2009-03-05 2011-09-29 Metabolix, Inc. Propagation of transgenic plants
WO2010141920A2 (en) 2009-06-04 2010-12-09 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol and related methods
SI3199511T1 (sl) 2009-06-04 2020-07-31 Genomatica, Inc. Proces separacije komponent fermentacijske brozge
US20120029556A1 (en) 2009-06-22 2012-02-02 Masters Steven J Sealing device and delivery system
US9636094B2 (en) 2009-06-22 2017-05-02 W. L. Gore & Associates, Inc. Sealing device and delivery system
US20120165500A1 (en) 2009-08-27 2012-06-28 Newlight Technologies, Llc Process for the production of polyhydroxyalkanoates
US20120174253A1 (en) 2009-09-15 2012-07-05 Nii Patterson Generation of high polyhydroxybutrate producing oilseeds
US8377666B2 (en) * 2009-10-13 2013-02-19 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-coa, putrescine and related compounds, and methods related thereto
WO2011063363A2 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
US8530210B2 (en) 2009-11-25 2013-09-10 Genomatica, Inc. Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
WO2011068952A1 (en) 2009-12-02 2011-06-09 Entrigue Surgical, Inc. Devices for tongue stabilization
US9084467B2 (en) 2010-02-11 2015-07-21 Metabolix, Inc. Process for gamma-butyrolactone production
US8637286B2 (en) 2010-02-23 2014-01-28 Genomatica, Inc. Methods for increasing product yields
US8048661B2 (en) 2010-02-23 2011-11-01 Genomatica, Inc. Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes
GB2478588A (en) * 2010-03-12 2011-09-14 G5 Internat Holdings Pte Ltd Microbial production of polyhydroxyalkanoates (PHAs) using culture medium containing hydrogen
ES2785076T3 (es) 2010-03-26 2020-10-05 Tepha Inc Recubrimientos para la fabricación y la aplicación de dispositivos médicos de polihidroxialcanoato
CA2802212C (en) 2010-06-15 2015-03-24 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers
US9511169B2 (en) 2010-06-15 2016-12-06 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
EP2425865A1 (en) 2010-08-06 2012-03-07 Aesculap AG Medicinal thread having a polyhydroxyalkanoate coating
WO2012037324A2 (en) 2010-09-15 2012-03-22 Metabolix, Inc. Increasing carbon flow for polyhydroxybutyrate production in biomass crops
EP2637734B1 (en) 2010-11-09 2017-09-13 Tepha, Inc. Drug eluting cochlear implants
US8956835B2 (en) 2010-11-24 2015-02-17 Suny Research Foundation Methods for producing polyhydroxyalkanoates from biodiesel-glycerol
EP2667811B1 (en) 2011-01-27 2015-12-30 Cryosa, Llc Apparatus for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
WO2012122343A2 (en) 2011-03-08 2012-09-13 Newlight Technologies, Llc Polyhydroxyalkanoate production method
WO2012149407A1 (en) 2011-04-29 2012-11-01 Metabolix, Inc. Process for latex production by melt emulsification
US9663791B2 (en) 2011-04-29 2017-05-30 Cj Research Center Llc Green process for producing polyhydroxyalkanoates and chemicals using a renewable feedstock
US20140114082A1 (en) 2011-06-08 2014-04-24 Metabolix, Inc. Biorefinery Process For THF Production
ES2599482T3 (es) 2011-07-29 2017-02-01 Mitsui Chemicals, Inc. Microorganismo que tiene un ciclo de fijación de dióxido de carbono introducido en el mismo
EP2742143A1 (en) 2011-08-10 2014-06-18 Metabolix, Inc. Post process purification for gamma-butyrolactone production
US9770232B2 (en) 2011-08-12 2017-09-26 W. L. Gore & Associates, Inc. Heart occlusion devices
WO2013035372A1 (ja) * 2011-09-05 2013-03-14 独立行政法人理化学研究所 長主鎖構造を有するポリヒドロキシアルカン酸の製造方法
US8680228B2 (en) 2011-09-27 2014-03-25 Tepha, Inc. Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers
ES2689558T3 (es) 2011-10-25 2018-11-14 Marrone Bio Innovations, Inc. Formulaciones, composiciones y metabolitos de Chromobacterium y sus usos
