AU4708293A - Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs - Google Patents

Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs

Info

Publication number
AU4708293A
AU4708293A AU47082/93A AU4708293A AU4708293A AU 4708293 A AU4708293 A AU 4708293A AU 47082/93 A AU47082/93 A AU 47082/93A AU 4708293 A AU4708293 A AU 4708293A AU 4708293 A AU4708293 A AU 4708293A
Authority
AU
Australia
Prior art keywords
seco
nucleosides
liponucleotides
preparation
viral drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU47082/93A
Other versions
AU672994B2 (en
Inventor
Dieter Herrmann
Harald Zilch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Heidelberg Pharma Holding GmbH
Original Assignee
Heidelberg Pharma Holding GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heidelberg Pharma Holding GmbH filed Critical Heidelberg Pharma Holding GmbH
Publication of AU4708293A publication Critical patent/AU4708293A/en
Application granted granted Critical
Publication of AU672994B2 publication Critical patent/AU672994B2/en
Assigned to ROCHE DIAGNOSTICS GMBH reassignment ROCHE DIAGNOSTICS GMBH Request to Amend Deed and Register Assignors: BOEHRINGER MANNHEIM GMBH
Assigned to HEIDELBERG PHARMA HOLDING GMBH reassignment HEIDELBERG PHARMA HOLDING GMBH Alteration of Name(s) in Register under S187 Assignors: ROCHE DIAGNOSTICS GMBH
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention concerns phospholipid derivatives of seco-nucleosides, in which a lipid with a substituted three-carbon-atom basic structure is linked to a seco-nucleoside via a phosphate or thiophosphate group. The invention also concerns the use of such derivatives as anti-viral drugs.
AU47082/93A 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs Ceased AU672994B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4226279A DE4226279A1 (en) 1992-08-08 1992-08-08 Lipo nucleotides of seco-nucleosides, their production and their use as antiviral drugs
DE4226279 1992-08-08
PCT/EP1993/002101 WO1994003465A1 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs

Publications (2)

Publication Number Publication Date
AU4708293A true AU4708293A (en) 1994-03-03
AU672994B2 AU672994B2 (en) 1996-10-24

Family

ID=6465143

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47082/93A Ceased AU672994B2 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs

Country Status (20)

Country Link
EP (1) EP0654036B1 (en)
JP (1) JP3479299B2 (en)
KR (1) KR100243440B1 (en)
CN (1) CN1040984C (en)
AT (1) ATE152114T1 (en)
AU (1) AU672994B2 (en)
CA (1) CA2141030A1 (en)
DE (2) DE4226279A1 (en)
DK (1) DK0654036T3 (en)
ES (1) ES2104163T3 (en)
FI (1) FI109699B (en)
GR (1) GR3023960T3 (en)
HU (1) HUT72605A (en)
IL (1) IL106588A (en)
MX (1) MX9304676A (en)
NO (1) NO304986B1 (en)
NZ (1) NZ254813A (en)
TW (1) TW306924B (en)
WO (1) WO1994003465A1 (en)
ZA (1) ZA935718B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
DE4402492A1 (en) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Process for the production of asymmetrical phosphoric acid diesters
KR100389558B1 (en) * 2000-10-11 2003-06-27 주식회사 한스환경엔지니어링 Surface Treating Fabric For FRP

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE4026265A1 (en) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability

Also Published As

Publication number Publication date
KR950702998A (en) 1995-08-23
DE4226279A1 (en) 1994-02-10
ATE152114T1 (en) 1997-05-15
IL106588A (en) 1998-01-04
WO1994003465A1 (en) 1994-02-17
EP0654036B1 (en) 1997-04-23
KR100243440B1 (en) 2000-03-02
DE59306286D1 (en) 1997-05-28
FI950533A0 (en) 1995-02-07
HUT72605A (en) 1996-05-28
JPH08500345A (en) 1996-01-16
NO950445L (en) 1995-02-07
MX9304676A (en) 1994-03-31
NZ254813A (en) 1996-05-28
GR3023960T3 (en) 1997-09-30
DK0654036T3 (en) 1997-11-03
JP3479299B2 (en) 2003-12-15
IL106588A0 (en) 1993-12-08
HU9500374D0 (en) 1995-03-28
ES2104163T3 (en) 1997-10-01
FI109699B (en) 2002-09-30
EP0654036A1 (en) 1995-05-24
NO950445D0 (en) 1995-02-07
AU672994B2 (en) 1996-10-24
CA2141030A1 (en) 1994-02-09
TW306924B (en) 1997-06-01
CN1040984C (en) 1998-12-02
CN1085908A (en) 1994-04-27
NO304986B1 (en) 1999-03-15
FI950533A (en) 1995-02-07
ZA935718B (en) 1995-02-06

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Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: ROCHE DIAGNOSTICS GMBH

Free format text: FORMER NAME WAS: BOEHRINGER MANNHEIM GMBH

PC Assignment registered

Owner name: HEIDELBERG PHARMA HOLDING GMBH

Free format text: FORMER OWNER WAS: ROCHE DIAGNOSTICS GMBH