AU2016323447B2 - Anti-pro/latent-Myostatin antibodies and uses thereof - Google Patents
Anti-pro/latent-Myostatin antibodies and uses thereof Download PDFInfo
- Publication number
- AU2016323447B2 AU2016323447B2 AU2016323447A AU2016323447A AU2016323447B2 AU 2016323447 B2 AU2016323447 B2 AU 2016323447B2 AU 2016323447 A AU2016323447 A AU 2016323447A AU 2016323447 A AU2016323447 A AU 2016323447A AU 2016323447 B2 AU2016323447 B2 AU 2016323447B2
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- antibody
- myostatin
- antigen
- latent
- seq
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2023203922A AU2023203922A1 (en) | 2015-09-15 | 2023-06-21 | Anti-pro/latent-Myostatin antibodies and uses thereof |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562219094P | 2015-09-15 | 2015-09-15 | |
| US62/219,094 | 2015-09-15 | ||
| PCT/US2016/052014 WO2017049011A1 (en) | 2015-09-15 | 2016-09-15 | Anti-pro/latent-myostatin antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023203922A Division AU2023203922A1 (en) | 2015-09-15 | 2023-06-21 | Anti-pro/latent-Myostatin antibodies and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2016323447A1 AU2016323447A1 (en) | 2018-04-12 |
| AU2016323447B2 true AU2016323447B2 (en) | 2023-03-30 |
Family
ID=57043000
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2016323447A Active AU2016323447B2 (en) | 2015-09-15 | 2016-09-15 | Anti-pro/latent-Myostatin antibodies and uses thereof |
| AU2023203922A Pending AU2023203922A1 (en) | 2015-09-15 | 2023-06-21 | Anti-pro/latent-Myostatin antibodies and uses thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2023203922A Pending AU2023203922A1 (en) | 2015-09-15 | 2023-06-21 | Anti-pro/latent-Myostatin antibodies and uses thereof |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US10751413B2 (enExample) |
| EP (3) | EP3922645B1 (enExample) |
| JP (2) | JP7107836B2 (enExample) |
| KR (3) | KR20250033313A (enExample) |
| CN (4) | CN113896789A (enExample) |
| AU (2) | AU2016323447B2 (enExample) |
| BR (1) | BR112018004981A2 (enExample) |
| CA (1) | CA3036652A1 (enExample) |
| CO (1) | CO2018002703A2 (enExample) |
| CY (1) | CY1124619T1 (enExample) |
| DK (2) | DK3922645T3 (enExample) |
| EA (1) | EA038146B1 (enExample) |
| ES (2) | ES2881642T3 (enExample) |
| FI (1) | FI3922645T3 (enExample) |
| HR (2) | HRP20211081T1 (enExample) |
| HU (2) | HUE055331T2 (enExample) |
| IL (2) | IL305148A (enExample) |
| LT (2) | LT3922645T (enExample) |
| MX (5) | MX2018003196A (enExample) |
| PL (2) | PL3350220T3 (enExample) |
| PT (2) | PT3350220T (enExample) |
| RS (2) | RS62330B1 (enExample) |
| SI (2) | SI3922645T1 (enExample) |
| SM (2) | SMT202100432T1 (enExample) |
| WO (1) | WO2017049011A1 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PT2708559T (pt) | 2008-04-11 | 2018-05-16 | Chugai Pharmaceutical Co Ltd | Molรฉcula de ligaรงรฃo ao antigรฉnio capaz de se ligar repetidamente a duas ou mais molรฉculas de antigรฉnio |
| MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molรฉcula de uniรณn a antรญgeno capaz de unir repetidamente a la pluralidad de molรฉculas de antรญgeno. |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | ไธญๅค่ฃฝ่ฌๆ ชๅผไผ็คพ | ใใฆในFcฮณRII็น็ฐ็Fcๆไฝ |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | ๆฅๅไธญๅค่ฃฝ่ฅ่กไปฝๆ้ๅ ฌๅธ | FcฮณRIIb็น็ฐๆงFcๅๅ่ฎ็ฐ้ซ |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| JP6706617B2 (ja) | 2014-11-06 | 2020-06-10 | ในใซใฉใผ ใญใใฏ ใคใณใณใผใใฌใคใใใ๏ผณ๏ฝ๏ฝ๏ฝ๏ฝ๏ฝ๏ฝ ๏ผฒ๏ฝ๏ฝ๏ฝ๏ผ๏ผฉ๏ฝ๏ฝ๏ผ | ๆใใญ๏ผๆฝๅจๅโใใชในใฟใใณๆไฝใใใณใใฎไฝฟ็จ |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| SG11201706014PA (en) | 2015-02-05 | 2017-08-30 | Chugai Pharmaceutical Co Ltd | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| RS62330B1 (sr) | 2015-09-15 | 2021-10-29 | Scholar Rock Inc | Antitela pro/latentnog miostatina i njihova upotreba |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | ไธญๅค่ฃฝ่ฌๆ ชๅผไผ็คพ | ๆใใชในใฟใใณๆไฝใใใณไฝฟ็จๆนๆณ |
| US10287345B2 (en) | 2016-01-08 | 2019-05-14 | Scholar Rock, Inc. | Methods for inhibiting myostatin activation by administering anti-pro/latent myostatin antibodies |
| KR20210082548A (ko) | 2016-06-13 | 2021-07-05 | ์ค์นผ๋ฌ ๋ฝ, ์ธํฌ. | ๋ฏธ์ค์คํํด ์ต์ ์ ์ ์ฉ๋ ๋ฐ ์กฐํฉ ์๋ฒ |
| KR102538749B1 (ko) | 2016-08-05 | 2023-06-01 | ์ถ๊ฐ์ด ์ธ์ด์ผ์ฟ ๊ฐ๋ถ์ํค๊ฐ์ด์ค | Il-8 ๊ด๋ จ ์งํ์ ์น๋ฃ์ฉ ๋๋ ์๋ฐฉ์ฉ ์กฐ์ฑ๋ฌผ |
| PT3565592T (pt) * | 2017-01-06 | 2023-05-31 | Scholar Rock Inc | Tratamento de doenรงas metabรณlicas atravรฉs da inibiรงรฃo da ativaรงรฃo da miostatina |
| SI3565592T1 (sl) * | 2017-01-06 | 2023-05-31 | Scholar Rock, Inc. | Zdravljenje presnovnih bolezni z zaviranjem aktivacije miostatina |
| PT3677278T (pt) | 2018-07-11 | 2022-02-03 | Scholar Rock Inc | Inibidores seletivos da isoforma tgfbeta1 e sua utilizaรงรฃo |
| JP7540994B2 (ja) | 2018-07-11 | 2024-08-27 | ในใซใฉใผ ใญใใฏ ใคใณใณใผใใฌใคใใใ | ้ซ่ฆชๅๆงใฎใขใคใฝใใฉใผใ ้ธๆ็๏ผด๏ผง๏ผฆฮฒ๏ผ้ปๅฎณๅคใใใใณใใฎไฝฟ็จ |
| EA202192130A1 (ru) * | 2019-01-30 | 2021-12-28 | ะกะบะพะปะฐั ะ ะพะบ, ะะฝะบ. | ะกะฟะตัะธัะธัะฝัะต ะบ ltbp-ะบะพะผะฟะปะตะบัั ะธะฝะณะธะฑะธัะพัั tgf ะธ ะธั ะฟัะธะผะตะฝะตะฝะธะต |
| CN110429214B (zh) | 2019-08-07 | 2021-12-07 | ๅฎๅพทๆถไปฃๆฐ่ฝๆบ็งๆ่กไปฝๆ้ๅ ฌๅธ | ไบๆฌก็ตๆฑ ็็็ปไปถๅไบๆฌก็ตๆฑ |
| SG11202009970VA (en) * | 2019-08-28 | 2021-04-29 | Chugai Pharmaceutical Co Ltd | Cross-Species Anti-Latent TGF-Beta 1 Antibodies And Methods Of Use |
| JP2023511255A (ja) | 2020-01-11 | 2023-03-17 | ในใซใฉใผ ใญใใฏ ใคใณใณใผใใฌใคใใใ | ๏ผด๏ผง๏ผฆ๏ผฮฒ้ปๅฎณๅคๅใณใใฎไฝฟ็จ |
| RU2750267C1 (ru) * | 2020-02-07 | 2021-06-25 | ะะฑัะตััะฒะพ ั ะพะณัะฐะฝะธัะตะฝะฝะพะน ะพัะฒะตัััะฒะตะฝะฝะพัััั ยซะะะฃะงะะ-ะะ ะะะะะะะกะขะะะะะะ ะะะชะะะะะะะะ ะะ-ะะะขยป | ะ ะตะบะพะผะฑะธะฝะฐะฝัะฝัะน ัะพััะพะฒะพะน ะดะธััะตัะตะฝัะธัะพะฒะพัะฝัะน ัะฐะบัะพั ัะพััะฐ 11 (GDF11), ัะฟะพัะพะฑ ะตะณะพ ะฟะพะปััะตะฝะธั, ะธะฝัะตะบัะธะพะฝะฝัะน ะฟัะตะฟะฐัะฐั ะดะปั ะฟะพะฒััะตะฝะธั ะผััะตัะฝะพะน ะผะฐััั ะผะปะตะบะพะฟะธัะฐััะธั ะถะธะฒะพัะฝัั ะธ ะฟัะธัั, ะฐ ัะฐะบะถะต ัะฟะพัะพะฑ ะธัะฟะพะปัะทะพะฒะฐะฝะธั ะฟัะตะฟะฐัะฐัะฐ |
| EP4232151B1 (en) | 2020-10-26 | 2025-10-22 | Scholar Rock, Inc. | Use of anti-pro/latent myostatin antibody for treating spinal muscular atrophy |
| WO2022204581A2 (en) | 2021-03-26 | 2022-09-29 | Scholar Rock, Inc. | Tgf-beta inhibitors and use thereof |
| WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
| WO2022271867A1 (en) | 2021-06-23 | 2022-12-29 | Scholar Rock, Inc. | A myostatin pathway inhibitor in combination with a glp-1 pathway activator for use in treating metabolic disorders |
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| KR102836354B1 (ko) * | 2021-11-25 | 2025-07-22 | (์ฃผ)๋ค์คํฌ๋ ๋ง | ๊ทผ์์ธํฌ์ ์ฆ์๊ณผ ๊ทผ์ก์ธํฌ๋ก์ ๋ถํ๋ฅผ ์ด์งํ๋ ์ ๊ท ํฉํฐ๋ ๋ฐ ์ด์ ์ฉ๋ |
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