BR112014010448A2 (pt) 2011-11-02 2017-04-18 Genomatica Inc microorganismos e métodos para a produção de caprolactona
US12060597B2 (en) 2011-12-02 2024-08-13 Newlight Technologies, Inc. Polyhydroxyalkanoate production methods and systems for same
US9085784B1 (en) 2012-03-29 2015-07-21 Newlight Technologies, Llc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
US20200347417A1 (en) 2012-03-29 2020-11-05 Newlight Technologies, Inc Polyhydroxyalkanoate production methods and materials and microorganisms used in same
CN104520433A (zh) * 2012-04-11 2015-04-15 赫姆霍尔兹传染病研究中心有限责任公司 产生pha的基因工程微生物
ES2734126T3 (es) 2012-05-21 2019-12-04 Tepha Inc Composiciones biocerámicas reabsorbibles de poli-4-hidroxibutirato y copolímeros
WO2013184602A2 (en) 2012-06-04 2013-12-12 Genomatica, Inc. Microorganisms and methods for production of 4-hydroxybutyrate, 1,4-butanediol and related compounds
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
WO2014028943A1 (en) 2012-08-17 2014-02-20 Metabolix, Inc. Biobased rubber modifiers for polymer blends
US20150240273A1 (en) 2012-10-10 2015-08-27 Metabolix, Inc. Polyhydroxyalkanoate copolymer compositions and methods of making the same
US20160068463A1 (en) 2012-11-14 2016-03-10 Metabolix, Inc. Production of salts of 4-hydroxybutyrate using biobased raw materials
WO2014113268A1 (en) 2013-01-15 2014-07-24 Tepha, Inc. Implants for soft and hard tissue regeneration
US10828019B2 (en) 2013-01-18 2020-11-10 W.L. Gore & Associates, Inc. Sealing device and delivery system
CN104718292B (zh) 2013-01-24 2019-09-10 三井化学株式会社 导入了二氧化碳固定循环的微生物
WO2014127053A2 (en) 2013-02-13 2014-08-21 Metabolix, Inc. Process for ultra pure chemical production from biobased raw starting materials
US10201640B2 (en) 2013-03-13 2019-02-12 Tepha, Inc. Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof
US9687585B2 (en) 2013-08-20 2017-06-27 Tepha, Inc. Thermoformed poly-4-hydroxybutyrate medical implants
EP3036277B1 (en) 2013-08-20 2021-05-26 Tepha, Inc. Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof
US9302029B2 (en) 2013-10-31 2016-04-05 Tepha, Inc. Pultrusion of poly-4-hydroxybutyrate and copolymers thereof
CA2928731A1 (en) 2013-11-05 2015-05-14 Tepha, Inc. Compositions and devices of poly-4-hydroxybutyrate
WO2015094619A1 (en) 2013-12-19 2015-06-25 Tornier, Inc. High-strength bioabsorbable suture
EP3086820B1 (en) 2013-12-26 2020-10-28 Tepha, Inc. Medical implants including laminates of poly-4-hydroxybutyrate and copolymers thereof
EP3119930B1 (en) 2014-03-18 2018-06-13 Tepha, Inc. Micro-fiber webs of poly-4-hydroxybutyrate and copolymers thereof produced by centrifugal spinning
CA2947141C (en) 2014-04-30 2019-01-15 Tepha, Inc. Three-dimensional resorbable implants for tissue reinforcement and hernia repair
WO2016057083A2 (en) 2014-05-16 2016-04-14 Tepha, Inc. Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties
US9808230B2 (en) 2014-06-06 2017-11-07 W. L. Gore & Associates, Inc. Sealing device and delivery system
WO2016025329A1 (en) 2014-08-15 2016-02-18 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
ES2661648T3 (es) 2014-08-20 2018-04-02 Tepha, Inc. Implantes médicos de poli-4-hidroxibutirato termoformados
CA2960395C (en) 2014-09-22 2021-03-30 Tepha, Inc. Oriented p4hb implants containing antimicrobial agents
US11534335B2 (en) 2014-10-01 2022-12-27 Cryosa, Inc. Apparatus and methods for treatment of obstructive sleep apnea utilizing cryolysis of adipose tissues
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3230500B1 (en) 2014-12-11 2025-06-18 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
