CN103534255B - 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 - Google Patents

作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 Download PDF

Info

Publication number
CN103534255B
CN103534255B CN201180066859.7A CN201180066859A CN103534255B CN 103534255 B CN103534255 B CN 103534255B CN 201180066859 A CN201180066859 A CN 201180066859A CN 103534255 B CN103534255 B CN 103534255B
Authority
CN
China
Prior art keywords
pyrimidine
carboxamide
alkyl
difluoromethyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201180066859.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN103534255A (zh
Inventor
胡安·乔斯·马鲁甘
诺埃尔·索撒尔
埃胡德·戈尔金
伟·郑
S·帕特奈克
艾伦·西德兰斯基
奥米德·莫塔巴尔
文迪·韦斯特布鲁克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Original Assignee
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Health and Human Services filed Critical US Department of Health and Human Services
Publication of CN103534255A publication Critical patent/CN103534255A/zh
Application granted granted Critical
Publication of CN103534255B publication Critical patent/CN103534255B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201180066859.7A 2010-12-08 2011-12-08 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶 Active CN103534255B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
US61/420,946 2010-12-08
PCT/US2011/063928 WO2012078855A1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (2)

Publication Number Publication Date
CN103534255A CN103534255A (zh) 2014-01-22
CN103534255B true CN103534255B (zh) 2016-12-21

Family

ID=45498099

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201180066859.7A Active CN103534255B (zh) 2010-12-08 2011-12-08 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶

Country Status (24)

