AU2016342045A1 - Human cytomegalovirus vaccine - Google Patents

Info

Publication number

AU2016342045A1

AU2016342045A1 AU2016342045A AU2016342045A AU2016342045A1 AU 2016342045 A1 AU2016342045 A1 AU 2016342045A1 AU 2016342045 A AU2016342045 A AU 2016342045A AU 2016342045 A AU2016342045 A AU 2016342045A AU 2016342045 A1 AU2016342045 A1 AU 2016342045A1

Authority

AU

Australia

Prior art keywords

hcmv

vaccine

subject

group

alkyl

Prior art date

2015-10-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• Discuss

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• 229960005486 vaccine Drugs 0.000 title claims abstract description 217
• 238000000034 method Methods 0.000 claims abstract description 84
• 239000000203 mixture Substances 0.000 claims abstract description 17
• 230000000890 antigenic effect Effects 0.000 claims description 290
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 277
• 229920001184 polypeptide Polymers 0.000 claims description 274
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 274
• 108091033319 polynucleotide Proteins 0.000 claims description 232
• 102000040430 polynucleotide Human genes 0.000 claims description 232
• 239000002157 polynucleotide Substances 0.000 claims description 232
• 229940023143 protein vaccine Drugs 0.000 claims description 80
• 108020004999 messenger RNA Proteins 0.000 claims description 78
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• 102000036639 antigens Human genes 0.000 claims description 51
• 108091007433 antigens Proteins 0.000 claims description 51
• 108020004414 DNA Proteins 0.000 claims description 43
• 230000002238 attenuated effect Effects 0.000 claims description 43
• 230000009467 reduction Effects 0.000 claims description 37
• 230000028993 immune response Effects 0.000 claims description 36
• 101150088904 UL130 gene Proteins 0.000 claims description 35
• -1 cationic lipid Chemical class 0.000 claims description 35
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• 238000007385 chemical modification Methods 0.000 claims description 31
• 101100315698 Human cytomegalovirus (strain Merlin) UL131A gene Proteins 0.000 claims description 27
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• ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 18
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• HOCJTJWYMOSXMU-XUTVFYLZSA-N 4-Methoxypseudouridine Chemical compound COC1=C(C=NC(=O)N1)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O HOCJTJWYMOSXMU-XUTVFYLZSA-N 0.000 claims description 3
• DDHOXEOVAJVODV-GBNDHIKLSA-N 5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidene-1h-pyrimidin-4-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=S)NC1=O DDHOXEOVAJVODV-GBNDHIKLSA-N 0.000 claims description 3
• BNAWMJKJLNJZFU-GBNDHIKLSA-N 5-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidene-1h-pyrimidin-2-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=S BNAWMJKJLNJZFU-GBNDHIKLSA-N 0.000 claims description 3
• ZXIATBNUWJBBGT-JXOAFFINSA-N 5-methoxyuridine Chemical compound O=C1NC(=O)C(OC)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 ZXIATBNUWJBBGT-JXOAFFINSA-N 0.000 claims description 3
• YKWUPFSEFXSGRT-JWMKEVCDSA-N Dihydropseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1C(=O)NC(=O)NC1 YKWUPFSEFXSGRT-JWMKEVCDSA-N 0.000 claims description 3
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• 239000003814 drug Substances 0.000 claims description 3
• PTJWIQPHWPFNBW-GBNDHIKLSA-N pseudouridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1C1=CNC(=O)NC1=O PTJWIQPHWPFNBW-GBNDHIKLSA-N 0.000 claims description 3
• DGNMJYUPWDTKJB-ZDSKVHJSSA-N bis[(z)-non-2-enyl] 9-[4-(dimethylamino)butanoyloxy]heptadecanedioate Chemical compound CCCCCC\C=C/COC(=O)CCCCCCCC(OC(=O)CCCN(C)C)CCCCCCCC(=O)OC\C=C/CCCCCC DGNMJYUPWDTKJB-ZDSKVHJSSA-N 0.000 claims description 2
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• 241000880493 Leptailurus serval Species 0.000 claims 31
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• PMGDADKJMCOXHX-UHFFFAOYSA-N L-Arginyl-L-glutamin-acetat Natural products NC(=N)NCCCC(N)C(=O)NC(CCC(N)=O)C(O)=O PMGDADKJMCOXHX-UHFFFAOYSA-N 0.000 claims 19
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• 108010049041 glutamylalanine Proteins 0.000 claims 13
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• 125000006592 (C2-C3) alkenyl group Chemical group 0.000 claims 12
• XVZCXCTYGHPNEM-UHFFFAOYSA-N Leu-Leu-Pro Natural products CC(C)CC(N)C(=O)NC(CC(C)C)C(=O)N1CCCC1C(O)=O XVZCXCTYGHPNEM-UHFFFAOYSA-N 0.000 claims 12
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• AKJRHDMTEJXTPV-ACZMJKKPSA-N Glu-Asn-Ala Chemical compound C[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CCC(O)=O)C(O)=O AKJRHDMTEJXTPV-ACZMJKKPSA-N 0.000 claims 2
• VAZZOGXDUQSVQF-NUMRIWBASA-N Glu-Asn-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)N)O VAZZOGXDUQSVQF-NUMRIWBASA-N 0.000 claims 2
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• JVSBYEDSSRZQGV-GUBZILKMSA-N Glu-Asp-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCC(O)=O JVSBYEDSSRZQGV-GUBZILKMSA-N 0.000 claims 2
• PAQUJCSYVIBPLC-AVGNSLFASA-N Glu-Asp-Phe Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PAQUJCSYVIBPLC-AVGNSLFASA-N 0.000 claims 2
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