AU667327B2 - Composition and method of treating hepatitis C - Google Patents

Composition and method of treating hepatitis C Download PDF

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Publication number
AU667327B2
AU667327B2 AU26447/92A AU2644792A AU667327B2 AU 667327 B2 AU667327 B2 AU 667327B2 AU 26447/92 A AU26447/92 A AU 26447/92A AU 2644792 A AU2644792 A AU 2644792A AU 667327 B2 AU667327 B2 AU 667327B2
Authority
AU
Australia
Prior art keywords
thymosin
interferon
hepatitis
international
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU26447/92A
Other languages
English (en)
Other versions
AU2644792A (en
Inventor
Paul Chretian
Milton Mutchnick
Kenneth E. Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wayne State University
Sciclone Pharmaceuticals LLC
United States Department of the Army
Original Assignee
Wayne State University
Alpha 1 Biomedicals Inc
United States Department of the Army
Government of the United States of America
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wayne State University, Alpha 1 Biomedicals Inc, United States Department of the Army, Government of the United States of America filed Critical Wayne State University
Publication of AU2644792A publication Critical patent/AU2644792A/en
Assigned to BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE, ALPHA 1 BIOMEDICALS, INC., SHERMAN, KENNETH E. reassignment BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE Alteration of Name(s) of Applicant(s) under S113 Assignors: ALPHA 1 BIOMEDICALS, INC., MUTCHNICK, MILTON, SHERMAN, KENNETH E.
Assigned to ALPHA 1 BIOMEDICALS, INC., UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, THE, BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE reassignment ALPHA 1 BIOMEDICALS, INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: ALPHA 1 BIOMEDICALS, INC., BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE, SHERMAN, KENNETH E.
Application granted granted Critical
Publication of AU667327B2 publication Critical patent/AU667327B2/en
Assigned to UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, THE, SCICLONE PHARMACEUTICALS, INC., BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE reassignment UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, THE Alteration of Name(s) in Register under S187 Assignors: ALPHA 1 BIOMEDICALS, INC., BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY, THE, UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE ARMY, THE
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2292Thymosin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Beans For Foods Or Fodder (AREA)
AU26447/92A 1991-09-13 1992-09-08 Composition and method of treating hepatitis C Ceased AU667327B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75954491A 1991-09-13 1991-09-13
US759544 1991-09-13
PCT/US1992/007556 WO1993005806A1 (en) 1991-09-13 1992-09-08 Composition and method of treating hepatitis c

Publications (2)

Publication Number Publication Date
AU2644792A AU2644792A (en) 1993-04-27
AU667327B2 true AU667327B2 (en) 1996-03-21

Family

ID=25056052

Family Applications (1)

Application Number Title Priority Date Filing Date
AU26447/92A Ceased AU667327B2 (en) 1991-09-13 1992-09-08 Composition and method of treating hepatitis C

Country Status (23)

Country Link
US (3) US6001799A (OSRAM)
EP (1) EP0603305B1 (OSRAM)
JP (1) JP3228512B2 (OSRAM)
KR (1) KR100254082B1 (OSRAM)
AT (1) ATE152914T1 (OSRAM)
AU (1) AU667327B2 (OSRAM)
CA (1) CA2119006C (OSRAM)
CZ (1) CZ286827B6 (OSRAM)
DE (1) DE69219782T2 (OSRAM)
DK (1) DK0603305T3 (OSRAM)
ES (1) ES2103966T3 (OSRAM)
FI (1) FI107879B (OSRAM)
GR (1) GR3024025T3 (OSRAM)
HK (1) HK1021687A1 (OSRAM)
HU (1) HU221006B1 (OSRAM)
MX (1) MX9205240A (OSRAM)
NO (1) NO941310D0 (OSRAM)
RO (1) RO111991B1 (OSRAM)
RU (1) RU2104010C1 (OSRAM)
SG (1) SG64897A1 (OSRAM)
TW (1) TW224053B (OSRAM)
WO (1) WO1993005806A1 (OSRAM)
ZA (1) ZA926964B (OSRAM)

