AU725302C - Amino acid ester containing azole antifungals - Google Patents

Amino acid ester containing azole antifungals

Info

Publication number
AU725302C
AU725302C AU66207/98A AU6620798A AU725302C AU 725302 C AU725302 C AU 725302C AU 66207/98 A AU66207/98 A AU 66207/98A AU 6620798 A AU6620798 A AU 6620798A AU 725302 C AU725302 C AU 725302C
Authority
AU
Australia
Prior art keywords
formula
phenyl
triazol
piperazinyl
methylpropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU66207/98A
Other languages
English (en)
Other versions
AU725302B2 (en
AU6620798A (en
Inventor
Jan Heeres
Robert Jozef Maria Hendrickx
Lieven Meerpoel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of AU6620798A publication Critical patent/AU6620798A/en
Publication of AU725302B2 publication Critical patent/AU725302B2/en
Application granted granted Critical
Publication of AU725302C publication Critical patent/AU725302C/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU66207/98A 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals Expired AU725302C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP97200374 1997-02-11
EP97200374 1997-02-11
EP97203228 1997-10-15
EP97203228 1997-10-15
PCT/EP1998/000646 WO1998034934A1 (en) 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals

Publications (3)

Publication Number Publication Date
AU6620798A AU6620798A (en) 1998-08-26
AU725302B2 AU725302B2 (en) 2000-10-12
AU725302C true AU725302C (en) 2001-08-23

Family

ID=26146124

Family Applications (1)

Application Number Title Priority Date Filing Date
AU66207/98A Expired AU725302C (en) 1997-02-11 1998-02-03 Amino acid ester containing azole antifungals

Country Status (31)

Country Link
US (3) US6262052B1 (no)
EP (1) EP0958289B1 (no)
JP (1) JP4347911B2 (no)
KR (1) KR100509171B1 (no)
CN (1) CN1238353C (no)
AT (1) ATE270290T1 (no)
AU (1) AU725302C (no)
BG (1) BG63872B1 (no)
BR (1) BR9809744A (no)
CA (1) CA2262791C (no)
CZ (1) CZ297197B6 (no)
DE (1) DE69824834T2 (no)
DK (1) DK0958289T3 (no)
EE (1) EE03876B1 (no)
ES (1) ES2224364T3 (no)
HU (1) HU227744B1 (no)
ID (1) ID21755A (no)
IL (2) IL128513A (no)
MY (1) MY129537A (no)
NO (1) NO316668B1 (no)
NZ (1) NZ334477A (no)
PL (1) PL191152B1 (no)
PT (1) PT958289E (no)
RU (1) RU2197489C2 (no)
SI (1) SI0958289T1 (no)
SK (1) SK284910B6 (no)
TR (1) TR199900584T2 (no)
TW (1) TW495508B (no)
UA (1) UA61919C2 (no)
WO (1) WO1998034934A1 (no)
ZA (1) ZA981079B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
WO2000030655A1 (en) 1998-11-20 2000-06-02 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
EA200101172A1 (ru) 1999-05-04 2002-04-25 Янссен Фармацевтика Н.В. Противогрибковые эфиры
WO2003052117A2 (en) * 2001-09-19 2003-06-26 Massachusetts Institute Of Technology Methods and products related to non-viral transfection
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
RU2585760C2 (ru) * 2010-05-19 2016-06-10 Сандоз Аг Способ получения хиральных триазолонов
AU2015380298B2 (en) 2014-12-30 2019-02-21 Corteva Agriscience Llc Picolinamide compounds with fungicidal activity
BR102019004480B1 (pt) * 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4267179A (en) 1978-06-23 1981-05-12 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4791111A (en) * 1985-12-23 1988-12-13 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties
US4916134A (en) 1987-03-25 1990-04-10 Janssen Pharmacuetica N.V. 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones
CA1331757C (en) 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
HU221189B1 (en) 1992-03-18 2002-08-28 Janssen Pharmaceutica Nv Itraconazole and saperconazole stereoisomers, their cyclodextrin complexes and pharmaceutical compositions containing them and process for producing them
ES2159623T3 (es) * 1993-12-21 2001-10-16 Schering Corp Antifungicos de tetrahidrofurano.
WO1995019983A1 (en) * 1994-01-24 1995-07-27 Janssen Pharmaceutica N.V. Watersoluble azole antifungals
CA2197672C (en) * 1995-06-02 2011-05-17 Anil K. Saksena Tetrahydrofuran antifungals
AU6257396A (en) * 1995-06-19 1997-01-15 Schering Corporation Tetrahydrofuran antifungals

