PL2649075T3 - Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy - Google Patents

Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy

Info

Publication number
PL2649075T3
PL2649075T3 PL11810714T PL11810714T PL2649075T3 PL 2649075 T3 PL2649075 T3 PL 2649075T3 PL 11810714 T PL11810714 T PL 11810714T PL 11810714 T PL11810714 T PL 11810714T PL 2649075 T3 PL2649075 T3 PL 2649075T3
Authority
PL
Poland
Prior art keywords
substituted pyrazolopyrimidines
glucocerebrosidase
activators
glucocerebrosidase activators
pyrazolopyrimidines
Prior art date
Application number
PL11810714T
Other languages
English (en)
Inventor
Juan Jose Marugan
Noel Southall
Ehud Goldin
Samarjit Patnaik
Ellen Sidransky
Omid Motabar
Wendy Westbrook
Wei Zheng
Original Assignee
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The U.S.A. As Represented By The Secretary, Department Of Health And Human Services filed Critical The U.S.A. As Represented By The Secretary, Department Of Health And Human Services
Publication of PL2649075T3 publication Critical patent/PL2649075T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
PL11810714T 2010-12-08 2011-12-08 Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy PL2649075T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
PCT/US2011/063928 WO2012078855A1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators
EP11810714.3A EP2649075B1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (1)

Publication Number Publication Date
PL2649075T3 true PL2649075T3 (pl) 2018-09-28

Family

ID=45498099

Family Applications (2)

Application Number Title Priority Date Filing Date
PL11810714T PL2649075T3 (pl) 2010-12-08 2011-12-08 Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy
PL18165005T PL3366688T3 (pl) 2010-12-08 2011-12-08 Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL18165005T PL3366688T3 (pl) 2010-12-08 2011-12-08 Podstawione pirazolopirymidyny jako aktywatory glukocerebrozydazy

Country Status (23)

Country Link
US (3) US9353117B2 (pl)
EP (2) EP3366688B1 (pl)
JP (1) JP6154746B2 (pl)
KR (1) KR101931224B1 (pl)
CN (1) CN103534255B (pl)
AU (1) AU2011338377B2 (pl)
BR (1) BR112013014242B1 (pl)
CA (1) CA2820362C (pl)
DK (2) DK3366688T3 (pl)
ES (2) ES2681218T3 (pl)
HR (1) HRP20220512T1 (pl)
HU (1) HUE038635T2 (pl)
IL (2) IL226767B (pl)
LT (1) LT3366688T (pl)
MX (1) MX354506B (pl)
PL (2) PL2649075T3 (pl)
PT (2) PT3366688T (pl)
RS (1) RS63320B1 (pl)
RU (1) RU2603637C2 (pl)
SI (2) SI3366688T1 (pl)
TR (1) TR201810523T4 (pl)
WO (1) WO2012078855A1 (pl)
ZA (1) ZA201304215B (pl)

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Also Published As

Publication number Publication date
BR112013014242B1 (pt) 2022-02-22
KR20140010012A (ko) 2014-01-23
CA2820362A1 (en) 2012-06-14
LT3366688T (lt) 2022-05-25
US9353117B2 (en) 2016-05-31
MX2013006462A (es) 2013-10-01
EP2649075B1 (en) 2018-04-25
AU2011338377A1 (en) 2013-07-04
TR201810523T4 (tr) 2018-08-27
WO2012078855A1 (en) 2012-06-14
EP3366688A1 (en) 2018-08-29
ES2912284T3 (es) 2022-05-25
AU2011338377A8 (en) 2015-10-29
PL3366688T3 (pl) 2022-05-23
HRP20220512T1 (hr) 2022-05-27
US20140249145A1 (en) 2014-09-04
US20180263988A1 (en) 2018-09-20
DK2649075T3 (en) 2018-07-30
KR101931224B1 (ko) 2018-12-20
EP3366688B1 (en) 2022-02-09
US9974789B2 (en) 2018-05-22
PT2649075T (pt) 2018-07-30
CA2820362C (en) 2020-03-24
CN103534255A (zh) 2014-01-22
PT3366688T (pt) 2022-05-11
HUE038635T2 (hu) 2018-11-28
US10925874B2 (en) 2021-02-23
RU2013126094A (ru) 2015-01-20
ZA201304215B (en) 2014-03-26
ES2681218T3 (es) 2018-09-12
IL259648A (en) 2018-07-31
MX354506B (es) 2018-01-16
JP6154746B2 (ja) 2017-06-28
DK3366688T3 (da) 2022-05-02
BR112013014242A2 (pt) 2018-06-26
SI2649075T1 (sl) 2018-10-30
SI3366688T1 (sl) 2022-07-29
AU2011338377B2 (en) 2016-08-04
EP2649075A1 (en) 2013-10-16
RU2603637C2 (ru) 2016-11-27
RS63320B1 (sr) 2022-07-29
CN103534255B (zh) 2016-12-21
US20160346284A1 (en) 2016-12-01
IL226767B (en) 2018-06-28
JP2013544893A (ja) 2013-12-19
IL259648B (en) 2021-03-25

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