MX385600B - Pirazolopirimidinas sustituidas como activadores de la glucocerebrosidasa. - Google Patents
Pirazolopirimidinas sustituidas como activadores de la glucocerebrosidasa.Info
- Publication number
- MX385600B MX385600B MX2018000385A MX2018000385A MX385600B MX 385600 B MX385600 B MX 385600B MX 2018000385 A MX2018000385 A MX 2018000385A MX 2018000385 A MX2018000385 A MX 2018000385A MX 385600 B MX385600 B MX 385600B
- Authority
- MX
- Mexico
- Prior art keywords
- sub
- compounds
- substituted pyrazolopyrimidines
- glucocerebrosidase
- activators
- Prior art date
Links
- 102000004547 Glucosylceramidase Human genes 0.000 title 1
- 108010017544 Glucosylceramidase Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 2
- APXRHPDHORGIEB-UHFFFAOYSA-N 1H-pyrazolo[4,3-d]pyrimidine Chemical class N1=CN=C2C=NNC2=C1 APXRHPDHORGIEB-UHFFFAOYSA-N 0.000 abstract 1
- 208000015872 Gaucher disease Diseases 0.000 abstract 1
- 208000015439 Lysosomal storage disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42094610P | 2010-12-08 | 2010-12-08 | |
| PCT/US2011/063928 WO2012078855A1 (en) | 2010-12-08 | 2011-12-08 | Substituted pyrazolopyrimidines as glucocerebrosidase activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX385600B true MX385600B (es) | 2025-03-18 |
Family
ID=45498099
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000385A MX385600B (es) | 2010-12-08 | 2011-12-08 | Pirazolopirimidinas sustituidas como activadores de la glucocerebrosidasa. |
| MX2013006462A MX354506B (es) | 2010-12-08 | 2011-12-08 | Pirazolopirimidinas sustituidas como activadores de glucocerebrosidasa. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013006462A MX354506B (es) | 2010-12-08 | 2011-12-08 | Pirazolopirimidinas sustituidas como activadores de glucocerebrosidasa. |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US9353117B2 (OSRAM) |
| EP (2) | EP2649075B1 (OSRAM) |
| JP (1) | JP6154746B2 (OSRAM) |
| KR (1) | KR101931224B1 (OSRAM) |
| CN (1) | CN103534255B (OSRAM) |
| AU (1) | AU2011338377B2 (OSRAM) |
| BR (1) | BR112013014242B1 (OSRAM) |
| CA (1) | CA2820362C (OSRAM) |
| CY (1) | CY1125186T1 (OSRAM) |
| DK (2) | DK2649075T3 (OSRAM) |
| ES (2) | ES2681218T3 (OSRAM) |
| HR (1) | HRP20220512T1 (OSRAM) |
| HU (1) | HUE038635T2 (OSRAM) |
| IL (2) | IL226767B (OSRAM) |
| LT (1) | LT3366688T (OSRAM) |
| MX (2) | MX385600B (OSRAM) |
| PL (2) | PL2649075T3 (OSRAM) |
| PT (2) | PT2649075T (OSRAM) |
| RS (1) | RS63320B1 (OSRAM) |
| RU (1) | RU2603637C2 (OSRAM) |
| SI (2) | SI2649075T1 (OSRAM) |
| TR (1) | TR201810523T4 (OSRAM) |
| WO (1) | WO2012078855A1 (OSRAM) |
| ZA (1) | ZA201304215B (OSRAM) |
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| JP2014517079A (ja) | 2011-06-22 | 2014-07-17 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ａｔｒキナーゼ阻害剤として有用な化合物 |
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| EP2723717A2 (en) | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
| MX2013015058A (es) | 2011-06-24 | 2014-01-20 | Amgen Inc | Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos. |
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| JP2016512239A (ja) | 2013-03-15 | 2016-04-25 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ａｔｒキナーゼの阻害剤として有用な化合物 |
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2011
- 2011-12-08 SI SI201131532T patent/SI2649075T1/sl unknown
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- 2011-12-08 CN CN201180066859.7A patent/CN103534255B/zh active Active
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- 2011-12-08 KR KR1020137017520A patent/KR101931224B1/ko active Active
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2013
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2016
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2018
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2022
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