DE3884445T2 - Acylierungsverfahren für die Synthese von HMG-COA-Reductase-Inhibitoren. - Google Patents

Acylierungsverfahren für die Synthese von HMG-COA-Reductase-Inhibitoren.

Info

Publication number
DE3884445T2
DE3884445T2 DE88303304T DE3884445T DE3884445T2 DE 3884445 T2 DE3884445 T2 DE 3884445T2 DE 88303304 T DE88303304 T DE 88303304T DE 3884445 T DE3884445 T DE 3884445T DE 3884445 T2 DE3884445 T2 DE 3884445T2
Authority
DE
Germany
Prior art keywords
hmg
synthesis
coa reductase
reductase inhibitors
acylation process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88303304T
Other languages
English (en)
Other versions
DE3884445D1 (de
Inventor
Ann Elisabeth Decamp
Leonard M Weinstock
Thomas R Verhoeven
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE3884445D1 publication Critical patent/DE3884445D1/de
Application granted granted Critical
Publication of DE3884445T2 publication Critical patent/DE3884445T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
DE88303304T 1987-04-15 1988-04-13 Acylierungsverfahren für die Synthese von HMG-COA-Reductase-Inhibitoren. Expired - Fee Related DE3884445T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/038,580 US4845237A (en) 1987-04-15 1987-04-15 Acylation process for the synthesis of HMG-CoA reductase inhibitors

Publications (2)

Publication Number Publication Date
DE3884445D1 DE3884445D1 (de) 1993-11-04
DE3884445T2 true DE3884445T2 (de) 1994-04-21

Family

ID=21900723

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88303304T Expired - Fee Related DE3884445T2 (de) 1987-04-15 1988-04-13 Acylierungsverfahren für die Synthese von HMG-COA-Reductase-Inhibitoren.

Country Status (6)

Country Link
US (1) US4845237A (de)
EP (1) EP0287340B1 (de)
JP (1) JP2688357B2 (de)
CA (1) CA1317295C (de)
DE (1) DE3884445T2 (de)
IE (1) IE62185B1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5166364A (en) * 1989-02-27 1992-11-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
SI9800057A (sl) * 1998-02-26 1999-08-31 Krka, Tovarna Zdravil, D.D. Postopek za pripravo simvastatina in njegovih derivatov
SI20116A (sl) 1998-12-02 2000-06-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nov postopek za pripravo simvastatina in njegovih analogov
EP1228057A2 (de) 1999-10-27 2002-08-07 Merck & Co., Inc. Laktonbildungsverfahren
WO2007096753A2 (en) * 2006-02-21 2007-08-30 Cadila Healthcare Limited Process for preparing highly pure simvastatin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618202C3 (de) * 1967-02-03 1980-09-18 Chemische Fabrik Kalk Gmbh, 5000 Koeln Verfahren zur Herstellung von Carbonsä'urebromiden
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4611068A (en) * 1984-11-19 1986-09-09 Merck Frosst Canada, Inc. Process for the preparation of HMG-CoA reductase inhibitors and intermediate compounds employed therein
US4668699A (en) * 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4864038A (en) * 1986-05-05 1989-09-05 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0245004A3 (de) * 1986-05-05 1989-07-26 Merck & Co. Inc. Antihypercholesterolemische Verbindungen
EP0245990A3 (de) * 1986-05-05 1989-07-19 Merck & Co. Inc. Antihypercholesterolemische Verbindungen
EP0245003A3 (de) * 1986-05-05 1989-07-19 Merck & Co. Inc. Antihypercholesterolemische Verbindungen
US4661483A (en) * 1986-05-05 1987-04-28 Merck & Co., Inc. Antihypercholesterolemic lactone compounds, compositions and use

Also Published As

Publication number Publication date
DE3884445D1 (de) 1993-11-04
EP0287340B1 (de) 1993-09-29
JPS63277668A (ja) 1988-11-15
JP2688357B2 (ja) 1997-12-10
IE881128L (en) 1988-10-15
IE62185B1 (en) 1994-12-28
CA1317295C (en) 1993-05-04
EP0287340A2 (de) 1988-10-19
EP0287340A3 (en) 1989-12-27
US4845237A (en) 1989-07-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee