AU2017367872B2 - Tau-protein targeting protacs and associated methods of use - Google Patents

Tau-protein targeting protacs and associated methods of use Download PDF

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AU2017367872B2
AU2017367872B2 AU2017367872A AU2017367872A AU2017367872B2 AU 2017367872 B2 AU2017367872 B2 AU 2017367872B2 AU 2017367872 A AU2017367872 A AU 2017367872A AU 2017367872 A AU2017367872 A AU 2017367872A AU 2017367872 B2 AU2017367872 B2 AU 2017367872B2
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AU2017367872A1 (en
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Michael Berlin
Andrew P. Crew
Hanqing Dong
John J. Flanagan
Alexey Ishchenko
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Arvinas Inc
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Arvinas Inc
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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AU2017367872A 2016-11-01 2017-11-01 Tau-protein targeting protacs and associated methods of use Active AU2017367872B2 (en)

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US201662415830P 2016-11-01 2016-11-01
US62/415,830 2016-11-01
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EP (1) EP3535265A4 (enExample)
JP (3) JP7286539B2 (enExample)
KR (2) KR102570992B1 (enExample)
CN (1) CN110234646B (enExample)
AU (2) AU2017367872B2 (enExample)
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CO (1) CO2019005712A2 (enExample)
IL (3) IL290809B2 (enExample)
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US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
US12312316B2 (en) 2015-01-20 2025-05-27 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
JP6817962B2 (ja) 2015-01-20 2021-01-20 アルビナス・オペレーションズ・インコーポレイテッドＡｒｖｉｎａｓ Ｏｐｅｒａｔｉｏｎｓ， Ｉｎｃ． ターゲティングされたアンドロゲン受容体分解のための化合物および方法
WO2016197114A1 (en) 2015-06-05 2016-12-08 Arvinas, Inc. Tank-binding kinase-1 protacs and associated methods of use
EP3319944A4 (en) 2015-07-10 2019-04-24 Arvinas, Inc. MDM2-BASED MODULATORS OF PROTEOLYSIS AND RELATED USE METHODS
EP3337476A4 (en) 2015-08-19 2019-09-04 Arvinas, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
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