ATE216388T1 - Pyrroloazepin-derivate - Google Patents
Pyrroloazepin-derivateInfo
- Publication number
- ATE216388T1 ATE216388T1 AT96939340T AT96939340T ATE216388T1 AT E216388 T1 ATE216388 T1 AT E216388T1 AT 96939340 T AT96939340 T AT 96939340T AT 96939340 T AT96939340 T AT 96939340T AT E216388 T1 ATE216388 T1 AT E216388T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- chem
- group
- bond
- represented
- Prior art date
Links
- CTVOZUFKICZROL-UHFFFAOYSA-N pyrrolo[3,2-b]azepine Chemical class C1=CC=CC2=NC=CC2=N1 CTVOZUFKICZROL-UHFFFAOYSA-N 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004450 alkenylene group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 102000056834 5-HT2 Serotonin Receptors Human genes 0.000 abstract 1
- 108091005479 5-HT2 receptors Proteins 0.000 abstract 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 208000031225 myocardial ischemia Diseases 0.000 abstract 1
- 230000002093 peripheral effect Effects 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP33571495 | 1995-12-01 | ||
| JP4692896 | 1996-02-09 | ||
| PCT/JP1996/003522 WO1997020845A1 (fr) | 1995-12-01 | 1996-12-02 | Derives de pyrroloazepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE216388T1 true ATE216388T1 (de) | 2002-05-15 |
Family
ID=26387089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939340T ATE216388T1 (de) | 1995-12-01 | 1996-12-02 | Pyrroloazepin-derivate |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US5962448A (de) |
| EP (1) | EP0807632B1 (de) |
| JP (1) | JP3563076B2 (de) |
| KR (1) | KR19980701788A (de) |
| AT (1) | ATE216388T1 (de) |
| AU (1) | AU719230B2 (de) |
| CA (1) | CA2212092A1 (de) |
| DE (1) | DE69620745T2 (de) |
| ES (1) | ES2179218T3 (de) |
| HU (1) | HUP9900672A3 (de) |
| IL (1) | IL121432A (de) |
| WO (1) | WO1997020845A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69620745T2 (de) | 1995-12-01 | 2002-10-31 | Suntory Limited, Osaka | Pyrroloazepin-derivate |
| JPH10251258A (ja) * | 1997-03-14 | 1998-09-22 | Suntory Ltd | ピロロアゼピン系化合物 |
| JPH11193290A (ja) * | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド系化合物 |
| JPH11193289A (ja) | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
| IL139064A0 (en) * | 1999-02-17 | 2001-11-25 | Suntory Ltd | Intermittent claudication therapeutic drugs comprising pyrroloazepines |
| ATE260916T1 (de) * | 1999-12-16 | 2004-03-15 | Daiichi Suntory Pharma Co Ltd | Verfahren zur herstellung von optisch aktiven pyrroloazepinderivaten |
| FR3008975A1 (fr) | 2013-07-23 | 2015-01-30 | Servier Lab | Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US10556013B2 (en) | 2017-06-20 | 2020-02-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| JP7387605B2 (ja) * | 2018-07-23 | 2023-11-28 | 住友ファーマ株式会社 | 縮環ラクタム誘導体 |
| EP4497474A3 (de) | 2018-10-17 | 2025-04-23 | Imbria Pharmaceuticals, Inc. | Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
| CN113788777B (zh) * | 2021-09-07 | 2023-04-11 | 华中科技大学 | 一种制备1-取代-3-羰基吡咯的方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2419119A (en) * | 1943-07-02 | 1947-04-15 | Westinghouse Electric Corp | Apparatus for treating and storing meat |
| US2545491A (en) * | 1945-10-25 | 1951-03-20 | American Instr Co Inc | Apparatus for precision control of climatic conditions |
| US2825680A (en) * | 1953-03-31 | 1958-03-04 | Niagara Blower Co | Apparatus for concentrating aqueous solutions of hygroscopic organic substances |
| US3424231A (en) * | 1967-03-23 | 1969-01-28 | Andrew Truhan | Environmental chamber |
| US3415313A (en) * | 1967-06-12 | 1968-12-10 | Niagara Blower Co | Apparatus for producing air at widely different temperatures and relative humidities |
| US3671273A (en) * | 1968-05-20 | 1972-06-20 | Alec C Gunter | Apparatus for preparing a cocoa concentrate |
| US3617699A (en) * | 1969-03-10 | 1971-11-02 | Donald F Othmer | A system for electrically heating a fluid being transported in a pipe |
