AU2018306328B2 - Macrocyclic compounds and uses thereof - Google Patents

Macrocyclic compounds and uses thereof Download PDF

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Publication number
AU2018306328B2
AU2018306328B2 AU2018306328A AU2018306328A AU2018306328B2 AU 2018306328 B2 AU2018306328 B2 AU 2018306328B2 AU 2018306328 A AU2018306328 A AU 2018306328A AU 2018306328 A AU2018306328 A AU 2018306328A AU 2018306328 B2 AU2018306328 B2 AU 2018306328B2
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alkyl
compound
nhs
cancer
pharmaceutically acceptable
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AU2018306328A1 (en
Inventor
Jingrong Jean Cui
Wei Deng
Zhongdong HUANG
Jing Liu
Evan W. ROGERS
Jane Ung
Jeffrey WHITTEN
Dayong Zhai
Han Zhang
Xin Zhang
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Turning Point Therapeutics Inc
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Turning Point Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
AU2018306328A 2017-07-28 2018-07-26 Macrocyclic compounds and uses thereof Active AU2018306328B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762538193P 2017-07-28 2017-07-28
US62/538,193 2017-07-28
US201862700990P 2018-07-20 2018-07-20
US62/700,990 2018-07-20
PCT/US2018/043817 WO2019023417A1 (en) 2017-07-28 2018-07-26 MACROCYCLIC COMPOUNDS AND USES THEREOF

Publications (2)

Publication Number Publication Date
AU2018306328A1 AU2018306328A1 (en) 2020-01-16
AU2018306328B2 true AU2018306328B2 (en) 2023-03-09

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AU2018306328A Active AU2018306328B2 (en) 2017-07-28 2018-07-26 Macrocyclic compounds and uses thereof

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EP (1) EP3658148B1 (enExample)
JP (2) JP7224334B2 (enExample)
KR (1) KR102645316B1 (enExample)
CN (1) CN111182903A (enExample)
AU (1) AU2018306328B2 (enExample)
BR (1) BR112020001695A2 (enExample)
CA (1) CA3069232A1 (enExample)
CL (1) CL2020000169A1 (enExample)
CO (1) CO2020000633A2 (enExample)
DK (1) DK3658148T3 (enExample)
ES (1) ES2986593T3 (enExample)
FI (1) FI3658148T3 (enExample)
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LT (1) LT3658148T (enExample)
MY (1) MY201925A (enExample)
PE (1) PE20200700A1 (enExample)
PH (1) PH12020500033A1 (enExample)
PL (1) PL3658148T3 (enExample)
PT (1) PT3658148T (enExample)
RS (1) RS65884B1 (enExample)
SA (1) SA520411108B1 (enExample)
SG (1) SG11202000356VA (enExample)
SI (1) SI3658148T1 (enExample)
SM (1) SMT202400343T1 (enExample)
TW (1) TWI818917B (enExample)
UA (1) UA126158C2 (enExample)
WO (1) WO2019023417A1 (enExample)

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SA520411108B1 (ar) 2024-03-03
US20220324879A1 (en) 2022-10-13
WO2019023417A1 (en) 2019-01-31
SI3658148T1 (sl) 2024-10-30
EP3658148A4 (en) 2021-04-28
DK3658148T3 (da) 2024-10-07
TW201920198A (zh) 2019-06-01
MY201925A (en) 2024-03-23
CN111182903A (zh) 2020-05-19
IL271964B2 (en) 2024-12-01
KR102645316B1 (ko) 2024-03-07
PL3658148T3 (pl) 2024-10-07
JP2020528907A (ja) 2020-10-01
US11981684B2 (en) 2024-05-14
US20210214373A1 (en) 2021-07-15
JP7224334B2 (ja) 2023-02-17
IL271964A (en) 2020-02-27
CA3069232A1 (en) 2019-01-31
CO2020000633A2 (es) 2020-01-31
PH12020500033A1 (en) 2020-09-28
TWI818917B (zh) 2023-10-21
US20240391935A1 (en) 2024-11-28
RS65884B1 (sr) 2024-09-30
SMT202400343T1 (it) 2024-11-15
EP3658148B1 (en) 2024-07-10
BR112020001695A2 (pt) 2020-07-21
LT3658148T (lt) 2024-09-10
US11155563B2 (en) 2021-10-26
UA126158C2 (uk) 2022-08-25
ES2986593T3 (es) 2024-11-12
FI3658148T3 (fi) 2024-09-20
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EP3658148A1 (en) 2020-06-03
IL271964B1 (en) 2024-08-01
HRP20241197T1 (hr) 2024-11-22
PE20200700A1 (es) 2020-06-23
AU2018306328A1 (en) 2020-01-16
KR20200034998A (ko) 2020-04-01
PT3658148T (pt) 2024-08-26
US20200157119A1 (en) 2020-05-21
US11286264B2 (en) 2022-03-29
JP7554300B2 (ja) 2024-09-19
JP2023065403A (ja) 2023-05-12
SG11202000356VA (en) 2020-02-27

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