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TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien
SG64892A1 (en) * 1992-02-06 1999-05-25 Sciclone Pharmaceuticals Method for treating hepatitis b carriers with minimal disease
AU751199B2 (en) * 1992-07-13 2002-08-08 Government Of The United States Of America As Represented By The Secretary Of The Army Composition and method of treating hepatitis B
EP0627930A4 (en) * 1992-07-13 1997-08-20 Kenneth E Sherman COMPOSITION AND METHOD FOR TREATING HEPATITIS B.
CN1072961C (zh) * 1993-03-05 2001-10-17 施塞克龙药品公司 治疗对干扰素治疗无反应者的丙型肝炎的方法
US6200952B1 (en) 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
TW249754B (OSRAM) * 1993-10-26 1995-06-21 Alpha I Biomedicals Inc
DE69332982T2 (de) * 1993-11-05 2004-09-09 Alpha 1 Biomedicals, Inc. Thymosin-alpha-1 enthaltende zusammensetzungen zur behandlung von hepatitis b bei patienten mit dekompensierter lebererkrankung
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
GEP20012489B (en) * 1996-02-28 2001-07-25 Ifi Inst Farmacoterapico Italiano S P A Use of Natural Human α-Interferon
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CZ301182B6 (cs) 2000-05-26 2009-12-02 Idenix (Cayman) Limited Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
US7208167B2 (en) * 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
ES2275711T3 (es) * 2000-08-07 2007-06-16 Sciclone Pharmaceuticals, Inc. Tratamiento de la hepatitis c con timosina, interferon y ribavirina.
AU2002227252A1 (en) * 2000-12-01 2002-06-11 Cornell Research Foundation Animal model for flaviviridae infection
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
EP1435974A4 (en) * 2001-09-28 2006-09-06 Idenix Cayman Ltd METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATITIS C VIRUS USING 4 'MODIFIED NUCLEOSIDES
PL371683A1 (en) * 2001-10-05 2005-06-27 Intermune, Inc. Methods of treating liver fibrosis and hepatitis c virus infection
CA2464795A1 (en) 2001-10-26 2003-05-01 Jack R. Wands Thymosin augmentation of genetic immunization
UA80957C2 (en) * 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
US20040002476A1 (en) * 2002-02-14 2004-01-01 Stuyver Lieven J. Modified fluorinated nucleoside analogues
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
MXPA04012802A (es) 2002-06-28 2005-04-19 Idenix Cayman Ltd Ester 2'-c-metil-3'-o-l-valina de ribofuranosil-citidina para el tratamiento de infecciones por flaviviridae.
CN104193791A (zh) 2002-06-28 2014-12-10 埃迪尼克斯医药公司 用于治疗黄病毒感染的修饰的2’和3’-核苷前药
WO2004046331A2 (en) 2002-11-15 2004-06-03 Idenix (Cayman) Limited 2’-branched nucleosides and flaviviridae mutation
US7598373B2 (en) 2002-12-12 2009-10-06 Idenix Pharmaceuticals, Inc. Process for the production of 2-C-methyl-D-ribonolactone
GB0301879D0 (en) * 2003-01-27 2003-02-26 Regent Res Llp HCV combination therapy
JP4149296B2 (ja) * 2003-03-26 2008-09-10 株式会社ルネサステクノロジ 半導体記憶装置
KR101089145B1 (ko) 2003-03-28 2011-12-02 사이클론 파아머슈티컬 인코오퍼레이티드 티모신 알파 1에 의한 아스퍼르길러스 감염의 치료 의약품
CN100342907C (zh) * 2003-03-28 2007-10-17 希克龙制药公司 胸腺素α1在制备用于治疗或预防哺乳动物中曲霉菌感染的药物组合物中的应用
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
EP2345659A1 (en) 2003-05-30 2011-07-20 Pharmasset, Inc. Modified fluorinated nucleoside analogues
DE602004028841D1 (de) * 2003-07-25 2010-10-07 Centre Nat Rech Scient Purin nucleoside für die behandlung von durch flavividrae verursachten krankheiten, einschliesslich hepatitis c
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b
KR20070011451A (ko) 2004-05-05 2007-01-24 예일 유니버시티 신규의 항바이러스 헬리오크산틴 유사체
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
ES2769377T3 (es) 2004-09-14 2020-06-25 Gilead Pharmasset Llc Intermedios de D-ribonolactona con sustitución de 2-fluoro-2-alquilo
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス,インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
CN101437535B (zh) * 2006-05-02 2013-01-30 希格马托制药工业公司 胸腺素α1单独地或与PTX3或更昔洛韦联合在治疗巨细胞病毒感染中的用途
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US20110195048A1 (en) * 2008-10-08 2011-08-11 Podack Eckhard R Regulation of lymphocytes and uses therefor
CN102695513A (zh) 2008-12-23 2012-09-26 吉利德制药有限责任公司 核苷氨基磷酸酯
AU2009329917B2 (en) 2008-12-23 2016-03-31 Gilead Pharmasset Llc Nucleoside analogs
BRPI0923815A2 (pt) 2008-12-23 2015-07-14 Pharmasset Inc Síntese de nucleosídeos de purina
JP2012526149A (ja) 2009-05-08 2012-10-25 サイクローン・ファーマシューティカルズ・インコーポレイテッド ワクチン増強剤としてのαチモシンペプチド
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
SMT201700412T1 (it) 2010-03-31 2017-11-15 Gilead Pharmasset Llc Procedimento per la cristallizzazione di (s)-isopropil 2-(((s)-(perfluorofenossi)(fenossi)fosforil)ammino)propanoato
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US8809354B2 (en) 2011-12-31 2014-08-19 Sheikh Riazuddin 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections
CN103800293B (zh) * 2012-11-09 2015-10-21 长春海悦药业有限公司 一种含有胸腺法新的药物组合物及其制剂
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Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

