AU578840B2 - Substituted androsta-1, 4-diene-3,17-diones and process for their preparation - Google Patents

Substituted androsta-1, 4-diene-3,17-diones and process for their preparation

Info

Publication number
AU578840B2
AU578840B2 AU59799/86A AU5979986A AU578840B2 AU 578840 B2 AU578840 B2 AU 578840B2 AU 59799/86 A AU59799/86 A AU 59799/86A AU 5979986 A AU5979986 A AU 5979986A AU 578840 B2 AU578840 B2 AU 578840B2
Authority
AU
Australia
Prior art keywords
diones
diene
preparation
substituted androsta
androsta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired, expires
Application number
AU59799/86A
Other languages
English (en)
Other versions
AU5979986A (en
Inventor
Natale Barbugian
Franco Buzzetti
Enrico Di Salle
Paolo Lombardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU578840(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of AU5979986A publication Critical patent/AU5979986A/en
Application granted granted Critical
Publication of AU578840B2 publication Critical patent/AU578840B2/en
Assigned to PHARMACIA S.P.A. reassignment PHARMACIA S.P.A. Alteration of Name(s) in Register under S187 Assignors: FARMITALIA CARLO ERBA S.R.L.
Assigned to PHARMACIA & UPJOHN S.P.A. reassignment PHARMACIA & UPJOHN S.P.A. Alteration of Name(s) in Register under S187 Assignors: PHARMACIA S.P.A.
Assigned to PHARMACIA ITALIA S.P.A. reassignment PHARMACIA ITALIA S.P.A. Alteration of Name(s) in Register under S187 Assignors: PHARMACIA & UPJOHN S.P.A.
Adjusted expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU59799/86A 1985-07-09 1986-07-07 Substituted androsta-1, 4-diene-3,17-diones and process for their preparation Expired AU578840B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8517360 1985-07-09
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (2)

Publication Number Publication Date
AU5979986A AU5979986A (en) 1987-01-15
AU578840B2 true AU578840B2 (en) 1988-11-03

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
AU59799/86A Expired AU578840B2 (en) 1985-07-09 1986-07-07 Substituted androsta-1, 4-diene-3,17-diones and process for their preparation

Country Status (38)

