ES2179218T3 - Derivados de pirroloacepina. - Google Patents

Derivados de pirroloacepina.

Info

Publication number
ES2179218T3
ES2179218T3 ES96939340T ES96939340T ES2179218T3 ES 2179218 T3 ES2179218 T3 ES 2179218T3 ES 96939340 T ES96939340 T ES 96939340T ES 96939340 T ES96939340 T ES 96939340T ES 2179218 T3 ES2179218 T3 ES 2179218T3
Authority
ES
Spain
Prior art keywords
sub
rent
similar
represent
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96939340T
Other languages
English (en)
Inventor
Akira Mizuno
Makoto Shibata
Tomoe Iwamori
Tetsuo Shimamoto
Kyoko Nakanishi
Norio Inomata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suntory Ltd
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of ES2179218T3 publication Critical patent/ES2179218T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN DERIVADO DE PIRROLOACEPINA O UNA DE SUS SALES.EL DERIVADO DE PIRROLOACEPINA POR LA SIGUIENTE FORMULA (I): EN LA QUE EL ANILLO P REPRESENTADO POR SIGNIFICA UN ANILLO PIRROL REPRESENTADO POR LA SIGUIENTE ESTRUCTURA: EN LA QUE R {SUB,1} REPRESENTA ALQUILO,CICLOALQUILO O SIMILAR, Y R {SUB,2} REPRESENTA H O ALQUILO; LA LINEA DE RAYOS INDICA LA PRESENCIA O AUSENCIA DE UN ENLACE; Y CUANDO ESTA PRESENTE EL ENLACE Z {SUB,2} NO ESTA PRESENTE/Y Z {SUB,1} REPRESENTA H, PERO CUANDO EL ENLACE ESTA AUSENTE, Z {SUB,1} Y Z {SUB,2} SON AMBOS H; 2 {SUB,1} REPRESENTA H Y Z {SUB,2} REPRESENTA UN GRUPO OR {SUB,3} EN EL QUE R {SUB,3} REPRESENTA H, ALQUILO, ARALQUILO O SIMILAR; Z {SUB,1} Y Z {SUB,2} REPRESENTAN AMBOS GRUPOS SR {SUB,4} EN LOS QUE R {SUB,4} REPRESENTA ALQUILO, ARALQUILO O SIMILAR; O Z {SUB,1} Y Z {SUB,2} SE COMBINAN JUNTO PARA REPRESENTAR O, UN GRUPO NOR {SUB,5} EN EL QUE R {SUB,5} REPRESENTA H, ALQUILO O SIMILAR, O UN C {SUB,2}-C {SUB,3} ALQUILENODITIO; A REPRESENTA ALQUILENO, ALQUILENO O ALQUENILENO; E Y REPRESENTA UN GRUPO EN EL QUE W REPRESENTA CH, C= O N, M ES IGUAL A 0 O 1, N ES IGUAL A 1, 2 O 3, G REPRESENTA O,S,C=0, SULFINILO, SULFONILO, ALQUILENO, ALQUENILENO, ACETAL O SIMILAR; E {SUB,1} Y E {SUB,2} REPRESENTAN H O UN GRUPO ALQUILO INFERIOR; Y D REPRESENTA UN HIDROCARBURO AROMATICO O UN ANILLO HETEROCICLICO AROMATICO. EL COMPUESTO (I) TIENE UNA FUERTE ACCION ANTAGONISTA DE RECEPTOR DE SEROTONINA 2 Y UNA BAJA TOXICIDAD Y MENOS EFECTOS SECUNDARIOS, Y ES UTIL COMO AGENTE TERAPEUTICO PARA ENFERMEDADES CIRCULATORIAS COMO ENFERMEDADES CARDIACAS ISQUEMICAS TRASTORNOS CEREBROVASCULARES Y TRASTORNOS CIRCULATORIOS PERIFERICOS.
ES96939340T 1995-12-01 1996-12-02 Derivados de pirroloacepina. Expired - Lifetime ES2179218T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP33571495 1995-12-01
JP4692896 1996-02-09

Publications (1)

Publication Number Publication Date
ES2179218T3 true ES2179218T3 (es) 2003-01-16

Family

ID=26387089

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96939340T Expired - Lifetime ES2179218T3 (es) 1995-12-01 1996-12-02 Derivados de pirroloacepina.

