HK1021687A1 - Use of a thymosin in the treatment of hepatitis c - Google Patents

Use of a thymosin in the treatment of hepatitis c Download PDF

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Publication number
HK1021687A1
HK1021687A1 HK98105712A HK98105712A HK1021687A1 HK 1021687 A1 HK1021687 A1 HK 1021687A1 HK 98105712 A HK98105712 A HK 98105712A HK 98105712 A HK98105712 A HK 98105712A HK 1021687 A1 HK1021687 A1 HK 1021687A1
Authority
HK
Hong Kong
Prior art keywords
thymosin
interferon
patients
hepatitis
treatment
Prior art date
Application number
HK98105712A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1021687B (en
Inventor
Mutchnick Milton
Chretian Paul
E. Sherman Kenneth
Original Assignee
The Board Of Governors Of Wayne State University
The United States Of America As Represented By The Secretary Of The Army
Sciclone Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Governors Of Wayne State University, The United States Of America As Represented By The Secretary Of The Army, Sciclone Pharmaceuticals, Inc. filed Critical The Board Of Governors Of Wayne State University
Publication of HK1021687B publication Critical patent/HK1021687B/en
Publication of HK1021687A1 publication Critical patent/HK1021687A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2292—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Beans For Foods Or Fodder (AREA)
HK98105712A 1991-09-13 1992-09-08 Use of a thymosin in the treatment of hepatitis c HK1021687A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75954491A 1991-09-13 1991-09-13
US759544 1991-09-13
PCT/US1992/007556 WO1993005806A1 (en) 1991-09-13 1992-09-08 Composition and method of treating hepatitis c

Publications (2)

Publication Number Publication Date
HK1021687B HK1021687B (en) 2000-06-23
HK1021687A1 true HK1021687A1 (en) 2000-06-23

Family

ID=25056052

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98105712A HK1021687A1 (en) 1991-09-13 1992-09-08 Use of a thymosin in the treatment of hepatitis c

Country Status (23)

Country Link
US (3) US6001799A (OSRAM)
EP (1) EP0603305B1 (OSRAM)
JP (1) JP3228512B2 (OSRAM)
KR (1) KR100254082B1 (OSRAM)
AT (1) ATE152914T1 (OSRAM)
AU (1) AU667327B2 (OSRAM)
CA (1) CA2119006C (OSRAM)
CZ (1) CZ286827B6 (OSRAM)
DE (1) DE69219782T2 (OSRAM)
DK (1) DK0603305T3 (OSRAM)
ES (1) ES2103966T3 (OSRAM)
FI (1) FI107879B (OSRAM)
GR (1) GR3024025T3 (OSRAM)
HK (1) HK1021687A1 (OSRAM)
HU (1) HU221006B1 (OSRAM)
MX (1) MX9205240A (OSRAM)
NO (1) NO941310L (OSRAM)
RO (1) RO111991B1 (OSRAM)
RU (1) RU2104010C1 (OSRAM)
SG (1) SG64897A1 (OSRAM)
TW (1) TW224053B (OSRAM)
WO (1) WO1993005806A1 (OSRAM)
ZA (1) ZA926964B (OSRAM)

Families Citing this family (60)

