AU541020B2 - 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine maleate - Google Patents

2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine maleate

Info

Publication number
AU541020B2
AU541020B2 AU75163/81A AU7516381A AU541020B2 AU 541020 B2 AU541020 B2 AU 541020B2 AU 75163/81 A AU75163/81 A AU 75163/81A AU 7516381 A AU7516381 A AU 7516381A AU 541020 B2 AU541020 B2 AU 541020B2
Authority
AU
Australia
Prior art keywords
carbethoxyamino
benzylamino
fluoro
amino
pyridine maleate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU75163/81A
Other languages
English (en)
Other versions
AU7516381A (en
Inventor
Siegfried Pauluhn
Walter Von Bebenburg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asta Medica GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of AU7516381A publication Critical patent/AU7516381A/en
Application granted granted Critical
Publication of AU541020B2 publication Critical patent/AU541020B2/en
Assigned to ASTA MEDICA AKTIENGESELLSCHAFT reassignment ASTA MEDICA AKTIENGESELLSCHAFT Alteration of Name(s) in Register under S187 Assignors: DEGUSSA A.G.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/76Nitrogen atoms to which a second hetero atom is attached
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/75Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU75163/81A 1980-09-13 1981-09-11 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine maleate Expired AU541020B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3034638 1980-09-13
DE30346384 1980-09-13

Publications (2)

Publication Number Publication Date
AU7516381A AU7516381A (en) 1982-03-25
AU541020B2 true AU541020B2 (en) 1984-12-13

Family

ID=6111900

Family Applications (1)

Application Number Title Priority Date Filing Date
AU75163/81A Expired AU541020B2 (en) 1980-09-13 1981-09-11 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine maleate

Country Status (31)

Country Link
US (1) US4481205A (es)
JP (1) JPS5781465A (es)
KR (1) KR860000585B1 (es)
AR (1) AR229101A1 (es)
AT (1) AT375924B (es)
AU (1) AU541020B2 (es)
BE (1) BE890331A (es)
CA (1) CA1147736A (es)
CH (1) CH646952A5 (es)
CS (1) CS226037B2 (es)
DD (1) DD201786A5 (es)
DK (1) DK159878C (es)
EG (1) EG15446A (es)
ES (1) ES8206481A1 (es)
FI (1) FI79531C (es)
FR (1) FR2490225B1 (es)
GB (1) GB2084138B (es)
GR (1) GR75777B (es)
HU (1) HU182720B (es)
IE (1) IE51547B1 (es)
IL (1) IL63801A (es)
IN (1) IN155674B (es)
IT (1) IT1171520B (es)
LU (1) LU83633A1 (es)
NL (1) NL189856C (es)
NO (1) NO160919C (es)
PL (1) PL130030B1 (es)
SE (1) SE454693B (es)
SU (1) SU1091855A3 (es)
YU (1) YU43037B (es)
ZA (1) ZA816336B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416609A1 (de) * 1984-05-05 1985-11-07 Degussa Ag, 6000 Frankfurt 2-amino-3-ethoxycarbonylamino-6-(p-fluor-benzylamino)- pyridin-gluconat und pharmazeutische zubereitungen, die diese substanz enthalten
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
JPH0568848U (ja) * 1991-11-18 1993-09-17 京都機械工具株式会社 チューブ絞り器
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
DE19625582A1 (de) * 1996-06-27 1998-01-02 Asta Medica Ag Verwendung von Flupirtin zur Prophylaxe und Therapie von Erkrankungen die mit einer unphysiologisch hohen Zellsterberate einhergehen
DE19716984A1 (de) * 1997-04-23 1998-10-29 Asta Medica Ag Verfahren zur Herstellung von reinem Flupirtin-Maleat und dessen Modifikation A
US6187324B1 (en) * 1998-08-11 2001-02-13 Kabushiki Kaisha Ogi Kogei Cosmetic composition comprising at least one of Kumazasa extract and medicinal carbon
US6821995B1 (en) 1999-12-01 2004-11-23 Duke University Method of treating batten disease
DE10327674A1 (de) * 2003-06-20 2005-01-05 Awd.Pharma Gmbh & Co. Kg Injizierbare Darreichungsform von Flupirtin
US7741358B2 (en) * 2005-04-14 2010-06-22 N.V. Organon Crystal form of asenapine maleate
US20080279930A1 (en) * 2007-05-07 2008-11-13 Bernd Terhaag Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof
US8501778B2 (en) 2008-06-20 2013-08-06 Nhwa Pharma. Corporation Aralkyl piperidine derivatives and their uses as antalgic or ataractic agent
AU2009279604A1 (en) * 2008-08-06 2010-02-11 Bionevia Pharmaceuticals, Inc. Flupirtine hydrochloride maleic acid cocrystal
DE102009023162B4 (de) * 2009-05-29 2011-07-07 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Flupirtin
CN102140077A (zh) * 2010-01-28 2011-08-03 范扶民 氟吡汀a晶型及其制备方法
WO2012004391A1 (en) 2010-07-09 2012-01-12 K.H.S. Pharma Holding Gmbh Process for the preparation of flupirtine maleate
CN102241626B (zh) * 2011-05-03 2013-07-03 北京华睿鼎信科技有限公司 一种马来酸氟吡汀的合成工艺
WO2013080215A1 (en) 2011-11-30 2013-06-06 Arch Pharmalabs Limited An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof
CN103086963A (zh) * 2013-01-29 2013-05-08 吉林修正药业新药开发有限公司 一种马来酸氟吡汀a晶型化合物及中间体的合成方法
CN104086481B (zh) * 2014-07-18 2016-05-11 四川新斯顿制药股份有限公司 一种马来酸氟吡汀的合成方法
CN111100010A (zh) * 2019-12-30 2020-05-05 山东省越兴化工有限公司 一种对氟苄胺的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795858C2 (de) * 1968-07-19 1979-01-11 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Benzylaminopyridine
US3969361A (en) * 1972-05-10 1976-07-13 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler 2-Benzoyl-3-amino-pyridines