WO2017068385A1 (en) 2015-10-23 2017-04-27 Metabolic Explorer Microorganism modified for the assimilation of levulinic acid
EP3400100B1 (en) 2016-01-06 2020-09-23 Archer Daniels Midland Company Process for producing 1,3-butanediol and for optionally further producing (r)-3-hydroxybutyl (r)-3-hydroxybutyrate
KR101774431B1 (ko) * 2016-01-28 2017-09-05 한국과학기술원 자일로즈로부터 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체 생산능을 가지는 재조합 미생물 및 이를 이용한 폴리(락테이트-co-글라이콜레이트) 또는 그 공중합체의 제조방법
US11040170B2 (en) 2017-05-25 2021-06-22 Tepha, Inc. Continuous formation of tubes of poly-4-hydroxybutyrate and copolymers thereof
CN109112151B (zh) * 2017-06-23 2021-10-29 北京蓝晶微生物科技有限公司 一种精细调控共聚物中4-羟基丁酸组成比例的基因盒及其应用
EP3678715B1 (en) 2017-09-06 2024-10-30 Tepha, Inc. Calendered surgical meshes comprising polyhydroxyalkanoates
WO2019112925A1 (en) 2017-12-04 2019-06-13 Tepha, Inc. Vacuum membrane thermoformed poly-4-hydroxybutyrate medical implants
EP3802062B1 (en) 2018-06-11 2024-09-18 Tepha, Inc. Methods for 3d printing of poly-4-hydroxybutyrate
WO2020092065A1 (en) 2018-10-29 2020-05-07 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
JP2022520156A (ja) 2018-12-31 2022-03-29 クライオサ, インク. 閉塞性睡眠時無呼吸の処置の為のシステム及び方法
TWI827804B (zh) * 2019-03-06 2024-01-01 日商三菱商事生命科學股份有限公司 蕈菌絲體之製造方法、含有蕈菌絲體的組成物、以及使用了蕈菌絲體之食品材料
US12305179B2 (en) 2019-06-10 2025-05-20 Nuseed Nutritional Us Inc. Transgenic land plants that express a polyhydroxyalkanoate synthase seed specifically with cytosolic localization
US12551259B2 (en) 2020-02-19 2026-02-17 Cryosa, Inc. Systems and methods for treatment of obstructive sleep apnea
FR3109290B1 (fr) 2020-04-17 2025-04-11 Ph Tech Dispositif médical comprenant une matrice biologique acellulaire et au moins un polymère
FR3110077B1 (fr) 2020-05-12 2024-12-06 Ph Tech Procédé de fabrication d’un dispositif médical en trois dimensions et dispositif médical obtenu
FR3113371A1 (fr) 2020-08-12 2022-02-18 Ph Tech Dispositif médical comprenant un assemblage d’éléments de matrices biologiques acellulaires et au moins un polymère
EP4304525A1 (en) 2021-03-11 2024-01-17 Tepha, Inc. Breast reconstruction implant
CN113832084B (zh) * 2021-09-29 2024-01-05 北京化工大学 一种生产聚羟基脂肪酸酯的溶藻弧菌及其应用
WO2023130069A2 (en) 2021-12-30 2023-07-06 Cryosa, Inc. Systems and methods for treatment of obstructive sleep apnea
AU2023354862A1 (en) * 2022-09-30 2025-05-01 Kimberly-Clark Worldwide, Inc. In vitro bioproduction of specific chain length poly(hydroxyalkanoate) monomers
FR3165166A1 (fr) 2024-08-05 2026-02-06 Ph Tech Utilisation de l’Éther de dipropylène glycol monométhylique pour purifier un biomatériau

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS575693A (en) 1980-06-13 1982-01-12 Ajinomoto Co Inc Production of l-arginine through fermentation process
IE50442B1 (en) * 1980-11-21 1986-04-16 Loctite Corp Two part adhesive composition
US5250430A (en) 1987-06-29 1993-10-05 Massachusetts Institute Of Technology Polyhydroxyalkanoate polymerase
US5245023A (en) 1987-06-29 1993-09-14 Massachusetts Institute Of Technology Method for producing novel polyester biopolymers
US4876331A (en) 1987-08-18 1989-10-24 Mitsubishi Kasei Corporation Copolyester and process for producing the same
US4876831A (en) * 1988-03-14 1989-10-31 Runyon John F Folding modular building structure
US5004664A (en) 1989-02-27 1991-04-02 Xerox Corporation Toner and developer compositions containing biodegradable semicrystalline polyesters
US5371002A (en) 1989-06-07 1994-12-06 James Madison University Method of production of poly-beta-hydroxyalkanoate copolymers
ES2131489T3 (es) 1989-07-10 2003-05-16 Massachusetts Inst Technology Una planta o una celula vegetal recombinante capaz de producir polihidroxibutirato u otro polihidroxialcanoato.
