AU2013311573B2 - Methods of treating Alzheimer's disease and pharmaceutical compositions thereof - Google Patents

Methods of treating Alzheimer's disease and pharmaceutical compositions thereof Download PDF

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Publication number
AU2013311573B2
AU2013311573B2 AU2013311573A AU2013311573A AU2013311573B2 AU 2013311573 B2 AU2013311573 B2 AU 2013311573B2 AU 2013311573 A AU2013311573 A AU 2013311573A AU 2013311573 A AU2013311573 A AU 2013311573A AU 2013311573 B2 AU2013311573 B2 AU 2013311573B2
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AU
Australia
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dose
indol
ethyl
compound
benzylamine
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AU2013311573A
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AU2013311573A8 (en
AU2013311573A1 (en
Inventor
Johan AREBERG
Ellen Schmidt
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H Lundbeck AS
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H Lundbeck AS
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Publication of AU2013311573A8 publication Critical patent/AU2013311573A8/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013311573A 2012-09-09 2013-09-06 Methods of treating Alzheimer's disease and pharmaceutical compositions thereof Active AU2013311573B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261698664P 2012-09-09 2012-09-09
US61/698,664 2012-09-09
US201361782084P 2013-03-14 2013-03-14
US61/782,084 2013-03-14
PCT/EP2013/068516 WO2014037532A1 (en) 2012-09-09 2013-09-06 Methods of treating alzheimer's disease and pharmaceutical compositions thereof

Publications (3)

Publication Number Publication Date
AU2013311573A1 AU2013311573A1 (en) 2015-03-12
AU2013311573A8 AU2013311573A8 (en) 2015-03-19
AU2013311573B2 true AU2013311573B2 (en) 2017-10-12

Family

ID=49118521

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013311573A Active AU2013311573B2 (en) 2012-09-09 2013-09-06 Methods of treating Alzheimer's disease and pharmaceutical compositions thereof

Country Status (33)

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US (4) US9375418B2 (OSRAM)
EP (1) EP2892563B1 (OSRAM)
JP (2) JP6693744B2 (OSRAM)
KR (2) KR102342127B1 (OSRAM)
CN (1) CN104619344A (OSRAM)
AP (1) AP2015008306A0 (OSRAM)
AU (1) AU2013311573B2 (OSRAM)
BR (1) BR112015005117B1 (OSRAM)
CA (1) CA2883751C (OSRAM)
CL (1) CL2015000578A1 (OSRAM)
CY (1) CY1121062T1 (OSRAM)
DK (1) DK2892563T3 (OSRAM)
EA (1) EA030448B1 (OSRAM)
ES (1) ES2703630T3 (OSRAM)
GE (1) GEP201706776B (OSRAM)
HR (1) HRP20182069T1 (OSRAM)
IL (1) IL237369B (OSRAM)
JO (1) JO3459B1 (OSRAM)
LT (1) LT2892563T (OSRAM)
MX (1) MX368305B (OSRAM)
MY (1) MY182539A (OSRAM)
NI (1) NI201500031A (OSRAM)
NZ (1) NZ630589A (OSRAM)
PL (1) PL2892563T3 (OSRAM)
PT (1) PT2892563T (OSRAM)
RS (1) RS58104B1 (OSRAM)
RU (1) RU2675786C2 (OSRAM)
SG (1) SG11201501774QA (OSRAM)
SI (1) SI2892563T1 (OSRAM)
SM (1) SMT201800678T1 (OSRAM)
TN (1) TN2015000076A1 (OSRAM)
TW (1) TWI632909B (OSRAM)
WO (1) WO2014037532A1 (OSRAM)

