EA030448B1 - Способы лечения болезни альцгеймера и фармацевтические композиции - Google Patents

Способы лечения болезни альцгеймера и фармацевтические композиции Download PDF

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Publication number
EA030448B1
EA030448B1 EA201590353A EA201590353A EA030448B1 EA 030448 B1 EA030448 B1 EA 030448B1 EA 201590353 A EA201590353 A EA 201590353A EA 201590353 A EA201590353 A EA 201590353A EA 030448 B1 EA030448 B1 EA 030448B1
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EA
Eurasian Patent Office
Prior art keywords
dose
compound
occupation
administered
disease
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EA201590353A
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English (en)
Russian (ru)
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EA201590353A1 (ru
Inventor
Эллен Шмидт
Джохан Ареберг
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Х. Лундбекк А/С
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49118521&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA030448(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA201590353A1 publication Critical patent/EA201590353A1/ru
Publication of EA030448B1 publication Critical patent/EA030448B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EA201590353A 2012-09-09 2013-09-06 Способы лечения болезни альцгеймера и фармацевтические композиции EA030448B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261698664P 2012-09-09 2012-09-09
US201361782084P 2013-03-14 2013-03-14
PCT/EP2013/068516 WO2014037532A1 (en) 2012-09-09 2013-09-06 Methods of treating alzheimer's disease and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EA201590353A1 EA201590353A1 (ru) 2016-03-31
EA030448B1 true EA030448B1 (ru) 2018-08-31

Family

ID=49118521

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590353A EA030448B1 (ru) 2012-09-09 2013-09-06 Способы лечения болезни альцгеймера и фармацевтические композиции

Country Status (33)

Country Link
US (4) US9375418B2 (OSRAM)
EP (1) EP2892563B1 (OSRAM)
JP (2) JP6693744B2 (OSRAM)
KR (2) KR102342127B1 (OSRAM)
CN (1) CN104619344A (OSRAM)
AP (1) AP2015008306A0 (OSRAM)
AU (1) AU2013311573B2 (OSRAM)
BR (1) BR112015005117B1 (OSRAM)
CA (1) CA2883751C (OSRAM)
CL (1) CL2015000578A1 (OSRAM)
CY (1) CY1121062T1 (OSRAM)
DK (1) DK2892563T3 (OSRAM)
EA (1) EA030448B1 (OSRAM)
ES (1) ES2703630T3 (OSRAM)
GE (1) GEP201706776B (OSRAM)
HR (1) HRP20182069T1 (OSRAM)
IL (1) IL237369B (OSRAM)
JO (1) JO3459B1 (OSRAM)
LT (1) LT2892563T (OSRAM)
MX (1) MX368305B (OSRAM)
MY (1) MY182539A (OSRAM)
NI (1) NI201500031A (OSRAM)
NZ (1) NZ630589A (OSRAM)
PL (1) PL2892563T3 (OSRAM)
PT (1) PT2892563T (OSRAM)
RS (1) RS58104B1 (OSRAM)
RU (1) RU2675786C2 (OSRAM)
SG (1) SG11201501774QA (OSRAM)
SI (1) SI2892563T1 (OSRAM)
SM (1) SMT201800678T1 (OSRAM)
TN (1) TN2015000076A1 (OSRAM)
TW (1) TWI632909B (OSRAM)
WO (1) WO2014037532A1 (OSRAM)

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JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
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DK3448430T3 (da) * 2016-04-26 2023-07-03 H Lundbeck As Anvendelse af en acetylcholinesterase-inhibitor og idalopirdin til reduktion af fald hos patienter med parkinsons sygdom
US10864191B2 (en) 2016-05-11 2020-12-15 H. Lundbeck A/S 5-HT6 receptor antagonists for use in the treatment of Alzheimer's disease with apathy as comorbidity
CN114642667A (zh) 2016-05-18 2022-06-21 苏文生命科学有限公司 纯5-ht6受体拮抗剂与乙酰胆碱酯酶抑制剂的组合
CN106309436A (zh) * 2016-07-25 2017-01-11 宁波大学 可用作乙酰胆碱酯酶抑制剂的色胺衍生物及其用途
CN107118146B (zh) * 2017-04-13 2019-09-03 宁波大学 一种6-溴色胺衍生物及其制备方法和用途
PT3630098T (pt) * 2017-05-24 2021-04-21 H Lundbeck As Combinação de um antagonista do receptor 5-ht6 e de um inibidor de acetilcolinesterase para utilização no tratamento da doença de alzheimer numa subpopulação de pacientes portadores de alelos apoe4
CA3111309A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
MX2021003737A (es) 2018-09-28 2021-05-14 Janssen Pharmaceutica Nv Moduladores de monoacilglicerol lipasa.
MX2022003819A (es) 2019-09-30 2022-05-11 Janssen Pharmaceutica Nv Ligandos de pet de mgl radiomarcados.
NL2024431B1 (en) 2019-12-11 2021-09-07 Sulfateq Bv Compounds for treatment of alzheimer’s disease
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PL2892563T3 (pl) 2019-04-30
JP6693744B2 (ja) 2020-05-13
HRP20182069T1 (hr) 2019-02-08
PT2892563T (pt) 2019-01-10
SI2892563T1 (sl) 2019-02-28
US9789085B2 (en) 2017-10-17
MY182539A (en) 2021-01-25
EP2892563A1 (en) 2015-07-15
KR102342127B1 (ko) 2021-12-21
AU2013311573A8 (en) 2015-03-19
AP2015008306A0 (en) 2015-03-31
CL2015000578A1 (es) 2015-05-15
IL237369B (en) 2018-11-29
US9375418B2 (en) 2016-06-28
SG11201501774QA (en) 2015-05-28
CY1121062T1 (el) 2019-12-11
ES2703630T3 (es) 2019-03-11
KR20200137028A (ko) 2020-12-08
AU2013311573B2 (en) 2017-10-12
CA2883751C (en) 2020-11-24
US9687473B2 (en) 2017-06-27
MX368305B (es) 2019-09-27
NI201500031A (es) 2016-02-15
RU2675786C2 (ru) 2018-12-25
AU2013311573A1 (en) 2015-03-12
BR112015005117A2 (pt) 2017-07-04
US20160354343A1 (en) 2016-12-08
TWI632909B (zh) 2018-08-21
US20180071254A1 (en) 2018-03-15
WO2014037532A1 (en) 2014-03-13
TN2015000076A1 (en) 2016-06-29
BR112015005117B1 (pt) 2022-06-21
US10660878B2 (en) 2020-05-26
LT2892563T (lt) 2019-01-10
CA2883751A1 (en) 2014-03-13
JP2015528471A (ja) 2015-09-28
GEP201706776B (en) 2017-11-27
HK1212217A1 (en) 2016-06-10
JP2019059760A (ja) 2019-04-18
RS58104B1 (sr) 2019-02-28
US20160256437A1 (en) 2016-09-08
KR20150065680A (ko) 2015-06-15
TW201414474A (zh) 2014-04-16
CN104619344A (zh) 2015-05-13
US20140073681A1 (en) 2014-03-13
DK2892563T3 (en) 2019-01-21
RU2015107877A (ru) 2016-10-27
EP2892563B1 (en) 2018-11-14
MX2015002879A (es) 2015-07-06
EA201590353A1 (ru) 2016-03-31
IL237369A0 (en) 2015-04-30
NZ630589A (en) 2015-12-24
JO3459B1 (ar) 2020-07-05
SMT201800678T1 (it) 2019-02-28

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