NO304986B1 - Liponucleotides of seconucleosides, drugs containing them, and their use in the preparation of antiviral drugs - Google Patents

Liponucleotides of seconucleosides, drugs containing them, and their use in the preparation of antiviral drugs

Info

Publication number
NO304986B1
NO304986B1 NO950445A NO950445A NO304986B1 NO 304986 B1 NO304986 B1 NO 304986B1 NO 950445 A NO950445 A NO 950445A NO 950445 A NO950445 A NO 950445A NO 304986 B1 NO304986 B1 NO 304986B1
Authority
NO
Norway
Prior art keywords
drugs
seconucleosides
liponucleotides
preparation
antiviral
Prior art date
Application number
NO950445A
Other languages
Norwegian (no)
Other versions
NO950445D0 (en
NO950445L (en
Inventor
Harald Zilch
Dieter Herrmann
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO950445D0 publication Critical patent/NO950445D0/en
Publication of NO950445L publication Critical patent/NO950445L/en
Publication of NO304986B1 publication Critical patent/NO304986B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention concerns phospholipid derivatives of seco-nucleosides, in which a lipid with a substituted three-carbon-atom basic structure is linked to a seco-nucleoside via a phosphate or thiophosphate group. The invention also concerns the use of such derivatives as anti-viral drugs.
NO950445A 1992-08-08 1995-02-07 Liponucleotides of seconucleosides, drugs containing them, and their use in the preparation of antiviral drugs NO304986B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4226279A DE4226279A1 (en) 1992-08-08 1992-08-08 Lipo nucleotides of seco-nucleosides, their production and their use as antiviral drugs
PCT/EP1993/002101 WO1994003465A1 (en) 1992-08-08 1993-08-06 Liponucleotides of seco-nucleosides, their preparation and their use as anti-viral drugs

Publications (3)

Publication Number Publication Date
NO950445D0 NO950445D0 (en) 1995-02-07
NO950445L NO950445L (en) 1995-02-07
NO304986B1 true NO304986B1 (en) 1999-03-15

Family

ID=6465143

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950445A NO304986B1 (en) 1992-08-08 1995-02-07 Liponucleotides of seconucleosides, drugs containing them, and their use in the preparation of antiviral drugs

Country Status (20)

Country Link
EP (1) EP0654036B1 (en)
JP (1) JP3479299B2 (en)
KR (1) KR100243440B1 (en)
CN (1) CN1040984C (en)
AT (1) ATE152114T1 (en)
AU (1) AU672994B2 (en)
CA (1) CA2141030A1 (en)
DE (2) DE4226279A1 (en)
DK (1) DK0654036T3 (en)
ES (1) ES2104163T3 (en)
FI (1) FI109699B (en)
GR (1) GR3023960T3 (en)
HU (1) HUT72605A (en)
IL (1) IL106588A (en)
MX (1) MX9304676A (en)
NO (1) NO304986B1 (en)
NZ (1) NZ254813A (en)
TW (1) TW306924B (en)
WO (1) WO1994003465A1 (en)
ZA (1) ZA935718B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5817638A (en) * 1988-07-07 1998-10-06 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6252060B1 (en) 1988-07-07 2001-06-26 Nexstar Pharmaceuticals, Inc. Antiviral liponucleosides: treatment of hepatitis B
US6599887B2 (en) 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
DE4402492A1 (en) * 1994-01-28 1995-08-03 Boehringer Mannheim Gmbh Process for the production of asymmetrical phosphoric acid diesters
US7517858B1 (en) 1995-06-07 2009-04-14 The Regents Of The University Of California Prodrugs of pharmaceuticals with improved bioavailability
KR100389558B1 (en) * 2000-10-11 2003-06-27 주식회사 한스환경엔지니어링 Surface Treating Fabric For FRP

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223263A (en) * 1988-07-07 1993-06-29 Vical, Inc. Liponucleotide-containing liposomes
DE4026265A1 (en) * 1990-08-20 1992-02-27 Boehringer Mannheim Gmbh NEW PHOSPHOLIPID DERIVATIVES OF NUCLEOSIDES, THEIR PRODUCTION AND THEIR USE AS ANTIVIRAL MEDICINAL PRODUCTS

Also Published As

Publication number Publication date
HUT72605A (en) 1996-05-28
HU9500374D0 (en) 1995-03-28
MX9304676A (en) 1994-03-31
NO950445D0 (en) 1995-02-07
JPH08500345A (en) 1996-01-16
AU4708293A (en) 1994-03-03
FI950533A (en) 1995-02-07
FI950533A0 (en) 1995-02-07
DK0654036T3 (en) 1997-11-03
GR3023960T3 (en) 1997-09-30
FI109699B (en) 2002-09-30
NZ254813A (en) 1996-05-28
DE59306286D1 (en) 1997-05-28
KR100243440B1 (en) 2000-03-02
JP3479299B2 (en) 2003-12-15
EP0654036A1 (en) 1995-05-24
WO1994003465A1 (en) 1994-02-17
DE4226279A1 (en) 1994-02-10
IL106588A (en) 1998-01-04
ATE152114T1 (en) 1997-05-15
NO950445L (en) 1995-02-07
CA2141030A1 (en) 1994-02-09
TW306924B (en) 1997-06-01
AU672994B2 (en) 1996-10-24
CN1040984C (en) 1998-12-02
CN1085908A (en) 1994-04-27
ES2104163T3 (en) 1997-10-01
ZA935718B (en) 1995-02-06
KR950702998A (en) 1995-08-23
EP0654036B1 (en) 1997-04-23
IL106588A0 (en) 1993-12-08

Similar Documents

Publication Publication Date Title
FI945363A (en) Novel mercaptoacetylamidopyridazo (1,2) pyridazine, pyrazolo (1,2) pyridazine, pyridazo (1,2-a) (1,2) diazepine and pyrazolo (1,2-a) (1,2) diazepine derivatives, which are useful as inhibitors of encephalase and ACE
MX9202934A (en) DERIVATIVES OF CARBOSTIRILE AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
DK401089A (en) PHARMACEUTICAL COMBINATIONS FOR USE AS ANTINEOPLASTIC MEDICINES
IT8821535A0 (en) 4' PHOSPHATE DERIVATIVES OF GLUCOSIDES OF EPIPODOPHYLLOTOXIN AND RELATED PHARMACEUTICAL COMPOSITIONS.
MX9203394A (en) SUBSTITUTED BENZAZEPINES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
KR950007856A (en) Rapamycin formulations for oral administration
MX9203040A (en) DERIVATIVES OF QUINONA AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
BR9803880A (en) Pyrazole derivatives, their preparation and their use in medicines.
ES2033426T3 (en) PROCEDURE FOR THE PREPARATION OF CONTROLLED RELEASE PHARMACEUTICAL COMPOSITIONS CONTAINING 3'-AZIDO-3'-DEOXYTIMIDINE.
AR002039A1 (en) PIRIDO [3.2-E] PIRAZINONAS WITH ANTI-ASMATIC EFFECT, AND PROCEDURE FOR ITS PREPARATION AND THE MEDICINAL PRODUCTS CONTAINING THEM AND THEIR PREPARATION
ES2052603T3 (en) DERIVATIVES OF BENCIMIDAZOLE, PROCEDURE FOR ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION THAT CONTAIN THEM.
ES2045484T3 (en) NEW DERIVATIVES OF VITAMIN D: THERAPEUTIC APPLICATIONS AND TO THE DOSAGES OF METABOLITES OF VITAMIN D.
NO304986B1 (en) Liponucleotides of seconucleosides, drugs containing them, and their use in the preparation of antiviral drugs
GR3004440T3 (en)
MX9303709A (en) SUBSTITUTED PURINE NUCLEOSIDES AND INTERMEDIARIES OF THE SAME, WHICH HAVE ANTI-VIRAL AND ANTI-CANCERIGEN ACTIVITY AND PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM.
ES8504127A1 (en) 1,4-Dihydropyridine compounds
MX9203613A (en) DERIVATIVES OF ADENOSINE AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.
NO905141D0 (en) PREPARATION OF ALKALIMETAL CHLORATE OR PERCHLORATE.
IT1232819B (en) USE OF NUCLEOBASE SOURCES TO STIMULATE THE IMMUNE FUNCTION, RELATIVE PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH SOURCE OF NUCLEOBASE
SE9403137D0 (en) Derivatives of carbohydrates and compositions containing them
IT8723280A0 (en) DERIVATIVES OF 3 PIPERIDINOCARBALDEHYDE OXYME, THEIR PREPARATION PROCEDURE AND THEIR APPLICATION AS DRUGS
JPS6416890A (en) Antioxidant
MX9304133A (en) NEW DERIVATIVES OF PHOSPHOLIPIDS.
NO982755D0 (en) Covalent lipid phosphonocarboxylic acid derivatives and their use as antiviral drugs
ES2032209T3 (en) DERIVATIVES OF PROTEINS THAT CONTAIN IRON IN A HIGHLY BIOAVAILABLE FORM, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees