AU672994B2 - Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs - Google Patents

Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs Download PDF

Info

Publication number
AU672994B2
AU672994B2 AU47082/93A AU4708293A AU672994B2 AU 672994 B2 AU672994 B2 AU 672994B2 AU 47082/93 A AU47082/93 A AU 47082/93A AU 4708293 A AU4708293 A AU 4708293A AU 672994 B2 AU672994 B2 AU 672994B2
Authority
AU
Australia
Prior art keywords
liponucleotides
substituted
group
formula
denotes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47082/93A
Other languages
English (en)
Other versions
AU4708293A (en
Inventor
Dieter Herrmann
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heidelberg Pharma Holding GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of AU4708293A publication Critical patent/AU4708293A/en
Application granted granted Critical
Publication of AU672994B2 publication Critical patent/AU672994B2/en
Assigned to ROCHE DIAGNOSTICS GMBH reassignment ROCHE DIAGNOSTICS GMBH Request to Amend Deed and Register Assignors: BOEHRINGER MANNHEIM GMBH
Assigned to HEIDELBERG PHARMA HOLDING GMBH reassignment HEIDELBERG PHARMA HOLDING GMBH Alteration of Name(s) in Register under S187 Assignors: ROCHE DIAGNOSTICS GMBH
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AU47082/93A 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs Ceased AU672994B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4226279 1992-08-08
DE4226279A DE4226279A1 (de) 1992-08-08 1992-08-08 Liponucleotide von Seco-Nucleosiden, deren Herstellung sowie deren Verwendung als antivirale Arzneimittel
PCT/EP1993/002101 WO1994003465A1 (de) 1992-08-08 1993-08-06 Liponucleotide von seco-nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Publications (2)

Publication Number Publication Date
AU4708293A AU4708293A (en) 1994-03-03
AU672994B2 true AU672994B2 (en) 1996-10-24

Family

ID=6465143

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47082/93A Ceased AU672994B2 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs

Country Status (20)

Country Link
EP (1) EP0654036B1 (cg-RX-API-DMAC7.html)
JP (1) JP3479299B2 (cg-RX-API-DMAC7.html)
KR (1) KR100243440B1 (cg-RX-API-DMAC7.html)
CN (1) CN1040984C (cg-RX-API-DMAC7.html)
AT (1) ATE152114T1 (cg-RX-API-DMAC7.html)
AU (1) AU672994B2 (cg-RX-API-DMAC7.html)
CA (1) CA2141030A1 (cg-RX-API-DMAC7.html)
DE (2) DE4226279A1 (cg-RX-API-DMAC7.html)
DK (1) DK0654036T3 (cg-RX-API-DMAC7.html)
ES (1) ES2104163T3 (cg-RX-API-DMAC7.html)
FI (1) FI109699B (cg-RX-API-DMAC7.html)
GR (1) GR3023960T3 (cg-RX-API-DMAC7.html)
HU (1) HUT72605A (cg-RX-API-DMAC7.html)
IL (1) IL106588A (cg-RX-API-DMAC7.html)
MX (1) MX9304676A (cg-RX-API-DMAC7.html)
NO (1) NO304986B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ254813A (cg-RX-API-DMAC7.html)
TW (1) TW306924B (cg-RX-API-DMAC7.html)
WO (1) WO1994003465A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA935718B (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
DE4402492A1 (de) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Verfahren zur Herstellung von unsymmetrischen Phosphorsäurediestern
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
KR100389558B1 (ko) * 2000-10-11 2003-06-27 주식회사 한스환경엔지니어링 유리섬유 강화플라스틱 성형품의 표면처리용 직물

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992003462A1 (de) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel
EP0350287B1 (en) * 1988-07-07 2000-09-27 Chimerix, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350287B1 (en) * 1988-07-07 2000-09-27 Chimerix, Inc. Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use
WO1992003462A1 (de) * 1990-08-20 1992-03-05 Boehringer Mannheim Gmbh Neue phospholipid-derivate von nucleosiden, deren herstellung sowie deren verwendung als antivirale arzneimittel