Also Published As

Publication number Publication date
US20010039281A1 (en) 2001-11-08
EP0958289B1 (en) 2004-06-30
US6703506B2 (en) 2004-03-09
PL332008A1 (en) 1999-08-16
MY129537A (en) 2007-04-30
CN1236366A (zh) 1999-11-24
ATE270290T1 (de) 2004-07-15
RU2197489C2 (ru) 2003-01-27
NZ334477A (en) 2001-05-25
CZ297197B6 (cs) 2006-09-13
EE9900100A (et) 1999-10-15
KR100509171B1 (ko) 2005-08-22
BG63872B1 (bg) 2003-04-30
NO990484D0 (no) 1999-02-02
BR9809744A (pt) 2000-06-20
IL149285A0 (en) 2002-11-10
IL149285A (en) 2007-08-19
US6512116B2 (en) 2003-01-28
SK284910B6 (sk) 2006-02-02
DK0958289T3 (da) 2004-11-01
EE03876B1 (et) 2002-10-15
HUP0001050A2 (hu) 2001-04-28
CZ283599A3 (cs) 2000-02-16
IL128513A0 (en) 2000-01-31
DE69824834T2 (de) 2005-07-21
IL128513A (en) 2002-11-10
TW495508B (en) 2002-07-21
HUP0001050A3 (en) 2001-07-30
EP0958289A1 (en) 1999-11-24
NO990484L (no) 1999-10-11
JP4347911B2 (ja) 2009-10-21
ZA981079B (en) 1999-08-10
HU227744B1 (en) 2012-02-28
JP2001508080A (ja) 2001-06-19
ES2224364T3 (es) 2005-03-01
DE69824834D1 (de) 2004-08-05
NO316668B1 (no) 2004-03-29
TR199900584T2 (xx) 1999-10-21
ID21755A (id) 1999-07-22
UA61919C2 (uk) 2003-12-15
PT958289E (pt) 2004-11-30
CN1238353C (zh) 2006-01-25
BG103171A (en) 1999-09-30
PL191152B1 (pl) 2006-03-31
CA2262791A1 (en) 1998-08-13
KR20000068526A (ko) 2000-11-25
US20030158210A1 (en) 2003-08-21
SI0958289T1 (en) 2004-12-31
AU725302B2 (en) 2000-10-12
WO1998034934A1 (en) 1998-08-13
SK105999A3 (en) 2000-06-12
US6262052B1 (en) 2001-07-17
AU6620798A (en) 1998-08-26
CA2262791C (en) 2008-10-28

Similar Documents

Publication Publication Date Title
ES2199291T3 (es) Antifungicos de tetrahidrofurano.
US6812238B1 (en) N-substituted carbamoyloxyalkyl-azolium derivatives
CZ294823B6 (cs) Fungicidní tetrahydrofurany
AU2835201A (en) N-substituted carbamoyloxyalkyl-azolium derivatives
NZ278882A (en) Piperazine-containing azole antifungal compounds
AU725302C (en) Amino acid ester containing azole antifungals
AU751135B2 (en) Water soluble azoles as broad-spectrum antifungals
JP2004501867A (ja) 真菌感染症に対する治療薬としてのアゾール化合物
CA2372691C (en) Antifungal ethers
MXPA99002021A (en) Amino acid ester containing azole antifungals
JPS62201872A (ja) アゾリルプロパノ−ル誘導体および抗真菌剤

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
DA2 Applications for amendment section 104

Free format text: THE NATURE OF THE PROPOSED AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 20010105

DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS AS WAS NOTIFIED IN THE OFFICIAL JOURNAL DATED 20010222