AU701436B2 - Synthetic method of hymenialdisine and its derivatives and their synthetic intermediates, and those synthetic intermediates - Google Patents

Synthetic method of hymenialdisine and its derivatives and their synthetic intermediates, and those synthetic intermediates Download PDF

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Publication number
AU701436B2
AU701436B2 AU24541/95A AU2454195A AU701436B2 AU 701436 B2 AU701436 B2 AU 701436B2 AU 24541/95 A AU24541/95 A AU 24541/95A AU 2454195 A AU2454195 A AU 2454195A AU 701436 B2 AU701436 B2 AU 701436B2
Authority
AU
Australia
Prior art keywords
group
compound
tert
formula
butyldiphenylsiloxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU24541/95A
Other languages
English (en)
Other versions
AU2454195A (en
Inventor
Hirokazu Annoura
Toshio Tatsuoka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asubio Pharma Co Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of AU2454195A publication Critical patent/AU2454195A/en
Application granted granted Critical
Publication of AU701436B2 publication Critical patent/AU701436B2/en
Assigned to DAIICHI SUNTORY PHARMA CO., LTD reassignment DAIICHI SUNTORY PHARMA CO., LTD Alteration of Name(s) in Register under S187 Assignors: SUNTORY LIMITED
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU24541/95A 1994-05-18 1995-05-17 Synthetic method of hymenialdisine and its derivatives and their synthetic intermediates, and those synthetic intermediates Ceased AU701436B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10403094A JP3714685B2 (ja) 1994-05-18 1994-05-18 ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体
JP6-104030 1994-05-18
PCT/JP1995/000941 WO1995031462A1 (en) 1994-05-18 1995-05-17 Hymenialdisine and derivative thereof, process for producing intermediate for synthesizing the same, and said intermediate

Publications (2)

Publication Number Publication Date
AU2454195A AU2454195A (en) 1995-12-05
AU701436B2 true AU701436B2 (en) 1999-01-28

Family

ID=14369852

Family Applications (1)

Application Number Title Priority Date Filing Date
AU24541/95A Ceased AU701436B2 (en) 1994-05-18 1995-05-17 Synthetic method of hymenialdisine and its derivatives and their synthetic intermediates, and those synthetic intermediates

Country Status (9)

Country Link
US (1) US5621099A (enExample)
EP (1) EP0711773B1 (enExample)
JP (1) JP3714685B2 (enExample)
KR (1) KR960703916A (enExample)
AU (1) AU701436B2 (enExample)
CA (1) CA2167515A1 (enExample)
DE (1) DE69522642T2 (enExample)
ES (1) ES2160164T3 (enExample)
WO (1) WO1995031462A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08511241A (ja) * 1993-04-08 1996-11-26 ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク ２−アミノイミダゾールとアルデヒドから４−および／または５−（ジ）置換された２−アミノイミダゾールを合成するための方法
ES2179218T3 (es) * 1995-12-01 2003-01-16 Suntory Ltd Derivados de pirroloacepina.
CA2216559A1 (en) * 1997-09-25 1999-03-25 Michel Roberge G2 checkpoint inhibitors and assay
US6197954B1 (en) 1998-01-30 2001-03-06 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and processes thereof
US6211361B1 (en) * 1999-07-20 2001-04-03 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon, State Univeristy Method for making debromohymenialdisine and analogs thereof
DE69912808T2 (de) 1999-12-08 2004-09-30 Centre National De La Recherche Scientifique (C.N.R.S.) Verwendung von Hymenialdisin und dessen Derivaten zur Herstellung therapeutischer Mittel
AU2968701A (en) * 2000-01-24 2001-07-31 Genzyme Corporation Jak/stat pathway inhibitors and the uses thereof
DE60129222T2 (de) 2000-05-11 2008-03-06 Consejo Superior de Investigaciónes Científicas Heterocyclischen inhibitoren von glycogen synthase kinase gsk-3
BR0317430A (pt) * 2002-12-20 2005-10-25 Pharmacia Corp Compostos inibidores de quinase-2 de proteìna ativada por quinase de proteìna ativada por mitógeno
US7423031B2 (en) * 2003-05-01 2008-09-09 Irm Llc Compounds and compositions as protein kinase inhibitors
US7385055B2 (en) * 2003-05-19 2008-06-10 Board Of Trustees Of Michigan State University Preparation of hymenialdisine derivatives and use thereof
CN115245170B (zh) * 2021-04-28 2024-10-22 南开大学 Aldisin及其生物碱衍生物在防治植物病毒、杀虫、杀菌方面的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
US5565448A (en) * 1992-02-24 1996-10-15 Smithkline Beecham Corporation Medicament

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use

Also Published As

Publication number Publication date
JP3714685B2 (ja) 2005-11-09
US5621099A (en) 1997-04-15
WO1995031462A1 (en) 1995-11-23
DE69522642D1 (de) 2001-10-18
AU2454195A (en) 1995-12-05
KR960703916A (ko) 1996-08-31
DE69522642T2 (de) 2002-04-18
JPH07309874A (ja) 1995-11-28
EP0711773A1 (en) 1996-05-15
ES2160164T3 (es) 2001-11-01
EP0711773A4 (enExample) 1996-06-19
CA2167515A1 (en) 1995-11-23
EP0711773B1 (en) 2001-09-12

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