RU2104010C1 - Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с - Google Patents

Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с Download PDF

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RU2104010C1
RU2104010C1 RU94022480A RU94022480A RU2104010C1 RU 2104010 C1 RU2104010 C1 RU 2104010C1 RU 94022480 A RU94022480 A RU 94022480A RU 94022480 A RU94022480 A RU 94022480A RU 2104010 C1 RU2104010 C1 RU 2104010C1
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Prior art keywords
thymosin
interferon
amount
hepatitis
treatment
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RU94022480A
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English (en)
Russian (ru)
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RU94022480A (ru
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Кретьен Поль
Мучник Мильтон
Е.Шерман Кеннет
Original Assignee
Альфа I биомедикалз, Инк.
Дзе Боард оф Говернорс оф Вайн Стейт Юниверсити
Юнайтед Стейтс оф Америка эз Репрезентед бай дзе Секретари оф дзе Армии
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2292Thymosin; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Beans For Foods Or Fodder (AREA)
RU94022480A 1991-09-13 1992-09-08 Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с RU2104010C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75954491A 1991-09-13 1991-09-13
US759544 1991-09-13
US759,544 1991-09-13
PCT/US1992/007556 WO1993005806A1 (en) 1991-09-13 1992-09-08 Composition and method of treating hepatitis c

Publications (2)

Publication Number Publication Date
RU94022480A RU94022480A (ru) 1996-07-20
RU2104010C1 true RU2104010C1 (ru) 1998-02-10

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Family Applications (1)

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RU94022480A RU2104010C1 (ru) 1991-09-13 1992-09-08 Способ лечения гепатита, композиция, усиливающая ин виво инактивацию вируса гепатита с, препарат для лечения гепатита с

Country Status (23)

Country Link
US (3) US6001799A (OSRAM)
EP (1) EP0603305B1 (OSRAM)
JP (1) JP3228512B2 (OSRAM)
KR (1) KR100254082B1 (OSRAM)
AT (1) ATE152914T1 (OSRAM)
AU (1) AU667327B2 (OSRAM)
CA (1) CA2119006C (OSRAM)
CZ (1) CZ286827B6 (OSRAM)
DE (1) DE69219782T2 (OSRAM)
DK (1) DK0603305T3 (OSRAM)
ES (1) ES2103966T3 (OSRAM)
FI (1) FI107879B (OSRAM)
GR (1) GR3024025T3 (OSRAM)
HK (1) HK1021687A1 (OSRAM)
HU (1) HU221006B1 (OSRAM)
MX (1) MX9205240A (OSRAM)
NO (1) NO941310L (OSRAM)
RO (1) RO111991B1 (OSRAM)
RU (1) RU2104010C1 (OSRAM)
SG (1) SG64897A1 (OSRAM)
TW (1) TW224053B (OSRAM)
WO (1) WO1993005806A1 (OSRAM)
ZA (1) ZA926964B (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b