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TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien
WO1995011688A1 (en) * 1992-02-06 1995-05-04 Sciclone Pharmaceuticals Method for treating hepatitis b carriers with minimal disease
AU4671193A (en) * 1992-07-13 1994-01-31 Kenneth E. Sherman Composition and method of treating hepatitis b
AU751199B2 (en) * 1992-07-13 2002-08-08 Government Of The United States Of America As Represented By The Secretary Of The Army Composition and method of treating hepatitis B
CN1072961C (zh) * 1993-03-05 2001-10-17 施塞克龙药品公司 治疗对干扰素治疗无反应者的丙型肝炎的方法
US6200952B1 (en) * 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
TW249754B (OSRAM) * 1993-10-26 1995-06-21 Alpha I Biomedicals Inc
KR100298859B1 (ko) * 1993-11-05 2001-10-22 더 보드 오브 가버너스 오브 웨인 스테이트 유니버시티 대상부전성간질환을가진환자의치료방법및조성물
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
WO1997031649A1 (en) * 1996-02-28 1997-09-04 Ifi Istituto Farmacoterapico Italiano S.P.A. PHARMACEUTICAL COMPOSITIONS COMPRISING NATURAL HUMAN α-INTERFERON
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
YU92202A (sh) 2000-05-26 2006-01-16 Idenix (Cayman) Limited Metode i smeše za lečenje flavi virusa i pesti virusa
US7208167B2 (en) * 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
EP1311279B1 (en) * 2000-08-07 2006-12-20 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis c with thymosin, interferon and ribavirin
AU2002227252A1 (en) * 2000-12-01 2002-06-11 Cornell Research Foundation Animal model for flaviviridae infection
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
JP2005504087A (ja) * 2001-09-28 2005-02-10 イデニクス（ケイマン）リミテツド ４’が修飾されたヌクレオシドを使用するｃ型肝炎ウイルス治療のための方法および組成物
PL371683A1 (en) * 2001-10-05 2005-06-27 Intermune, Inc. Methods of treating liver fibrosis and hepatitis c virus infection
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UA80957C2 (en) * 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
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PT1523489E (pt) 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
PT1576138T (pt) 2002-11-15 2017-05-03 Idenix Pharmaceuticals Llc 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
GB0301879D0 (en) * 2003-01-27 2003-02-26 Regent Res Llp HCV combination therapy
JP4149296B2 (ja) * 2003-03-26 2008-09-10 株式会社ルネサステクノロジ 半導体記憶装置
BRPI0408892A (pt) * 2003-03-28 2006-04-11 Sciclone Pharmaceuticals Inc uso de timosina alfa 1 para tratar as infecções por arpergillus
CN100342907C (zh) * 2003-03-28 2007-10-17 希克龙制药公司 胸腺素α1在制备用于治疗或预防哺乳动物中曲霉菌感染的药物组合物中的应用
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
SI2604620T2 (sl) 2003-05-30 2024-10-30 Gilead Pharmasset Llc Modificirani fluorirani nukleozidni analogi
US20050075309A1 (en) 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b
CN1980657A (zh) 2004-05-05 2007-06-13 耶鲁大学 新颖的抗病毒赛菊宁黄质类似物
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US8492539B2 (en) 2004-09-14 2013-07-23 Gilead Pharmasset Llc Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
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KR101380360B1 (ko) * 2006-05-02 2014-04-09 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 거대세포바이러스 감염의 치료를 위한, 단독으로 또는 피티엑스 3 또는 강시클로비어와 병용되는 티모신 알파1의 용도
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010042697A1 (en) * 2008-10-08 2010-04-15 University Of Miami Regulation of lymphocytes and uses therefor
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8716012B2 (en) 2009-05-08 2014-05-06 Sciclone Pharmaceuticals, Inc. Alpha thymosin peptides as vaccine enhancers
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
WO2011123668A2 (en) 2010-03-31 2011-10-06 Pharmasset, Inc. Stereoselective synthesis of phosphorus containing actives
EP2646453A1 (en) 2010-11-30 2013-10-09 Gilead Pharmasset LLC Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
US8809354B2 (en) 2011-12-31 2014-08-19 Sheikh Riazuddin 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections
CN103800293B (zh) * 2012-11-09 2015-10-21 长春海悦药业有限公司 一种含有胸腺法新的药物组合物及其制剂
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1216056B (it) * 1988-03-11 1990-02-22 Sclavo Spa Composizioni farmaceutiche contenenti timosina alfa 1.
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien

Also Published As

Publication number Publication date
ATE152914T1 (de) 1997-05-15
US6001799A (en) 1999-12-14
CZ55194A3 (en) 1994-10-19
RU94022480A (ru) 1996-07-20
NO941310D0 (no) 1994-04-12
NO941310L (no) 1994-04-12
RO111991B1 (ro) 1997-04-30
ZA926964B (en) 1993-04-26
US5849696A (en) 1998-12-15
HU9400758D0 (en) 1994-06-28
EP0603305A1 (en) 1994-06-29
AU2644792A (en) 1993-04-27
SG64897A1 (en) 1999-05-25
GR3024025T3 (en) 1997-10-31
KR100254082B1 (ko) 2000-09-01
JPH06510998A (ja) 1994-12-08
CZ286827B6 (cs) 2000-07-12
FI941133A0 (fi) 1994-03-10
FI107879B (fi) 2001-10-31
RU2104010C1 (ru) 1998-02-10
HUT75166A (en) 1997-04-28
DE69219782T2 (de) 1997-10-09
HU221006B1 (hu) 2002-07-29
WO1993005806A1 (en) 1993-04-01
ES2103966T3 (es) 1997-10-01
DE69219782D1 (de) 1997-06-19
FI941133L (fi) 1994-03-10
EP0603305B1 (en) 1997-05-14
CA2119006A1 (en) 1993-04-01
MX9205240A (es) 1993-07-01
US20070218033A1 (en) 2007-09-20
CA2119006C (en) 2005-08-23
AU667327B2 (en) 1996-03-21
DK0603305T3 (da) 1997-09-01
TW224053B (OSRAM) 1994-05-21
JP3228512B2 (ja) 2001-11-12

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110908