Also Published As

Publication number Publication date
JPH0259149B2 (es) 1990-12-11
YU43037B (en) 1989-02-28
DK159878B (da) 1990-12-24
HU182720B (en) 1984-03-28
NO160919C (no) 1989-06-14
ES505423A0 (es) 1982-08-16
EG15446A (en) 1986-06-30
IE51547B1 (en) 1987-01-07
NL8104211A (nl) 1982-04-01
PL130030B1 (en) 1984-07-31
CH646952A5 (de) 1984-12-28
CA1147736A (en) 1983-06-07
ZA816336B (en) 1982-09-29
SE8105425L (sv) 1982-03-14
FI79531B (fi) 1989-09-29
PL232999A1 (es) 1982-08-16
GB2084138A (en) 1982-04-07
LU83633A1 (de) 1982-01-21
NO160919B (no) 1989-03-06
FI812836L (fi) 1982-03-14
YU215781A (en) 1984-02-29
IT1171520B (it) 1987-06-10
FI79531C (fi) 1990-01-10
IL63801A (en) 1984-10-31
AU7516381A (en) 1982-03-25
IE812055L (en) 1982-03-13
US4481205A (en) 1984-11-06
BE890331A (fr) 1982-03-11
JPS5781465A (en) 1982-05-21
KR860000585B1 (ko) 1986-05-17
FR2490225A1 (fr) 1982-03-19
DK159878C (da) 1991-05-13
IL63801A0 (en) 1981-12-31
CS226037B2 (en) 1984-03-19
IT8149272A0 (it) 1981-09-11
NO813082L (no) 1982-03-15
NL189856B (nl) 1993-03-16
DK404681A (da) 1982-03-14
IN155674B (es) 1985-02-23
FR2490225B1 (fr) 1985-09-06
SE454693B (sv) 1988-05-24
GR75777B (es) 1984-08-02
NL189856C (nl) 1993-08-16
AT375924B (de) 1984-09-25
ES8206481A1 (es) 1982-08-16
KR830007556A (ko) 1983-10-21
DD201786A5 (de) 1983-08-10
ATA393481A (de) 1984-02-15
AR229101A1 (es) 1983-06-15
SU1091855A3 (ru) 1984-05-07
GB2084138B (en) 1984-07-25

Similar Documents

Publication Publication Date Title
AU544099B2 (en) Triazolylpentenols
AU537992B2 (en) Polusilanes
AU535792B2 (en) l
AU542600B2 (en) Platinum-diamines
AU541020B2 (en) 2-amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)- pyridine maleate
AU545667B2 (en) Diamino-pyridines
AU542463B2 (en) Pyridoxine derivatives
AU538782B2 (en) Triazoloquinoxalin-4-ones
AU536754B2 (en) Imidodisulfamides
AU539188B2 (en) Skin-packaging
AU3206284A (en) 2-guanidno-4-heteroarylthiazoles
AU6941181A (en) Morpholinoalkylene dihydropyridines
AU541912B2 (en) 2-nitroimidazoles
AU534189B2 (en) Triazolylphenacyl pyridyl ethers
AU537824B2 (en) Oxygensensor
AU527275B2 (en) Auto-diaphragm hemodialyser
AU540787B2 (en) 4-indenyl-alkyl-piperidenes
AU1254183A (en) 2,4 substituted pyridines
AU551532B2 (en) Substituted pyridines
AU1045283A (en) Substituted pyridines
AU543520B2 (en) Kijanimicin
AU534814B2 (en) Showstand
AU537073B2 (en) Haloacetanilide
AU540680B2 (en) Piperidinyl 3-chloroquinolines
AU540683B2 (en) Photocomposer

Legal Events

Date Code Title Description
PC Assignment registered

Owner name: ASTA MEDICA AKTIENGESELLSCHAFT

Free format text: FORMER OWNER WAS: DEGUSSA AKTIENGESELLSCHAFT

MK14 Patent ceased section 143(a) (annual fees not paid) or expired