DE69620745D1 - Pyrroloazepin-derivate - Google Patents

Pyrroloazepin-derivate

Info

Publication number
DE69620745D1
DE69620745D1 DE69620745T DE69620745T DE69620745D1 DE 69620745 D1 DE69620745 D1 DE 69620745D1 DE 69620745 T DE69620745 T DE 69620745T DE 69620745 T DE69620745 T DE 69620745T DE 69620745 D1 DE69620745 D1 DE 69620745D1
Authority
DE
Germany
Prior art keywords
alkyl
chem
group
bond
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69620745T
Other languages
English (en)
Other versions
DE69620745T2 (de
Inventor
Akira Mizuno
Makoto Shibata
Tomoe Iwamori
Tetsuo Shimamoto
Kyoko Nakanishi
Norio Inomata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daichi Suntory Pharma Co Ltd Tokio/tokyo Jp
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Application granted granted Critical
Publication of DE69620745D1 publication Critical patent/DE69620745D1/de
Publication of DE69620745T2 publication Critical patent/DE69620745T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69620745T 1995-12-01 1996-12-02 Pyrroloazepin-derivate Expired - Fee Related DE69620745T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP33571495 1995-12-01
JP4692896 1996-02-09
PCT/JP1996/003522 WO1997020845A1 (en) 1995-12-01 1996-12-02 Pyrroloazepine derivatives

Publications (2)

Publication Number Publication Date
DE69620745D1 true DE69620745D1 (de) 2002-05-23
DE69620745T2 DE69620745T2 (de) 2002-10-31

Family

ID=26387089

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620745T Expired - Fee Related DE69620745T2 (de) 1995-12-01 1996-12-02 Pyrroloazepin-derivate

Country Status (12)

Country Link
US (4) US5962448A (de)
EP (1) EP0807632B1 (de)
JP (1) JP3563076B2 (de)
KR (1) KR19980701788A (de)
AT (1) ATE216388T1 (de)
AU (1) AU719230B2 (de)
CA (1) CA2212092A1 (de)
DE (1) DE69620745T2 (de)
ES (1) ES2179218T3 (de)
HU (1) HUP9900672A3 (de)
IL (1) IL121432A (de)
WO (1) WO1997020845A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2212092A1 (en) 1995-12-01 1997-06-12 Makoto Shibata Pyrroloazepine derivatives
JPH10251258A (ja) * 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193290A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
JPH11193289A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
ES2220396T3 (es) * 1999-02-17 2004-12-16 Daiichi Suntory Pharma Co., Ltd. Farmacos terapeuticos para la claudicacion intermitente que comprenden pirroloazepinas.
EP1152003B1 (de) * 1999-12-16 2004-03-03 Daiichi Suntory Pharma Co., Ltd. Verfahren zur herstellung von optisch aktiven pyrroloazepinderivaten
FR3008975A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2018289303B2 (en) 2017-06-20 2023-12-21 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
CA3105428A1 (en) * 2018-07-23 2020-01-30 Sumitomo Dainippon Pharma Co., Ltd. Condensed lactam derivative
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
CN113788777B (zh) * 2021-09-07 2023-04-11 华中科技大学 一种制备1-取代-3-羰基吡咯的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2419119A (en) * 1943-07-02 1947-04-15 Westinghouse Electric Corp Apparatus for treating and storing meat
US2545491A (en) * 1945-10-25 1951-03-20 American Instr Co Inc Apparatus for precision control of climatic conditions
US2825680A (en) * 1953-03-31 1958-03-04 Niagara Blower Co Apparatus for concentrating aqueous solutions of hygroscopic organic substances
US3424231A (en) * 1967-03-23 1969-01-28 Andrew Truhan Environmental chamber
US3415313A (en) * 1967-06-12 1968-12-10 Niagara Blower Co Apparatus for producing air at widely different temperatures and relative humidities
US3671273A (en) * 1968-05-20 1972-06-20 Alec C Gunter Apparatus for preparing a cocoa concentrate
US3617699A (en) * 1969-03-10 1971-11-02 Donald F Othmer A system for electrically heating a fluid being transported in a pipe
US4103508A (en) * 1977-02-04 1978-08-01 Apple Hugh C Method and apparatus for conditioning air
FR2578842B1 (fr) 1985-03-15 1987-04-10 Rhone Poulenc Sante Nouveaux derives de la pyrrolo(1,2-a) azepinone, leur preparation et les compositions pharmaceutiques qui les contiennent
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4769998A (en) * 1986-04-25 1988-09-13 Advantage Electronics, Incorporated Precision-controlled water chiller
DK170506B1 (da) * 1987-09-03 1995-10-02 Glaxo Group Ltd Pyrido- og azepino-indolforbindelser, fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende dem samt anvendelse af forbindelserne
DE68926553T2 (de) * 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactamderivate
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体
JPH0525128A (ja) * 1990-05-11 1993-02-02 Suntory Ltd ピロロアゼピン誘導体の製造方法
CA2093631C (en) * 1991-08-07 2003-09-23 Akira Mizuno Pyrroloazepine derivative
ATE236163T1 (de) * 1991-08-07 2003-04-15 Suntory Ltd Pyrroloazepinverbindungen
US5544275A (en) * 1993-03-17 1996-08-06 Applied Materials, Inc. Electrically heated fluid carrying conduit having integrated heating elements and electrical conductors
JP3714685B2 (ja) * 1994-05-18 2005-11-09 第一サントリーファーマ株式会社 ハイメニアルディシン及びその誘導体並びにそれらの合成中間体の製造法並びにその合成中間体
EP0771790B1 (de) * 1995-11-02 2003-10-01 Daiichi Suntory Pharma Co., Ltd. Verfahren zur Herstellung von 1-substituierten Pyrrol-3-carbonsäure-Derivaten
CA2212092A1 (en) 1995-12-01 1997-06-12 Makoto Shibata Pyrroloazepine derivatives
JPH10251258A (ja) 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体

Also Published As

Publication number Publication date
US5962448A (en) 1999-10-05
WO1997020845A1 (en) 1997-06-12
IL121432A0 (en) 1998-01-04
US20020072515A1 (en) 2002-06-13
KR19980701788A (ko) 1998-06-25
US6258805B1 (en) 2001-07-10
US6713634B2 (en) 2004-03-30
IL121432A (en) 2000-09-28
DE69620745T2 (de) 2002-10-31
EP0807632A1 (de) 1997-11-19
EP0807632B1 (de) 2002-04-17
HUP9900672A2 (hu) 1999-06-28
US20030166926A1 (en) 2003-09-04
EP0807632A4 (de) 1998-12-09
US6489473B2 (en) 2002-12-03
JP3563076B2 (ja) 2004-09-08
CA2212092A1 (en) 1997-06-12
AU7655896A (en) 1997-06-27
ATE216388T1 (de) 2002-05-15
AU719230B2 (en) 2000-05-04
HUP9900672A3 (en) 2001-11-28
ES2179218T3 (es) 2003-01-16

Similar Documents

Publication Publication Date Title
ATE216388T1 (de) Pyrroloazepin-derivate
NO990227L (no) Heterocykliske forbindelser som farmas°ytika
DE69118082D1 (de) Imidazolderivate, starke und selektive Angiotensin-II-Rezeptor-Antagonisten
ES2105099T3 (es) Derivados de imidazopiridina condensados con actividad psicotropica.
ES2063452T3 (es) Preparacion y uso de esteres y derivados de n-yodopropargil oxicarbonil aminoacido como agentes antimicrobianos.
ES2095855T3 (es) Derivados de tetrahidrobencimidazol.
MX9101232A (es) Derivados de benceno,piridina y pirimidina
ES2074719T3 (es) Derivados de nucleosido de pirimidina.
EP0371805A3 (de) Piperidin-Derivate und diese enthaltende Hypotensiva
DK0595111T4 (da) Carbazolonderivater og fremgangsmåde til deres fremstilling
PE25998A1 (es) DERIVADOS DE OCTAHIDRO-PIRROLO(1,2-a)-PIRAZINA 2,7-SUSTITUIDOS
WO1999033840A3 (en) Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha1-blocking action
NO174848C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte
KR920004392A (ko) 플루오로에틸캄프토테신 유도체
DK0613896T3 (da) Fremgangsmåde til fremstilling af sulfonylurinstofderivater
ES2087173T3 (es) Uso de derivados de piridoindol en el tratamiento de enfermedades isquemicas.
ES2109936T3 (es) Derivados de piperacina.
DE69303847D1 (de) Indolderivate
DE69303352D1 (de) Verfahren zur Herstellung 5-Pyrazolomerkaptan-Derivate und dessen zwischenprodukte
DE69834853D1 (de) 1H-pyrrolo i1,2-böi1,2,4ötriazolederivate, Zwischenprodukte und Verfahren zur Herstellung von 1H-1,2,4,-triazol-5-yl Essigsäureesterderivate
MX9706123A (es) Derivados de pirazolil-benzoilo.
KR940002252A (ko) 우수한 항균작용을 갖는 신규한 피리돈 카르복실산 유도체 및 그의 제조방법

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DAICHI SUNTORY PHARMA CO., LTD., TOKIO/TOKYO, JP

8339 Ceased/non-payment of the annual fee