Country Link
US (2) US4808616A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS6212797A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR950003614B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN86104664B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT395157B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU578840B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE905067A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BG (1) BG61370B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BR (1) BR1100240A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1277656C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH668599A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CS (2) CS257794B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ413591A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE10199030I1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK163520C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (2) ES8801304A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI83424C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2584725B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (2) GB8517360D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR861780B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK94190A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU194274B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE58949B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL79336A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT1196436B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY102294A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (2) NL193616C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (2) NO165547C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ216763A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH21785A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT82944B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE468988B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG80490G (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK413591A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (2) SU1442077A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
UA (1) UA6046A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (2) YU44585B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA865079B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU589269B2 (en) * 1986-07-14 1989-10-05 Farmitalia Carlo Erba S.P.A. New 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
AU652038B2 (en) * 1991-03-28 1994-08-11 Teikoku Hormone Mfg. Co., Ltd. Novel oxa- or azasteroid derivative
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
NZ256130A (en) * 1992-09-30 1996-05-28 Teikoku Hormone Mfg Co Ltd 7-substituted oxasteroid derivatives; pharmaceutical compositions
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
EP1322333A2 (en) * 2000-08-09 2003-07-02 Pharmacia Italia S.p.A. Composition for combined use of aromatase inhibitors
BR0113625A (pt) * 2000-09-08 2003-07-22 Pharmacia Italia Spa Exemestano como agente de quimioprevenção
ES2269682T3 (es) * 2001-01-26 2007-04-01 Pfizer Italia S.R.L. Exemestano para tratar transtornos que dependen de hormonas.
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
CZ309178B6 (cs) 2001-02-19 2022-04-20 Novartis Pharma Ag 40-O-(2-hydroxyethyl)rapamycin pro použití při léčení
BR0209647A (pt) 2001-05-16 2004-07-27 Novartis Ag Combinação que compreende n-{5-[4-(4-metil-piperazino-metil)-benzoilamido]-2-metil fenil}-4-(3-piridil)-2-pirimidina-amina e um agente quimioterapêutico
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
PT1505959E (pt) 2002-05-16 2009-02-05 Novartis Ag Utilização de agentes de ligação do receptor edg em cancro
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
US8183401B2 (en) 2004-01-16 2012-05-22 Cedarburg Pharmaceuticals, Inc. Exemestane and its intermediates and methods of making the same
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
BRPI0616639A2 (pt) 2005-09-30 2011-06-28 Endece Llc compostos de exemestano de (s)-6-metiloxaalquila e métodos de uso relacionados
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
NZ572299A (en) 2006-05-09 2010-07-30 Novartis Ag Combination comprising a substituted 3,5-diphenyl-1,2,4-triazole and a platinum compound and use thereof
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
CA2702710C (en) 2007-10-16 2013-05-07 Repros Therapeutics, Inc. Trans-clomiphene for metabolic syndrome
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
US8288571B2 (en) * 2008-01-21 2012-10-16 Cadila Healthcare Limited Process for preparing aromatiase inhibitor exemestane
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
WO2010127297A1 (en) 2009-05-01 2010-11-04 Parviz Gharagozloo Treating male infertility secondary to sperm oxidative stress
RU2425052C1 (ru) * 2010-03-04 2011-07-27 Татьяна Степановна Савинова Способ получения 6-метиленандрост-4-ен-3,17-диона из андрост-4-ен-3,17-диона, способ получения 6-метиленандроста-1,4-диен-3,17-диона (эксеместана) с использованием полученного 6-метиленандрост-4-ен-3,17-диона
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CN102884072A (zh) 2010-04-08 2013-01-16 爱默蕾大学 被取代的雄甾-4-烯二酮
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
BR112013005843A2 (pt) 2010-09-14 2019-12-10 Endece Llc derivativos de er-beta 6-substituído por desmetil-estradiol
CN104244953A (zh) 2012-02-29 2014-12-24 利普生物药剂公司 用于治疗雄激素缺乏的联合治疗
BR112016014903A8 (pt) 2014-02-11 2018-05-02 Novartis Ag combinações farmacêuticas que compreendem um inibidor de pi3k, seu uso, sua preparação combinada, e embalagem comercial
WO2017081171A1 (en) 2015-11-10 2017-05-18 Paracrine Therapeutics Ab Treatment of er-negative breast cancer with an pdgf-cc inhibitor and an anti estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB929985A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU589269B2 (en) * 1986-07-14 1989-10-05 Farmitalia Carlo Erba S.P.A. New 6- or 7-methylenandrosta-1,4-diene-3,17-dione derivatives and process for their preparation

Also Published As

Publication number Publication date
GB2177700A (en) 1987-01-28
YU103687A (en) 1988-08-31
DK324386D0 (da) 1986-07-08
MY102294A (en) 1992-05-15
BR1100240A (pt) 1999-12-28
IL79336A (en) 1991-06-10
CS521486A2 (en) 1987-09-17
FI83424B (fi) 1991-03-28
KR950003614B1 (ko) 1995-04-17
CN86104664B (zh) 1988-06-29
BE905067A (fr) 1987-01-08
NO165547B (no) 1990-11-19
YU44628B (en) 1990-10-31
JPH0443919B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-07-20
FR2584725A1 (fr) 1987-01-16
YU120186A (en) 1988-02-29
ES8801304A1 (es) 1987-12-16
DK163520C (da) 1992-07-27
NL193616B (nl) 1999-12-01
ZA865079B (en) 1987-03-25
PT82944A (en) 1986-08-01
FI862871A7 (fi) 1987-01-10
HUT42780A (en) 1987-08-28
IT1196436B (it) 1988-11-16
US4808616A (en) 1989-02-28
SU1501923A3 (ru) 1989-08-15
ATA181986A (de) 1992-02-15
NO165547C (no) 1991-02-27
GR861780B (en) 1986-11-11
FI83424C (fi) 1991-07-10
NZ216763A (en) 1988-05-30
SU1442077A3 (ru) 1988-11-30
IL79336A0 (en) 1986-10-31
IE58949B1 (en) 1993-12-01
YU44585B (en) 1990-10-31
CN86104664A (zh) 1987-02-18
GB2177700B (en) 1988-12-07
FI862871A0 (fi) 1986-07-07
SE8603046L (sv) 1987-01-10
NL300017I2 (nl) 2001-01-02
NO862753D0 (no) 1986-07-08
US4904650A (en) 1990-02-27
NL300017I1 (nl) 2000-11-01
SE468988B (sv) 1993-04-26
AT395157B (de) 1992-10-12
ES557466A0 (es) 1988-06-01
IT8621004A0 (it) 1986-07-02
NL8601785A (nl) 1987-02-02
PH21785A (en) 1988-02-24
GB8517360D0 (en) 1985-08-14
SK413591A3 (en) 1995-07-11
DK163520B (da) 1992-03-09
HK94190A (en) 1990-11-23
CH668599A5 (de) 1989-01-13
CS257794B2 (en) 1988-06-15
ES8802429A1 (es) 1988-06-01
GB8616585D0 (en) 1986-08-13
AU5979986A (en) 1987-01-15
CA1277656C (en) 1990-12-11
DE10199030I1 (de) 2001-10-04
KR870001140A (ko) 1987-03-11
NL193616C (nl) 2000-04-04
HU194274B (en) 1988-01-28
FR2584725B1 (fr) 1988-05-13
DK324386A (da) 1987-01-10
JPS6212797A (ja) 1987-01-21
BG61370B2 (bg) 1997-06-30
UA6046A1 (uk) 1994-12-29
CS258498B2 (en) 1988-08-16
NO2000009I1 (no) 2000-10-05
SG80490G (en) 1990-11-23
NO862753L (no) 1987-01-12
ES556550A0 (es) 1987-12-16
PT82944B (pt) 1989-01-30
IE861821L (en) 1987-01-09
SE8603046D0 (sv) 1986-07-08
CZ413591A3 (en) 1994-03-16

