AU2019262978B2 - C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors - Google Patents
C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors Download PDFInfo
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- AU2019262978B2 AU2019262978B2 AU2019262978A AU2019262978A AU2019262978B2 AU 2019262978 B2 AU2019262978 B2 AU 2019262978B2 AU 2019262978 A AU2019262978 A AU 2019262978A AU 2019262978 A AU2019262978 A AU 2019262978A AU 2019262978 B2 AU2019262978 B2 AU 2019262978B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/545—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2023241345A AU2023241345B2 (en) | 2018-05-01 | 2023-10-05 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
| AU2025252583A AU2025252583A1 (en) | 2018-05-01 | 2025-10-16 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862665435P | 2018-05-01 | 2018-05-01 | |
| US62/665,435 | 2018-05-01 | ||
| US201862752874P | 2018-10-30 | 2018-10-30 | |
| US62/752,874 | 2018-10-30 | ||
| US201962836036P | 2019-04-18 | 2019-04-18 | |
| US62/836,036 | 2019-04-18 | ||
| PCT/US2019/029737 WO2019212990A1 (en) | 2018-05-01 | 2019-04-29 | C40-, c28-, and c-32-linked rapamycin analogs as mtor inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023241345A Division AU2023241345B2 (en) | 2018-05-01 | 2023-10-05 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2019262978A1 AU2019262978A1 (en) | 2020-12-03 |
| AU2019262978B2 true AU2019262978B2 (en) | 2023-07-13 |
Family
ID=66484166
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2019262978A Active AU2019262978B2 (en) | 2018-05-01 | 2019-04-29 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
| AU2023241345A Active AU2023241345B2 (en) | 2018-05-01 | 2023-10-05 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
| AU2025252583A Pending AU2025252583A1 (en) | 2018-05-01 | 2025-10-16 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023241345A Active AU2023241345B2 (en) | 2018-05-01 | 2023-10-05 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
| AU2025252583A Pending AU2025252583A1 (en) | 2018-05-01 | 2025-10-16 | C40-, C28-, and C-32-linked rapamycin analogs as mTOR inhibitors |
Country Status (29)
| Country | Link |
|---|---|
| US (5) | US20190336609A1 (enExample) |
| EP (2) | EP3788049B1 (enExample) |
| JP (2) | JP7358387B2 (enExample) |
| KR (2) | KR102929388B1 (enExample) |
| CN (3) | CN112771054B (enExample) |
| AU (3) | AU2019262978B2 (enExample) |
| BR (1) | BR112020022201A2 (enExample) |
| CA (1) | CA3098692A1 (enExample) |
| CL (2) | CL2020002827A1 (enExample) |
| CO (1) | CO2020013865A2 (enExample) |
| CR (3) | CR20240382A (enExample) |
| DK (1) | DK3788049T3 (enExample) |
| ES (1) | ES2945560T3 (enExample) |
| FI (1) | FI3788049T3 (enExample) |
| HR (1) | HRP20230488T1 (enExample) |
| HU (1) | HUE062352T2 (enExample) |
| IL (2) | IL300091A (enExample) |
| LT (1) | LT3788049T (enExample) |
| MX (3) | MX2020011565A (enExample) |
| PE (2) | PE20252397A1 (enExample) |
| PH (1) | PH12020551795A1 (enExample) |
| PL (1) | PL3788049T3 (enExample) |
| PT (1) | PT3788049T (enExample) |
| RS (1) | RS64272B1 (enExample) |
| SA (1) | SA520420458B1 (enExample) |
| SG (1) | SG11202010559UA (enExample) |
| SI (1) | SI3788049T1 (enExample) |
| TW (1) | TWI911762B (enExample) |
| WO (1) | WO2019212990A1 (enExample) |
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| EP4302834A3 (en) | 2016-07-12 | 2024-07-17 | Revolution Medicines, Inc. | 2,5-disubstituted 3-methyl pyrazines and 2,5,6-trisubstituted 3-methyl pyrazines as allosteric shp2 inhibitors |
| JP7240319B2 (ja) | 2017-01-23 | 2023-03-15 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての二環式化合物 |
| KR20190110588A (ko) | 2017-01-23 | 2019-09-30 | 레볼루션 메디슨즈, 인크. | 알로스테릭 shp2 억제제로서의 피리딘 화합물 |
| TW201930292A (zh) | 2017-10-12 | 2019-08-01 | 美商銳新醫藥公司 | 作為變構ｓｈｐ２抑制劑的吡啶、吡嗪和三嗪化合物 |
| JP7361693B2 (ja) | 2017-12-15 | 2023-10-16 | レヴォリューション・メディスンズ，インコーポレイテッド | アロステリックｓｈｐ２阻害剤としての多環式化合物 |
| IL312291A (en) | 2018-05-01 | 2024-06-01 | Revolution Medicines Inc | C-26-linked rapamycin analogs as MTOR inhibitors |
| MX2020011565A (es) | 2018-05-01 | 2021-01-29 | Revolution Medicines Inc | Analogos de rapamicina ligados a c40, c28 y c-32 como inhibidores de mtor. |
| MX2021010319A (es) | 2019-03-01 | 2021-12-10 | Revolution Medicines Inc | Compuestos biciclicos de heteroarilo y usos de estos. |
| MX2021010323A (es) | 2019-03-01 | 2021-12-10 | Revolution Medicines Inc | Compuestos bicíclicos de heterociclilo y usos de este. |
| IL322454A (en) | 2019-11-04 | 2025-09-01 | Revolution Medicines Inc | ras inhibitors |
| TW202132316A (zh) | 2019-11-04 | 2021-09-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| AU2020377925A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
| CA3156359A1 (en) | 2019-11-08 | 2021-05-14 | Adrian Liam Gill | Bicyclic heteroaryl compounds and uses thereof |
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| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
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| GB202415232D0 (en) | 2024-10-16 | 2024-11-27 | Nacamed As | Composition |
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| WO1994011380A1 (en) * | 1992-11-19 | 1994-05-26 | American Home Products Corporation | Rapamycin carbonate esters as immunosuppressant agents |
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