Country Status (12)

Country Link
US (4) US5962448A (es)
EP (1) EP0807632B1 (es)
JP (1) JP3563076B2 (es)
KR (1) KR19980701788A (es)
AT (1) ATE216388T1 (es)
AU (1) AU719230B2 (es)
CA (1) CA2212092A1 (es)
DE (1) DE69620745T2 (es)
ES (1) ES2179218T3 (es)
HU (1) HUP9900672A3 (es)
IL (1) IL121432A (es)
WO (1) WO1997020845A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2179218T3 (es) 1995-12-01 2003-01-16 Suntory Ltd Derivados de pirroloacepina.
JPH10251258A (ja) * 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
WO2000048602A1 (en) * 1999-02-17 2000-08-24 Suntory Limited Intermittent claudication therapeutic drugs comprising pyrroloazepines
HUP0200247A3 (en) * 1999-12-16 2004-07-28 Daiichi Suntory Pharma Co Ltd Process for production of optically active pyrroloazepine derivatives
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN111093662B (zh) 2017-06-20 2023-10-03 安布里亚制药公司 用于提高心脏代谢效率的组合物和方法
JP7387605B2 (ja) * 2018-07-23 2023-11-28 住友ファーマ株式会社 縮環ラクタム誘導体
WO2020081361A1 (en) 2018-10-17 2020-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
EP3976101A4 (en) 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
CN113788777B (zh) * 2021-09-07 2023-04-11 华中科技大学 一种制备1-取代-3-羰基吡咯的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2419119A (en) * 1943-07-02 1947-04-15 Westinghouse Electric Corp Apparatus for treating and storing meat
US2545491A (en) * 1945-10-25 1951-03-20 American Instr Co Inc Apparatus for precision control of climatic conditions
US2825680A (en) * 1953-03-31 1958-03-04 Niagara Blower Co Apparatus for concentrating aqueous solutions of hygroscopic organic substances
US3424231A (en) * 1967-03-23 1969-01-28 Andrew Truhan Environmental chamber
US3415313A (en) * 1967-06-12 1968-12-10 Niagara Blower Co Apparatus for producing air at widely different temperatures and relative humidities
US3671273A (en) * 1968-05-20 1972-06-20 Alec C Gunter Apparatus for preparing a cocoa concentrate
US3617699A (en) * 1969-03-10 1971-11-02 Donald F Othmer A system for electrically heating a fluid being transported in a pipe
US4103508A (en) * 1977-02-04 1978-08-01 Apple Hugh C Method and apparatus for conditioning air
FR2578842B1 (fr) 1985-03-15 1987-04-10 Rhone Poulenc Sante Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4769998A (en) * 1986-04-25 1988-09-13 Advantage Electronics, Incorporated Precision-controlled water chiller
JP2602915B2 (ja) * 1987-09-03 1997-04-23 グラクソ、グループ、リミテッド ラクタム誘導体
EP0353983B1 (en) * 1988-08-02 1996-05-29 Glaxo Group Limited Lactam derivatives
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
JPH0525128A (ja) * 1990-05-11 1993-02-02 Suntory Ltd ピロロアゼピン誘導体の製造方法
WO1993003032A1 (fr) * 1991-08-07 1993-02-18 Suntory Limited Compose de pyrroloazepine
KR100243514B1 (ko) * 1991-08-07 2000-03-02 도리이 신이치로 피롤로아제핀 유도체
US5544275A (en) * 1993-03-17 1996-08-06 Applied Materials, Inc. Electrically heated fluid carrying conduit having integrated heating elements and electrical conductors
JP3714685B2 (ja) * 1994-05-18 2005-11-09 第一サントリーファーマ株式会社 ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体
DE69630184T2 (de) * 1995-11-02 2004-08-12 Daiichi Suntory Pharma Co., Ltd. Verfahren zur Herstellung von 1-substituierten Pyrrol-3-carbonsäure-Derivaten
ES2179218T3 (es) 1995-12-01 2003-01-16 Suntory Ltd Derivados de pirroloacepina.
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体

Also Published As

Publication number Publication date
KR19980701788A (ko) 1998-06-25
IL121432A (en) 2000-09-28
WO1997020845A1 (fr) 1997-06-12
CA2212092A1 (en) 1997-06-12
DE69620745D1 (de) 2002-05-23
AU7655896A (en) 1997-06-27
EP0807632A1 (en) 1997-11-19
HUP9900672A2 (hu) 1999-06-28
DE69620745T2 (de) 2002-10-31
AU719230B2 (en) 2000-05-04
US5962448A (en) 1999-10-05
ATE216388T1 (de) 2002-05-15
US20020072515A1 (en) 2002-06-13
IL121432A0 (en) 1998-01-04
US6489473B2 (en) 2002-12-03
EP0807632B1 (en) 2002-04-17
HUP9900672A3 (en) 2001-11-28
US20030166926A1 (en) 2003-09-04
JP3563076B2 (ja) 2004-09-08
US6258805B1 (en) 2001-07-10
US6713634B2 (en) 2004-03-30
EP0807632A4 (en) 1998-12-09

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