Country Link
US (3) US9353117B2 (OSRAM)
EP (2) EP2649075B1 (OSRAM)
JP (1) JP6154746B2 (OSRAM)
KR (1) KR101931224B1 (OSRAM)
CN (1) CN103534255B (OSRAM)
AU (1) AU2011338377B2 (OSRAM)
BR (1) BR112013014242B1 (OSRAM)
CA (1) CA2820362C (OSRAM)
CY (1) CY1125186T1 (OSRAM)
DK (2) DK2649075T3 (OSRAM)
ES (2) ES2681218T3 (OSRAM)
HR (1) HRP20220512T1 (OSRAM)
HU (1) HUE038635T2 (OSRAM)
IL (2) IL226767B (OSRAM)
LT (1) LT3366688T (OSRAM)
MX (2) MX385600B (OSRAM)
PL (2) PL2649075T3 (OSRAM)
PT (2) PT2649075T (OSRAM)
RS (1) RS63320B1 (OSRAM)
RU (1) RU2603637C2 (OSRAM)
SI (2) SI2649075T1 (OSRAM)
TR (1) TR201810523T4 (OSRAM)
WO (1) WO2012078855A1 (OSRAM)
ZA (1) ZA201304215B (OSRAM)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2649075T1 (sl) 2010-12-08 2018-10-30 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Substituirani pirazolopirimidini kot aktivatorji glukocerebrozidaze
JP2014517079A (ja) 2011-06-22 2014-07-17 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US9845327B2 (en) * 2011-06-22 2017-12-19 The General Hospital Corporation Treatment of proteinopathies
EP2723717A2 (en) 2011-06-24 2014-04-30 Amgen Inc. Trpm8 antagonists and their use in treatments
MX2013015058A (es) 2011-06-24 2014-01-20 Amgen Inc Antagonistas de melastatina 8 de potencial receptor transitorio y su uso en tratamientos.
WO2013059587A1 (en) * 2011-10-20 2013-04-25 Sirtris Pharmaceuticals, Inc. Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
US8940742B2 (en) 2012-04-10 2015-01-27 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
PT4190786T (pt) 2012-12-07 2025-05-29 Vertex Pharma Compostos úteis como inibidores da quinase atr
JP2016512816A (ja) 2013-03-15 2016-05-09 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
JP2016512239A (ja) 2013-03-15 2016-04-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物
EP2970286A1 (en) 2013-03-15 2016-01-20 Vertex Pharmaceuticals Inc. Fused pyrazolopyrimidine derivatives useful as inhibitors of atr kinase
MX389256B (es) 2013-10-04 2025-03-20 Infinity Pharmaceuticals Inc Compuestos heterociclicos y usos de los mismos.
US9751888B2 (en) 2013-10-04 2017-09-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
CA2932757C (en) 2013-12-06 2023-10-31 Vertex Pharmaceuticals Incorporated 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, its preparation, different solid forms and radiolabelled derivatives thereof
EA201691872A1 (ru) 2014-03-19 2017-04-28 Инфинити Фармасьютикалз, Инк. Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств
KR102575125B1 (ko) 2014-06-05 2023-09-07 버텍스 파마슈티칼스 인코포레이티드 Atr 키나제의 저해제로서 유용한 2-아미노-6-플루오로-n-[5-플루오로-피리딘-3-일]-피라졸로[1,5-a]피리미딘-3-카복스아미드 화합물의 방사성표지된 유도체, 상기 화합물의 제조 및 이의 다양한 고체 형태
RU2736219C2 (ru) 2014-06-17 2020-11-12 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации ингибиторов снк1 и atr
WO2016054491A1 (en) 2014-10-03 2016-04-07 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
MX2017005586A (es) 2014-11-03 2017-06-19 Bayer Pharma AG Piperidinilpirazolopirimidinonas y utilización de las mismas.
US20180185368A1 (en) 2014-11-06 2018-07-05 Lysosomal Therapeutics Inc. Substituted pyrrolo[1,2-a]pyrimidines and their use in the treatment of medical disorders
KR102662215B1 (ko) * 2014-11-06 2024-05-02 비알 - 알&디 인베스트먼츠, 에스.에이. 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도
ES2958391T3 (es) 2014-11-06 2024-02-08 Bial R&D Invest S A Imidazo[1,5-a]pirimidinas sustituidas y su uso en el tratamiento de trastornos médicos
EP3317282B1 (en) 2015-07-01 2020-12-09 Northwestern University Substituted 4-methyl-pyrrolo[1.2-a]pyrimidine-8-carboxamide compounds and uses thereof for modulating glucocerebrosidase activity