Also Published As

Publication number Publication date
SG64897A1 (en) 1999-05-25
ZA926964B (en) 1993-04-26
MX9205240A (es) 1993-07-01
JP3228512B2 (ja) 2001-11-12
GR3024025T3 (en) 1997-10-31
RU94022480A (ru) 1996-07-20
US20070218033A1 (en) 2007-09-20
HUT75166A (en) 1997-04-28
RO111991B1 (ro) 1997-04-30
FI941133L (fi) 1994-03-10
WO1993005806A1 (en) 1993-04-01
JPH06510998A (ja) 1994-12-08
EP0603305B1 (en) 1997-05-14
CA2119006C (en) 2005-08-23
TW224053B (OSRAM) 1994-05-21
US6001799A (en) 1999-12-14
DE69219782T2 (de) 1997-10-09
CZ55194A3 (en) 1994-10-19
NO941310L (no) 1994-04-12
HU221006B1 (hu) 2002-07-29
AU2644792A (en) 1993-04-27
ES2103966T3 (es) 1997-10-01
HK1021687A1 (en) 2000-06-23
DK0603305T3 (da) 1997-09-01
FI941133A0 (fi) 1994-03-10
FI107879B (fi) 2001-10-31
EP0603305A1 (en) 1994-06-29
ATE152914T1 (de) 1997-05-15
US5849696A (en) 1998-12-15
RU2104010C1 (ru) 1998-02-10
HU9400758D0 (en) 1994-06-28
DE69219782D1 (de) 1997-06-19
NO941310D0 (no) 1994-04-12
CA2119006A1 (en) 1993-04-01
KR100254082B1 (ko) 2000-09-01
CZ286827B6 (cs) 2000-07-12

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Legal Events

Date Code Title Description
PC Assignment registered

Owner name: SCICLONE PHARMACEUTICALS, INC., THE UNITED STATES

Free format text: FORMER OWNER WAS: ALPHA 1 BIOMEDICALS, INC., THE UNITED STATES OF ASMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY, THE BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY