CN107397745A - 唑类化合物眼用制剂 - Google Patents

唑类化合物眼用制剂 Download PDF

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Publication number
CN107397745A
CN107397745A CN201610717956.2A CN201610717956A CN107397745A CN 107397745 A CN107397745 A CN 107397745A CN 201610717956 A CN201610717956 A CN 201610717956A CN 107397745 A CN107397745 A CN 107397745A
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CN
China
Prior art keywords
eye
drops preparations
drops
preparations
another preference
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610717956.2A
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English (en)
Chinese (zh)
Inventor
郑钦元
责祎旦·加帕尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Bi Aotu Biotechnology Co Ltd
Original Assignee
Shanghai Bi Aotu Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Bi Aotu Biotechnology Co Ltd filed Critical Shanghai Bi Aotu Biotechnology Co Ltd
Priority to CN201610717956.2A priority Critical patent/CN107397745A/zh
Priority to AU2017317154A priority patent/AU2017317154B2/en
Priority to PCT/CN2017/098662 priority patent/WO2018036523A1/zh
Priority to CN201780051907.2A priority patent/CN109689049B/zh
Priority to KR1020197008376A priority patent/KR20190052005A/ko
Priority to CA3034766A priority patent/CA3034766A1/en
Priority to JP2019531514A priority patent/JP6890794B2/ja
Priority to EP17842945.2A priority patent/EP3505170B1/en
Priority to EA201990550A priority patent/EA201990550A1/ru
Priority to SG11201901617PA priority patent/SG11201901617PA/en
Priority to US16/327,238 priority patent/US20190192427A1/en
Publication of CN107397745A publication Critical patent/CN107397745A/zh
Priority to US17/367,863 priority patent/US20210330586A1/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/4174Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201610717956.2A 2016-08-24 2016-08-24 唑类化合物眼用制剂 Pending CN107397745A (zh)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CN201610717956.2A CN107397745A (zh) 2016-08-24 2016-08-24 唑类化合物眼用制剂
CA3034766A CA3034766A1 (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation
PCT/CN2017/098662 WO2018036523A1 (zh) 2016-08-24 2017-08-23 唑类化合物眼用制剂
CN201780051907.2A CN109689049B (zh) 2016-08-24 2017-08-23 唑类化合物眼用制剂
KR1020197008376A KR20190052005A (ko) 2016-08-24 2017-08-23 아졸계 화합물 안구용 제제
AU2017317154A AU2017317154B2 (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation
JP2019531514A JP6890794B2 (ja) 2016-08-24 2017-08-23 アゾール系化合物の眼用製剤
EP17842945.2A EP3505170B1 (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation
EA201990550A EA201990550A1 (ru) 2016-08-24 2017-08-23 Офтальмологический препарат, включающий азоловое соединение
SG11201901617PA SG11201901617PA (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation
US16/327,238 US20190192427A1 (en) 2016-08-24 2017-08-23 Azole compound ophthalmic preparation
US17/367,863 US20210330586A1 (en) 2016-08-24 2021-07-06 Azole comopund ophthalmic preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610717956.2A CN107397745A (zh) 2016-08-24 2016-08-24 唑类化合物眼用制剂

Publications (1)

Publication Number Publication Date
CN107397745A true CN107397745A (zh) 2017-11-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
CN201610717956.2A Pending CN107397745A (zh) 2016-08-24 2016-08-24 唑类化合物眼用制剂
CN201780051907.2A Active CN109689049B (zh) 2016-08-24 2017-08-23 唑类化合物眼用制剂

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201780051907.2A Active CN109689049B (zh) 2016-08-24 2017-08-23 唑类化合物眼用制剂

Country Status (10)

Country Link
US (2) US20190192427A1 (enExample)
EP (1) EP3505170B1 (enExample)
JP (1) JP6890794B2 (enExample)
KR (1) KR20190052005A (enExample)
CN (2) CN107397745A (enExample)
AU (1) AU2017317154B2 (enExample)
CA (1) CA3034766A1 (enExample)
EA (1) EA201990550A1 (enExample)
SG (1) SG11201901617PA (enExample)
WO (1) WO2018036523A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109985071A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 桦褐孔菌提取物的新用途
US20210315815A1 (en) * 2018-08-28 2021-10-14 Cloudbreak Therapeutics, Llc Emulsion formulations of multikinase inhibitors

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021009520A (es) * 2021-08-06 2023-02-07 Foodvica S A De C V Composicion oftalmica para el tratamiento de trastornos visuales.
CN115737654B (zh) * 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1843358A (zh) * 2005-04-06 2006-10-11 河南省眼科研究所 一种酮康唑滴眼液及其制造方法
WO2016029199A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat vision disorders

Family Cites Families (12)

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JPH02290815A (ja) * 1989-05-01 1990-11-30 Santen Pharmaceut Co Ltd 抗真菌点眼剤
WO1999063968A1 (fr) * 1998-06-10 1999-12-16 Wakamoto Pharmaceutical Co., Ltd. Preparations aqueuses contenant des medicaments faiblement solubles
GB0122318D0 (en) * 2001-09-14 2001-11-07 Novartis Ag Organic compounds
CN100418536C (zh) * 2005-04-06 2008-09-17 河南省眼科研究所 一种用于眼科的抗真菌药物组合物
US20070249546A1 (en) * 2006-04-22 2007-10-25 Sawaya Assad S Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them
JP2011505409A (ja) * 2007-12-04 2011-02-24 ノバガリ ファーマ エスエー パルミチン酸デキサメタゾンのようなコルチコステロイドプロドラッグを含有する眼障害の治療用の組成物
CN101766628B (zh) * 2010-01-20 2012-07-04 广东宏盈科技有限公司 一种眼科外用抗细菌感染药物
CN101786993A (zh) * 2010-03-26 2010-07-28 复旦大学 1,2,3-三氮唑化合物及其在制备吲哚胺2,3-双加氧酶抑制剂中的用途
CN104027302B (zh) * 2013-03-07 2019-04-05 中国医药工业研究总院 17α-乙炔基雄甾-5-烯-3β,7β,17β-三醇眼用制剂
JP2015093869A (ja) * 2013-11-14 2015-05-18 国立大学法人東北大学 網膜保護薬剤、及び網膜疾患治療用徐放デバイス
CN103736093A (zh) * 2013-12-27 2014-04-23 于运红 一种包含咪唑斯汀及甾族化合物的药物制剂
WO2016029197A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat and/or prevent vision disorders of the lens of the eye

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1843358A (zh) * 2005-04-06 2006-10-11 河南省眼科研究所 一种酮康唑滴眼液及其制造方法
WO2016029199A1 (en) * 2014-08-22 2016-02-25 Kang Zhang Compositions and methods to treat vision disorders

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109985071A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 桦褐孔菌提取物的新用途
US20210315815A1 (en) * 2018-08-28 2021-10-14 Cloudbreak Therapeutics, Llc Emulsion formulations of multikinase inhibitors

Also Published As

Publication number Publication date
SG11201901617PA (en) 2019-03-28
JP2019532095A (ja) 2019-11-07
CN109689049A (zh) 2019-04-26
US20190192427A1 (en) 2019-06-27
AU2017317154A1 (en) 2019-04-11
AU2017317154B2 (en) 2020-04-30
EP3505170B1 (en) 2021-08-11
US20210330586A1 (en) 2021-10-28
EA201990550A1 (ru) 2019-11-29
CN109689049B (zh) 2021-04-27
CA3034766A1 (en) 2018-03-01
EP3505170A1 (en) 2019-07-03
WO2018036523A1 (zh) 2018-03-01
EP3505170A4 (en) 2020-04-29
JP6890794B2 (ja) 2021-06-18
KR20190052005A (ko) 2019-05-15

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Application publication date: 20171128