WO2017040879A1 (en) * 2015-09-04 2017-03-09 Lysosomal Therapeutics Inc. Thiazolo(3,2-a) pyrimidinone and other heterobicyclic pyrimidinone compounds for use in medical therapy
EP3344632A4 (en) * 2015-09-04 2019-03-20 Lysosomal Therapeutics Inc. Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
CN108349985A (zh) 2015-09-14 2018-07-31 无限药品股份有限公司 异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
AU2016331955B2 (en) 2015-09-30 2022-07-21 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of DNA damaging agents and ATR inhibitors
EP3429590A4 (en) * 2016-03-16 2020-02-19 Lysosomal Therapeutics Inc. METHOD AND COMPOSITIONS FOR THE TREATMENT OF A NEURODEGENERATIVE DISEASE IN A SUBJECT CARRIING THE SPHINGOLIPIDOSIS GENE
WO2017161116A1 (en) 2016-03-17 2017-09-21 Infinity Pharmaceuticals, Inc. Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors
CA3020310A1 (en) * 2016-04-06 2017-10-12 Lysosomal Therapeutics Inc. Pyrrolo[1,2-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
KR20230104752A9 (ko) * 2016-04-06 2024-11-15 비알 - 알&디 인베스트먼츠, 에스.에이. 피라졸로[1,5-a]피리미디닐 카르복스아미드 화합물및 의학적 장애의 치료에서의 그의 용도
US10787454B2 (en) 2016-04-06 2020-09-29 BIAL—BioTech Investments, Inc. Imidazo[1,5-a]pyrimidinyl carboxamide compounds and their use in the treatment of medical disorders
EP3452455A4 (en) * 2016-05-05 2019-11-13 Lysosomal Therapeutics Inc. SUBSTITUTED IMDAZO [1,2-] PYRIDINES, SUBSTITUTED IMIDAZO [1,2-] PYRAZINES, RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF ILLNESSES
WO2017192929A1 (en) * 2016-05-05 2017-11-09 Lysosomal Therapeutics Inc. SUBSTITUTED PYRROLO[1,2-α]TRIAZINES AND RELATED COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS
JP7164774B2 (ja) * 2016-05-05 2022-11-02 ビアル－アール・アンド・ディ・インベストメンツ・ソシエダーデ・アノニマ 置換イミダゾ［１，２－ｂ］ピリダジン、置換イミダゾ［１，５－ｂ］ピリダジン、関連化合物、および医学的障害の治療におけるその使用
WO2017214269A1 (en) 2016-06-08 2017-12-14 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
EP3535273A1 (en) * 2016-11-02 2019-09-11 H. Hoffnabb-La Roche Ag PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS
EP3658557B1 (en) * 2017-07-28 2024-06-05 Takeda Pharmaceutical Company Limited Tyk2 inhibitors and uses thereof
US12291533B2 (en) 2017-08-02 2025-05-06 Northwestern University Substituted fused pyrimidine compounds and uses thereof
ES2950757T3 (es) 2017-10-06 2023-10-13 Forma Therapeutics Inc Inhibición de la peptidasa específica de la ubiquitina 30
JP7317721B2 (ja) 2018-01-31 2023-07-31 武田薬品工業株式会社 複素環化合物
BR112020021921A2 (pt) 2018-05-17 2021-01-26 Forma Therapeutics, Inc. compostos bicíclicos fundidos úteis como inibidores de peptidase 30 específica de ubiquitina
US10882865B2 (en) 2018-08-31 2021-01-05 Northwestern University Pyrrolopyrimidine compounds and uses thereof for modulating glucocerebrosidase activity
ES2938751T3 (es) 2018-09-10 2023-04-14 Lilly Co Eli Derivados de pirazol[1,5-a]pirimidina-3-carboxamida útiles en el tratamiento de la psoriasis y el lupus eritematoso sistémico
LT3860989T (lt) 2018-10-05 2023-06-12 Forma Therapeutics, Inc. Sulieti pirolinai, kurie veikia kaip ubikvitinui specifinės proteazės 30 (ups30) inhibitoriai
WO2020081508A1 (en) * 2018-10-15 2020-04-23 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
AR117177A1 (es) 2018-12-10 2021-07-14 Lilly Co Eli DERIVADOS DE 7-(METILAMINO)PIRAZOLO[1,5-A]PIRIMIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE IL-23 E INFa
KR102821711B1 (ko) * 2019-08-21 2025-06-16 더 스크립스 리서치 인스티튜트 인터페론 유전자의 자극인자 sting의 비시클릭 효능제
CN114901652A (zh) 2019-09-17 2022-08-12 比亚尔R&D投资股份公司 用于治疗医学病症的经取代的饱和和不饱和n-杂环甲酰胺及相关化合物
WO2021055612A1 (en) 2019-09-17 2021-03-25 BIAL-BioTech Investments, Inc. Substituted imidazole carboxamides and their use in the treatment of medical disorders