Also Published As

Publication number Publication date
FI950533L (fi) 1995-02-07
EP0654036B1 (de) 1997-04-23
TW306924B (cg-RX-API-DMAC7.html) 1997-06-01
ATE152114T1 (de) 1997-05-15
DK0654036T3 (da) 1997-11-03
ZA935718B (en) 1995-02-06
GR3023960T3 (en) 1997-09-30
AU4708293A (en) 1994-03-03
ES2104163T3 (es) 1997-10-01
IL106588A0 (en) 1993-12-08
DE4226279A1 (de) 1994-02-10
NZ254813A (en) 1996-05-28
HUT72605A (en) 1996-05-28
JPH08500345A (ja) 1996-01-16
MX9304676A (es) 1994-03-31
CN1085908A (zh) 1994-04-27
HU9500374D0 (en) 1995-03-28
CA2141030A1 (en) 1994-02-09
FI950533A0 (fi) 1995-02-07
JP3479299B2 (ja) 2003-12-15
CN1040984C (zh) 1998-12-02
NO304986B1 (no) 1999-03-15
KR950702998A (ko) 1995-08-23
NO950445D0 (no) 1995-02-07
NO950445L (no) 1995-02-07
IL106588A (en) 1998-01-04
WO1994003465A1 (de) 1994-02-17
KR100243440B1 (ko) 2000-03-02
EP0654036A1 (de) 1995-05-24
DE59306286D1 (de) 1997-05-28
FI109699B (fi) 2002-09-30

Similar Documents

Publication Publication Date Title
AU707196B2 (en) Chemical compounds
RU2126405C1 (ru) (-)-4-амино-5-фтор-1-(2-гидроксиметил-1,3-оксатиолан-5-ил)-(1h)-пиримидин- 2-он, смесь его энантиомеров, способы их получения, способ лечения
US5512671A (en) Ether lipid-nucleoside covalent conjugates
EP0533825B1 (en) Ether lipid-nucleoside covalent conjugates
SK281826B6 (sk) Deriváty fosfolipidov nukleozidov, ich použitie a farmaceutický prostriedok na ich báze
US6194398B1 (en) Phosphonate nucleotide compound
HK1039337A1 (en) Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents
US6686462B2 (en) Antiviral compounds and methods of administration
US6197775B1 (en) Phosphonate nucleotide derivatives
US5744600A (en) Phosphonomethoxy carbocyclic nucleosides and nucleotides
PT98341A (pt) Processo para a preparacao de derivados de purina
AU672994B2 (en) Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs
HUT54697A (en) Process for producing sulfur- and phosphorus-containing purine derivatives and pharmaceutical compositions comprising same as active ingredient
US6080734A (en) Liponucleotides of seco-nucleosides, their production as well as their use as antiviral pharmaceutical agents
US5955452A (en) Covalent lipid-phosphono-carboxylic acid conjugates and application thereof as antiviral medicaments
CA2165979A1 (en) Liponucleotides of deoxynucleosides, the production thereof and their use as antiviral pharmaceutical agents
NO833526L (no) Fremgangsmaate for fremstilling av guanidinderivater med anti-virus-virkning
CZ287942B6 (cs) Deriváty fosfolipidů nukleotidů, je obsahující léčivo a použití
MXPA01008129A (es) Esteres de fosforamidato, y mono-, di-, y tri-fosfato de (1r, cis)-4-(6-amino-9h-purin-9-il)-2- ciclopenteno-1-metanol como agentes antivirales.
JPWO2001064693A1 (ja) ホスホナートヌクレオチド化合物

Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: ROCHE DIAGNOSTICS GMBH

Free format text: FORMER NAME WAS: BOEHRINGER MANNHEIM GMBH

PC Assignment registered

Owner name: HEIDELBERG PHARMA HOLDING GMBH

Free format text: FORMER OWNER WAS: ROCHE DIAGNOSTICS GMBH