AU2015204558B2 - Aerosol pirfenidone and pyridone analog compounds and uses thereof - Google Patents

Aerosol pirfenidone and pyridone analog compounds and uses thereof Download PDF

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Publication number
AU2015204558B2
AU2015204558B2 AU2015204558A AU2015204558A AU2015204558B2 AU 2015204558 B2 AU2015204558 B2 AU 2015204558B2 AU 2015204558 A AU2015204558 A AU 2015204558A AU 2015204558 A AU2015204558 A AU 2015204558A AU 2015204558 B2 AU2015204558 B2 AU 2015204558B2
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AU
Australia
Prior art keywords
pirfenidone
pyridone analog
aqueous solution
dose
lung
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AU2015204558A
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AU2015204558A1 (en
Inventor
Mark William Surber
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Avalyn Pharma Inc
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Avalyn Pharma Inc
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Publication of AU2015204558A1 publication Critical patent/AU2015204558A1/en
Assigned to AVALYN PHARMA INC. reassignment AVALYN PHARMA INC. Alteration of Name(s) of Applicant(s) under S113 Assignors: GENOA PHARMACEUTICALS INC.
Application granted granted Critical
Publication of AU2015204558B2 publication Critical patent/AU2015204558B2/en
Priority to AU2020210246A priority Critical patent/AU2020210246A1/en
Priority to AU2022202932A priority patent/AU2022202932B2/en
Priority to AU2023251480A priority patent/AU2023251480B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/005—Sprayers or atomisers specially adapted for therapeutic purposes using ultrasonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2015204558A 2014-01-10 2015-01-09 Aerosol pirfenidone and pyridone analog compounds and uses thereof Active AU2015204558B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020210246A AU2020210246A1 (en) 2014-01-10 2020-07-30 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2022202932A AU2022202932B2 (en) 2014-01-10 2022-05-03 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2023251480A AU2023251480B2 (en) 2014-01-10 2023-10-19 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201461925791P 2014-01-10 2014-01-10
US61/925,791 2014-01-10
US201461951686P 2014-03-12 2014-03-12
US61/951,686 2014-03-12
US201461977529P 2014-04-09 2014-04-09
US61/977,529 2014-04-09
US201462000473P 2014-05-19 2014-05-19
US62/000,473 2014-05-19
PCT/US2015/010890 WO2015106150A1 (en) 2014-01-10 2015-01-09 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020210246A Division AU2020210246A1 (en) 2014-01-10 2020-07-30 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Publications (2)

Publication Number Publication Date
AU2015204558A1 AU2015204558A1 (en) 2016-08-25
AU2015204558B2 true AU2015204558B2 (en) 2020-04-30

Family

ID=53520401

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2015204558A Active AU2015204558B2 (en) 2014-01-10 2015-01-09 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2020210246A Abandoned AU2020210246A1 (en) 2014-01-10 2020-07-30 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2022202932A Active AU2022202932B2 (en) 2014-01-10 2022-05-03 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2023251480A Active AU2023251480B2 (en) 2014-01-10 2023-10-19 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2020210246A Abandoned AU2020210246A1 (en) 2014-01-10 2020-07-30 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2022202932A Active AU2022202932B2 (en) 2014-01-10 2022-05-03 Aerosol pirfenidone and pyridone analog compounds and uses thereof
AU2023251480A Active AU2023251480B2 (en) 2014-01-10 2023-10-19 Aerosol pirfenidone and pyridone analog compounds and uses thereof

Country Status (7)

Country Link
US (6) US9770443B2 (enExample)
EP (2) EP4491180A1 (enExample)
JP (4) JP7066321B2 (enExample)
AU (4) AU2015204558B2 (enExample)
CA (1) CA2936330C (enExample)
NZ (2) NZ760541A (enExample)
WO (1) WO2015106150A1 (enExample)

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