AU2011338377B2 - Substituted pyrazolopyrimidines as glucocerebrosidase activators - Google Patents

Substituted pyrazolopyrimidines as glucocerebrosidase activators Download PDF

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Publication number
AU2011338377B2
AU2011338377B2 AU2011338377A AU2011338377A AU2011338377B2 AU 2011338377 B2 AU2011338377 B2 AU 2011338377B2 AU 2011338377 A AU2011338377 A AU 2011338377A AU 2011338377 A AU2011338377 A AU 2011338377A AU 2011338377 B2 AU2011338377 B2 AU 2011338377B2
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carboxamide
pyrimidine
difluoromethyl
phenyl
methyl
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AU2011338377A1 (en
AU2011338377A8 (en
Inventor
Ehud Goldin
Juan Jose Marugan
Omid Motabar
Samarjit Patnaik
Ellen Sidransky
Noel Southall
Wendy Westbrook
Wei Zheng
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US Department of Health and Human Services
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Government of the United States of America
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2011338377A 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators Active AU2011338377B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
US61/420,946 2010-12-08
PCT/US2011/063928 WO2012078855A1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (3)

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AU2011338377A1 AU2011338377A1 (en) 2013-07-04
AU2011338377A8 AU2011338377A8 (en) 2015-10-29
AU2011338377B2 true AU2011338377B2 (en) 2016-08-04

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AU2011338377A Active AU2011338377B2 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

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US (3) US9353117B2 (OSRAM)
EP (2) EP2649075B1 (OSRAM)
JP (1) JP6154746B2 (OSRAM)
KR (1) KR101931224B1 (OSRAM)
CN (1) CN103534255B (OSRAM)
AU (1) AU2011338377B2 (OSRAM)
BR (1) BR112013014242B1 (OSRAM)
CA (1) CA2820362C (OSRAM)
CY (1) CY1125186T1 (OSRAM)
DK (2) DK2649075T3 (OSRAM)
ES (2) ES2681218T3 (OSRAM)
HR (1) HRP20220512T1 (OSRAM)
HU (1) HUE038635T2 (OSRAM)
IL (2) IL226767B (OSRAM)
LT (1) LT3366688T (OSRAM)
MX (2) MX385600B (OSRAM)
PL (2) PL2649075T3 (OSRAM)
PT (2) PT2649075T (OSRAM)
RS (1) RS63320B1 (OSRAM)
RU (1) RU2603637C2 (OSRAM)
SI (2) SI2649075T1 (OSRAM)
TR (1) TR201810523T4 (OSRAM)
WO (1) WO2012078855A1 (OSRAM)
ZA (1) ZA201304215B (OSRAM)

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US9353117B2 (en) 2016-05-31
BR112013014242B1 (pt) 2022-02-22
EP3366688A1 (en) 2018-08-29
EP2649075A1 (en) 2013-10-16
KR101931224B1 (ko) 2018-12-20
AU2011338377A1 (en) 2013-07-04
JP6154746B2 (ja) 2017-06-28
IL259648A (en) 2018-07-31
RU2603637C2 (ru) 2016-11-27
SI3366688T1 (sl) 2022-07-29
RU2013126094A (ru) 2015-01-20
US20180263988A1 (en) 2018-09-20
BR112013014242A2 (pt) 2018-06-26
PT2649075T (pt) 2018-07-30
PL2649075T3 (pl) 2018-09-28
CN103534255A (zh) 2014-01-22
KR20140010012A (ko) 2014-01-23
WO2012078855A1 (en) 2012-06-14
EP2649075B1 (en) 2018-04-25
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IL259648B (en) 2021-03-25
SI2649075T1 (sl) 2018-10-30
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AU2011338377A8 (en) 2015-10-29
US10925874B2 (en) 2021-02-23
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