ATE255582T1 - Verfahren zur synthese von 4-und/oder 5-(di) substituierten 2-aminoimidazolen aus 2- aminoimidazolen und aldehyden - Google Patents

Verfahren zur synthese von 4-und/oder 5-(di) substituierten 2-aminoimidazolen aus 2- aminoimidazolen und aldehyden

Info

Publication number
ATE255582T1
ATE255582T1 AT94913392T AT94913392T ATE255582T1 AT E255582 T1 ATE255582 T1 AT E255582T1 AT 94913392 T AT94913392 T AT 94913392T AT 94913392 T AT94913392 T AT 94913392T AT E255582 T1 ATE255582 T1 AT E255582T1
Authority
AT
Austria
Prior art keywords
compound
aminoimidazoles
aminoimidazole
aldehydes
synthesis
Prior art date
Application number
AT94913392T
Other languages
English (en)
Inventor
David A Horne
Kenichi Yakushijin
Original Assignee
Univ Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Columbia filed Critical Univ Columbia
Application granted granted Critical
Publication of ATE255582T1 publication Critical patent/ATE255582T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
AT94913392T 1993-04-08 1994-04-08 Verfahren zur synthese von 4-und/oder 5-(di) substituierten 2-aminoimidazolen aus 2- aminoimidazolen und aldehyden ATE255582T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4463993A 1993-04-08 1993-04-08
PCT/US1994/003883 WO1994024136A1 (en) 1993-04-08 1994-04-08 Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes

Publications (1)

Publication Number Publication Date
ATE255582T1 true ATE255582T1 (de) 2003-12-15

Family

ID=21933482

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94913392T ATE255582T1 (de) 1993-04-08 1994-04-08 Verfahren zur synthese von 4-und/oder 5-(di) substituierten 2-aminoimidazolen aus 2- aminoimidazolen und aldehyden

Country Status (8)

Country Link
US (3) US5834609A (de)
EP (1) EP0693072B9 (de)
JP (1) JPH08511241A (de)
AT (1) ATE255582T1 (de)
AU (1) AU6557194A (de)
CA (1) CA2159510A1 (de)
DE (1) DE69433379T2 (de)
WO (1) WO1994024136A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197954B1 (en) * 1998-01-30 2001-03-06 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and processes thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
MXPA00011889A (es) 1998-06-02 2003-04-25 Osi Pharm Inc Composiciones de pirrolo (2,3d) piridina y su uso.
AUPP433398A0 (en) * 1998-06-25 1998-07-16 Australian National University, The Compounds and processes
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
WO2001052892A2 (en) * 2000-01-24 2001-07-26 Genzyme Corporation Jak/stat pathway inhibitors and the uses thereof
KR100404580B1 (ko) * 2000-04-20 2003-11-05 한국해양연구원 원도닌 ａ 및 그의 제조방법
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) * 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
EP1270008B1 (de) * 2001-05-31 2006-07-12 Yung Shin Pharmaceutical Ind. Co., Ltd. Kondensierte trizyklische Derivate des Guanosins zur Behandlung von Tumoren
EP1450811B1 (de) * 2001-11-30 2009-10-21 OSI Pharmaceuticals, Inc. Verbindungen, die für Adenosin A1 und A3 Rezeptoren spezifisch sind, und deren Anwendungen
CN1620294A (zh) 2001-12-20 2005-05-25 Osi药物公司 嘧啶a2b选择性拮抗剂化合物,它们的合成及用途
CN1816551A (zh) 2001-12-20 2006-08-09 Osi药物公司 吡咯并嘧啶A2b选择性拮抗剂化合物,它们的合成及用途
DE60334453D1 (de) * 2002-05-30 2010-11-18 Macrogenics Inc Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten
WO2004103958A2 (en) * 2003-05-19 2004-12-02 Michigan State University Preparation of hymenialdisine derivatives and use thereof
EP2257167B1 (de) * 2008-02-28 2015-07-22 Merck Sharp & Dohme Corp. 2-aminoimidazol-beta-sekretasehemmer zur behandlung von morbus alzheimer
TW201038569A (en) * 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
WO2012135016A2 (en) * 2011-03-25 2012-10-04 North Carolina State University Inhibition of bacterial biofilms and microbial growth with imidazole derivatives
EP3210017B1 (de) 2014-10-26 2021-10-06 King Abdullah University Of Science And Technology Alkaloide aus schwamm, gerüste zur hemmung des humanen immunschwächevirus (hiv)
GB201602576D0 (en) 2016-02-12 2016-03-30 Bergen Teknologioverforing As Process
WO2023014672A1 (en) * 2021-08-04 2023-02-09 Isp Investments Llc Compositions comprising guanidine compounds, process for preparing the same and methods of use thereof
CN115466219B (zh) * 2022-07-28 2023-09-08 中国科学院天津工业生物技术研究所 一种1-[3-(2-氨基-4-乙基-1h-咪唑-5-基)丙基]胍的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1315575A (en) * 1970-11-20 1973-05-02 Lepetit Spa Schiffs bases from 2-aminoimidazole derivatives and the preparation thereof
US4812462A (en) * 1986-04-01 1989-03-14 Warner-Lambert Company 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
FR2646849A1 (fr) * 1989-05-12 1990-11-16 Rhone Poulenc Sante Procede de preparation d'une nouvelle substance antitumorale, l'amino-3 (amino-2 1h-imidazolyl-4)-1 chloro-2 propanol-1 et de ses sels sous forme racemique threo, utilisable comme medicament
US5091390A (en) * 1990-09-20 1992-02-25 E. I. Du Pont De Nemours And Company Treatment of CNS disorders with 4,5,6,7-tetrahydro-1H-imidazo (4,5-)-pyridines and analogs
JP3714685B2 (ja) * 1994-05-18 2005-11-09 第一サントリーファーマ株式会社 ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体

Also Published As

Publication number Publication date
EP0693072A4 (de) 1997-09-24
DE69433379D1 (de) 2004-01-15
CA2159510A1 (en) 1994-10-27
EP0693072A1 (de) 1996-01-24
WO1994024136A1 (en) 1994-10-27
DE69433379T2 (de) 2004-10-14
EP0693072B1 (de) 2003-12-03
JPH08511241A (ja) 1996-11-26
US5834609A (en) 1998-11-10
AU6557194A (en) 1994-11-08
EP0693072B9 (de) 2004-09-15
US6218549B1 (en) 2001-04-17
US6103899A (en) 2000-08-15

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