Similar Documents

Publication Publication Date Title
AU578840B2 (en) Substituted androsta-1, 4-diene-3,17-diones and process for their preparation
AU551471B2 (en) 9lamda-chloro-11beba-hydroxy-16beta-methyl-17lamda,21- dipropionyl-oxypregna-1,4-diene-3,20-dione
AU6206686A (en) Insulin analogues and process for their preparation
AU3431389A (en) 9-alpha-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids
AU584158B2 (en) New process for the preparation of certain steroids, especially intermediates for the preparation of proligestone and related compounds, and new intermediates formed in this process
AU587841B2 (en) Poly-4-aminopyrrole-2-carboxamido derivatives and process for their preparation
AU7429087A (en) New androst-4-ene-3,17-diones and process for their preparation
IE902490L (en) 4-Hydroxy- or 4-C2-C12-Acyloxy-4-androstene-3,17-dione in¹micronised form
AU2761488A (en) Steroidal compounds and process for lengthening the side-chain of certain steroids
AU587031B2 (en) 11-B substituted steroids and process for their preparation
AU589594B2 (en) Process for the preparation of arylglycidyl ethers and 3-substituted 1-alkylamino-2-propanlos
AU7812287A (en) Bromofluoroethylhypofluorite and process for its preparation
AU7429187A (en) Methylene derivatives of androst-4-ene-3,17-diones and their preparation
CS240886A2 (en) Method of 1-methyl-1, 4-androstadiene-3, 17-dione production
FI873489A7 (fi) Menetelmä 4-androsteeni-3,17-dionin ja 1,4-androstadieeni-3,17-dionin valmistamiseksi.
AU288104B2 (en) New 16-alkyl pregnane derivatives and process for the preparation thereof
AU5025364A (en) New 16-alkyl pregnane derivatives and process for the preparation thereof
BA97185B1 (bs) Postupak za dobijanje supstituisanih androsta-1,4-dien-3,17-diona
AU5742690A (en) Novel methods for obtaining 6-methyl 19-nor steroids and converting them into 17alpha-substituted 19-nor pregnadienes
AU607565C (en) Improvement in the synthesis of 6-methylene derivatives of androsta-1, 4-diene-3,17-dione
IE871594L (en) Androst-4-ene-3,20-dione derivatives
IE871593L (en) Androst-4-ene-3,20-dione derivatives
PL251409A2 (en) Method of obtaining 2-methylene-4,6-androstadiene-3,17-dione

Legal Events

Date Code Title Description
NC Extension of term for standard patent requested (sect. 70)

Free format text: PRODUCT NAME: AROMASIN

NDA Extension of term for standard patent accepted (sect.70)

Free format text: PRODUCT NAME: AROMASIN

Extension date: 20110707

NDB Extension of term for standard patent granted (sect.76)

Free format text: PRODUCT NAME: AROMASIN EXEMESTANE

Extension date: 20110707

PC Assignment registered

Owner name: PHARMACIA ITALIA S.P.A.

Free format text: FORMER OWNER WAS: PHARMACIA AND UPJOHN S.P.A.