IE893328A1 (en) 1989-10-16 1991-04-24 Mcdaid Denis Telephone lock
GB9108756D0 (en) 1991-04-24 1991-06-12 Ici Plc Production of polyalkanoate in plants
US5286842A (en) 1991-07-01 1994-02-15 Mitsubishi Kasei Corporation Process for producing a biodegradable polymer
GB9115245D0 (en) 1991-07-16 1991-08-28 Ici Plc Production of polyalkanoate
US5610041A (en) 1991-07-19 1997-03-11 Board Of Trustees Operating Michigan State University Processes for producing polyhydroxybutyrate and related polyhydroxyalkanoates in the plastids of higher plants
DE69233512T2 (de) 1991-07-19 2005-10-13 Michigan State University, East Lansing Transgene pflanzen die polyhydroxyalkanoate produzieren
BR9203053A (pt) 1991-08-07 1993-03-30 Ajinomoto Kk Processo para produzir acido l-glutamico pro fermentacao
JP2777757B2 (ja) 1991-09-17 1998-07-23 鐘淵化学工業株式会社 共重合体およびその製造方法
GB9223332D0 (en) * 1992-11-06 1992-12-23 Ici Plc Production of polyhydroxyalkanoate in plants
EP0625006A4 (en) 1992-11-20 1996-04-24 Agracetus Transgenic cotton plants producing heterologous bioplastic.
JP3263710B2 (ja) 1992-12-11 2002-03-11 高砂香料工業株式会社 生分解性光学活性ポリマー及びその製造方法
IL108947A0 (en) 1993-03-12 1994-06-24 Osteopharm Ltd Bone stimulating factor
US6849427B1 (en) 1993-03-12 2005-02-01 Immulogic Pharmaceutical Corp. Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor
JP3241505B2 (ja) 1993-08-11 2001-12-25 高砂香料工業株式会社 生分解性光学活性コポリマー及びその製造方法
ID23491A (id) 1994-01-28 1995-09-07 Procter & Gamble Kopolimer-kopolimer yang dapat dibiodegradasi dan baha-bahan plastik yang terdiri dari kopolimer-kopolimer yang dapat dibiodegradasi
FI962996A0 (fi) 1994-01-28 1996-07-26 Procter & Gamble Biohajoavia kopolymeerejä ja muoviartikkeleita, jotka sisältävät 3-hydroksiheksanoaatin biohajoavia kopolymeerejä
CA2125313A1 (en) * 1994-06-07 1995-12-08 Gerald E. O'grady Method and apparatus for producing electrical energy within the body of a ruminant
US5563239A (en) 1994-11-09 1996-10-08 Eastman Chemical Company Composition and process for the production of poly(3-hydroxyalkanoates)
BE1008983A6 (fr) 1994-12-30 1996-10-01 Faco Sa Bigoudi.
US5763270A (en) * 1995-06-07 1998-06-09 Genemedicine, Inc. Plasmid for delivery of nucleic acids to cells and methods of use
GB9602796D0 (en) 1996-02-12 1996-04-10 Innes John Centre Innov Ltd Genetic control of plant growth and development
EP0977865A1 (en) * 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FEMS MICROBIOLOGY LETTERS VOL 153 P411-418 (1997) *
J OF BIOTECHNOLOGY VOL 58 P33-38 (1997) *

Also Published As

Publication number Publication date
US6689589B2 (en) 2004-02-10
CA2303070C (en) 2011-03-15
US6316262B1 (en) 2001-11-13
DE69838768D1 (de) 2008-01-03
DE69834199T2 (de) 2006-12-14
JP2001516574A (ja) 2001-10-02
DE69834199D1 (de) 2006-05-24
CA2303070A1 (en) 1999-03-25
US20060084155A1 (en) 2006-04-20
DE69838768T2 (de) 2008-10-30
WO1999014313A2 (en) 1999-03-25
JP2009171960A (ja) 2009-08-06
US20040137586A1 (en) 2004-07-15
AU9496898A (en) 1999-04-05
WO1999014313A3 (en) 1999-06-03
JP2003310262A (ja) 2003-11-05
JP2009082147A (ja) 2009-04-23
US7229804B2 (en) 2007-06-12
EP1015565B1 (en) 2006-04-12
ATE323152T1 (de) 2006-04-15
US20110008856A1 (en) 2011-01-13
US20020187530A1 (en) 2002-12-12
EP1015565A2 (en) 2000-07-05
US20100093043A1 (en) 2010-04-15
US7081357B2 (en) 2006-07-25

Similar Documents

Publication Publication Date Title
AU725516B2 (en) Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
US6913911B2 (en) Transgenic microbial polyhydroxyalkanoate producers
EP1208208B1 (en) Transgenic systems for the manufacture of poly(3-hydroxy -butyrate -co -3- hydroxyhexanoate)
Valentin et al. Poly (3‐hydroxybutyrate‐co‐4‐hydroxybutyrate) formation from γ‐aminobutyrate and glutamate
EP1710302B1 (en) Biological systems for manufacture of polyhydroxyalkanoate polymers containing 4-hydroxyacids
EP1700909B1 (en) Transgenic microbial polyhydroxyalkanoate producers

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)