| US4103508A (en) * | 1977-02-04 | 1978-08-01 | Apple Hugh C | Method and apparatus for conditioning air |
| FR2578842B1 (fr) | 1985-03-15 | 1987-04-10 | Rhone Poulenc Sante | Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| JPS62161786A (ja) * | 1986-01-08 | 1987-07-17 | Mitsubishi Chem Ind Ltd | ピロ−ル化合物 |
| US4769998A (en) * | 1986-04-25 | 1988-09-13 | Advantage Electronics, Incorporated | Precision-controlled water chiller |
| DK170506B1 (da) * | 1987-09-03 | 1995-10-02 | Glaxo Group Ltd | Pyrido- og azepino-indolforbindelser, fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende dem samt anvendelse af forbindelserne |
| CA1336906C (en) * | 1988-08-02 | 1995-09-05 | Peter Charles North | Lactam derivatives |
| JP3198117B2 (ja) * | 1990-02-07 | 2001-08-13 | サントリー株式会社 | ピロロアゼピン誘導体 |
| JPH0525128A (ja) * | 1990-05-11 | 1993-02-02 | Suntory Ltd | ピロロアゼピン誘導体の製造方法 |
| EP0551527B8 (de) * | 1991-08-07 | 2003-08-13 | Daiichi Suntory Pharma Co., Ltd. | Pyrroloazepinderivate |
| DE69232981T2 (de) * | 1991-08-07 | 2004-01-08 | Daiichi Suntory Pharma Co., Ltd. | Pyrroloazepinverbindungen |
| US5544275A (en) * | 1993-03-17 | 1996-08-06 | Applied Materials, Inc. | Electrically heated fluid carrying conduit having integrated heating elements and electrical conductors |
| JP3714685B2 (ja) * | 1994-05-18 | 2005-11-09 | 第一サントリーファーマ株式会社 | ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体 |
| ATE251135T1 (de) * | 1995-11-02 | 2003-10-15 | Daiichi Suntory Pharma Co Ltd | Verfahren zur herstellung von 1-substituierten pyrrol-3-carbonsäure-derivaten |
| DE69620745T2 (de) | 1995-12-01 | 2002-10-31 | Suntory Limited, Osaka | Pyrroloazepin-derivate |
| JPH10251258A (ja) | 1997-03-14 | 1998-09-22 | Suntory Ltd | ピロロアゼピン系化合物 |
| JPH11193289A (ja) | 1997-12-26 | 1999-07-21 | Suntory Ltd | ピロールスルホンアミド誘導体 |
-
1996
- 1996-12-02 DE DE69620745T patent/DE69620745T2/de not_active Expired - Fee Related
- 1996-12-02 JP JP52115297A patent/JP3563076B2/ja not_active Expired - Fee Related
- 1996-12-02 EP EP96939340A patent/EP0807632B1/de not_active Expired - Lifetime
- 1996-12-02 ES ES96939340T patent/ES2179218T3/es not_active Expired - Lifetime
- 1996-12-02 HU HU9900672A patent/HUP9900672A3/hu unknown
- 1996-12-02 WO PCT/JP1996/003522 patent/WO1997020845A1/ja not_active Ceased
- 1996-12-02 US US08/875,495 patent/US5962448A/en not_active Expired - Fee Related
- 1996-12-02 AT AT96939340T patent/ATE216388T1/de active
- 1996-12-02 CA CA002212092A patent/CA2212092A1/en not_active Abandoned
- 1996-12-02 IL IL12143296A patent/IL121432A/xx not_active IP Right Cessation
- 1996-12-02 AU AU76558/96A patent/AU719230B2/en not_active Ceased
- 1996-12-02 KR KR1019970705185A patent/KR19980701788A/ko not_active Abandoned
-
1999
- 1999-05-17 US US09/312,713 patent/US6258805B1/en not_active Expired - Fee Related
-
2001
- 2001-03-09 US US09/801,816 patent/US6489473B2/en not_active Expired - Fee Related
-
2002
- 2002-07-03 US US10/188,234 patent/US6713634B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0807632B1 (de) | 2002-04-17 |
| DE69620745T2 (de) | 2002-10-31 |
| KR19980701788A (ko) | 1998-06-25 |
| US20030166926A1 (en) | 2003-09-04 |
| EP0807632A4 (de) | 1998-12-09 |
| DE69620745D1 (de) | 2002-05-23 |
| CA2212092A1 (en) | 1997-06-12 |
| US5962448A (en) | 1999-10-05 |
| IL121432A (en) | 2000-09-28 |
| WO1997020845A1 (fr) | 1997-06-12 |
| US6489473B2 (en) | 2002-12-03 |
| IL121432A0 (en) | 1998-01-04 |
| ES2179218T3 (es) | 2003-01-16 |
| US6713634B2 (en) | 2004-03-30 |
| US6258805B1 (en) | 2001-07-10 |
| AU719230B2 (en) | 2000-05-04 |
| HUP9900672A2 (hu) | 1999-06-28 |
| US20020072515A1 (en) | 2002-06-13 |
| HUP9900672A3 (en) | 2001-11-28 |
| EP0807632A1 (de) | 1997-11-19 |
| JP3563076B2 (ja) | 2004-09-08 |
| AU7655896A (en) | 1997-06-27 |
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