WO2021055627A1 (en) 2019-09-17 2021-03-25 Bial- Biotech Investments, Inc. Substituted n-heterocyclic carboxamides as acid ceramidase inhibitors and their use as medicaments
AU2020393174A1 (en) * 2019-11-25 2022-06-30 Gt Gain Therapeutics Sa Aryl and heteroaryl compounds, and therapeutic uses thereof in conditions associated with the alteration of the activity of galactocerebrosidase
AR121251A1 (es) 2020-02-12 2022-05-04 Lilly Co Eli Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089471A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF
WO2006087120A2 (de) * 2005-02-17 2006-08-24 Bayer Cropscience Ag Pyrazolopyrimidine
WO2007048066A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators
WO2009152083A1 (en) * 2008-06-10 2009-12-17 Plexxikon, Inc. 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004037373A2 (en) 2002-10-21 2004-05-06 The Scripps Research Institute CHEMICAL CHAPERONES AND THEIR EFFECT UPON THE CELLULAR ACTIVITY OF β-GLUCOSIDASE
JP2004277337A (ja) 2003-03-14 2004-10-07 Sumitomo Pharmaceut Co Ltd ピラゾロ［１，５−ａ］ピリミジン誘導体
CN1901907A (zh) 2003-11-12 2007-01-24 阿米库斯治疗学公司 用于治疗戈谢病的葡糖并咪唑和多羟基环己烯基胺衍生物
CA2507348C (en) * 2004-05-13 2013-07-16 The Hospital For Sick Children Real time methylumbelliferone-based assay
DE602005007215D1 (de) * 2004-05-14 2008-07-10 Cleveland Clinic Foundation Kleinmolekülige hemmer für mrp1 und andere multiarzneimitteltransporter
SI1761541T1 (sl) 2004-06-21 2008-06-30 Hoffmann La Roche Derivati pirazolo-pirimidina
US20070155737A1 (en) 2005-05-20 2007-07-05 Alantos Pharmaceuticals, Inc. Heterobicyclic metalloprotease inhibitors
KR20080087070A (ko) 2005-05-20 2008-09-30 알란토스 파마슈티컬즈 홀딩, 인코포레이티드 피리미딘 또는 트리아진 융합된 비시클릭 메탈로프로테아제억제제
WO2007008541A2 (en) 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
AU2006281497B2 (en) * 2005-08-15 2012-06-07 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as P2X3 antagonists
AU2006305104B2 (en) * 2005-10-21 2009-10-22 Mitsubishi Tanabe Pharma Corporation Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists
WO2008054947A2 (en) 2006-10-02 2008-05-08 The Brigham And Women's Hospital, Inc. Structure of acid beta-glucosidase and methods for identifying therapeutic agents
US20090275586A1 (en) 2006-10-06 2009-11-05 Kalypsys, Inc. Heterocyclic inhibitors of pde4
EP2102211A2 (en) 2006-11-20 2009-09-23 Alantos Pharmaceuticals Holding, Inc. Heterobicyclic metalloprotease inhibitors
WO2008128106A1 (en) 2007-04-13 2008-10-23 Amicus Therapeutics, Inc. Treatment of gaucher disease with specific pharmacological chaperones and monitoring treatment using surrogate markers
US20090215778A1 (en) 2007-04-27 2009-08-27 Panacos Pharmaceuticals, Inc. Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives
HUE027278T2 (en) 2007-05-16 2016-11-28 Brigham & Womens Hospital Inc Treatment of synucleinopathies
US20090118135A1 (en) 2007-06-08 2009-05-07 The Burnham Institute Methods and compounds for regulating apoptosis
JP5337405B2 (ja) 2007-09-17 2013-11-06 ザ・ホスピタル・フォー・シック・チルドレン ゴーシェ病の治療方法
WO2009049421A1 (en) 2007-10-18 2009-04-23 The Hospital For Sick Children Compositions and methods for enhancing enzyme activity in gaucher, gm1-gangliosidosis/morquio b disease, and parkinson's disease
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2010003023A2 (en) 2008-07-01 2010-01-07 Zacharon Pharmaceuticals, Inc. Heparan sulfate inhibitors
SI2649075T1 (sl) * 2010-12-08 2018-10-30 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Substituirani pirazolopirimidini kot aktivatorji glukocerebrozidaze
KR102662215B1 (ko) * 2014-11-06 2024-05-02 비알 - 알&디 인베스트먼츠, 에스.에이. 치환된 피라졸로(1,5-a)피리미딘 및 의학적 장애의 치료에서의 그의 용도