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WO2009123714A2 (en) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor
US9126946B2 (en) 2008-10-28 2015-09-08 Arena Pharmaceuticals, Inc. Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
JO3459B1 (ar) * 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
WO2014152537A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
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TWI599567B (zh) 2013-03-14 2017-09-21 健生藥品公司 Ｐ２ｘ７調節劑
KR102295740B1 (ko) 2013-03-14 2021-09-01 베링거 인겔하임 인터내셔날 게엠베하 카텝신 c의 억제제로서 치환된 2-아자-바이사이클로[2.2.1]헵탄-3-카복실산(벤질-시아노-메틸)-아미드
TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
JO3639B1 (ar) * 2014-07-04 2020-08-27 H Lundbeck As صورة متعددة الشكل جديدة لـ n-[2-(6-فلورو-1h-إندول-3-يل)إيثيل]-3-(2،2،3،3-تترا فلورو بروبوكسي)بنزيل أمين هيدروكلوريد
AU2015315687B2 (en) 2014-09-12 2019-07-11 Janssen Pharmaceutica Nv P2X7 modulators
BR112017003433B1 (pt) 2014-09-12 2023-11-14 Boehringer Ingelheim International Gmbh Inibidores espirocíclicos de catepsina c, composição farmacêutica e uso dos mesmos
AU2015315693B2 (en) 2014-09-12 2020-01-16 Janssen Pharmaceutica Nv P2X7 modulating n-acyl-triazolopyrazines
CN105175307A (zh) * 2014-11-18 2015-12-23 苏州晶云药物科技有限公司 Lu AE58054的盐酸盐晶型A及其制备方法和用途
EP3291816A4 (en) * 2015-05-07 2019-01-02 Axovant Sciences GmbH Compositions and methods of treating a neurodegenerative disease
AU2016276966A1 (en) 2015-06-12 2018-01-18 Axovant Sciences Gmbh Diaryl and arylheteroaryl urea derivatives useful for the prophylaxis and treatment of REM sleep behavior disorder
EP3322415A4 (en) 2015-07-15 2019-03-13 Axovant Sciences GmbH DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR FOR PROPHYLAXIS AND TREATMENT OF HALLUCINATIONS RELATED TO A NEUROGENERATIVE DISEASE
AU2017256623B2 (en) * 2016-04-26 2022-07-21 H. Lundbeck A/S Use of an acetylcholinesterase inhibitor and idalopirdine for reducing falls in Parkinson's disease patients
US10864191B2 (en) 2016-05-11 2020-12-15 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity
CN114642667A (zh) 2016-05-18 2022-06-21 苏文生命科学有限公司 纯5-ht6受体拮抗剂与乙酰胆碱酯酶抑制剂的组合
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN107118146B (zh) * 2017-04-13 2019-09-03 宁波大学 一种6-溴色胺衍生物及其制备方法和用途
MX385719B (es) 2017-05-24 2025-03-18 H Lundbeck As Combinacion de un antagonista del receptor 5-ht6 y un inhibidor de acetilcolinesterasa para su uso en el tratamiento de la enfermedad de alzheimer en una subpoblacion de pacientes portadores de alelos apoe4
AU2019350624B2 (en) 2018-09-28 2025-07-24 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
WO2020065614A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
CN114555596B (zh) 2019-09-30 2025-02-25 詹森药业有限公司 放射性标记的mgl pet配体
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease
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EP3960174B1 (en) 2020-08-28 2024-10-30 Westfälische Wilhelms-Universität Münster Parasympathetic active phenyl-glycosid-substituted hydroxy-methyl-piperidine and -pyrrolidine alkaloids for medicinal use
CN121013715A (zh) * 2024-03-22 2025-11-25 艾瑞克·奎因 镁和利多卡因组合物

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SG11201501774QA (en) 2015-05-28
SMT201800678T1 (it) 2019-02-28
BR112015005117B1 (pt) 2022-06-21
MX2015002879A (es) 2015-07-06
EA030448B1 (ru) 2018-08-31
CY1121062T1 (el) 2019-12-11
JP6693744B2 (ja) 2020-05-13
PT2892563T (pt) 2019-01-10
US20160256437A1 (en) 2016-09-08
RS58104B1 (sr) 2019-02-28
JO3459B1 (ar) 2020-07-05
EA201590353A1 (ru) 2016-03-31
ES2703630T3 (es) 2019-03-11
KR20150065680A (ko) 2015-06-15
WO2014037532A1 (en) 2014-03-13
EP2892563A1 (en) 2015-07-15
AU2013311573A8 (en) 2015-03-19
AU2013311573A1 (en) 2015-03-12
IL237369B (en) 2018-11-29
TN2015000076A1 (en) 2016-06-29
SI2892563T1 (sl) 2019-02-28
US20160354343A1 (en) 2016-12-08
DK2892563T3 (en) 2019-01-21
JP2015528471A (ja) 2015-09-28
LT2892563T (lt) 2019-01-10
US9375418B2 (en) 2016-06-28
KR20200137028A (ko) 2020-12-08
IL237369A0 (en) 2015-04-30
CA2883751A1 (en) 2014-03-13
US20140073681A1 (en) 2014-03-13
NZ630589A (en) 2015-12-24
HRP20182069T1 (hr) 2019-02-08
TW201414474A (zh) 2014-04-16
RU2015107877A (ru) 2016-10-27
CA2883751C (en) 2020-11-24
CN104619344A (zh) 2015-05-13
US9687473B2 (en) 2017-06-27
KR102342127B1 (ko) 2021-12-21
TWI632909B (zh) 2018-08-21
GEP201706776B (en) 2017-11-27
CL2015000578A1 (es) 2015-05-15
US10660878B2 (en) 2020-05-26
BR112015005117A2 (pt) 2017-07-04
RU2675786C2 (ru) 2018-12-25
HK1212217A1 (en) 2016-06-10
PL2892563T3 (pl) 2019-04-30
NI201500031A (es) 2016-02-15
EP2892563B1 (en) 2018-11-14
US9789085B2 (en) 2017-10-17
MY182539A (en) 2021-01-25
MX368305B (es) 2019-09-27
AP2015008306A0 (en) 2015-03-31
US20180071254A1 (en) 2018-03-15
JP2019059760A (ja) 2019-04-18

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Free format text: IN VOL 29 , NO 9 , PAGE(S) 1439 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME H. LUNDBECK A/S, APPLICATION NO. 2013311573, UNDER INID (54) CORRECT THE TITLE TO READ METHODS OF TREATING ALZHEIMER'S DISEASE AND PHARMACEUTICAL COMPOSITIONS THEREOF

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