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TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien
WO1995011688A1 (en) * 1992-02-06 1995-05-04 Sciclone Pharmaceuticals Method for treating hepatitis b carriers with minimal disease
AU4671193A (en) * 1992-07-13 1994-01-31 Kenneth E. Sherman Composition and method of treating hepatitis b
AU751199B2 (en) * 1992-07-13 2002-08-08 Government Of The United States Of America As Represented By The Secretary Of The Army Composition and method of treating hepatitis B
CN1072961C (zh) * 1993-03-05 2001-10-17 施塞克龙药品公司 治疗对干扰素治疗无反应者的丙型肝炎的方法
US6200952B1 (en) * 1993-06-02 2001-03-13 Sciclone Pharmaceuticals, Inc. Combination therapy method for treating chronic hepatitis B
TW249754B (OSRAM) * 1993-10-26 1995-06-21 Alpha I Biomedicals Inc
KR100298859B1 (ko) * 1993-11-05 2001-10-22 더 보드 오브 가버너스 오브 웨인 스테이트 유니버시티 대상부전성간질환을가진환자의치료방법및조성물
JP3837769B2 (ja) * 1995-06-12 2006-10-25 大塚製薬株式会社 抗ウイルス剤
WO1997031649A1 (en) * 1996-02-28 1997-09-04 Ifi Istituto Farmacoterapico Italiano S.P.A. PHARMACEUTICAL COMPOSITIONS COMPRISING NATURAL HUMAN α-INTERFERON
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
YU92202A (sh) 2000-05-26 2006-01-16 Idenix (Cayman) Limited Metode i smeše za lečenje flavi virusa i pesti virusa
US7208167B2 (en) * 2000-08-07 2007-04-24 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis C with thymosin and peptide combination therapy
EP1311279B1 (en) * 2000-08-07 2006-12-20 Sciclone Pharmaceuticals, Inc. Treatment of hepatitis c with thymosin, interferon and ribavirin
AU2002227252A1 (en) * 2000-12-01 2002-06-11 Cornell Research Foundation Animal model for flaviviridae infection
JP2005504087A (ja) * 2001-09-28 2005-02-10 イデニクス(ケイマン)リミテツド 4’が修飾されたヌクレオシドを使用するc型肝炎ウイルス治療のための方法および組成物
PL371683A1 (en) * 2001-10-05 2005-06-27 Intermune, Inc. Methods of treating liver fibrosis and hepatitis c virus infection
WO2003035010A2 (en) * 2001-10-26 2003-05-01 Rhode Island Hospital Thymosin augmentation of genetic immunization
UA80957C2 (en) * 2001-11-01 2007-11-26 Sciclone Pharmaceuticals Inc Method of administering a thymosin alpha 1 peptide
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
PT1523489E (pt) 2002-06-28 2014-06-24 Centre Nat Rech Scient Profármacos de nucleósido modificado em 2' e 3' para tratamento de infecções por flaviridae
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
AU2003248748A1 (en) 2002-06-28 2004-01-19 Idenix (Cayman) Limited 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
PT1576138T (pt) 2002-11-15 2017-05-03 Idenix Pharmaceuticals Llc 2'-metil-nucleósidos em combinação com interferão e mutação de flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
GB0301879D0 (en) * 2003-01-27 2003-02-26 Regent Res Llp HCV combination therapy
JP4149296B2 (ja) * 2003-03-26 2008-09-10 株式会社ルネサステクノロジ 半導体記憶装置
BRPI0408892A (pt) * 2003-03-28 2006-04-11 Sciclone Pharmaceuticals Inc uso de timosina alfa 1 para tratar as infecções por arpergillus
CN100342907C (zh) * 2003-03-28 2007-10-17 希克龙制药公司 胸腺素α1在制备用于治疗或预防哺乳动物中曲霉菌感染的药物组合物中的应用
US20100311656A1 (en) * 2003-04-23 2010-12-09 Sciclone Pharmaceuticals, Inc. Treatment or prevention of respiratory viral infections with alpha thymosin peptides
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US20050075309A1 (en) 2003-07-25 2005-04-07 Richard Storer Purine nucleoside analogues for treating Flaviviridae including hepatitis C
CN1980657A (zh) 2004-05-05 2007-06-13 耶鲁大学 新颖的抗病毒赛菊宁黄质类似物
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US8492539B2 (en) 2004-09-14 2013-07-23 Gilead Pharmasset Llc Preparation of 2′-fluoro-2′-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
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EP1832295A1 (en) * 2006-03-10 2007-09-12 Tecnogen S.P.A. Use of PTX3 for the treatment of viral diseases
KR101380360B1 (ko) * 2006-05-02 2014-04-09 시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이. 거대세포바이러스 감염의 치료를 위한, 단독으로 또는 피티엑스 3 또는 강시클로비어와 병용되는 티모신 알파1의 용도
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
TW200946541A (en) * 2008-03-27 2009-11-16 Idenix Pharmaceuticals Inc Solid forms of an anti-HIV phosphoindole compound
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PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
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Citations (1)

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EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

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TW224053B (OSRAM) * 1991-09-13 1994-05-21 Paul B Chretien

Patent Citations (1)

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EP0331934A1 (en) * 1988-03-11 1989-09-13 SCLAVO S.p.A. New pharmaceutical compositions containing thymosin alpha 1

Non-Patent Citations (1)

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Title
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2211703C2 (ru) * 2001-06-08 2003-09-10 ООО НТЦ "Юпитер-2" Антистрессорное и ноотропное средство с антивирусным и иммуностимулирующим действием
WO2005021007A1 (fr) * 2003-08-28 2005-03-10 Obschestvo S Ogranichennoi Otvetstvennostju 'berezovy Mir' Prevention et traitement de l'hepatite virale b

Also Published As

Publication number Publication date
ATE152914T1 (de) 1997-05-15
US6001799A (en) 1999-12-14
CZ55194A3 (en) 1994-10-19
RU94022480A (ru) 1996-07-20
NO941310D0 (no) 1994-04-12
NO941310L (no) 1994-04-12
RO111991B1 (ro) 1997-04-30
ZA926964B (en) 1993-04-26
US5849696A (en) 1998-12-15
HU9400758D0 (en) 1994-06-28
EP0603305A1 (en) 1994-06-29
AU2644792A (en) 1993-04-27
SG64897A1 (en) 1999-05-25
GR3024025T3 (en) 1997-10-31
KR100254082B1 (ko) 2000-09-01
JPH06510998A (ja) 1994-12-08
CZ286827B6 (cs) 2000-07-12
FI941133A0 (fi) 1994-03-10
FI107879B (fi) 2001-10-31
HUT75166A (en) 1997-04-28
DE69219782T2 (de) 1997-10-09
HU221006B1 (hu) 2002-07-29
WO1993005806A1 (en) 1993-04-01
ES2103966T3 (es) 1997-10-01
DE69219782D1 (de) 1997-06-19
FI941133L (fi) 1994-03-10
EP0603305B1 (en) 1997-05-14
CA2119006A1 (en) 1993-04-01
MX9205240A (es) 1993-07-01
US20070218033A1 (en) 2007-09-20
CA2119006C (en) 2005-08-23
AU667327B2 (en) 1996-03-21
DK0603305T3 (da) 1997-09-01
HK1021687A1 (en) 2000-06-23
TW224053B (OSRAM) 1994-05-21
JP3228512B2 (ja) 2001-11-12

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