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004089471A2 (en) * 2003-04-11 2004-10-21 Novo Nordisk A/S NEW PYRAZOLO[1,5-a] PYRIMIDINES DERIVATIVES AND PHARMACEUTICAL USE THEREOF
WO2006087120A2 (de) * 2005-02-17 2006-08-24 Bayer Cropscience Ag Pyrazolopyrimidine
WO2007048066A2 (en) * 2005-10-21 2007-04-26 Exelixis, Inc. Pyrazolo-pyrimidines as casein kinase ii (ck2) modulators
WO2009152083A1 (en) * 2008-06-10 2009-12-17 Plexxikon, Inc. 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor
WO2010086040A1 (en) * 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy

Also Published As

Publication number Publication date
US9353117B2 (en) 2016-05-31
BR112013014242B1 (pt) 2022-02-22
EP3366688A1 (en) 2018-08-29
EP2649075A1 (en) 2013-10-16
KR101931224B1 (ko) 2018-12-20
AU2011338377A1 (en) 2013-07-04
JP6154746B2 (ja) 2017-06-28
IL259648A (en) 2018-07-31
RU2603637C2 (ru) 2016-11-27
SI3366688T1 (sl) 2022-07-29
RU2013126094A (ru) 2015-01-20
AU2011338377B2 (en) 2016-08-04
US20180263988A1 (en) 2018-09-20
BR112013014242A2 (pt) 2018-06-26
PT2649075T (pt) 2018-07-30
PL2649075T3 (pl) 2018-09-28
CN103534255A (zh) 2014-01-22
KR20140010012A (ko) 2014-01-23
WO2012078855A1 (en) 2012-06-14
EP2649075B1 (en) 2018-04-25
US9974789B2 (en) 2018-05-22
PL3366688T3 (pl) 2022-05-23
DK3366688T3 (da) 2022-05-02
TR201810523T4 (tr) 2018-08-27
MX354506B (es) 2018-01-16
IL226767B (en) 2018-06-28
DK2649075T3 (en) 2018-07-30
IL259648B (en) 2021-03-25
SI2649075T1 (sl) 2018-10-30
ES2681218T3 (es) 2018-09-12
HRP20220512T1 (hr) 2022-05-27
MX2013006462A (es) 2013-10-01
LT3366688T (lt) 2022-05-25
ES2912284T3 (es) 2022-05-25
JP2013544893A (ja) 2013-12-19
HUE038635T2 (hu) 2018-11-28
EP3366688B1 (en) 2022-02-09
CA2820362A1 (en) 2012-06-14
CY1125186T1 (el) 2024-12-13
PT3366688T (pt) 2022-05-11
MX385600B (es) 2025-03-18
CA2820362C (en) 2020-03-24
RS63320B1 (sr) 2022-07-29
AU2011338377A8 (en) 2015-10-29
US10925874B2 (en) 2021-02-23
US20160346284A1 (en) 2016-12-01
US20140249145A1 (en) 2014-09-04
ZA201304215B (en) 2014-03-26

Similar Documents

Publication Publication Date Title
CN103534255B (zh) 作为葡萄糖脑苷脂酶激活剂的取代的吡唑并嘧啶
CN112313231B (zh) Oga抑制剂化合物
US6825184B2 (en) 1,4-Disubstituted benzo-fused urea compounds
US9464035B2 (en) Salicylic acid derivatives useful as glucocerebrosidase activators
US6635647B2 (en) Decahydro-isoquinolines
JP2018533594A (ja) 筋萎縮性側索硬化症を処置するための化合物
US20210387953A1 (en) Benzoxazole and related compounds useful as chaperone-mediated autophagy modulators
TWI688565B (zh) 萘啶二酮（ｎａｐｈｔｈｙｒｉｄｉｎｅｄｉｏｎｅ）衍生物
CN114149432A (zh) 用于癌症治疗的双重clk/cdk1抑制剂
US11834424B2 (en) Compounds useful as chaperone-mediated autophagy modulators
TW202404591A (zh) 作為pi3k抑制劑之苯并嘧啶-4(3h)-酮
KR20240155871A (ko) 소르틸린 의존성 질병의 치료를 위한 아미노산 기반 카바메이트 및/또는 요소
JP2023507180A (ja) Ｏｇａ阻害剤化合物
JP2020514284A (ja) イソキノリン化合物、その調製の方法、およびベータガラクトシダーゼの活性の変質に伴う状態におけるその治療的使用
JP2023512482A (ja) Ｆｇｆｒキナーゼ阻害剤としてのピリダジンおよび１，２，４－トリアジン誘導体

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant