AU697167B2 - Chimeric proteins which block complement activation - Google Patents
Chimeric proteins which block complement activationInfo
- Publication number
- AU697167B2 AU697167B2 AU80719/94A AU8071994A AU697167B2 AU 697167 B2 AU697167 B2 AU 697167B2 AU 80719/94 A AU80719/94 A AU 80719/94A AU 8071994 A AU8071994 A AU 8071994A AU 697167 B2 AU697167 B2 AU 697167B2
- Authority
- AU
- Australia
- Prior art keywords
- protein
- mcp
- chimeric protein
- cab
- daf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- MFBOGIVSZKQAPD-UHFFFAOYSA-M sodium butyrate Chemical compound [Na+].CCCC([O-])=O MFBOGIVSZKQAPD-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12659693A | 1993-09-24 | 1993-09-24 | |
| US08/126596 | 1993-09-24 | ||
| US08/310416 | 1994-09-22 | ||
| US08/310,416 US5679546A (en) | 1993-09-24 | 1994-09-22 | Chimeric proteins which block complement activation |
| PCT/US1994/010786 WO1995008570A1 (en) | 1993-09-24 | 1994-09-23 | Chimeric proteins which block complement activation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU8071994A AU8071994A (en) | 1995-04-10 |
| AU697167B2 true AU697167B2 (en) | 1998-10-01 |
Family
ID=26824842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU80719/94A Ceased AU697167B2 (en) | 1993-09-24 | 1994-09-23 | Chimeric proteins which block complement activation |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US5679546A (enExample) |
| EP (1) | EP0723555B1 (enExample) |
| JP (2) | JP3860605B2 (enExample) |
| CN (1) | CN1057097C (enExample) |
| AT (1) | ATE380875T1 (enExample) |
| AU (1) | AU697167B2 (enExample) |
| CA (1) | CA2172610A1 (enExample) |
| DE (1) | DE69435049D1 (enExample) |
| WO (1) | WO1995008570A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482404B1 (en) | 1989-10-12 | 2002-11-19 | David James White | Transplantation of tissue comprising a DNA sequence encoding a homologous complement restriction factor |
| US5866402A (en) * | 1995-05-05 | 1999-02-02 | Chiron Corporation | Chimeric MCP and DAF proteins with cell surface localizing domain |
| FR2736916B1 (fr) * | 1995-07-21 | 1997-09-19 | Univ Paris Curie | Proteines hetero-multimeriques recombinantes du type alpha-beta c4bp |
| CA2298475A1 (en) * | 1997-10-31 | 1999-05-14 | Walter Reed Army Institute Of Research | Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules |
| ES2488819T3 (es) * | 1998-02-20 | 2014-08-29 | Genentech, Inc. | Inhibidores de la activación del complemento |
| US7112327B2 (en) | 1998-02-20 | 2006-09-26 | Tanox, Inc. | Inhibition of complement activation |
| US6956107B2 (en) * | 1998-02-20 | 2005-10-18 | Tanox, Inc. | Inhibitors of complement activation |
| US6297024B1 (en) | 1998-10-15 | 2001-10-02 | Cell Activation, Inc. | Methods for assessing complement activation |
| US6235494B1 (en) | 1999-02-08 | 2001-05-22 | The Scripps Research Institute | Substrates for assessing mannan-binding protein-associated serine protease activity and methods using the substrates |
| WO2001032901A1 (en) * | 1999-11-01 | 2001-05-10 | Chiron Corporation | Expression vectors, transfection systems, and method of use thereof |
| EP2896631A1 (en) | 2000-10-10 | 2015-07-22 | Genentech, Inc. | Inhibition of complement C5 activation for the treatment and prevention of delayed xenograft or acute vascular rejection |
| US6820011B2 (en) | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| NZ529044A (en) * | 2001-06-08 | 2008-03-28 | Novartis Ag | Treatment or prophylaxis of insulin-producing cell graft rejection |
| EP1539811A4 (en) * | 2002-09-16 | 2006-05-24 | Elusys Therapeutics Inc | PREPARATION OF BISPEQIFIC MOLECULES WITH POLYETHYLENE GLYCOL LINKER |
| PT1569685E (pt) * | 2002-11-15 | 2012-11-02 | Univ Colorado Regents | Recetor do complemento 2 direcionado a moduladores do complemento |
| WO2005069726A2 (en) * | 2004-01-21 | 2005-08-04 | Case Western Reserve University | Hybrid and chimeric polypeptides that regulate activation of complement |
| PT1713503E (pt) * | 2004-02-10 | 2013-11-14 | Nat Jewish Health | Inibição do factor b, a via alternativa do complemento e métodos relacionados |
| US8703693B2 (en) * | 2004-03-31 | 2014-04-22 | The Feinstein Institute For Medical Research | Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment |
| AU2005231395B2 (en) * | 2004-03-31 | 2011-06-16 | The Fernstein Institute For Medical Research | Adrenomedullin and adrenomedullin binding protein for ischemia/reperfusion treatment |
| CA2610340C (en) * | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
| KR20180002911A (ko) * | 2005-11-04 | 2018-01-08 | 제넨테크, 인크. | 안질환 치료를 위한 보체 경로 억제제의 용도 |
| EP2044111B1 (en) | 2006-06-21 | 2014-08-13 | MUSC Foundation For Research Development | Targeting complement factor h for treatment of diseases |
| CL2007003161A1 (es) * | 2006-11-02 | 2008-05-30 | Genentech Inc | Anticuerpos anti-factor d; acidos nucleicos que los codifican; vector y linea celular que los comprenden; metodo de produccion; composicion farmaceutica que comprende a los anticuerpos; y su uso para tratar trastornos mediados por el complemento como |
| JP5332064B2 (ja) * | 2007-03-01 | 2013-11-06 | ウェルスタット イムノセラピューティクス， エルエルシー | 炎症により特徴付けられる疾患の治療 |
| CA2680344A1 (en) | 2007-03-14 | 2008-11-20 | Woodruff Emlen | Humaneered anti-factor b antibody |
| CR20170001A (es) | 2008-04-28 | 2017-08-10 | Genentech Inc | Anticuerpos anti factor d humanizados |
| US20090324585A1 (en) * | 2008-06-12 | 2009-12-31 | The Trustees of the Leland Standford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| US10239937B2 (en) | 2009-11-05 | 2019-03-26 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| CN102234332B (zh) * | 2010-04-26 | 2014-12-17 | 浙江海正药业股份有限公司 | 一种重组人血白蛋白及其融合蛋白的分离纯化工艺 |
| CN103038252A (zh) | 2010-05-14 | 2013-04-10 | 科罗拉多大学董事会,法人团体 | 改良的补体受体2(cr2)靶向群 |
| WO2011163412A1 (en) | 2010-06-22 | 2011-12-29 | The Regents Of The University Of Colorado, A Body Corporate | Antibodies to the c3d fragment of complement component 3 |
| BR112013005116A2 (pt) | 2010-09-03 | 2019-09-24 | Stem Centrx Inc | moduladores e métodos de uso |
| US10039802B2 (en) | 2011-06-22 | 2018-08-07 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| AU2013243570B2 (en) | 2012-04-03 | 2017-12-14 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor Bb antibodies and uses thereof |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| BR112016002845A2 (pt) | 2013-08-12 | 2017-09-12 | Genentech Inc | composições e métodos para tratar condições associadas ao complemento |
| SG10202104175YA (en) | 2014-02-27 | 2021-06-29 | Allergan Inc | COMPLEMENT FACTOR Bb ANTIBODIES |
| EP3137503A1 (en) | 2014-05-01 | 2017-03-08 | Genentech, Inc. | Anti-factor d antibody variants and uses thereof |
| JP2018503368A (ja) | 2014-12-18 | 2018-02-08 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｄｃを誘発する抗体を決定するためのアッセイ法および方法 |
| IL296929B2 (en) * | 2015-09-24 | 2025-07-01 | Univ Pennsylvania | Composition and method for treating complement-mediated disease |
| WO2017075252A1 (en) | 2015-10-30 | 2017-05-04 | Genentech, Inc. | Anti-factor d antibody variant conjugates and uses thereof |
| JP2018534930A (ja) | 2015-10-30 | 2018-11-29 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体及びコンジュゲート |
| LT3394089T (lt) * | 2015-12-23 | 2021-11-25 | eleva GmbH | Polipeptidai, skirti komplemento aktyvacijos inhibicijai |
| DK3474883T3 (da) | 2016-06-28 | 2022-08-29 | Univ Ulm | Komplementinhibitorer og anvendelser deraf |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| EP3956347A4 (en) * | 2019-04-13 | 2023-09-20 | National Centre For Cell Science | DAF-MCP CHIMERIC PROTEINS, THEIR MANUFACTURING METHOD AND USE OF THE CHIMERIC PROTEIN TO TREAT PATHOLOGICAL CONDITIONS INVOLVING THE COMPLEMENT SYSTEM |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) * | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4774180A (en) * | 1986-02-26 | 1988-09-27 | Massachusetts Institute Of Technology | Construction and application of polyproteins |
| US5264357A (en) * | 1985-05-24 | 1993-11-23 | Genentech, Inc. | Nucleic acids vectors and cells for the synthesis of membrane anchor fusion polypeptides |
| IL82390A0 (en) * | 1986-05-02 | 1987-10-30 | Genentech Inc | Nucleic acid and methods for the synthesis of novel daf compositions |
| DK0489116T3 (da) * | 1989-08-22 | 1994-05-02 | Immunex Corp | Fusionsproteiner omfattende GM-CSF og IL-3 |
| CA2049964A1 (en) * | 1990-01-26 | 1991-07-27 | Mark P. Pasek | C4 binding protein fusion proteins |
| EP1413587A2 (en) * | 1991-05-03 | 2004-04-28 | Washington University | Modified complement system regulator |
| US5252216A (en) * | 1992-03-24 | 1993-10-12 | Smithkline Beecham Corporation | Protein purification |
| US5627264A (en) * | 1994-03-03 | 1997-05-06 | Alexion Pharmaceuticals, Inc. | Chimeric complement inhibitor proteins |
-
1994
- 1994-09-22 US US08/310,416 patent/US5679546A/en not_active Expired - Lifetime
- 1994-09-23 CA CA002172610A patent/CA2172610A1/en not_active Abandoned
- 1994-09-23 AU AU80719/94A patent/AU697167B2/en not_active Ceased
- 1994-09-23 CN CN94194284A patent/CN1057097C/zh not_active Expired - Fee Related
- 1994-09-23 WO PCT/US1994/010786 patent/WO1995008570A1/en not_active Ceased
- 1994-09-23 DE DE69435049T patent/DE69435049D1/de not_active Expired - Lifetime
- 1994-09-23 JP JP50995795A patent/JP3860605B2/ja not_active Expired - Fee Related
- 1994-09-23 EP EP94931763A patent/EP0723555B1/en not_active Expired - Lifetime
- 1994-09-23 AT AT94931763T patent/ATE380875T1/de not_active IP Right Cessation
-
1997
- 1997-07-03 US US08/888,171 patent/US5851528A/en not_active Expired - Lifetime
-
2004
- 2004-09-28 JP JP2004282827A patent/JP2005041882A/ja not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5212071A (en) * | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
Non-Patent Citations (2)
| Title |
|---|
| J. BIOCHEM, VOL. 111, NO 5, 1992, PP 573-578 * |
| NUCLEIC ACIDS RESEARCH, VOL 12, 1984, PP 6797-6811 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH09502985A (ja) | 1997-03-25 |
| JP3860605B2 (ja) | 2006-12-20 |
| CN1138863A (zh) | 1996-12-25 |
| WO1995008570A1 (en) | 1995-03-30 |
| US5679546A (en) | 1997-10-21 |
| AU8071994A (en) | 1995-04-10 |
| EP0723555A1 (en) | 1996-07-31 |
| EP0723555B1 (en) | 2007-12-12 |
| DE69435049D1 (de) | 2008-01-24 |
| EP0723555A4 (en) | 1999-04-28 |
| ATE380875T1 (de) | 2007-12-15 |
| CA2172610A1 (en) | 1995-03-30 |
| JP2005041882A (ja) | 2005-02-17 |
| US5851528A (en) | 1998-12-22 |
| CN1057097C (zh) | 2000-10-04 |
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