AU2017317154B2 - Azole compound ophthalmic preparation - Google Patents

Azole compound ophthalmic preparation Download PDF

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Publication number
AU2017317154B2
AU2017317154B2 AU2017317154A AU2017317154A AU2017317154B2 AU 2017317154 B2 AU2017317154 B2 AU 2017317154B2 AU 2017317154 A AU2017317154 A AU 2017317154A AU 2017317154 A AU2017317154 A AU 2017317154A AU 2017317154 B2 AU2017317154 B2 AU 2017317154B2
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AU
Australia
Prior art keywords
pharmaceutically acceptable
cataract
ophthalmic preparation
compound
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2017317154A
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English (en)
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AU2017317154A1 (en
Inventor
Zeyidan JIAPAER
Qinyuan Zheng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotool LLC
Inhibio Bioscience Pte Ltd
Original Assignee
Biotool LLC
Inhibio Bioscience Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotool LLC, Inhibio Bioscience Pte Ltd filed Critical Biotool LLC
Publication of AU2017317154A1 publication Critical patent/AU2017317154A1/en
Application granted granted Critical
Publication of AU2017317154B2 publication Critical patent/AU2017317154B2/en
Assigned to ZHENG, QINYUAN, BIOTOOL, LLC, Inhibio Bioscience Pte. Ltd reassignment ZHENG, QINYUAN Request for Assignment Assignors: BIOTOOL, LLC, ZHENG, QINYUAN
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2017317154A 2016-08-24 2017-08-23 Azole compound ophthalmic preparation Ceased AU2017317154B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610717956.2A CN107397745A (zh) 2016-08-24 2016-08-24 唑类化合物眼用制剂
CN201610717956.2 2016-08-24
PCT/CN2017/098662 WO2018036523A1 (zh) 2016-08-24 2017-08-23 唑类化合物眼用制剂

Publications (2)

Publication Number Publication Date
AU2017317154A1 AU2017317154A1 (en) 2019-04-11
AU2017317154B2 true AU2017317154B2 (en) 2020-04-30

Family

ID=60389600

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2017317154A Ceased AU2017317154B2 (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation

Country Status (10)

Country Link
US (2) US20190192427A1 (enExample)
EP (1) EP3505170B1 (enExample)
JP (1) JP6890794B2 (enExample)
KR (1) KR20190052005A (enExample)
CN (2) CN107397745A (enExample)
AU (1) AU2017317154B2 (enExample)
CA (1) CA3034766A1 (enExample)
EA (1) EA201990550A1 (enExample)
SG (1) SG11201901617PA (enExample)
WO (1) WO2018036523A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109985071A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 桦褐孔菌提取物的新用途
WO2020047146A1 (en) * 2018-08-28 2020-03-05 Cloudbreak Therapeutics, Llc Emulsion formulations of multikinase inhibitors
MX2021009520A (es) * 2021-08-06 2023-02-07 Foodvica S A De C V Composicion oftalmica para el tratamiento de trastornos visuales.
CN115737654B (zh) * 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027302A (zh) * 2013-03-07 2014-09-10 中国医药工业研究总院 17α-乙炔基雄甾-5-烯-3β,7β,17β-三醇眼用制剂
WO2016029197A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat and/or prevent vision disorders of the lens of the eye

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02290815A (ja) * 1989-05-01 1990-11-30 Santen Pharmaceut Co Ltd 抗真菌点眼剤
AU4061599A (en) * 1998-06-10 1999-12-30 Wakamoto Pharmaceutical Co., Ltd. Aqueous preparations containing hardly soluble drug
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
CN100418536C (zh) * 2005-04-06 2008-09-17 河南省眼科研究所 一种用于眼科的抗真菌药物组合物
CN100418530C (zh) * 2005-04-06 2008-09-17 河南省眼科研究所 一种酮康唑滴眼液及其制造方法
US20070249546A1 (en) * 2006-04-22 2007-10-25 Sawaya Assad S Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them
EP2564853B1 (en) * 2007-12-04 2019-02-27 Santen SAS Compositions comprising corticosteroid prodrug such as dexamethasone palmitate for the treatment of eye disorders
CN101766628B (zh) * 2010-01-20 2012-07-04 广东宏盈科技有限公司 一种眼科外用抗细菌感染药物
CN101786993A (zh) * 2010-03-26 2010-07-28 复旦大学 1，2，3-三氮唑化合物及其在制备吲哚胺2，3-双加氧酶抑制剂中的用途
JP2015093869A (ja) * 2013-11-14 2015-05-18 国立大学法人東北大学 網膜保護薬剤、及び網膜疾患治療用徐放デバイス
CN103736093A (zh) * 2013-12-27 2014-04-23 于运红 一种包含咪唑斯汀及甾族化合物的药物制剂
EP3182977B1 (en) * 2014-08-22 2021-05-05 The Regents Of The University Of California Lanosterol for use in treating vision disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104027302A (zh) * 2013-03-07 2014-09-10 中国医药工业研究总院 17α-乙炔基雄甾-5-烯-3β,7β,17β-三醇眼用制剂
WO2016029197A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat and/or prevent vision disorders of the lens of the eye

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SOBOLEWSKA, B. et al., 'Cytotoxic Effect of Voriconazole on Human Corneal Epithelial Cells', Ophthalmic Res. 2015, vol. 54, pages 41-47 *
Zhao L, et al., 'Lanosterol Reverses Protein Aggregation in Cataracts', Nature, 2015, Vol. 523, pages 607-611 *

Also Published As

Publication number Publication date
CN109689049B (zh) 2021-04-27
US20210330586A1 (en) 2021-10-28
SG11201901617PA (en) 2019-03-28
EA201990550A1 (ru) 2019-11-29
JP6890794B2 (ja) 2021-06-18
CN107397745A (zh) 2017-11-28
WO2018036523A1 (zh) 2018-03-01
AU2017317154A1 (en) 2019-04-11
CA3034766A1 (en) 2018-03-01
CN109689049A (zh) 2019-04-26
US20190192427A1 (en) 2019-06-27
EP3505170A1 (en) 2019-07-03
JP2019532095A (ja) 2019-11-07
EP3505170A4 (en) 2020-04-29
KR20190052005A (ko) 2019-05-15
EP3505170B1 (en) 2021-08-11

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PC Assignment registered

Owner name: BIOTOOL, LLC

Free format text: FORMER OWNER(S): ZHENG, QINYUAN; BIOTOOL, LLC

Owner name: ZHENG, QINYUAN

Free format text: FORMER OWNER(S): ZHENG, QINYUAN; BIOTOOL, LLC

Owner name: INHIBIO BIOSCIENCE PTE. LTD

Free format text: FORMER OWNER(S): ZHENG, QINYUAN; BIOTOOL, LLC

MK14 Patent ceased section 143(a) (annual fees not paid) or expired